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0.1 Volcano plot of feature difference between visits

0.2 Boxplots

0.2.1 Antigen: DT

0.2.1.1 DT_ADCD

0.2.1.2 DT_ADCP

0.2.1.3 DT_ADNP

0.2.1.4 DT_FcgR2a

0.2.1.5 DT_FcgR3b

0.2.1.6 DT_IgG

0.2.1.7 DT_IgG1

0.2.1.8 DT_IgG2

0.2.1.9 DT_IgG3

0.2.1.10 DT_IgG4

0.2.2 Antigen: FHA

0.2.2.1 FHA_ADCD

0.2.2.2 FHA_ADCP

0.2.2.3 FHA_ADNP

0.2.2.4 FHA_FcgR2a

0.2.2.5 FHA_FcgR3b

0.2.2.6 FHA_IgG

0.2.2.7 FHA_IgG1

0.2.2.8 FHA_IgG2

0.2.2.9 FHA_IgG3

0.2.2.10 FHA_IgG4

0.2.3 Antigen: PRN

0.2.3.1 PRN_ADCD

0.2.3.2 PRN_ADCP

0.2.3.3 PRN_ADNP

0.2.3.4 PRN_FcgR2a

0.2.3.5 PRN_FcgR3b

0.2.3.6 PRN_IgG

0.2.3.7 PRN_IgG1

0.2.3.8 PRN_IgG2

0.2.3.9 PRN_IgG3

0.2.3.10 PRN_IgG4

0.2.4 Antigen: PT

0.2.4.1 PT_ADCD

0.2.4.2 PT_ADCP

0.2.4.3 PT_ADNP

0.2.4.4 PT_FcgR2a

0.2.4.5 PT_FcgR3b

0.2.4.6 PT_IgG

0.2.4.7 PT_IgG1

0.2.4.8 PT_IgG2

0.2.4.9 PT_IgG3

0.2.4.10 PT_IgG4

0.2.5 Antigen: TT

0.2.5.1 TT_ADCD

0.2.5.2 TT_ADCP

0.2.5.3 TT_ADNP

0.2.5.4 TT_FcgR2a

0.2.5.5 TT_FcgR3b

0.2.5.6 TT_IgG

0.2.5.7 TT_IgG1

0.2.5.8 TT_IgG2

0.2.5.9 TT_IgG3

0.2.5.10 TT_IgG4

0.3 mTdap-

0.3.1 boosted

0.3.1.1 DT

group subgrp outcome covariate Beta pval
DT DT_ADCD boosted - vaccinated boosted 0.001.35-0.19 0.18613
DT DT_ADCP boosted - vaccinated boosted 0.001.100.65 <0.0001****
DT DT_ADNP boosted - vaccinated boosted 0.001.420.94 <0.0001****
DT DT_FcgR2a boosted - vaccinated boosted 0.000.70-1.79 0.46217
DT DT_FcgR3b boosted - vaccinated boosted 0.000.36-2.60 0.18613
DT DT_IgG boosted - vaccinated boosted 0.000.24-0.20 0.87825
DT DT_IgG1 boosted - vaccinated boosted 0.000.43-0.30 0.7551
DT DT_IgG2 boosted - vaccinated boosted 0.000.860.48 <0.0001****
DT DT_IgG3 boosted - vaccinated boosted 0.001.090.26 0.00458**
DT DT_IgG4 boosted - vaccinated boosted 0.000.940.42 <0.0001****
DT DT_ADCD boosted - vaccinated boosted 0.001.35-0.19 0.18613
DT DT_ADCP boosted - vaccinated boosted 0.001.100.65 <0.0001****
DT DT_ADNP boosted - vaccinated boosted 0.001.420.94 <0.0001****
DT DT_FcgR2a boosted - vaccinated boosted 0.000.70-1.79 0.46217
DT DT_FcgR3b boosted - vaccinated boosted 0.000.36-2.60 0.18613
DT DT_IgG boosted - vaccinated boosted 0.000.24-0.20 0.87825
DT DT_IgG1 boosted - vaccinated boosted 0.000.43-0.30 0.7551
DT DT_IgG2 boosted - vaccinated boosted 0.000.860.48 <0.0001****
DT DT_IgG3 boosted - vaccinated boosted 0.001.090.26 0.00458**
DT DT_IgG4 boosted - vaccinated boosted 0.000.940.42 <0.0001****

0.3.1.2 FHA

group subgrp outcome covariate Beta pval
FHA FHA_ADCD boosted - vaccinated boosted 0.001.180.16 0.0227*
FHA FHA_ADCP boosted - vaccinated boosted 0.000.440.12 0.00248**
FHA FHA_ADNP boosted - vaccinated boosted 0.000.790.32 0.0001****
FHA FHA_FcgR2a boosted - vaccinated boosted 0.00-0.17-1.45 0.02658*
FHA FHA_FcgR3b boosted - vaccinated boosted 0.000.14-1.12 0.17917
FHA FHA_IgG boosted - vaccinated boosted 0.000.32-0.08 0.3152
FHA FHA_IgG1 boosted - vaccinated boosted 0.000.670.24 0.00034***
FHA FHA_IgG2 boosted - vaccinated boosted 0.000.830.52 <0.0001****
FHA FHA_IgG3 boosted - vaccinated boosted 0.000.96-0.02 0.09516
FHA FHA_IgG4 boosted - vaccinated boosted 0.000.790.31 0.00012***
FHA FHA_ADCD boosted - vaccinated boosted 0.001.180.16 0.0227*
FHA FHA_ADCP boosted - vaccinated boosted 0.000.440.12 0.00248**
FHA FHA_ADNP boosted - vaccinated boosted 0.000.790.32 0.0001****
FHA FHA_FcgR2a boosted - vaccinated boosted 0.00-0.17-1.45 0.02658*
FHA FHA_FcgR3b boosted - vaccinated boosted 0.000.14-1.12 0.17917
FHA FHA_IgG boosted - vaccinated boosted 0.000.32-0.08 0.3152
FHA FHA_IgG1 boosted - vaccinated boosted 0.000.670.24 0.00034***
FHA FHA_IgG2 boosted - vaccinated boosted 0.000.830.52 <0.0001****
FHA FHA_IgG3 boosted - vaccinated boosted 0.000.96-0.02 0.09516
FHA FHA_IgG4 boosted - vaccinated boosted 0.000.790.31 0.00012***

0.3.1.3 PRN

group subgrp outcome covariate Beta pval
PRN PRN_ADCD boosted - vaccinated boosted 0.001.14-0.18 0.20233
PRN PRN_ADCP boosted - vaccinated boosted 0.000.450.10 0.00717**
PRN PRN_ADNP boosted - vaccinated boosted 0.001.020.60 <0.0001****
PRN PRN_FcgR2a boosted - vaccinated boosted 0.000.62-0.29 0.54305
PRN PRN_FcgR3b boosted - vaccinated boosted 0.000.56-0.58 0.97571
PRN PRN_IgG boosted - vaccinated boosted 0.000.25-0.04 0.20646
PRN PRN_IgG1 boosted - vaccinated boosted 0.000.730.23 0.00091***
PRN PRN_IgG2 boosted - vaccinated boosted 0.000.500.18 0.00031***
PRN PRN_IgG3 boosted - vaccinated boosted 0.001.060.12 0.02883*
PRN PRN_IgG4 boosted - vaccinated boosted 0.000.990.65 <0.0001****
PRN PRN_ADCD boosted - vaccinated boosted 0.001.14-0.18 0.20233
PRN PRN_ADCP boosted - vaccinated boosted 0.000.450.10 0.00717**
PRN PRN_ADNP boosted - vaccinated boosted 0.001.020.60 <0.0001****
PRN PRN_FcgR2a boosted - vaccinated boosted 0.000.62-0.29 0.54305
PRN PRN_FcgR3b boosted - vaccinated boosted 0.000.56-0.58 0.97571
PRN PRN_IgG boosted - vaccinated boosted 0.000.25-0.04 0.20646
PRN PRN_IgG1 boosted - vaccinated boosted 0.000.730.23 0.00091***
PRN PRN_IgG2 boosted - vaccinated boosted 0.000.500.18 0.00031***
PRN PRN_IgG3 boosted - vaccinated boosted 0.001.060.12 0.02883*
PRN PRN_IgG4 boosted - vaccinated boosted 0.000.990.65 <0.0001****

0.3.1.4 PT

group subgrp outcome covariate Beta pval
PT PT_ADCD boosted - vaccinated boosted 0.000.76-0.35 0.54305
PT PT_ADCP boosted - vaccinated boosted 0.000.17-0.52 0.39065
PT PT_ADNP boosted - vaccinated boosted 0.001.230.10 0.04004*
PT PT_FcgR2a boosted - vaccinated boosted 0.000.01-1.37 0.0896
PT PT_FcgR3b boosted - vaccinated boosted 0.000.65-0.38 0.657
PT PT_IgG boosted - vaccinated boosted 0.000.30-0.14 0.54305
PT PT_IgG1 boosted - vaccinated boosted 0.000.680.13 0.01023*
PT PT_IgG2 boosted - vaccinated boosted 0.000.33-0.10 0.34719
PT PT_IgG3 boosted - vaccinated boosted 0.000.69-0.09 0.18613
PT PT_IgG4 boosted - vaccinated boosted 0.000.900.52 <0.0001****
PT PT_ADCD boosted - vaccinated boosted 0.000.76-0.35 0.54305
PT PT_ADCP boosted - vaccinated boosted 0.000.17-0.52 0.39065
PT PT_ADNP boosted - vaccinated boosted 0.001.230.10 0.04004*
PT PT_FcgR2a boosted - vaccinated boosted 0.000.01-1.37 0.0896
PT PT_FcgR3b boosted - vaccinated boosted 0.000.65-0.38 0.657
PT PT_IgG boosted - vaccinated boosted 0.000.30-0.14 0.54305
PT PT_IgG1 boosted - vaccinated boosted 0.000.680.13 0.01023*
PT PT_IgG2 boosted - vaccinated boosted 0.000.33-0.10 0.34719
PT PT_IgG3 boosted - vaccinated boosted 0.000.69-0.09 0.18613
PT PT_IgG4 boosted - vaccinated boosted 0.000.900.52 <0.0001****

0.3.1.5 TT

group subgrp outcome covariate Beta pval
TT TT_ADCD boosted - vaccinated boosted 0.002.390.31 0.02383*
TT TT_ADCP boosted - vaccinated boosted 0.001.060.16 0.01894*
TT TT_ADNP boosted - vaccinated boosted 0.000.79-0.15 0.23399
TT TT_FcgR2a boosted - vaccinated boosted 0.002.05-1.45 0.76232
TT TT_FcgR3b boosted - vaccinated boosted 0.001.60-2.90 0.6194
TT TT_IgG boosted - vaccinated boosted 0.000.45-0.27 0.66552
TT TT_IgG1 boosted - vaccinated boosted 0.000.52-0.41 0.83411
TT TT_IgG2 boosted - vaccinated boosted 0.000.840.60 <0.0001****
TT TT_IgG3 boosted - vaccinated boosted 0.001.260.51 <0.0001****
TT TT_IgG4 boosted - vaccinated boosted 0.000.960.63 <0.0001****
TT TT_ADCD boosted - vaccinated boosted 0.002.390.31 0.02383*
TT TT_ADCP boosted - vaccinated boosted 0.001.060.16 0.01894*
TT TT_ADNP boosted - vaccinated boosted 0.000.79-0.15 0.23399
TT TT_FcgR2a boosted - vaccinated boosted 0.002.05-1.45 0.76232
TT TT_FcgR3b boosted - vaccinated boosted 0.001.60-2.90 0.6194
TT TT_IgG boosted - vaccinated boosted 0.000.45-0.27 0.66552
TT TT_IgG1 boosted - vaccinated boosted 0.000.52-0.41 0.83411
TT TT_IgG2 boosted - vaccinated boosted 0.000.840.60 <0.0001****
TT TT_IgG3 boosted - vaccinated boosted 0.001.260.51 <0.0001****
TT TT_IgG4 boosted - vaccinated boosted 0.000.960.63 <0.0001****

0.3.2 vaccinated

0.3.2.1 DT

group subgrp outcome covariate Beta pval
DT DT_ADCD boosted - vaccinated vaccinated 0.00-0.83-1.05 <0.0001****
DT DT_ADCP boosted - vaccinated vaccinated 0.00-0.39-1.17 0.00073***
DT DT_ADNP boosted - vaccinated vaccinated 0.00-0.91-1.61 <0.0001****
DT DT_FcgR2a boosted - vaccinated vaccinated 0.00-0.86-0.99 <0.0001****
DT DT_FcgR3b boosted - vaccinated vaccinated 0.00-0.88-0.98 <0.0001****
DT DT_IgG boosted - vaccinated vaccinated 0.00-0.21-0.50 <0.0001****
DT DT_IgG1 boosted - vaccinated vaccinated 0.00-0.44-0.76 <0.0001****
DT DT_IgG2 boosted - vaccinated vaccinated 0.000.02-0.73 0.09516
DT DT_IgG3 boosted - vaccinated vaccinated 0.00-0.64-1.05 <0.0001****
DT DT_IgG4 boosted - vaccinated vaccinated 0.00-0.33-0.93 0.00039***
DT DT_ADCD boosted - vaccinated vaccinated 0.00-0.83-1.05 <0.0001****
DT DT_ADCP boosted - vaccinated vaccinated 0.00-0.39-1.17 0.00073***
DT DT_ADNP boosted - vaccinated vaccinated 0.00-0.91-1.61 <0.0001****
DT DT_FcgR2a boosted - vaccinated vaccinated 0.00-0.86-0.99 <0.0001****
DT DT_FcgR3b boosted - vaccinated vaccinated 0.00-0.88-0.98 <0.0001****
DT DT_IgG boosted - vaccinated vaccinated 0.00-0.21-0.50 <0.0001****
DT DT_IgG1 boosted - vaccinated vaccinated 0.00-0.44-0.76 <0.0001****
DT DT_IgG2 boosted - vaccinated vaccinated 0.000.02-0.73 0.09516
DT DT_IgG3 boosted - vaccinated vaccinated 0.00-0.64-1.05 <0.0001****
DT DT_IgG4 boosted - vaccinated vaccinated 0.00-0.33-0.93 0.00039***

0.3.2.2 FHA

group subgrp outcome covariate Beta pval
FHA FHA_ADCD boosted - vaccinated vaccinated 0.00-0.72-1.06 <0.0001****
FHA FHA_ADCP boosted - vaccinated vaccinated 0.000.10-0.30 0.38648
FHA FHA_ADNP boosted - vaccinated vaccinated 0.00-0.18-0.75 0.00473**
FHA FHA_FcgR2a boosted - vaccinated vaccinated 0.00-0.69-0.85 <0.0001****
FHA FHA_FcgR3b boosted - vaccinated vaccinated 0.00-0.68-0.87 <0.0001****
FHA FHA_IgG boosted - vaccinated vaccinated 0.00-0.12-0.45 0.00285**
FHA FHA_IgG1 boosted - vaccinated vaccinated 0.00-0.05-0.58 0.04005*
FHA FHA_IgG2 boosted - vaccinated vaccinated 0.000.29-0.54 0.60217
FHA FHA_IgG3 boosted - vaccinated vaccinated 0.00-0.66-0.99 <0.0001****
FHA FHA_IgG4 boosted - vaccinated vaccinated 0.00-0.19-0.75 0.00424**
FHA FHA_ADCD boosted - vaccinated vaccinated 0.00-0.72-1.06 <0.0001****
FHA FHA_ADCP boosted - vaccinated vaccinated 0.000.10-0.30 0.38648
FHA FHA_ADNP boosted - vaccinated vaccinated 0.00-0.18-0.75 0.00473**
FHA FHA_FcgR2a boosted - vaccinated vaccinated 0.00-0.69-0.85 <0.0001****
FHA FHA_FcgR3b boosted - vaccinated vaccinated 0.00-0.68-0.87 <0.0001****
FHA FHA_IgG boosted - vaccinated vaccinated 0.00-0.12-0.45 0.00285**
FHA FHA_IgG1 boosted - vaccinated vaccinated 0.00-0.05-0.58 0.04005*
FHA FHA_IgG2 boosted - vaccinated vaccinated 0.000.29-0.54 0.60217
FHA FHA_IgG3 boosted - vaccinated vaccinated 0.00-0.66-0.99 <0.0001****
FHA FHA_IgG4 boosted - vaccinated vaccinated 0.00-0.19-0.75 0.00424**

0.3.2.3 PRN

group subgrp outcome covariate Beta pval
PRN PRN_ADCD boosted - vaccinated vaccinated 0.00-0.77-1.03 <0.0001****
PRN PRN_ADCP boosted - vaccinated vaccinated 0.000.04-0.36 0.16868
PRN PRN_ADNP boosted - vaccinated vaccinated 0.00-0.25-1.04 0.00458**
PRN PRN_FcgR2a boosted - vaccinated vaccinated 0.00-0.57-0.87 <0.0001****
PRN PRN_FcgR3b boosted - vaccinated vaccinated 0.00-0.66-0.90 <0.0001****
PRN PRN_IgG boosted - vaccinated vaccinated 0.000.00-0.28 0.09065
PRN PRN_IgG1 boosted - vaccinated vaccinated 0.00-0.18-0.71 0.00343**
PRN PRN_IgG2 boosted - vaccinated vaccinated 0.000.14-0.30 0.54305
PRN PRN_IgG3 boosted - vaccinated vaccinated 0.00-0.67-1.02 <0.0001****
PRN PRN_IgG4 boosted - vaccinated vaccinated 0.00-0.04-0.98 0.0574
PRN PRN_ADCD boosted - vaccinated vaccinated 0.00-0.77-1.03 <0.0001****
PRN PRN_ADCP boosted - vaccinated vaccinated 0.000.04-0.36 0.16868
PRN PRN_ADNP boosted - vaccinated vaccinated 0.00-0.25-1.04 0.00458**
PRN PRN_FcgR2a boosted - vaccinated vaccinated 0.00-0.57-0.87 <0.0001****
PRN PRN_FcgR3b boosted - vaccinated vaccinated 0.00-0.66-0.90 <0.0001****
PRN PRN_IgG boosted - vaccinated vaccinated 0.000.00-0.28 0.09065
PRN PRN_IgG1 boosted - vaccinated vaccinated 0.00-0.18-0.71 0.00343**
PRN PRN_IgG2 boosted - vaccinated vaccinated 0.000.14-0.30 0.54305
PRN PRN_IgG3 boosted - vaccinated vaccinated 0.00-0.67-1.02 <0.0001****
PRN PRN_IgG4 boosted - vaccinated vaccinated 0.00-0.04-0.98 0.0574

0.3.2.4 PT

group subgrp outcome covariate Beta pval
PT PT_ADCD boosted - vaccinated vaccinated 0.00-0.67-0.94 <0.0001****
PT PT_ADCP boosted - vaccinated vaccinated 0.00-0.44-0.70 <0.0001****
PT PT_ADNP boosted - vaccinated vaccinated 0.00-0.76-1.06 <0.0001****
PT PT_FcgR2a boosted - vaccinated vaccinated 0.00-0.71-0.88 <0.0001****
PT PT_FcgR3b boosted - vaccinated vaccinated 0.00-0.63-0.91 <0.0001****
PT PT_IgG boosted - vaccinated vaccinated 0.00-0.18-0.50 0.0003***
PT PT_IgG1 boosted - vaccinated vaccinated 0.00-0.26-0.73 0.00034***
PT PT_IgG2 boosted - vaccinated vaccinated 0.00-0.15-0.48 0.00107**
PT PT_IgG3 boosted - vaccinated vaccinated 0.00-0.51-0.86 <0.0001****
PT PT_IgG4 boosted - vaccinated vaccinated 0.00-0.02-0.80 0.06626
PT PT_ADCD boosted - vaccinated vaccinated 0.00-0.67-0.94 <0.0001****
PT PT_ADCP boosted - vaccinated vaccinated 0.00-0.44-0.70 <0.0001****
PT PT_ADNP boosted - vaccinated vaccinated 0.00-0.76-1.06 <0.0001****
PT PT_FcgR2a boosted - vaccinated vaccinated 0.00-0.71-0.88 <0.0001****
PT PT_FcgR3b boosted - vaccinated vaccinated 0.00-0.63-0.91 <0.0001****
PT PT_IgG boosted - vaccinated vaccinated 0.00-0.18-0.50 0.0003***
PT PT_IgG1 boosted - vaccinated vaccinated 0.00-0.26-0.73 0.00034***
PT PT_IgG2 boosted - vaccinated vaccinated 0.00-0.15-0.48 0.00107**
PT PT_IgG3 boosted - vaccinated vaccinated 0.00-0.51-0.86 <0.0001****
PT PT_IgG4 boosted - vaccinated vaccinated 0.00-0.02-0.80 0.06626

0.3.2.5 TT

group subgrp outcome covariate Beta pval
TT TT_ADCD boosted - vaccinated vaccinated 0.00-0.94-1.11 <0.0001****
TT TT_ADCP boosted - vaccinated vaccinated 0.00-0.65-1.02 <0.0001****
TT TT_ADNP boosted - vaccinated vaccinated 0.00-0.61-0.93 <0.0001****
TT TT_FcgR2a boosted - vaccinated vaccinated 0.00-0.93-1.03 <0.0001****
TT TT_FcgR3b boosted - vaccinated vaccinated 0.00-0.93-1.01 <0.0001****
TT TT_IgG boosted - vaccinated vaccinated 0.00-0.45-0.76 <0.0001****
TT TT_IgG1 boosted - vaccinated vaccinated 0.00-0.56-0.85 <0.0001****
TT TT_IgG2 boosted - vaccinated vaccinated 0.000.67-0.33 0.55499
TT TT_IgG3 boosted - vaccinated vaccinated 0.00-0.69-1.16 <0.0001****
TT TT_IgG4 boosted - vaccinated vaccinated 0.000.06-0.89 0.12859
TT TT_ADCD boosted - vaccinated vaccinated 0.00-0.94-1.11 <0.0001****
TT TT_ADCP boosted - vaccinated vaccinated 0.00-0.65-1.02 <0.0001****
TT TT_ADNP boosted - vaccinated vaccinated 0.00-0.61-0.93 <0.0001****
TT TT_FcgR2a boosted - vaccinated vaccinated 0.00-0.93-1.03 <0.0001****
TT TT_FcgR3b boosted - vaccinated vaccinated 0.00-0.93-1.01 <0.0001****
TT TT_IgG boosted - vaccinated vaccinated 0.00-0.45-0.76 <0.0001****
TT TT_IgG1 boosted - vaccinated vaccinated 0.00-0.56-0.85 <0.0001****
TT TT_IgG2 boosted - vaccinated vaccinated 0.000.67-0.33 0.55499
TT TT_IgG3 boosted - vaccinated vaccinated 0.00-0.69-1.16 <0.0001****
TT TT_IgG4 boosted - vaccinated vaccinated 0.000.06-0.89 0.12859

0.4 mTdap+

0.4.1 boosted

0.4.1.1 DT

group subgrp outcome covariate Beta pval
DT DT_ADCD boosted - vaccinated boosted 0.000.31-0.41 0.79122
DT DT_ADCP boosted - vaccinated boosted 0.001.060.47 <0.0001****
DT DT_ADNP boosted - vaccinated boosted 0.000.790.38 <0.0001****
DT DT_FcgR2a boosted - vaccinated boosted 0.000.15-1.21 0.14853
DT DT_FcgR3b boosted - vaccinated boosted 0.00-0.46-4.69 0.02816*
DT DT_IgG boosted - vaccinated boosted 0.001.120.64 <0.0001****
DT DT_IgG1 boosted - vaccinated boosted 0.000.960.29 0.00131**
DT DT_IgG2 boosted - vaccinated boosted 0.000.900.46 <0.0001****
DT DT_IgG3 boosted - vaccinated boosted 0.001.050.35 0.00074***
DT DT_IgG4 boosted - vaccinated boosted 0.001.100.66 <0.0001****
DT DT_ADCD boosted - vaccinated boosted 0.000.31-0.41 0.79122
DT DT_ADCP boosted - vaccinated boosted 0.001.060.47 <0.0001****
DT DT_ADNP boosted - vaccinated boosted 0.000.790.38 <0.0001****
DT DT_FcgR2a boosted - vaccinated boosted 0.000.15-1.21 0.14853
DT DT_FcgR3b boosted - vaccinated boosted 0.00-0.46-4.69 0.02816*
DT DT_IgG boosted - vaccinated boosted 0.001.120.64 <0.0001****
DT DT_IgG1 boosted - vaccinated boosted 0.000.960.29 0.00131**
DT DT_IgG2 boosted - vaccinated boosted 0.000.900.46 <0.0001****
DT DT_IgG3 boosted - vaccinated boosted 0.001.050.35 0.00074***
DT DT_IgG4 boosted - vaccinated boosted 0.001.100.66 <0.0001****

0.4.1.2 FHA

group subgrp outcome covariate Beta pval
FHA FHA_ADCD boosted - vaccinated boosted 0.000.56-0.09 0.18449
FHA FHA_ADCP boosted - vaccinated boosted 0.000.620.16 0.00361**
FHA FHA_ADNP boosted - vaccinated boosted 0.000.840.13 0.01581*
FHA FHA_FcgR2a boosted - vaccinated boosted 0.000.870.21 0.0041**
FHA FHA_FcgR3b boosted - vaccinated boosted 0.000.740.04 0.04362*
FHA FHA_IgG boosted - vaccinated boosted 0.001.110.68 <0.0001****
FHA FHA_IgG1 boosted - vaccinated boosted 0.001.120.53 <0.0001****
FHA FHA_IgG2 boosted - vaccinated boosted 0.001.070.53 <0.0001****
FHA FHA_IgG3 boosted - vaccinated boosted 0.001.040.17 0.01322*
FHA FHA_IgG4 boosted - vaccinated boosted 0.001.020.65 <0.0001****
FHA FHA_ADCD boosted - vaccinated boosted 0.000.56-0.09 0.18449
FHA FHA_ADCP boosted - vaccinated boosted 0.000.620.16 0.00361**
FHA FHA_ADNP boosted - vaccinated boosted 0.000.840.13 0.01581*
FHA FHA_FcgR2a boosted - vaccinated boosted 0.000.870.21 0.0041**
FHA FHA_FcgR3b boosted - vaccinated boosted 0.000.740.04 0.04362*
FHA FHA_IgG boosted - vaccinated boosted 0.001.110.68 <0.0001****
FHA FHA_IgG1 boosted - vaccinated boosted 0.001.120.53 <0.0001****
FHA FHA_IgG2 boosted - vaccinated boosted 0.001.070.53 <0.0001****
FHA FHA_IgG3 boosted - vaccinated boosted 0.001.040.17 0.01322*
FHA FHA_IgG4 boosted - vaccinated boosted 0.001.020.65 <0.0001****

0.4.1.3 PRN

group subgrp outcome covariate Beta pval
PRN PRN_ADCD boosted - vaccinated boosted 0.000.860.21 0.0041**
PRN PRN_ADCP boosted - vaccinated boosted 0.000.650.06 0.02816*
PRN PRN_ADNP boosted - vaccinated boosted 0.001.100.71 <0.0001****
PRN PRN_FcgR2a boosted - vaccinated boosted 0.000.51-0.06 0.14853
PRN PRN_FcgR3b boosted - vaccinated boosted 0.000.43-0.68 0.68774
PRN PRN_IgG boosted - vaccinated boosted 0.001.000.47 <0.0001****
PRN PRN_IgG1 boosted - vaccinated boosted 0.000.820.25 0.00116**
PRN PRN_IgG2 boosted - vaccinated boosted 0.000.970.41 <0.0001****
PRN PRN_IgG3 boosted - vaccinated boosted 0.001.030.19 0.00996**
PRN PRN_IgG4 boosted - vaccinated boosted 0.001.090.83 <0.0001****
PRN PRN_ADCD boosted - vaccinated boosted 0.000.860.21 0.0041**
PRN PRN_ADCP boosted - vaccinated boosted 0.000.650.06 0.02816*
PRN PRN_ADNP boosted - vaccinated boosted 0.001.100.71 <0.0001****
PRN PRN_FcgR2a boosted - vaccinated boosted 0.000.51-0.06 0.14853
PRN PRN_FcgR3b boosted - vaccinated boosted 0.000.43-0.68 0.68774
PRN PRN_IgG boosted - vaccinated boosted 0.001.000.47 <0.0001****
PRN PRN_IgG1 boosted - vaccinated boosted 0.000.820.25 0.00116**
PRN PRN_IgG2 boosted - vaccinated boosted 0.000.970.41 <0.0001****
PRN PRN_IgG3 boosted - vaccinated boosted 0.001.030.19 0.00996**
PRN PRN_IgG4 boosted - vaccinated boosted 0.001.090.83 <0.0001****

0.4.1.4 PT

group subgrp outcome covariate Beta pval
PT PT_ADCD boosted - vaccinated boosted 0.001.270.14 0.02559*
PT PT_ADCP boosted - vaccinated boosted 0.001.17-0.14 0.14853
PT PT_ADNP boosted - vaccinated boosted 0.000.890.28 0.0011**
PT PT_FcgR2a boosted - vaccinated boosted 0.000.68-1.01 0.72135
PT PT_FcgR3b boosted - vaccinated boosted 0.000.88-0.68 0.81642
PT PT_IgG boosted - vaccinated boosted 0.001.140.51 <0.0001****
PT PT_IgG1 boosted - vaccinated boosted 0.001.090.56 <0.0001****
PT PT_IgG2 boosted - vaccinated boosted 0.000.730.16 0.00624**
PT PT_IgG3 boosted - vaccinated boosted 0.001.040.25 0.00458**
PT PT_IgG4 boosted - vaccinated boosted 0.001.120.91 <0.0001****
PT PT_ADCD boosted - vaccinated boosted 0.001.270.14 0.02559*
PT PT_ADCP boosted - vaccinated boosted 0.001.17-0.14 0.14853
PT PT_ADNP boosted - vaccinated boosted 0.000.890.28 0.0011**
PT PT_FcgR2a boosted - vaccinated boosted 0.000.68-1.01 0.72135
PT PT_FcgR3b boosted - vaccinated boosted 0.000.88-0.68 0.81642
PT PT_IgG boosted - vaccinated boosted 0.001.140.51 <0.0001****
PT PT_IgG1 boosted - vaccinated boosted 0.001.090.56 <0.0001****
PT PT_IgG2 boosted - vaccinated boosted 0.000.730.16 0.00624**
PT PT_IgG3 boosted - vaccinated boosted 0.001.040.25 0.00458**
PT PT_IgG4 boosted - vaccinated boosted 0.001.120.91 <0.0001****

0.4.1.5 TT

group subgrp outcome covariate Beta pval
TT TT_ADCD boosted - vaccinated boosted 0.000.890.23 0.00309**
TT TT_ADCP boosted - vaccinated boosted 0.001.900.16 0.03171*
TT TT_ADNP boosted - vaccinated boosted 0.001.050.45 <0.0001****
TT TT_FcgR2a boosted - vaccinated boosted 0.000.60-1.14 0.57193
TT TT_FcgR3b boosted - vaccinated boosted 0.002.06-2.55 0.83363
TT TT_IgG boosted - vaccinated boosted 0.001.290.78 <0.0001****
TT TT_IgG1 boosted - vaccinated boosted 0.001.210.44 0.00038***
TT TT_IgG2 boosted - vaccinated boosted 0.000.840.64 <0.0001****
TT TT_IgG3 boosted - vaccinated boosted 0.001.270.57 <0.0001****
TT TT_IgG4 boosted - vaccinated boosted 0.000.960.51 <0.0001****
TT TT_ADCD boosted - vaccinated boosted 0.000.890.23 0.00309**
TT TT_ADCP boosted - vaccinated boosted 0.001.900.16 0.03171*
TT TT_ADNP boosted - vaccinated boosted 0.001.050.45 <0.0001****
TT TT_FcgR2a boosted - vaccinated boosted 0.000.60-1.14 0.57193
TT TT_FcgR3b boosted - vaccinated boosted 0.002.06-2.55 0.83363
TT TT_IgG boosted - vaccinated boosted 0.001.290.78 <0.0001****
TT TT_IgG1 boosted - vaccinated boosted 0.001.210.44 0.00038***
TT TT_IgG2 boosted - vaccinated boosted 0.000.840.64 <0.0001****
TT TT_IgG3 boosted - vaccinated boosted 0.001.270.57 <0.0001****
TT TT_IgG4 boosted - vaccinated boosted 0.000.960.51 <0.0001****

0.4.2 vaccinated

0.4.2.1 DT

group subgrp outcome covariate Beta pval
DT DT_ADCD boosted - vaccinated vaccinated 0.00-0.38-0.70 <0.0001****
DT DT_ADCP boosted - vaccinated vaccinated 0.00-0.37-1.07 0.00051***
DT DT_ADNP boosted - vaccinated vaccinated 0.000.11-0.63 0.19221
DT DT_FcgR2a boosted - vaccinated vaccinated 0.00-0.66-0.87 <0.0001****
DT DT_FcgR3b boosted - vaccinated vaccinated 0.00-0.89-0.97 <0.0001****
DT DT_IgG boosted - vaccinated vaccinated 0.00-0.33-1.22 0.00275**
DT DT_IgG1 boosted - vaccinated vaccinated 0.00-0.38-0.96 0.00014***
DT DT_IgG2 boosted - vaccinated vaccinated 0.00-0.02-0.83 0.05331
DT DT_IgG3 boosted - vaccinated vaccinated 0.00-0.46-1.04 <0.0001****
DT DT_IgG4 boosted - vaccinated vaccinated 0.00-0.26-1.23 0.00657**
DT DT_ADCD boosted - vaccinated vaccinated 0.00-0.38-0.70 <0.0001****
DT DT_ADCP boosted - vaccinated vaccinated 0.00-0.37-1.07 0.00051***
DT DT_ADNP boosted - vaccinated vaccinated 0.000.11-0.63 0.19221
DT DT_FcgR2a boosted - vaccinated vaccinated 0.00-0.66-0.87 <0.0001****
DT DT_FcgR3b boosted - vaccinated vaccinated 0.00-0.89-0.97 <0.0001****
DT DT_IgG boosted - vaccinated vaccinated 0.00-0.33-1.22 0.00275**
DT DT_IgG1 boosted - vaccinated vaccinated 0.00-0.38-0.96 0.00014***
DT DT_IgG2 boosted - vaccinated vaccinated 0.00-0.02-0.83 0.05331
DT DT_IgG3 boosted - vaccinated vaccinated 0.00-0.46-1.04 <0.0001****
DT DT_IgG4 boosted - vaccinated vaccinated 0.00-0.26-1.23 0.00657**

0.4.2.2 FHA

group subgrp outcome covariate Beta pval
FHA FHA_ADCD boosted - vaccinated vaccinated 0.00-0.30-0.72 <0.0001****
FHA FHA_ADCP boosted - vaccinated vaccinated 0.00-0.02-0.56 0.04658*
FHA FHA_ADNP boosted - vaccinated vaccinated 0.00-0.39-0.89 <0.0001****
FHA FHA_FcgR2a boosted - vaccinated vaccinated 0.00-0.34-0.89 0.00023***
FHA FHA_FcgR3b boosted - vaccinated vaccinated 0.00-0.36-0.83 <0.0001****
FHA FHA_IgG boosted - vaccinated vaccinated 0.00-0.25-1.26 0.00831**
FHA FHA_IgG1 boosted - vaccinated vaccinated 0.00-0.42-1.14 0.00033***
FHA FHA_IgG2 boosted - vaccinated vaccinated 0.00-0.33-1.10 0.00146**
FHA FHA_IgG3 boosted - vaccinated vaccinated 0.00-0.56-1.02 <0.0001****
FHA FHA_IgG4 boosted - vaccinated vaccinated 0.000.03-1.07 0.0827
FHA FHA_ADCD boosted - vaccinated vaccinated 0.00-0.30-0.72 <0.0001****
FHA FHA_ADCP boosted - vaccinated vaccinated 0.00-0.02-0.56 0.04658*
FHA FHA_ADNP boosted - vaccinated vaccinated 0.00-0.39-0.89 <0.0001****
FHA FHA_FcgR2a boosted - vaccinated vaccinated 0.00-0.34-0.89 0.00023***
FHA FHA_FcgR3b boosted - vaccinated vaccinated 0.00-0.36-0.83 <0.0001****
FHA FHA_IgG boosted - vaccinated vaccinated 0.00-0.25-1.26 0.00831**
FHA FHA_IgG1 boosted - vaccinated vaccinated 0.00-0.42-1.14 0.00033***
FHA FHA_IgG2 boosted - vaccinated vaccinated 0.00-0.33-1.10 0.00146**
FHA FHA_IgG3 boosted - vaccinated vaccinated 0.00-0.56-1.02 <0.0001****
FHA FHA_IgG4 boosted - vaccinated vaccinated 0.000.03-1.07 0.0827

0.4.2.3 PRN

group subgrp outcome covariate Beta pval
PRN PRN_ADCD boosted - vaccinated vaccinated 0.00-0.33-0.88 0.00024***
PRN PRN_ADCP boosted - vaccinated vaccinated 0.00-0.21-0.70 0.00135**
PRN PRN_ADNP boosted - vaccinated vaccinated 0.00-0.19-1.29 0.01661*
PRN PRN_FcgR2a boosted - vaccinated vaccinated 0.00-0.22-0.64 0.00067***
PRN PRN_FcgR3b boosted - vaccinated vaccinated 0.00-0.58-0.86 <0.0001****
PRN PRN_IgG boosted - vaccinated vaccinated 0.00-0.26-1.00 0.00348**
PRN PRN_IgG1 boosted - vaccinated vaccinated 0.00-0.20-0.80 0.00351**
PRN PRN_IgG2 boosted - vaccinated vaccinated 0.00-0.28-0.97 0.00194**
PRN PRN_IgG3 boosted - vaccinated vaccinated 0.00-0.54-1.01 <0.0001****
PRN PRN_IgG4 boosted - vaccinated vaccinated 0.000.09-1.56 0.09981
PRN PRN_ADCD boosted - vaccinated vaccinated 0.00-0.33-0.88 0.00024***
PRN PRN_ADCP boosted - vaccinated vaccinated 0.00-0.21-0.70 0.00135**
PRN PRN_ADNP boosted - vaccinated vaccinated 0.00-0.19-1.29 0.01661*
PRN PRN_FcgR2a boosted - vaccinated vaccinated 0.00-0.22-0.64 0.00067***
PRN PRN_FcgR3b boosted - vaccinated vaccinated 0.00-0.58-0.86 <0.0001****
PRN PRN_IgG boosted - vaccinated vaccinated 0.00-0.26-1.00 0.00348**
PRN PRN_IgG1 boosted - vaccinated vaccinated 0.00-0.20-0.80 0.00351**
PRN PRN_IgG2 boosted - vaccinated vaccinated 0.00-0.28-0.97 0.00194**
PRN PRN_IgG3 boosted - vaccinated vaccinated 0.00-0.54-1.01 <0.0001****
PRN PRN_IgG4 boosted - vaccinated vaccinated 0.000.09-1.56 0.09981

0.4.2.4 PT

group subgrp outcome covariate Beta pval
PT PT_ADCD boosted - vaccinated vaccinated 0.00-0.72-1.09 <0.0001****
PT PT_ADCP boosted - vaccinated vaccinated 0.00-0.73-1.04 <0.0001****
PT PT_ADNP boosted - vaccinated vaccinated 0.00-0.30-0.90 0.00074***
PT PT_FcgR2a boosted - vaccinated vaccinated 0.00-0.74-0.96 <0.0001****
PT PT_FcgR3b boosted - vaccinated vaccinated 0.00-0.74-0.98 <0.0001****
PT PT_IgG boosted - vaccinated vaccinated 0.00-0.47-1.15 <0.0001****
PT PT_IgG1 boosted - vaccinated vaccinated 0.00-0.35-1.14 0.00116**
PT PT_IgG2 boosted - vaccinated vaccinated 0.00-0.20-0.74 0.00275**
PT PT_IgG3 boosted - vaccinated vaccinated 0.00-0.52-1.03 <0.0001****
PT PT_IgG4 boosted - vaccinated vaccinated 0.00-0.13-2.23 0.04205*
PT PT_ADCD boosted - vaccinated vaccinated 0.00-0.72-1.09 <0.0001****
PT PT_ADCP boosted - vaccinated vaccinated 0.00-0.73-1.04 <0.0001****
PT PT_ADNP boosted - vaccinated vaccinated 0.00-0.30-0.90 0.00074***
PT PT_FcgR2a boosted - vaccinated vaccinated 0.00-0.74-0.96 <0.0001****
PT PT_FcgR3b boosted - vaccinated vaccinated 0.00-0.74-0.98 <0.0001****
PT PT_IgG boosted - vaccinated vaccinated 0.00-0.47-1.15 <0.0001****
PT PT_IgG1 boosted - vaccinated vaccinated 0.00-0.35-1.14 0.00116**
PT PT_IgG2 boosted - vaccinated vaccinated 0.00-0.20-0.74 0.00275**
PT PT_IgG3 boosted - vaccinated vaccinated 0.00-0.52-1.03 <0.0001****
PT PT_IgG4 boosted - vaccinated vaccinated 0.00-0.13-2.23 0.04205*

0.4.2.5 TT

group subgrp outcome covariate Beta pval
TT TT_ADCD boosted - vaccinated vaccinated 0.00-0.35-0.90 0.00022***
TT TT_ADCP boosted - vaccinated vaccinated 0.00-0.88-1.13 <0.0001****
TT TT_ADNP boosted - vaccinated vaccinated 0.00-0.37-1.06 0.00048***
TT TT_FcgR2a boosted - vaccinated vaccinated 0.00-0.75-0.95 <0.0001****
TT TT_FcgR3b boosted - vaccinated vaccinated 0.00-0.93-1.02 <0.0001****
TT TT_IgG boosted - vaccinated vaccinated 0.00-0.63-1.50 <0.0001****
TT TT_IgG1 boosted - vaccinated vaccinated 0.00-0.60-1.15 <0.0001****
TT TT_IgG2 boosted - vaccinated vaccinated 0.001.25-0.01 0.06927
TT TT_IgG3 boosted - vaccinated vaccinated 0.00-0.62-1.24 <0.0001****
TT TT_IgG4 boosted - vaccinated vaccinated 0.00-0.08-0.93 0.03171*
TT TT_ADCD boosted - vaccinated vaccinated 0.00-0.35-0.90 0.00022***
TT TT_ADCP boosted - vaccinated vaccinated 0.00-0.88-1.13 <0.0001****
TT TT_ADNP boosted - vaccinated vaccinated 0.00-0.37-1.06 0.00048***
TT TT_FcgR2a boosted - vaccinated vaccinated 0.00-0.75-0.95 <0.0001****
TT TT_FcgR3b boosted - vaccinated vaccinated 0.00-0.93-1.02 <0.0001****
TT TT_IgG boosted - vaccinated vaccinated 0.00-0.63-1.50 <0.0001****
TT TT_IgG1 boosted - vaccinated vaccinated 0.00-0.60-1.15 <0.0001****
TT TT_IgG2 boosted - vaccinated vaccinated 0.001.25-0.01 0.06927
TT TT_IgG3 boosted - vaccinated vaccinated 0.00-0.62-1.24 <0.0001****
TT TT_IgG4 boosted - vaccinated vaccinated 0.00-0.08-0.93 0.03171*
 

sessionInfo()
R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/New_York
tzcode source: internal

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] broom_1.0.5        e1071_1.7-13       glue_1.6.2         mvtnorm_1.2-3     
 [5] GGally_2.2.1       RColorBrewer_1.1-3 rstatix_0.7.2      lubridate_1.9.2   
 [9] forcats_1.0.0      purrr_1.0.1        readr_2.1.4        tidyverse_2.0.0   
[13] stringr_1.5.0      tibble_3.2.1       tidyr_1.3.0        mixOmics_6.26.0   
[17] lattice_0.21-8     MASS_7.3-60.0.1    data.table_1.14.8  pBrackets_1.0.1   
[21] gtExtras_0.5.0     plotly_4.10.4      cowplot_1.1.1      ggtext_0.1.2      
[25] ggridges_0.5.6     ggfortify_0.4.16   ggpubr_0.6.0       ggExtra_0.10.1    
[29] ggrepel_0.9.3      ggplot2_3.4.4      gtsummary_1.7.2    gt_0.10.1         
[33] gdata_2.19.0       tidyquery_0.2.4    DT_0.28            DBI_1.1.3         
[37] RPostgres_1.4.5    dplyr_1.1.2        here_1.0.1         workflowr_1.7.1   

loaded via a namespace (and not attached):
 [1] rstudioapi_0.15.0    jsonlite_1.8.7       magrittr_2.0.3      
 [4] farver_2.1.1         rmarkdown_2.25       ragg_1.2.6          
 [7] fs_1.6.3             vctrs_0.6.3          paletteer_1.6.0     
[10] htmltools_0.5.8      sass_0.4.9           bslib_0.7.0         
[13] htmlwidgets_1.6.2    fontawesome_0.5.2    plyr_1.8.9          
[16] cachem_1.0.8         whisker_0.4.1        igraph_1.5.1        
[19] mime_0.12            lifecycle_1.0.4      pkgconfig_2.0.3     
[22] Matrix_1.6-1.1       R6_2.5.1             fastmap_1.1.1       
[25] shiny_1.7.4.1        digest_0.6.33        colorspace_2.1-0    
[28] rARPACK_0.11-0       rematch2_2.1.2       ps_1.7.5            
[31] rprojroot_2.0.4      RSpectra_0.16-1      textshaping_0.3.7   
[34] ellipse_0.5.0        labeling_0.4.3       fansi_1.0.4         
[37] timechange_0.2.0     httr_1.4.7           abind_1.4-5         
[40] compiler_4.3.1       proxy_0.4-27         bit64_4.0.5         
[43] withr_3.0.0          backports_1.4.1      BiocParallel_1.36.0 
[46] carData_3.0-5        ggstats_0.5.1        ggsignif_0.6.4      
[49] corpcor_1.6.10       gtools_3.9.4         tools_4.3.1         
[52] httpuv_1.6.11        callr_3.7.5          promises_1.2.0.1    
[55] gridtext_0.1.5       grid_4.3.1           getPass_0.2-2       
[58] reshape2_1.4.4       generics_0.1.3       gtable_0.3.4        
[61] tzdb_0.4.0           class_7.3-22         hms_1.1.3           
[64] xml2_1.3.5           car_3.1-2            utf8_1.2.3          
[67] pillar_1.9.0         later_1.3.1          queryparser_0.3.2   
[70] bit_4.0.5            tidyselect_1.2.0     miniUI_0.1.1.1      
[73] knitr_1.44           git2r_0.32.0         gridExtra_2.3       
[76] svglite_2.1.2        xfun_0.40            matrixStats_1.0.0   
[79] stringi_1.7.12       lazyeval_0.2.2       yaml_2.3.7          
[82] evaluate_0.23        codetools_0.2-19     cli_3.6.1           
[85] systemfonts_1.0.5    xtable_1.8-4         munsell_0.5.0       
[88] processx_3.8.2       jquerylib_0.1.4      Rcpp_1.0.11         
[91] parallel_4.3.1       ellipsis_0.3.2       blob_1.2.4          
[94] viridisLite_0.4.2    broom.helpers_1.14.0 scales_1.3.0        
[97] rlang_1.1.1