Last updated: 2024-09-21

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Knit directory: madi-project3-sdy8003-pertussis-thailand/

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Covariate associations with PCA scores from clustering

arm_name

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.000.551.54 p<0.001 ****
Antigen Specific FHA mat+_iwp mat+_iap 0.00-1.42-0.52 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.00-0.110.93 p=0.211 ns
Antigen Specific PT mat+_iwp mat+_iap 0.00-2.06-1.21 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.87-0.85 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.250.70 p=0.541 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.920.39 p=0.572 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.09-0.35 p<0.001 ***
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.430.43 p=0.998 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.240.47 p=0.627 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.260.47 p=0.627 ns
Unsupervised RClust7 mat+_iwp mat+_iap 0.00-0.810.07 p=0.200 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-2.40-0.69 p=0.001 ***
Antigen Specific FHA mat+_iwp mat+_iap 0.00-3.49-1.70 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.001.393.24 p<0.001 ****
Antigen Specific PT mat+_iwp mat+_iap 0.000.762.77 p=0.002 ***
Antigen Specific TT mat+_iwp mat+_iap 0.00-2.02-0.07 p=0.046 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-1.010.52 p=0.536 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-2.79-0.68 p=0.003 **
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-2.64-1.02 p<0.001 ****
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-2.50-0.84 p<0.001 ***
Unsupervised RClust5 mat+_iwp mat+_iap 0.000.201.97 p=0.026 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.000.021.52 p=0.053 *
Unsupervised RClust7 mat+_iwp mat+_iap 0.002.914.34 p<0.001 ****
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.000.551.54 p<0.001 ****
Antigen Specific FHA mat+_iwp mat+_iap 0.00-1.42-0.52 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.00-0.110.93 p=0.193 ns
Antigen Specific PT mat+_iwp mat+_iap 0.00-2.06-1.21 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.87-0.85 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.250.70 p=0.496 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.920.39 p=0.524 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.09-0.35 p<0.001 ***
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-1.48-0.12 p=0.045 *
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.240.47 p=0.575 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.260.47 p=0.575 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-2.40-0.69 p=0.001 ***
Antigen Specific FHA mat+_iwp mat+_iap 0.00-3.49-1.70 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.001.393.24 p<0.001 ****
Antigen Specific PT mat+_iwp mat+_iap 0.000.762.77 p=0.002 ***
Antigen Specific TT mat+_iwp mat+_iap 0.00-2.02-0.07 p=0.047 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-1.010.52 p=0.536 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-2.79-0.68 p=0.003 **
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-2.64-1.02 p<0.001 ****
Unsupervised RClust4 mat+_iwp mat+_iap 0.003.034.79 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.000.201.97 p=0.026 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.000.021.52 p=0.053 *

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-2.11-1.22 p<0.001 ****
Antigen Specific FHA mat+_iwp mat+_iap 0.00-2.27-1.41 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.00-1.63-0.56 p<0.001 ***
Antigen Specific PT mat+_iwp mat+_iap 0.001.502.31 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.85-0.85 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.000.041.02 p=0.054 *
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.530.33 p=0.723 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-0.530.29 p=0.685 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-1.59-0.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.78-0.07 p=0.038 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.000.010.90 p=0.065 *
Unsupervised RClust7 mat+_iwp mat+_iap 0.00-0.520.63 p=0.854 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-1.360.10 p=0.226 ns
Antigen Specific FHA mat+_iwp mat+_iap 0.00-1.200.46 p=0.520 ns
Antigen Specific PRN mat+_iwp mat+_iap 0.00-1.290.18 p=0.243 ns
Antigen Specific PT mat+_iwp mat+_iap 0.00-0.201.58 p=0.243 ns
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.86-0.12 p=0.115 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.641.42 p=0.552 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.390.55 p=0.782 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.000.101.35 p=0.115 *
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-1.900.06 p=0.212 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.610.82 p=0.782 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.002.584.00 p<0.001 ****
Unsupervised RClust7 mat+_iwp mat+_iap 0.00-0.321.63 p=0.289 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-2.11-1.22 p<0.001 ****
Antigen Specific FHA mat+_iwp mat+_iap 0.00-2.27-1.41 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.000.561.63 p<0.001 ***
Antigen Specific PT mat+_iwp mat+_iap 0.001.502.31 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.85-0.85 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.000.041.02 p=0.050 *
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.570.45 p=0.854 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.59-0.59 p<0.001 ****
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.78-0.07 p=0.035 *
Unsupervised RClust5 mat+_iwp mat+_iap 0.000.010.90 p=0.060 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.520.63 p=0.854 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-1.360.10 p=0.207 ns
Antigen Specific FHA mat+_iwp mat+_iap 0.00-1.200.46 p=0.476 ns
Antigen Specific PRN mat+_iwp mat+_iap 0.00-1.290.18 p=0.223 ns
Antigen Specific PT mat+_iwp mat+_iap 0.00-0.201.58 p=0.223 ns
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.86-0.12 p=0.105 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.641.42 p=0.506 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-1.36-0.10 p=0.105 *
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.900.06 p=0.195 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.610.82 p=0.782 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.002.584.00 p<0.001 ****
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.321.63 p=0.265 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.001.101.99 p<0.001 ****
Antigen Specific FHA mat+_iwp mat+_iap 0.00-1.90-0.96 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.000.541.61 p<0.001 ***
Antigen Specific PT mat+_iwp mat+_iap 0.001.402.23 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.000.751.74 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.410.49 p=0.861 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.290.53 p=0.685 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-0.560.34 p=0.691 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.78-0.07 p=0.038 *
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.90-0.01 p=0.074 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.560.16 p=0.383 ns
Unsupervised RClust7 mat+_iwp mat+_iap 0.000.191.05 p=0.011 **
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-0.071.39 p=0.237 ns
Antigen Specific FHA mat+_iwp mat+_iap 0.00-0.351.31 p=0.396 ns
Antigen Specific PRN mat+_iwp mat+_iap 0.00-0.411.04 p=0.525 ns
Antigen Specific PT mat+_iwp mat+_iap 0.00-0.231.55 p=0.364 ns
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.93-0.23 p=0.090 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.800.79 p=0.981 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.000.101.35 p=0.107 *
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-0.751.27 p=0.737 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.820.61 p=0.853 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.002.584.00 p<0.001 ****
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.331.23 p=0.396 ns
Unsupervised RClust7 mat+_iwp mat+_iap 0.00-0.381.46 p=0.396 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.001.222.11 p<0.001 ****
Antigen Specific FHA mat+_iwp mat+_iap 0.00-2.27-1.41 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.000.561.63 p<0.001 ***
Antigen Specific PT mat+_iwp mat+_iap 0.001.502.31 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.000.851.85 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.410.49 p=0.861 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.290.53 p=0.628 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-0.460.85 p=0.628 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.78-0.07 p=0.035 *
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.90-0.01 p=0.067 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.05-0.19 p=0.010 **
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-1.360.10 p=0.259 ns
Antigen Specific FHA mat+_iwp mat+_iap 0.00-0.461.20 p=0.476 ns
Antigen Specific PRN mat+_iwp mat+_iap 0.00-1.290.18 p=0.260 ns
Antigen Specific PT mat+_iwp mat+_iap 0.00-0.201.58 p=0.260 ns
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.86-0.12 p=0.105 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.790.80 p=0.981 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-1.35-0.10 p=0.105 *
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-0.611.62 p=0.476 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.820.61 p=0.860 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.002.584.00 p<0.001 ****
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.381.46 p=0.400 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-1.32-0.27 p=0.010 **
Antigen Specific FHA mat+_iwp mat+_iap 0.00-1.10-0.18 p=0.014 **
Antigen Specific PRN mat+_iwp mat+_iap 0.000.571.50 p<0.001 ****
Antigen Specific PT mat+_iwp mat+_iap 0.001.652.49 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.79-0.61 p<0.001 ***

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.92-0.24 p=0.004 **
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.510.57 p=0.915 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-0.470.74 p=0.729 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.700.11 p=0.204 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.000.001.06 p=0.081 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.22-0.23 p=0.011 **
Unsupervised RClust7 mat+_iwp mat+_iap 0.00-0.670.23 p=0.408 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-0.381.33 p=0.481 ns
Antigen Specific FHA mat+_iwp mat+_iap 0.001.733.51 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.00-3.10-1.29 p<0.001 ****
Antigen Specific PT mat+_iwp mat+_iap 0.00-0.980.94 p=0.971 ns
Antigen Specific TT mat+_iwp mat+_iap 0.000.712.22 p<0.001 ***

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.551.20 p=0.700 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-1.90-0.61 p<0.001 ***
Unsupervised RClust3 mat+_iwp mat+_iap 0.001.333.36 p<0.001 ****
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-1.080.71 p=0.841 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.810.76 p=0.971 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.860.58 p=0.841 ns
Unsupervised RClust7 mat+_iwp mat+_iap 0.003.044.47 p<0.001 ****
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-1.32-0.27 p=0.009 **
Antigen Specific FHA mat+_iwp mat+_iap 0.00-1.10-0.18 p=0.011 **
Antigen Specific PRN mat+_iwp mat+_iap 0.000.571.50 p<0.001 ****
Antigen Specific PT mat+_iwp mat+_iap 0.001.652.49 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.79-0.61 p<0.001 ***

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.92-0.24 p=0.004 **
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.510.57 p=0.915 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.000.351.94 p=0.010 **
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.700.11 p=0.168 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.000.001.06 p=0.066 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.22-0.23 p=0.010 **
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-0.381.33 p=0.514 ns
Antigen Specific FHA mat+_iwp mat+_iap 0.001.733.51 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.00-3.10-1.29 p<0.001 ****
Antigen Specific PT mat+_iwp mat+_iap 0.00-0.980.94 p=0.971 ns
Antigen Specific TT mat+_iwp mat+_iap 0.000.712.22 p<0.001 ***

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.551.20 p=0.733 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-1.90-0.61 p<0.001 ***
Unsupervised RClust3 mat+_iwp mat+_iap 0.003.335.29 p<0.001 ****
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-1.080.71 p=0.857 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.810.76 p=0.971 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.860.58 p=0.857 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.000.251.38 p=0.018 **
Antigen Specific FHA mat+_iwp mat+_iap 0.000.621.59 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.000.982.05 p<0.001 ****
Antigen Specific PT mat+_iwp mat+_iap 0.001.002.04 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.00-0.400.70 p=0.714 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.670.14 p=0.355 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.960.09 p=0.214 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-0.520.71 p=0.832 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.450.44 p=0.971 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.030.71 p=0.186 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.660.34 p=0.711 ns
Unsupervised RClust7 mat+_iwp mat+_iap 0.00-0.580.17 p=0.420 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-0.880.45 p=0.585 ns
Antigen Specific FHA mat+_iwp mat+_iap 0.00-2.22-0.62 p=0.003 ***
Antigen Specific PRN mat+_iwp mat+_iap 0.00-1.120.34 p=0.398 ns
Antigen Specific PT mat+_iwp mat+_iap 0.000.702.24 p=0.002 ***
Antigen Specific TT mat+_iwp mat+_iap 0.00-2.33-0.96 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-1.030.79 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-1.040.53 p=0.585 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.000.102.40 p=0.073 *
Unsupervised RClust4 mat+_iwp mat+_iap 0.002.594.05 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.120.24 p=0.313 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.64-0.26 p=0.020 **
Unsupervised RClust7 mat+_iwp mat+_iap 0.00-1.26-0.03 p=0.076 *
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-1.38-0.25 p=0.013 **
Antigen Specific FHA mat+_iwp mat+_iap 0.00-1.59-0.62 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.000.982.05 p<0.001 ****
Antigen Specific PT mat+_iwp mat+_iap 0.001.002.04 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.00-0.400.70 p=0.727 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.000.361.75 p=0.011 **
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.960.09 p=0.168 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-0.520.71 p=0.839 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.450.44 p=0.971 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.030.71 p=0.142 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.580.17 p=0.385 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-0.880.45 p=0.590 ns
Antigen Specific FHA mat+_iwp mat+_iap 0.00-2.22-0.62 p=0.002 ***
Antigen Specific PRN mat+_iwp mat+_iap 0.00-1.120.34 p=0.410 ns
Antigen Specific PT mat+_iwp mat+_iap 0.000.702.24 p=0.001 ***
Antigen Specific TT mat+_iwp mat+_iap 0.00-2.33-0.96 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.771.08 p=0.745 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-1.040.53 p=0.590 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.000.102.40 p=0.080 *
Unsupervised RClust4 mat+_iwp mat+_iap 0.002.594.05 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.120.24 p=0.327 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.26-0.03 p=0.081 *

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-1.58-0.52 p<0.001 ***
Antigen Specific FHA mat+_iwp mat+_iap 0.00-1.40-0.39 p=0.002 ***
Antigen Specific PRN mat+_iwp mat+_iap 0.000.932.01 p<0.001 ****
Antigen Specific PT mat+_iwp mat+_iap 0.001.082.09 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.00-1.030.03 p=0.133 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.670.14 p=0.248 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.090.96 p=0.145 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-0.101.02 p=0.145 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.450.44 p=0.971 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.710.03 p=0.133 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-0.170.58 p=0.305 ns
Unsupervised RClust7 mat+_iwp mat+_iap 0.00-1.55-0.55 p<0.001 ***
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-0.510.81 p=0.768 ns
Antigen Specific FHA mat+_iwp mat+_iap 0.00-2.28-0.70 p=0.001 ***
Antigen Specific PRN mat+_iwp mat+_iap 0.00-0.580.86 p=0.768 ns
Antigen Specific PT mat+_iwp mat+_iap 0.00-2.19-0.67 p=0.001 ***
Antigen Specific TT mat+_iwp mat+_iap 0.00-2.36-1.00 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-1.040.53 p=0.768 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.357 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.120.24 p=0.357 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.000.031.26 p=0.107 *
Unsupervised RClust7 mat+_iwp mat+_iap 0.00-1.270.72 p=0.768 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.000.251.38 p=0.013 **
Antigen Specific FHA mat+_iwp mat+_iap 0.000.621.59 p<0.001 ****
Antigen Specific PRN mat+_iwp mat+_iap 0.000.982.05 p<0.001 ****
Antigen Specific PT mat+_iwp mat+_iap 0.001.002.04 p<0.001 ****
Antigen Specific TT mat+_iwp mat+_iap 0.00-0.400.70 p=0.655 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.670.14 p=0.285 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.960.09 p=0.171 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.020.10 p=0.171 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-0.450.44 p=0.971 ns
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-0.950.28 p=0.348 ns
Unsupervised RClust6 mat+_iwp mat+_iap 0.000.551.55 p<0.001 ***
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mat+_iwp mat+_iap 0.00-0.450.88 p=0.650 ns
Antigen Specific FHA mat+_iwp mat+_iap 0.000.622.22 p=0.002 ***
Antigen Specific PRN mat+_iwp mat+_iap 0.00-0.341.12 p=0.469 ns
Antigen Specific PT mat+_iwp mat+_iap 0.000.702.24 p=0.001 ***
Antigen Specific TT mat+_iwp mat+_iap 0.00-2.33-0.96 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns

birth_weight

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.909 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.909 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.909 ns
Antigen Specific PT continuous 0.000.000.00 p=0.909 ns
Antigen Specific TT continuous 0.000.000.00 p=0.909 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.909 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.909 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.623 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.909 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.909 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.909 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.909 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.988 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.988 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.988 ns
Antigen Specific PT continuous 0.000.000.00 p=0.988 ns
Antigen Specific TT continuous 0.000.000.00 p=0.988 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.988 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.988 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.988 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.988 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.988 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.988 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.988 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.954 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.954 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.954 ns
Antigen Specific PT continuous 0.000.000.00 p=0.954 ns
Antigen Specific TT continuous 0.000.000.00 p=0.954 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.954 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.954 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.571 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.954 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.954 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.954 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.994 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.994 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.994 ns
Antigen Specific PT continuous 0.000.000.00 p=0.994 ns
Antigen Specific TT continuous 0.000.000.00 p=0.994 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.994 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.994 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.994 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.994 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.994 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.994 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.942 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.798 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.798 ns
Antigen Specific PT continuous 0.000.000.00 p=0.942 ns
Antigen Specific TT continuous 0.000.000.00 p=0.798 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.798 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.798 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.798 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.798 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.798 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.798 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.798 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.933 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.933 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.933 ns
Antigen Specific PT continuous 0.000.000.00 p=0.933 ns
Antigen Specific TT continuous 0.000.000.00 p=0.933 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.933 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.933 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.933 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.933 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.933 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.933 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.933 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.942 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.914 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.914 ns
Antigen Specific PT continuous 0.000.000.00 p=0.942 ns
Antigen Specific TT continuous 0.000.000.00 p=0.914 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.914 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.942 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.914 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.914 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.914 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.914 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.917 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.893 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.917 ns
Antigen Specific PT continuous 0.000.000.00 p=0.893 ns
Antigen Specific TT continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.893 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.893 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.893 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.917 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.885 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.885 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.885 ns
Antigen Specific PT continuous 0.000.000.00 p=0.885 ns
Antigen Specific TT continuous 0.000.000.00 p=0.885 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.885 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.885 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.885 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.885 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.885 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.885 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.885 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.917 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.917 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.917 ns
Antigen Specific PT continuous 0.000.000.00 p=0.917 ns
Antigen Specific TT continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.917 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.942 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.932 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.932 ns
Antigen Specific PT continuous 0.000.000.00 p=0.942 ns
Antigen Specific TT continuous 0.000.000.00 p=0.932 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.942 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.932 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.932 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.932 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.932 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.932 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.917 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.877 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.917 ns
Antigen Specific PT continuous 0.000.000.00 p=0.877 ns
Antigen Specific TT continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.877 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.877 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.917 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.877 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.851 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.851 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.851 ns
Antigen Specific PT continuous 0.000.000.00 p=0.851 ns
Antigen Specific TT continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.851 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.982 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.982 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.982 ns
Antigen Specific PT continuous 0.000.000.00 p=0.982 ns
Antigen Specific TT continuous 0.000.000.00 p=0.982 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.982 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.310 *
Unsupervised RClust3 continuous 0.000.000.00 p=0.982 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.982 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.982 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.982 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.982 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.851 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.851 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.851 ns
Antigen Specific PT continuous 0.000.000.00 p=0.851 ns
Antigen Specific TT continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.851 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.851 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.981 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.981 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.981 ns
Antigen Specific PT continuous 0.000.000.00 p=0.981 ns
Antigen Specific TT continuous 0.000.000.00 p=0.981 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.981 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.284 *
Unsupervised RClust3 continuous 0.000.000.00 p=0.981 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.981 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.981 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.981 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.795 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.691 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.795 ns
Antigen Specific PT continuous 0.000.000.00 p=0.795 ns
Antigen Specific TT continuous 0.000.000.00 p=0.691 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.691 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.691 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.795 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.691 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.795 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.691 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.691 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.248 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.174 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.174 *
Antigen Specific PT continuous 0.000.000.00 p=0.559 ns
Antigen Specific TT continuous 0.000.000.00 p=0.174 *
Unsupervised RClust1 continuous 0.000.000.00 p=0.559 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.182 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.174 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.806 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.806 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.174 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.671 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.795 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.690 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.795 ns
Antigen Specific PT continuous 0.000.000.00 p=0.795 ns
Antigen Specific TT continuous 0.000.000.00 p=0.690 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.690 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.690 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.795 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.690 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.795 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.690 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.265 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.181 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.181 *
Antigen Specific PT continuous 0.000.000.00 p=0.576 ns
Antigen Specific TT continuous 0.000.000.00 p=0.181 *
Unsupervised RClust1 continuous 0.000.000.00 p=0.358 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.200 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.181 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.806 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.806 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.683 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.924 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.881 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.924 ns
Antigen Specific PT continuous 0.000.000.00 p=0.881 ns
Antigen Specific TT continuous 0.000.000.00 p=0.789 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.789 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.881 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.965 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.881 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.924 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.789 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.881 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.329 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.218 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.180 *
Antigen Specific PT continuous 0.000.000.00 p=0.635 ns
Antigen Specific TT continuous 0.000.000.00 p=0.180 *
Unsupervised RClust1 continuous 0.000.000.00 p=0.597 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.218 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.298 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.806 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.806 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.671 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.180 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.853 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.696 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.853 ns
Antigen Specific PT continuous 0.000.000.00 p=0.853 ns
Antigen Specific TT continuous 0.000.000.00 p=0.696 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.696 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.696 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.965 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.696 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.696 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.853 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.234 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.181 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.153 *
Antigen Specific PT continuous 0.000.000.00 p=0.512 ns
Antigen Specific TT continuous 0.000.000.00 p=0.153 *
Unsupervised RClust1 continuous 0.000.000.00 p=0.512 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.200 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.234 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.887 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.950 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.153 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mat+_iwp mat+_iap 0.00-0.791.03 p=0.799 ns
Unsupervised RClust2 mat+_iwp mat+_iap 0.00-0.531.04 p=0.650 ns
Unsupervised RClust3 mat+_iwp mat+_iap 0.00-1.130.22 p=0.344 ns
Unsupervised RClust4 mat+_iwp mat+_iap 0.00-4.05-2.59 p<0.001 ****
Unsupervised RClust5 mat+_iwp mat+_iap 0.00-1.40-0.03 p=0.099 *
Unsupervised RClust6 mat+_iwp mat+_iap 0.00-1.270.72 p=0.650 ns

infant_sex

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.18-0.13 p=0.211 *
Antigen Specific FHA Male Female 0.00-0.380.62 p=0.764 ns
Antigen Specific PRN Male Female 0.00-0.760.29 p=0.503 ns
Antigen Specific PT Male Female 0.00-0.011.10 p=0.320 ns
Antigen Specific TT Male Female 0.00-0.320.86 p=0.503 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.430.52 p=0.931 ns
Unsupervised RClust2 Male Female 0.00-1.100.20 p=0.427 ns
Unsupervised RClust3 Male Female 0.00-0.210.60 p=0.503 ns
Unsupervised RClust4 Male Female 0.00-0.430.43 p=0.988 ns
Unsupervised RClust5 Male Female 0.00-0.530.17 p=0.503 ns
Unsupervised RClust6 Male Female 0.00-0.620.10 p=0.427 ns
Unsupervised RClust7 Male Female 0.00-0.040.83 p=0.320 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.621.22 p=0.646 ns
Antigen Specific FHA Male Female 0.00-0.721.42 p=0.646 ns
Antigen Specific PRN Male Female 0.00-1.560.56 p=0.646 ns
Antigen Specific PT Male Female 0.00-1.560.60 p=0.646 ns
Antigen Specific TT Male Female 0.00-0.621.38 p=0.646 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.380.14 p=0.646 ns
Unsupervised RClust2 Male Female 0.00-0.881.36 p=0.676 ns
Unsupervised RClust3 Male Female 0.00-0.531.29 p=0.646 ns
Unsupervised RClust4 Male Female 0.00-0.361.45 p=0.646 ns
Unsupervised RClust5 Male Female 0.00-1.210.63 p=0.646 ns
Unsupervised RClust6 Male Female 0.00-0.970.57 p=0.667 ns
Unsupervised RClust7 Male Female 0.00-1.900.25 p=0.646 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.18-0.13 p=0.193 *
Antigen Specific FHA Male Female 0.00-0.380.62 p=0.778 ns
Antigen Specific PRN Male Female 0.00-0.760.29 p=0.519 ns
Antigen Specific PT Male Female 0.00-0.011.10 p=0.314 ns
Antigen Specific TT Male Female 0.00-0.320.86 p=0.519 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.430.52 p=0.861 ns
Unsupervised RClust2 Male Female 0.00-1.100.20 p=0.490 ns
Unsupervised RClust3 Male Female 0.00-0.210.60 p=0.519 ns
Unsupervised RClust4 Male Female 0.00-0.640.77 p=0.861 ns
Unsupervised RClust5 Male Female 0.00-0.530.17 p=0.519 ns
Unsupervised RClust6 Male Female 0.00-0.620.10 p=0.490 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.621.22 p=0.657 ns
Antigen Specific FHA Male Female 0.00-0.721.42 p=0.657 ns
Antigen Specific PRN Male Female 0.00-1.560.56 p=0.657 ns
Antigen Specific PT Male Female 0.00-1.560.60 p=0.657 ns
Antigen Specific TT Male Female 0.00-0.621.38 p=0.657 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.380.14 p=0.657 ns
Unsupervised RClust2 Male Female 0.00-0.881.36 p=0.676 ns
Unsupervised RClust3 Male Female 0.00-0.531.29 p=0.657 ns
Unsupervised RClust4 Male Female 0.00-2.220.24 p=0.657 ns
Unsupervised RClust5 Male Female 0.00-1.210.63 p=0.657 ns
Unsupervised RClust6 Male Female 0.00-0.970.57 p=0.673 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.000.181.31 p=0.135 *
Antigen Specific FHA Male Female 0.00-0.270.92 p=0.687 ns
Antigen Specific PRN Male Female 0.00-0.620.55 p=0.917 ns
Antigen Specific PT Male Female 0.00-1.22-0.07 p=0.189 *
Antigen Specific TT Male Female 0.00-0.530.64 p=0.917 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.360.65 p=0.774 ns
Unsupervised RClust2 Male Female 0.00-0.600.26 p=0.764 ns
Unsupervised RClust3 Male Female 0.00-0.300.53 p=0.774 ns
Unsupervised RClust4 Male Female 0.00-0.300.81 p=0.735 ns
Unsupervised RClust5 Male Female 0.00-0.350.39 p=0.917 ns
Unsupervised RClust6 Male Female 0.00-0.900.00 p=0.210 ns
Unsupervised RClust7 Male Female 0.00-0.950.20 p=0.608 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.000.49 p=0.609 ns
Antigen Specific FHA Male Female 0.00-1.010.66 p=0.739 ns
Antigen Specific PRN Male Female 0.00-0.411.07 p=0.609 ns
Antigen Specific PT Male Female 0.00-0.950.85 p=0.917 ns
Antigen Specific TT Male Female 0.00-0.331.44 p=0.609 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.810.24 p=0.609 ns
Unsupervised RClust2 Male Female 0.00-0.690.25 p=0.609 ns
Unsupervised RClust3 Male Female 0.00-0.940.35 p=0.609 ns
Unsupervised RClust4 Male Female 0.00-0.601.40 p=0.609 ns
Unsupervised RClust5 Male Female 0.00-0.470.96 p=0.609 ns
Unsupervised RClust6 Male Female 0.00-1.750.29 p=0.609 ns
Unsupervised RClust7 Male Female 0.00-0.581.39 p=0.609 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.000.181.31 p=0.123 *
Antigen Specific FHA Male Female 0.00-0.270.92 p=0.629 ns
Antigen Specific PRN Male Female 0.00-0.550.62 p=0.917 ns
Antigen Specific PT Male Female 0.00-1.22-0.07 p=0.174 *
Antigen Specific TT Male Female 0.00-0.530.64 p=0.917 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.360.65 p=0.791 ns
Unsupervised RClust2 Male Female 0.00-0.720.31 p=0.692 ns
Unsupervised RClust3 Male Female 0.00-0.300.81 p=0.674 ns
Unsupervised RClust4 Male Female 0.00-0.350.39 p=0.917 ns
Unsupervised RClust5 Male Female 0.00-0.900.00 p=0.193 ns
Unsupervised RClust6 Male Female 0.00-0.950.20 p=0.558 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.000.49 p=0.621 ns
Antigen Specific FHA Male Female 0.00-1.010.66 p=0.745 ns
Antigen Specific PRN Male Female 0.00-0.411.07 p=0.621 ns
Antigen Specific PT Male Female 0.00-0.950.85 p=0.917 ns
Antigen Specific TT Male Female 0.00-0.331.44 p=0.621 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.810.24 p=0.621 ns
Unsupervised RClust2 Male Female 0.00-0.370.93 p=0.621 ns
Unsupervised RClust3 Male Female 0.00-0.601.40 p=0.621 ns
Unsupervised RClust4 Male Female 0.00-0.470.96 p=0.621 ns
Unsupervised RClust5 Male Female 0.00-1.750.29 p=0.621 ns
Unsupervised RClust6 Male Female 0.00-0.581.39 p=0.621 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.29-0.21 p=0.095 **
Antigen Specific FHA Male Female 0.00-0.360.78 p=0.816 ns
Antigen Specific PRN Male Female 0.00-0.550.62 p=0.998 ns
Antigen Specific PT Male Female 0.00-1.19-0.05 p=0.210 *
Antigen Specific TT Male Female 0.00-0.570.57 p=0.998 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.550.36 p=0.919 ns
Unsupervised RClust2 Male Female 0.00-0.530.30 p=0.871 ns
Unsupervised RClust3 Male Female 0.00-0.280.62 p=0.816 ns
Unsupervised RClust4 Male Female 0.00-0.350.39 p=0.998 ns
Unsupervised RClust5 Male Female 0.000.000.90 p=0.210 ns
Unsupervised RClust6 Male Female 0.00-0.100.62 p=0.392 ns
Unsupervised RClust7 Male Female 0.00-0.770.12 p=0.392 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.500.98 p=0.703 ns
Antigen Specific FHA Male Female 0.00-0.680.99 p=0.781 ns
Antigen Specific PRN Male Female 0.00-1.000.44 p=0.703 ns
Antigen Specific PT Male Female 0.00-0.940.87 p=0.936 ns
Antigen Specific TT Male Female 0.00-0.301.45 p=0.615 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.101.46 p=0.615 ns
Unsupervised RClust2 Male Female 0.00-0.940.35 p=0.703 ns
Unsupervised RClust3 Male Female 0.00-0.781.25 p=0.781 ns
Unsupervised RClust4 Male Female 0.00-0.960.47 p=0.703 ns
Unsupervised RClust5 Male Female 0.00-1.750.29 p=0.615 ns
Unsupervised RClust6 Male Female 0.00-0.231.33 p=0.615 ns
Unsupervised RClust7 Male Female 0.00-1.280.57 p=0.703 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.31-0.18 p=0.123 *
Antigen Specific FHA Male Female 0.00-0.270.92 p=0.629 ns
Antigen Specific PRN Male Female 0.00-0.550.62 p=0.917 ns
Antigen Specific PT Male Female 0.00-1.22-0.07 p=0.174 *
Antigen Specific TT Male Female 0.00-0.640.53 p=0.917 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.550.36 p=0.917 ns
Unsupervised RClust2 Male Female 0.00-0.530.30 p=0.912 ns
Unsupervised RClust3 Male Female 0.00-0.350.96 p=0.665 ns
Unsupervised RClust4 Male Female 0.00-0.350.39 p=0.917 ns
Unsupervised RClust5 Male Female 0.000.000.90 p=0.193 ns
Unsupervised RClust6 Male Female 0.00-0.120.77 p=0.435 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.000.49 p=0.621 ns
Antigen Specific FHA Male Female 0.00-0.661.01 p=0.745 ns
Antigen Specific PRN Male Female 0.00-0.411.07 p=0.621 ns
Antigen Specific PT Male Female 0.00-0.950.85 p=0.917 ns
Antigen Specific TT Male Female 0.00-0.331.44 p=0.621 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.460.10 p=0.621 ns
Unsupervised RClust2 Male Female 0.00-0.350.94 p=0.621 ns
Unsupervised RClust3 Male Female 0.00-0.681.55 p=0.621 ns
Unsupervised RClust4 Male Female 0.00-0.960.47 p=0.621 ns
Unsupervised RClust5 Male Female 0.00-1.750.29 p=0.621 ns
Unsupervised RClust6 Male Female 0.00-1.280.57 p=0.621 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.610.51 p=0.929 ns
Antigen Specific FHA Male Female 0.00-0.040.91 p=0.461 ns
Antigen Specific PRN Male Female 0.00-0.790.26 p=0.519 ns
Antigen Specific PT Male Female 0.00-1.090.18 p=0.490 ns
Antigen Specific TT Male Female 0.000.011.28 p=0.461 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.350.39 p=0.931 ns
Unsupervised RClust2 Male Female 0.00-0.900.18 p=0.490 ns
Unsupervised RClust3 Male Female 0.00-0.380.84 p=0.589 ns
Unsupervised RClust4 Male Female 0.00-0.140.67 p=0.490 ns
Unsupervised RClust5 Male Female 0.00-0.280.81 p=0.519 ns
Unsupervised RClust6 Male Female 0.00-0.710.34 p=0.589 ns
Unsupervised RClust7 Male Female 0.00-0.690.21 p=0.519 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.220.50 p=0.814 ns
Antigen Specific FHA Male Female 0.00-1.590.57 p=0.814 ns
Antigen Specific PRN Male Female 0.00-0.331.73 p=0.814 ns
Antigen Specific PT Male Female 0.00-0.721.21 p=0.814 ns
Antigen Specific TT Male Female 0.00-0.900.76 p=0.870 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.040.72 p=0.814 ns
Unsupervised RClust2 Male Female 0.00-0.590.83 p=0.814 ns
Unsupervised RClust3 Male Female 0.00-1.730.57 p=0.814 ns
Unsupervised RClust4 Male Female 0.00-0.651.15 p=0.814 ns
Unsupervised RClust5 Male Female 0.00-0.610.98 p=0.814 ns
Unsupervised RClust6 Male Female 0.00-0.530.92 p=0.814 ns
Unsupervised RClust7 Male Female 0.00-2.35-0.14 p=0.358 *
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.610.51 p=0.931 ns
Antigen Specific FHA Male Female 0.00-0.040.91 p=0.422 ns
Antigen Specific PRN Male Female 0.00-0.790.26 p=0.475 ns
Antigen Specific PT Male Female 0.00-1.090.18 p=0.450 ns
Antigen Specific TT Male Female 0.000.011.28 p=0.422 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.350.39 p=0.931 ns
Unsupervised RClust2 Male Female 0.00-0.900.18 p=0.450 ns
Unsupervised RClust3 Male Female 0.00-1.320.36 p=0.475 ns
Unsupervised RClust4 Male Female 0.00-0.140.67 p=0.450 ns
Unsupervised RClust5 Male Female 0.00-0.280.81 p=0.475 ns
Unsupervised RClust6 Male Female 0.00-0.710.34 p=0.600 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.220.50 p=0.821 ns
Antigen Specific FHA Male Female 0.00-1.590.57 p=0.821 ns
Antigen Specific PRN Male Female 0.00-0.331.73 p=0.821 ns
Antigen Specific PT Male Female 0.00-0.721.21 p=0.821 ns
Antigen Specific TT Male Female 0.00-0.900.76 p=0.870 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.040.72 p=0.821 ns
Unsupervised RClust2 Male Female 0.00-0.590.83 p=0.821 ns
Unsupervised RClust3 Male Female 0.00-2.670.09 p=0.779 ns
Unsupervised RClust4 Male Female 0.00-0.651.15 p=0.821 ns
Unsupervised RClust5 Male Female 0.00-0.610.98 p=0.821 ns
Unsupervised RClust6 Male Female 0.00-0.530.92 p=0.821 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.800.40 p=0.871 ns
Antigen Specific FHA Male Female 0.00-1.11-0.05 p=0.429 *
Antigen Specific PRN Male Female 0.00-1.160.11 p=0.441 ns
Antigen Specific PT Male Female 0.00-0.730.53 p=0.871 ns
Antigen Specific TT Male Female 0.00-1.050.04 p=0.429 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.370.46 p=0.871 ns
Unsupervised RClust2 Male Female 0.00-0.580.49 p=0.871 ns
Unsupervised RClust3 Male Female 0.00-0.400.84 p=0.871 ns
Unsupervised RClust4 Male Female 0.00-0.530.36 p=0.871 ns
Unsupervised RClust5 Male Female 0.00-0.500.26 p=0.871 ns
Unsupervised RClust6 Male Female 0.00-0.200.80 p=0.717 ns
Unsupervised RClust7 Male Female 0.00-0.450.30 p=0.871 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.980.35 p=0.794 ns
Antigen Specific FHA Male Female 0.00-0.541.19 p=0.794 ns
Antigen Specific PRN Male Female 0.00-0.650.83 p=0.922 ns
Antigen Specific PT Male Female 0.00-1.370.31 p=0.794 ns
Antigen Specific TT Male Female 0.00-0.361.21 p=0.794 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.831.01 p=0.922 ns
Unsupervised RClust2 Male Female 0.00-1.56-0.01 p=0.300 *
Unsupervised RClust3 Male Female 0.00-1.670.71 p=0.794 ns
Unsupervised RClust4 Male Female 0.00-2.18-0.11 p=0.300 *
Unsupervised RClust5 Male Female 0.00-0.680.70 p=0.982 ns
Unsupervised RClust6 Male Female 0.00-0.510.94 p=0.836 ns
Unsupervised RClust7 Male Female 0.00-0.480.79 p=0.841 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.400.80 p=0.837 ns
Antigen Specific FHA Male Female 0.000.051.11 p=0.393 *
Antigen Specific PRN Male Female 0.00-1.160.11 p=0.404 ns
Antigen Specific PT Male Female 0.00-0.730.53 p=0.837 ns
Antigen Specific TT Male Female 0.00-1.050.04 p=0.393 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.960.51 p=0.837 ns
Unsupervised RClust2 Male Female 0.00-0.580.49 p=0.871 ns
Unsupervised RClust3 Male Female 0.00-0.400.84 p=0.837 ns
Unsupervised RClust4 Male Female 0.00-0.530.36 p=0.837 ns
Unsupervised RClust5 Male Female 0.00-0.500.26 p=0.837 ns
Unsupervised RClust6 Male Female 0.00-0.450.30 p=0.837 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.980.35 p=0.728 ns
Antigen Specific FHA Male Female 0.00-0.541.19 p=0.728 ns
Antigen Specific PRN Male Female 0.00-0.650.83 p=0.982 ns
Antigen Specific PT Male Female 0.00-1.370.31 p=0.728 ns
Antigen Specific TT Male Female 0.00-0.361.21 p=0.728 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.920.95 p=0.982 ns
Unsupervised RClust2 Male Female 0.00-1.56-0.01 p=0.275 *
Unsupervised RClust3 Male Female 0.00-1.670.71 p=0.728 ns
Unsupervised RClust4 Male Female 0.00-2.18-0.11 p=0.275 *
Unsupervised RClust5 Male Female 0.00-0.680.70 p=0.982 ns
Unsupervised RClust6 Male Female 0.00-0.480.79 p=0.867 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.310.85 p=0.871 ns
Antigen Specific FHA Male Female 0.000.001.07 p=0.313 ns
Antigen Specific PRN Male Female 0.00-1.140.13 p=0.481 ns
Antigen Specific PT Male Female 0.00-0.740.52 p=0.871 ns
Antigen Specific TT Male Female 0.000.101.15 p=0.263 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.370.46 p=0.871 ns
Unsupervised RClust2 Male Female 0.00-0.490.58 p=0.871 ns
Unsupervised RClust3 Male Female 0.00-0.500.64 p=0.871 ns
Unsupervised RClust4 Male Female 0.00-0.530.36 p=0.871 ns
Unsupervised RClust5 Male Female 0.00-0.260.50 p=0.871 ns
Unsupervised RClust6 Male Female 0.00-0.300.45 p=0.871 ns
Unsupervised RClust7 Male Female 0.00-0.240.88 p=0.786 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.340.99 p=0.757 ns
Antigen Specific FHA Male Female 0.00-0.521.20 p=0.757 ns
Antigen Specific PRN Male Female 0.00-0.740.71 p=0.982 ns
Antigen Specific PT Male Female 0.00-0.301.36 p=0.757 ns
Antigen Specific TT Male Female 0.00-0.361.21 p=0.757 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.010.83 p=0.982 ns
Unsupervised RClust2 Male Female 0.00-1.56-0.01 p=0.300 *
Unsupervised RClust3 Male Female 0.00-0.390.98 p=0.757 ns
Unsupervised RClust4 Male Female 0.000.112.18 p=0.300 *
Unsupervised RClust5 Male Female 0.00-0.680.70 p=0.982 ns
Unsupervised RClust6 Male Female 0.00-0.790.48 p=0.841 ns
Unsupervised RClust7 Male Female 0.00-0.691.31 p=0.824 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.800.40 p=0.871 ns
Antigen Specific FHA Male Female 0.00-1.11-0.05 p=0.393 *
Antigen Specific PRN Male Female 0.00-1.160.11 p=0.404 ns
Antigen Specific PT Male Female 0.00-0.730.53 p=0.871 ns
Antigen Specific TT Male Female 0.00-1.050.04 p=0.393 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.370.46 p=0.871 ns
Unsupervised RClust2 Male Female 0.00-0.580.49 p=0.871 ns
Unsupervised RClust3 Male Female 0.00-0.640.50 p=0.871 ns
Unsupervised RClust4 Male Female 0.00-0.530.36 p=0.871 ns
Unsupervised RClust5 Male Female 0.00-0.500.74 p=0.871 ns
Unsupervised RClust6 Male Female 0.00-0.880.24 p=0.721 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.350.98 p=0.728 ns
Antigen Specific FHA Male Female 0.00-1.190.54 p=0.728 ns
Antigen Specific PRN Male Female 0.00-0.830.65 p=0.845 ns
Antigen Specific PT Male Female 0.00-1.370.31 p=0.728 ns
Antigen Specific TT Male Female 0.00-0.361.21 p=0.728 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.010.83 p=0.845 ns
Unsupervised RClust2 Male Female 0.000.011.56 p=0.275 *
Unsupervised RClust3 Male Female 0.00-0.390.98 p=0.728 ns
Unsupervised RClust4 Male Female 0.000.112.18 p=0.275 *
Unsupervised RClust5 Male Female 0.00-0.640.78 p=0.845 ns
Unsupervised RClust6 Male Female 0.00-0.691.31 p=0.756 ns

delivery_mode

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.960.14 p=0.704 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.190.83 p=0.704 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.000.06 p=0.704 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.220.92 p=0.704 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.400.82 p=0.766 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.580.39 p=0.766 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.860.48 p=0.766 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.220.60 p=0.766 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.320.55 p=0.766 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.370.36 p=0.987 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.450.29 p=0.766 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.310.60 p=0.766 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.731.16 p=0.810 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.451.72 p=0.540 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.280.89 p=0.810 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-2.35-0.22 p=0.185 *
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.441.59 p=0.540 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.180.39 p=0.553 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.000.142.36 p=0.185 *
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.501.35 p=0.553 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.821.05 p=0.810 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-1.550.31 p=0.540 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.910.67 p=0.810 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-1.930.27 p=0.540 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.960.14 p=0.600 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.190.83 p=0.600 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.000.06 p=0.600 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.220.92 p=0.600 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.400.82 p=0.773 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.580.39 p=0.773 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.860.48 p=0.773 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.220.60 p=0.681 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.311.12 p=0.600 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.370.36 p=0.987 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.450.29 p=0.773 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.731.16 p=0.764 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.451.72 p=0.495 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.280.89 p=0.764 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-2.35-0.22 p=0.170 *
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.441.59 p=0.495 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.180.39 p=0.507 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.000.142.36 p=0.170 *
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.501.35 p=0.507 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-2.010.53 p=0.495 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-1.550.31 p=0.495 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.910.67 p=0.764 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.260.93 p=0.759 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.181.03 p=0.759 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.390.80 p=0.759 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.23-0.05 p=0.450 *
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.270.92 p=0.759 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.370.65 p=0.759 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.470.41 p=0.898 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.290.55 p=0.759 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.290.84 p=0.759 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.470.28 p=0.759 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.500.44 p=0.898 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.440.74 p=0.759 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.770.75 p=0.977 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.501.19 p=0.977 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.331.18 p=0.977 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.120.72 p=0.977 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.801.03 p=0.977 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.440.67 p=0.977 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.430.53 p=0.977 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.780.54 p=0.977 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.821.23 p=0.977 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.760.71 p=0.977 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-1.820.26 p=0.977 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-1.280.72 p=0.977 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.260.93 p=0.765 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.181.03 p=0.765 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.800.39 p=0.773 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.23-0.05 p=0.413 *
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.270.92 p=0.765 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.370.65 p=0.773 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.440.62 p=0.813 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.290.84 p=0.765 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.470.28 p=0.773 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.500.44 p=0.886 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.440.74 p=0.773 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.770.75 p=0.977 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.501.19 p=0.977 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.331.18 p=0.977 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.120.72 p=0.977 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.801.03 p=0.977 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.440.67 p=0.977 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.550.78 p=0.977 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.821.23 p=0.977 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.760.71 p=0.977 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-1.820.26 p=0.977 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-1.280.72 p=0.977 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.910.23 p=0.843 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.151.00 p=0.843 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.800.39 p=0.843 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.090.08 p=0.843 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.840.32 p=0.843 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.340.59 p=0.843 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.550.29 p=0.843 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.530.40 p=0.939 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.470.28 p=0.843 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.440.50 p=0.967 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.380.37 p=0.985 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.700.21 p=0.843 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.750.77 p=0.989 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.210.48 p=0.970 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.130.34 p=0.970 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.100.74 p=0.989 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.731.07 p=0.989 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.451.17 p=0.970 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.780.54 p=0.989 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-1.011.06 p=0.989 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.710.76 p=0.989 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-1.820.26 p=0.970 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-1.140.46 p=0.970 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-1.020.88 p=0.989 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.930.26 p=0.663 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.181.03 p=0.663 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.800.39 p=0.696 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.23-0.05 p=0.413 *
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.920.27 p=0.663 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.340.59 p=0.696 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.550.29 p=0.696 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.900.44 p=0.696 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.470.28 p=0.696 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.440.50 p=0.886 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.210.70 p=0.663 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.770.75 p=0.977 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.190.50 p=0.977 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.331.18 p=0.977 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.120.72 p=0.977 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.801.03 p=0.977 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.170.45 p=0.977 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.540.78 p=0.977 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-1.330.95 p=0.977 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.710.76 p=0.977 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-1.820.26 p=0.977 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-1.020.88 p=0.977 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.290.85 p=0.702 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.260.73 p=0.702 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.08-0.02 p=0.264 *
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.210.07 p=0.335 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.620.72 p=0.961 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.300.45 p=0.918 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.370.74 p=0.760 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.620.62 p=0.997 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.190.65 p=0.702 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.790.33 p=0.729 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.000.031.08 p=0.264 *
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.390.54 p=0.918 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.780.98 p=0.991 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.370.84 p=0.991 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.001.13 p=0.991 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.010.96 p=0.991 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-1.400.28 p=0.991 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.421.37 p=0.991 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.371.08 p=0.991 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-1.071.29 p=0.991 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.930.92 p=0.991 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.950.66 p=0.991 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.730.75 p=0.991 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-2.110.17 p=0.991 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.290.85 p=0.551 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.260.73 p=0.551 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.08-0.02 p=0.230 *
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.210.07 p=0.230 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.620.72 p=0.881 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.300.45 p=0.777 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.370.74 p=0.619 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-1.650.04 p=0.230 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.190.65 p=0.551 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.790.33 p=0.585 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.000.031.08 p=0.230 *
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.780.98 p=0.991 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.370.84 p=0.991 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.001.13 p=0.991 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.010.96 p=0.991 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-1.400.28 p=0.991 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.421.37 p=0.991 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.371.08 p=0.991 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-2.030.84 p=0.991 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.930.92 p=0.991 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.950.66 p=0.991 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.730.75 p=0.991 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.570.65 p=0.964 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.020.08 p=0.426 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.050.25 p=0.692 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.31-0.05 p=0.426 *
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.560.58 p=0.964 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.630.20 p=0.773 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.360.73 p=0.908 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.720.54 p=0.964 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.310.60 p=0.908 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.370.41 p=0.964 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.080.93 p=0.426 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.310.46 p=0.964 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.820.55 p=0.801 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.461.30 p=0.801 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.550.96 p=0.801 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.870.86 p=0.986 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.591.02 p=0.801 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.731.15 p=0.801 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.670.95 p=0.801 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.971.47 p=0.801 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-2.070.06 p=0.801 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.221.18 p=0.801 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.431.05 p=0.801 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.241.05 p=0.801 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.650.57 p=0.964 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.081.02 p=0.527 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.050.25 p=0.757 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.31-0.05 p=0.409 *
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.560.58 p=0.964 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.170.33 p=0.757 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.360.73 p=0.964 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.720.54 p=0.964 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.310.60 p=0.964 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.370.41 p=0.964 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.310.46 p=0.964 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.820.55 p=0.860 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.461.30 p=0.860 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.550.96 p=0.860 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.870.86 p=0.986 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.591.02 p=0.860 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.821.09 p=0.860 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.670.95 p=0.860 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.971.47 p=0.860 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-2.070.06 p=0.743 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.221.18 p=0.807 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.241.05 p=0.807 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.410.78 p=0.718 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.170.94 p=0.645 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.060.24 p=0.645 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.33-0.08 p=0.355 *
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.270.83 p=0.645 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.630.20 p=0.645 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.730.36 p=0.718 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.950.20 p=0.645 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.310.60 p=0.718 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.410.37 p=0.922 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.460.31 p=0.842 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.530.61 p=0.922 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.590.78 p=0.939 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.461.30 p=0.939 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.940.54 p=0.939 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.840.87 p=0.969 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.551.06 p=0.939 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.150.73 p=0.939 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.670.95 p=0.939 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.760.64 p=0.947 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.062.07 p=0.811 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.221.18 p=0.880 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-1.050.24 p=0.880 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-1.200.85 p=0.939 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.570.65 p=0.964 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.020.08 p=0.527 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.050.25 p=0.634 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.31-0.05 p=0.409 *
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.560.58 p=0.964 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.630.20 p=0.708 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.360.73 p=0.832 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.200.95 p=0.634 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.310.60 p=0.832 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.510.76 p=0.964 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.610.53 p=0.964 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.550.82 p=0.904 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.300.46 p=0.904 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.960.55 p=0.904 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.870.86 p=0.986 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.591.02 p=0.904 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.150.73 p=0.904 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.950.67 p=0.904 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.760.64 p=0.955 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.062.07 p=0.534 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.101.32 p=0.534 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-1.200.85 p=0.904 ns

parity

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.550.57 p=0.974 ns
Antigen Specific FHA 1 2+ 0.00-0.030.98 p=0.419 ns
Antigen Specific PRN 1 2+ 0.00-0.750.33 p=0.826 ns
Antigen Specific PT 1 2+ 0.00-0.160.99 p=0.474 ns
Antigen Specific TT 1 2+ 0.00-0.310.91 p=0.800 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.340.64 p=0.826 ns
Unsupervised RClust2 1 2+ 0.00-0.161.16 p=0.474 ns
Unsupervised RClust3 1 2+ 0.000.060.86 p=0.337 *
Unsupervised RClust4 1 2+ 0.00-0.300.58 p=0.826 ns
Unsupervised RClust5 1 2+ 0.00-0.350.38 p=0.974 ns
Unsupervised RClust6 1 2+ 0.00-0.330.42 p=0.974 ns
Unsupervised RClust7 1 2+ 0.00-0.450.46 p=0.974 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.731.17 p=0.865 ns
Antigen Specific FHA 1 2+ 0.00-0.311.87 p=0.697 ns
Antigen Specific PRN 1 2+ 0.00-1.660.51 p=0.697 ns
Antigen Specific PT 1 2+ 0.00-1.041.18 p=0.958 ns
Antigen Specific TT 1 2+ 0.00-0.731.33 p=0.850 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.371.21 p=0.697 ns
Unsupervised RClust2 1 2+ 0.00-1.121.19 p=0.958 ns
Unsupervised RClust3 1 2+ 0.00-0.461.40 p=0.697 ns
Unsupervised RClust4 1 2+ 0.00-0.541.33 p=0.697 ns
Unsupervised RClust5 1 2+ 0.00-1.380.51 p=0.697 ns
Unsupervised RClust6 1 2+ 0.00-0.760.83 p=0.958 ns
Unsupervised RClust7 1 2+ 0.00-2.000.20 p=0.697 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.550.57 p=0.974 ns
Antigen Specific FHA 1 2+ 0.00-0.030.98 p=0.384 ns
Antigen Specific PRN 1 2+ 0.00-0.750.33 p=0.757 ns
Antigen Specific PT 1 2+ 0.00-0.160.99 p=0.434 ns
Antigen Specific TT 1 2+ 0.00-0.310.91 p=0.733 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.340.64 p=0.757 ns
Unsupervised RClust2 1 2+ 0.00-0.161.16 p=0.434 ns
Unsupervised RClust3 1 2+ 0.000.060.86 p=0.309 *
Unsupervised RClust4 1 2+ 0.00-0.470.97 p=0.757 ns
Unsupervised RClust5 1 2+ 0.00-0.350.38 p=0.974 ns
Unsupervised RClust6 1 2+ 0.00-0.330.42 p=0.974 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.731.17 p=0.893 ns
Antigen Specific FHA 1 2+ 0.00-0.311.87 p=0.678 ns
Antigen Specific PRN 1 2+ 0.00-1.660.51 p=0.678 ns
Antigen Specific PT 1 2+ 0.00-1.041.18 p=0.958 ns
Antigen Specific TT 1 2+ 0.00-0.731.33 p=0.891 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.371.21 p=0.678 ns
Unsupervised RClust2 1 2+ 0.00-1.121.19 p=0.958 ns
Unsupervised RClust3 1 2+ 0.00-0.461.40 p=0.678 ns
Unsupervised RClust4 1 2+ 0.00-2.220.31 p=0.678 ns
Unsupervised RClust5 1 2+ 0.00-1.380.51 p=0.678 ns
Unsupervised RClust6 1 2+ 0.00-0.760.83 p=0.958 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.200.99 p=0.346 ns
Antigen Specific FHA 1 2+ 0.00-0.131.09 p=0.346 ns
Antigen Specific PRN 1 2+ 0.00-0.071.11 p=0.346 ns
Antigen Specific PT 1 2+ 0.00-0.870.35 p=0.438 ns
Antigen Specific TT 1 2+ 0.00-0.111.07 p=0.346 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.780.25 p=0.425 ns
Unsupervised RClust2 1 2+ 0.00-0.140.74 p=0.346 ns
Unsupervised RClust3 1 2+ 0.00-0.720.12 p=0.346 ns
Unsupervised RClust4 1 2+ 0.00-0.061.06 p=0.346 ns
Unsupervised RClust5 1 2+ 0.00-0.180.58 p=0.425 ns
Unsupervised RClust6 1 2+ 0.00-0.360.58 p=0.647 ns
Unsupervised RClust7 1 2+ 0.00-0.320.87 p=0.436 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.640.88 p=0.895 ns
Antigen Specific FHA 1 2+ 0.00-0.251.44 p=0.828 ns
Antigen Specific PRN 1 2+ 0.00-0.770.76 p=0.997 ns
Antigen Specific PT 1 2+ 0.00-1.210.64 p=0.828 ns
Antigen Specific TT 1 2+ 0.00-0.811.03 p=0.895 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.891.24 p=0.895 ns
Unsupervised RClust2 1 2+ 0.00-0.700.26 p=0.828 ns
Unsupervised RClust3 1 2+ 0.00-0.930.40 p=0.828 ns
Unsupervised RClust4 1 2+ 0.00-1.400.67 p=0.828 ns
Unsupervised RClust5 1 2+ 0.00-1.160.31 p=0.828 ns
Unsupervised RClust6 1 2+ 0.00-1.910.18 p=0.828 ns
Unsupervised RClust7 1 2+ 0.00-1.410.60 p=0.828 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.200.99 p=0.444 ns
Antigen Specific FHA 1 2+ 0.00-0.131.09 p=0.342 ns
Antigen Specific PRN 1 2+ 0.00-1.110.07 p=0.342 ns
Antigen Specific PT 1 2+ 0.00-0.870.35 p=0.491 ns
Antigen Specific TT 1 2+ 0.00-0.111.07 p=0.342 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.780.25 p=0.491 ns
Unsupervised RClust2 1 2+ 0.00-0.700.35 p=0.566 ns
Unsupervised RClust3 1 2+ 0.00-0.061.06 p=0.342 ns
Unsupervised RClust4 1 2+ 0.00-0.180.58 p=0.491 ns
Unsupervised RClust5 1 2+ 0.00-0.360.58 p=0.647 ns
Unsupervised RClust6 1 2+ 0.00-0.320.87 p=0.491 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.640.88 p=0.903 ns
Antigen Specific FHA 1 2+ 0.00-0.251.44 p=0.867 ns
Antigen Specific PRN 1 2+ 0.00-0.770.76 p=0.997 ns
Antigen Specific PT 1 2+ 0.00-1.210.64 p=0.867 ns
Antigen Specific TT 1 2+ 0.00-0.811.03 p=0.903 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.891.24 p=0.903 ns
Unsupervised RClust2 1 2+ 0.00-0.350.98 p=0.867 ns
Unsupervised RClust3 1 2+ 0.00-1.400.67 p=0.867 ns
Unsupervised RClust4 1 2+ 0.00-1.160.31 p=0.867 ns
Unsupervised RClust5 1 2+ 0.00-1.910.18 p=0.867 ns
Unsupervised RClust6 1 2+ 0.00-1.410.60 p=0.867 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.910.24 p=0.401 ns
Antigen Specific FHA 1 2+ 0.00-0.011.14 p=0.339 ns
Antigen Specific PRN 1 2+ 0.00-1.110.07 p=0.354 ns
Antigen Specific PT 1 2+ 0.00-0.930.26 p=0.401 ns
Antigen Specific TT 1 2+ 0.00-1.030.13 p=0.400 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.720.21 p=0.401 ns
Unsupervised RClust2 1 2+ 0.00-0.120.72 p=0.401 ns
Unsupervised RClust3 1 2+ 0.00-0.470.46 p=0.994 ns
Unsupervised RClust4 1 2+ 0.00-0.180.58 p=0.401 ns
Unsupervised RClust5 1 2+ 0.00-0.580.36 p=0.776 ns
Unsupervised RClust6 1 2+ 0.00-0.420.33 p=0.898 ns
Unsupervised RClust7 1 2+ 0.00-0.99-0.10 p=0.237 *
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.890.64 p=0.916 ns
Antigen Specific FHA 1 2+ 0.00-1.450.23 p=0.778 ns
Antigen Specific PRN 1 2+ 0.00-0.710.78 p=0.927 ns
Antigen Specific PT 1 2+ 0.00-1.210.63 p=0.811 ns
Antigen Specific TT 1 2+ 0.00-0.771.05 p=0.916 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.100.53 p=0.811 ns
Unsupervised RClust2 1 2+ 0.00-0.930.40 p=0.811 ns
Unsupervised RClust3 1 2+ 0.00-1.120.97 p=0.927 ns
Unsupervised RClust4 1 2+ 0.00-0.311.16 p=0.778 ns
Unsupervised RClust5 1 2+ 0.00-1.910.18 p=0.778 ns
Unsupervised RClust6 1 2+ 0.00-1.290.31 p=0.778 ns
Unsupervised RClust7 1 2+ 0.00-0.611.30 p=0.811 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.990.20 p=0.370 ns
Antigen Specific FHA 1 2+ 0.00-0.131.09 p=0.342 ns
Antigen Specific PRN 1 2+ 0.00-1.110.07 p=0.342 ns
Antigen Specific PT 1 2+ 0.00-0.870.35 p=0.442 ns
Antigen Specific TT 1 2+ 0.00-1.070.11 p=0.342 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.720.21 p=0.379 ns
Unsupervised RClust2 1 2+ 0.00-0.120.72 p=0.370 ns
Unsupervised RClust3 1 2+ 0.00-1.020.32 p=0.379 ns
Unsupervised RClust4 1 2+ 0.00-0.180.58 p=0.379 ns
Unsupervised RClust5 1 2+ 0.00-0.580.36 p=0.647 ns
Unsupervised RClust6 1 2+ 0.000.100.99 p=0.217 *
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.640.88 p=0.903 ns
Antigen Specific FHA 1 2+ 0.00-1.440.25 p=0.759 ns
Antigen Specific PRN 1 2+ 0.00-0.770.76 p=0.997 ns
Antigen Specific PT 1 2+ 0.00-1.210.64 p=0.759 ns
Antigen Specific TT 1 2+ 0.00-0.811.03 p=0.903 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.531.10 p=0.759 ns
Unsupervised RClust2 1 2+ 0.00-0.400.93 p=0.759 ns
Unsupervised RClust3 1 2+ 0.00-1.500.79 p=0.759 ns
Unsupervised RClust4 1 2+ 0.00-0.311.16 p=0.759 ns
Unsupervised RClust5 1 2+ 0.00-1.910.18 p=0.759 ns
Unsupervised RClust6 1 2+ 0.00-0.611.30 p=0.759 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.000.171.25 p=0.072 *
Antigen Specific FHA 1 2+ 0.00-0.510.47 p=0.950 ns
Antigen Specific PRN 1 2+ 0.00-0.910.15 p=0.258 ns
Antigen Specific PT 1 2+ 0.00-1.46-0.22 p=0.072 **
Antigen Specific TT 1 2+ 0.00-0.191.11 p=0.258 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.150.59 p=0.327 ns
Unsupervised RClust2 1 2+ 0.000.041.10 p=0.160 *
Unsupervised RClust3 1 2+ 0.00-1.120.08 p=0.230 ns
Unsupervised RClust4 1 2+ 0.00-0.110.71 p=0.258 ns
Unsupervised RClust5 1 2+ 0.00-0.640.47 p=0.922 ns
Unsupervised RClust6 1 2+ 0.00-0.050.99 p=0.230 ns
Unsupervised RClust7 1 2+ 0.00-0.420.50 p=0.947 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-1.170.57 p=0.670 ns
Antigen Specific FHA 1 2+ 0.00-2.31-0.20 p=0.133 *
Antigen Specific PRN 1 2+ 0.00-0.641.46 p=0.668 ns
Antigen Specific PT 1 2+ 0.00-0.501.43 p=0.601 ns
Antigen Specific TT 1 2+ 0.00-0.740.94 p=0.917 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.370.40 p=0.566 ns
Unsupervised RClust2 1 2+ 0.00-0.750.68 p=0.917 ns
Unsupervised RClust3 1 2+ 0.00-1.820.49 p=0.566 ns
Unsupervised RClust4 1 2+ 0.00-0.371.44 p=0.566 ns
Unsupervised RClust5 1 2+ 0.00-0.750.85 p=0.917 ns
Unsupervised RClust6 1 2+ 0.00-0.281.17 p=0.566 ns
Unsupervised RClust7 1 2+ 0.00-2.48-0.27 p=0.133 *
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.000.171.25 p=0.066 *
Antigen Specific FHA 1 2+ 0.00-0.510.47 p=0.950 ns
Antigen Specific PRN 1 2+ 0.00-0.910.15 p=0.236 ns
Antigen Specific PT 1 2+ 0.00-1.46-0.22 p=0.066 **
Antigen Specific TT 1 2+ 0.00-0.191.11 p=0.236 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.150.59 p=0.300 ns
Unsupervised RClust2 1 2+ 0.000.041.10 p=0.146 *
Unsupervised RClust3 1 2+ 0.00-1.450.23 p=0.236 ns
Unsupervised RClust4 1 2+ 0.00-0.110.71 p=0.236 ns
Unsupervised RClust5 1 2+ 0.00-0.640.47 p=0.845 ns
Unsupervised RClust6 1 2+ 0.00-0.050.99 p=0.216 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-1.170.57 p=0.691 ns
Antigen Specific FHA 1 2+ 0.00-2.31-0.20 p=0.241 *
Antigen Specific PRN 1 2+ 0.00-0.641.46 p=0.691 ns
Antigen Specific PT 1 2+ 0.00-0.501.43 p=0.643 ns
Antigen Specific TT 1 2+ 0.00-0.740.94 p=0.917 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.370.40 p=0.623 ns
Unsupervised RClust2 1 2+ 0.00-0.750.68 p=0.917 ns
Unsupervised RClust3 1 2+ 0.00-2.83-0.07 p=0.241 *
Unsupervised RClust4 1 2+ 0.00-0.371.44 p=0.623 ns
Unsupervised RClust5 1 2+ 0.00-0.750.85 p=0.917 ns
Unsupervised RClust6 1 2+ 0.00-0.281.17 p=0.623 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-1.28-0.11 p=0.265 *
Antigen Specific FHA 1 2+ 0.00-0.930.17 p=0.308 ns
Antigen Specific PRN 1 2+ 0.00-1.190.09 p=0.308 ns
Antigen Specific PT 1 2+ 0.00-1.090.16 p=0.308 ns
Antigen Specific TT 1 2+ 0.00-0.790.32 p=0.455 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.700.12 p=0.308 ns
Unsupervised RClust2 1 2+ 0.00-0.370.71 p=0.539 ns
Unsupervised RClust3 1 2+ 0.00-0.930.31 p=0.452 ns
Unsupervised RClust4 1 2+ 0.00-0.260.64 p=0.455 ns
Unsupervised RClust5 1 2+ 0.00-0.640.12 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.260.76 p=0.452 ns
Unsupervised RClust7 1 2+ 0.00-0.670.07 p=0.308 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.151.18 p=0.270 ns
Antigen Specific FHA 1 2+ 0.00-0.691.06 p=0.677 ns
Antigen Specific PRN 1 2+ 0.00-0.141.32 p=0.270 ns
Antigen Specific PT 1 2+ 0.00-1.630.04 p=0.194 ns
Antigen Specific TT 1 2+ 0.00-0.591.01 p=0.664 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.200.65 p=0.664 ns
Unsupervised RClust2 1 2+ 0.000.481.97 p=0.023 **
Unsupervised RClust3 1 2+ 0.00-1.980.40 p=0.341 ns
Unsupervised RClust4 1 2+ 0.00-2.18-0.09 p=0.194 *
Unsupervised RClust5 1 2+ 0.00-0.021.34 p=0.194 ns
Unsupervised RClust6 1 2+ 0.00-0.451.01 p=0.601 ns
Unsupervised RClust7 1 2+ 0.00-0.290.99 p=0.428 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.000.111.28 p=0.243 *
Antigen Specific FHA 1 2+ 0.00-0.170.93 p=0.330 ns
Antigen Specific PRN 1 2+ 0.00-1.190.09 p=0.330 ns
Antigen Specific PT 1 2+ 0.00-1.090.16 p=0.330 ns
Antigen Specific TT 1 2+ 0.00-0.790.32 p=0.510 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.970.52 p=0.563 ns
Unsupervised RClust2 1 2+ 0.00-0.370.71 p=0.563 ns
Unsupervised RClust3 1 2+ 0.00-0.930.31 p=0.510 ns
Unsupervised RClust4 1 2+ 0.00-0.260.64 p=0.510 ns
Unsupervised RClust5 1 2+ 0.00-0.640.12 p=0.330 ns
Unsupervised RClust6 1 2+ 0.00-0.670.07 p=0.330 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.151.18 p=0.248 ns
Antigen Specific FHA 1 2+ 0.00-0.691.06 p=0.677 ns
Antigen Specific PRN 1 2+ 0.00-0.141.32 p=0.248 ns
Antigen Specific PT 1 2+ 0.00-1.630.04 p=0.178 ns
Antigen Specific TT 1 2+ 0.00-0.591.01 p=0.670 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.300.58 p=0.557 ns
Unsupervised RClust2 1 2+ 0.000.481.97 p=0.021 **
Unsupervised RClust3 1 2+ 0.00-1.980.40 p=0.312 ns
Unsupervised RClust4 1 2+ 0.00-2.18-0.09 p=0.178 *
Unsupervised RClust5 1 2+ 0.00-0.021.34 p=0.178 ns
Unsupervised RClust6 1 2+ 0.00-0.290.99 p=0.392 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.000.161.29 p=0.178 *
Antigen Specific FHA 1 2+ 0.00-0.320.78 p=0.501 ns
Antigen Specific PRN 1 2+ 0.00-1.190.08 p=0.270 ns
Antigen Specific PT 1 2+ 0.00-1.150.10 p=0.270 ns
Antigen Specific TT 1 2+ 0.00-0.350.75 p=0.518 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.700.12 p=0.270 ns
Unsupervised RClust2 1 2+ 0.00-0.710.37 p=0.539 ns
Unsupervised RClust3 1 2+ 0.00-0.980.16 p=0.270 ns
Unsupervised RClust4 1 2+ 0.00-0.260.64 p=0.501 ns
Unsupervised RClust5 1 2+ 0.00-0.120.64 p=0.270 ns
Unsupervised RClust6 1 2+ 0.00-0.070.67 p=0.270 ns
Unsupervised RClust7 1 2+ 0.00-0.160.95 p=0.270 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-1.110.23 p=0.399 ns
Antigen Specific FHA 1 2+ 0.00-0.641.11 p=0.708 ns
Antigen Specific PRN 1 2+ 0.00-1.260.18 p=0.356 ns
Antigen Specific PT 1 2+ 0.000.001.64 p=0.186 ns
Antigen Specific TT 1 2+ 0.00-0.610.98 p=0.708 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.651.20 p=0.708 ns
Unsupervised RClust2 1 2+ 0.000.481.97 p=0.023 **
Unsupervised RClust3 1 2+ 0.00-0.570.82 p=0.723 ns
Unsupervised RClust4 1 2+ 0.000.092.18 p=0.186 *
Unsupervised RClust5 1 2+ 0.00-0.021.34 p=0.186 ns
Unsupervised RClust6 1 2+ 0.00-0.990.29 p=0.489 ns
Unsupervised RClust7 1 2+ 0.00-0.611.41 p=0.657 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-1.28-0.11 p=0.243 *
Antigen Specific FHA 1 2+ 0.00-0.930.17 p=0.280 ns
Antigen Specific PRN 1 2+ 0.00-1.190.09 p=0.280 ns
Antigen Specific PT 1 2+ 0.00-1.090.16 p=0.280 ns
Antigen Specific TT 1 2+ 0.00-0.790.32 p=0.510 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.700.12 p=0.280 ns
Unsupervised RClust2 1 2+ 0.00-0.370.71 p=0.593 ns
Unsupervised RClust3 1 2+ 0.00-0.160.98 p=0.280 ns
Unsupervised RClust4 1 2+ 0.00-0.260.64 p=0.510 ns
Unsupervised RClust5 1 2+ 0.00-0.620.64 p=0.976 ns
Unsupervised RClust6 1 2+ 0.00-0.950.16 p=0.280 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-1.180.15 p=0.248 ns
Antigen Specific FHA 1 2+ 0.00-1.060.69 p=0.723 ns
Antigen Specific PRN 1 2+ 0.00-1.320.14 p=0.248 ns
Antigen Specific PT 1 2+ 0.00-1.630.04 p=0.178 ns
Antigen Specific TT 1 2+ 0.00-0.591.01 p=0.723 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.651.20 p=0.723 ns
Unsupervised RClust2 1 2+ 0.00-1.97-0.48 p=0.021 **
Unsupervised RClust3 1 2+ 0.00-0.570.82 p=0.723 ns
Unsupervised RClust4 1 2+ 0.000.092.18 p=0.134 *
Unsupervised RClust5 1 2+ 0.000.071.46 p=0.134 *
Unsupervised RClust6 1 2+ 0.00-0.611.41 p=0.688 ns

gravidity

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.470.63 p=0.841 ns
Antigen Specific FHA 1 2+ 0.00-0.450.55 p=0.841 ns
Antigen Specific PRN 1 2+ 0.00-0.660.39 p=0.841 ns
Antigen Specific PT 1 2+ 0.00-0.280.84 p=0.841 ns
Antigen Specific TT 1 2+ 0.00-0.460.73 p=0.841 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.110.83 p=0.841 ns
Unsupervised RClust2 1 2+ 0.00-0.400.91 p=0.841 ns
Unsupervised RClust3 1 2+ 0.00-0.260.54 p=0.841 ns
Unsupervised RClust4 1 2+ 0.00-0.250.60 p=0.841 ns
Unsupervised RClust5 1 2+ 0.00-0.460.25 p=0.841 ns
Unsupervised RClust6 1 2+ 0.00-0.320.41 p=0.841 ns
Unsupervised RClust7 1 2+ 0.00-0.380.51 p=0.841 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.990.85 p=0.951 ns
Antigen Specific FHA 1 2+ 0.00-0.521.61 p=0.951 ns
Antigen Specific PRN 1 2+ 0.00-1.101.03 p=0.951 ns
Antigen Specific PT 1 2+ 0.00-0.821.34 p=0.951 ns
Antigen Specific TT 1 2+ 0.00-0.481.51 p=0.951 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.710.83 p=0.951 ns
Unsupervised RClust2 1 2+ 0.00-1.350.89 p=0.951 ns
Unsupervised RClust3 1 2+ 0.00-0.491.32 p=0.951 ns
Unsupervised RClust4 1 2+ 0.00-0.840.98 p=0.951 ns
Unsupervised RClust5 1 2+ 0.00-1.470.35 p=0.951 ns
Unsupervised RClust6 1 2+ 0.00-0.610.93 p=0.951 ns
Unsupervised RClust7 1 2+ 0.00-1.390.77 p=0.951 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.470.63 p=0.841 ns
Antigen Specific FHA 1 2+ 0.00-0.450.55 p=0.841 ns
Antigen Specific PRN 1 2+ 0.00-0.660.39 p=0.841 ns
Antigen Specific PT 1 2+ 0.00-0.280.84 p=0.841 ns
Antigen Specific TT 1 2+ 0.00-0.460.73 p=0.841 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.110.83 p=0.841 ns
Unsupervised RClust2 1 2+ 0.00-0.400.91 p=0.841 ns
Unsupervised RClust3 1 2+ 0.00-0.260.54 p=0.841 ns
Unsupervised RClust4 1 2+ 0.00-0.570.83 p=0.841 ns
Unsupervised RClust5 1 2+ 0.00-0.460.25 p=0.841 ns
Unsupervised RClust6 1 2+ 0.00-0.320.41 p=0.841 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.990.85 p=0.951 ns
Antigen Specific FHA 1 2+ 0.00-0.521.61 p=0.951 ns
Antigen Specific PRN 1 2+ 0.00-1.101.03 p=0.951 ns
Antigen Specific PT 1 2+ 0.00-0.821.34 p=0.951 ns
Antigen Specific TT 1 2+ 0.00-0.481.51 p=0.951 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.710.83 p=0.951 ns
Unsupervised RClust2 1 2+ 0.00-1.350.89 p=0.951 ns
Unsupervised RClust3 1 2+ 0.00-0.491.32 p=0.951 ns
Unsupervised RClust4 1 2+ 0.00-1.530.96 p=0.951 ns
Unsupervised RClust5 1 2+ 0.00-1.470.35 p=0.951 ns
Unsupervised RClust6 1 2+ 0.00-0.610.93 p=0.951 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.410.76 p=0.808 ns
Antigen Specific FHA 1 2+ 0.00-0.490.71 p=0.808 ns
Antigen Specific PRN 1 2+ 0.00-0.400.76 p=0.808 ns
Antigen Specific PT 1 2+ 0.00-0.700.48 p=0.808 ns
Antigen Specific TT 1 2+ 0.00-0.360.80 p=0.808 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.580.42 p=0.808 ns
Unsupervised RClust2 1 2+ 0.00-0.290.56 p=0.808 ns
Unsupervised RClust3 1 2+ 0.00-0.570.25 p=0.808 ns
Unsupervised RClust4 1 2+ 0.00-0.230.87 p=0.808 ns
Unsupervised RClust5 1 2+ 0.00-0.170.56 p=0.808 ns
Unsupervised RClust6 1 2+ 0.00-0.570.34 p=0.808 ns
Unsupervised RClust7 1 2+ 0.00-0.510.65 p=0.808 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.740.75 p=0.989 ns
Antigen Specific FHA 1 2+ 0.00-0.161.48 p=0.698 ns
Antigen Specific PRN 1 2+ 0.00-0.930.56 p=0.808 ns
Antigen Specific PT 1 2+ 0.00-1.180.61 p=0.808 ns
Antigen Specific TT 1 2+ 0.00-0.701.09 p=0.808 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.090.97 p=0.989 ns
Unsupervised RClust2 1 2+ 0.00-0.860.06 p=0.698 ns
Unsupervised RClust3 1 2+ 0.00-0.490.80 p=0.808 ns
Unsupervised RClust4 1 2+ 0.00-1.570.42 p=0.808 ns
Unsupervised RClust5 1 2+ 0.00-0.980.45 p=0.808 ns
Unsupervised RClust6 1 2+ 0.00-1.390.67 p=0.808 ns
Unsupervised RClust7 1 2+ 0.00-1.260.70 p=0.808 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.410.76 p=0.808 ns
Antigen Specific FHA 1 2+ 0.00-0.490.71 p=0.808 ns
Antigen Specific PRN 1 2+ 0.00-0.760.40 p=0.808 ns
Antigen Specific PT 1 2+ 0.00-0.700.48 p=0.808 ns
Antigen Specific TT 1 2+ 0.00-0.360.80 p=0.808 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.580.42 p=0.808 ns
Unsupervised RClust2 1 2+ 0.00-0.830.19 p=0.808 ns
Unsupervised RClust3 1 2+ 0.00-0.230.87 p=0.808 ns
Unsupervised RClust4 1 2+ 0.00-0.170.56 p=0.808 ns
Unsupervised RClust5 1 2+ 0.00-0.570.34 p=0.808 ns
Unsupervised RClust6 1 2+ 0.00-0.510.65 p=0.808 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.740.75 p=0.989 ns
Antigen Specific FHA 1 2+ 0.00-0.161.48 p=0.902 ns
Antigen Specific PRN 1 2+ 0.00-0.930.56 p=0.902 ns
Antigen Specific PT 1 2+ 0.00-1.180.61 p=0.902 ns
Antigen Specific TT 1 2+ 0.00-0.701.09 p=0.902 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.090.97 p=0.989 ns
Unsupervised RClust2 1 2+ 0.00-0.760.54 p=0.902 ns
Unsupervised RClust3 1 2+ 0.00-1.570.42 p=0.902 ns
Unsupervised RClust4 1 2+ 0.00-0.980.45 p=0.902 ns
Unsupervised RClust5 1 2+ 0.00-1.390.67 p=0.902 ns
Unsupervised RClust6 1 2+ 0.00-1.260.70 p=0.902 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.780.34 p=0.744 ns
Antigen Specific FHA 1 2+ 0.00-0.450.69 p=0.744 ns
Antigen Specific PRN 1 2+ 0.00-0.770.40 p=0.744 ns
Antigen Specific PT 1 2+ 0.00-0.790.38 p=0.744 ns
Antigen Specific TT 1 2+ 0.00-0.730.41 p=0.744 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.830.06 p=0.572 ns
Unsupervised RClust2 1 2+ 0.00-0.250.57 p=0.744 ns
Unsupervised RClust3 1 2+ 0.00-0.400.51 p=0.812 ns
Unsupervised RClust4 1 2+ 0.00-0.170.56 p=0.744 ns
Unsupervised RClust5 1 2+ 0.00-0.340.57 p=0.744 ns
Unsupervised RClust6 1 2+ 0.00-0.500.23 p=0.744 ns
Unsupervised RClust7 1 2+ 0.00-0.97-0.11 p=0.191 *
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.750.74 p=0.989 ns
Antigen Specific FHA 1 2+ 0.00-1.490.15 p=0.901 ns
Antigen Specific PRN 1 2+ 0.00-0.570.88 p=0.901 ns
Antigen Specific PT 1 2+ 0.00-1.190.60 p=0.901 ns
Antigen Specific TT 1 2+ 0.00-0.651.11 p=0.901 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.760.82 p=0.989 ns
Unsupervised RClust2 1 2+ 0.00-0.490.80 p=0.901 ns
Unsupervised RClust3 1 2+ 0.00-1.070.96 p=0.989 ns
Unsupervised RClust4 1 2+ 0.00-0.450.98 p=0.901 ns
Unsupervised RClust5 1 2+ 0.00-1.390.67 p=0.901 ns
Unsupervised RClust6 1 2+ 0.00-1.060.50 p=0.901 ns
Unsupervised RClust7 1 2+ 0.00-0.501.35 p=0.901 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.760.41 p=0.722 ns
Antigen Specific FHA 1 2+ 0.00-0.490.71 p=0.722 ns
Antigen Specific PRN 1 2+ 0.00-0.760.40 p=0.722 ns
Antigen Specific PT 1 2+ 0.00-0.700.48 p=0.722 ns
Antigen Specific TT 1 2+ 0.00-0.800.36 p=0.722 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.830.06 p=0.524 ns
Unsupervised RClust2 1 2+ 0.00-0.250.57 p=0.722 ns
Unsupervised RClust3 1 2+ 0.00-0.820.48 p=0.722 ns
Unsupervised RClust4 1 2+ 0.00-0.170.56 p=0.722 ns
Unsupervised RClust5 1 2+ 0.00-0.340.57 p=0.722 ns
Unsupervised RClust6 1 2+ 0.000.110.97 p=0.175 *
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.740.75 p=0.989 ns
Antigen Specific FHA 1 2+ 0.00-1.480.16 p=0.824 ns
Antigen Specific PRN 1 2+ 0.00-0.930.56 p=0.824 ns
Antigen Specific PT 1 2+ 0.00-1.180.61 p=0.824 ns
Antigen Specific TT 1 2+ 0.00-0.701.09 p=0.824 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.820.76 p=0.989 ns
Unsupervised RClust2 1 2+ 0.00-0.800.49 p=0.824 ns
Unsupervised RClust3 1 2+ 0.00-1.360.88 p=0.824 ns
Unsupervised RClust4 1 2+ 0.00-0.450.98 p=0.824 ns
Unsupervised RClust5 1 2+ 0.00-1.390.67 p=0.824 ns
Unsupervised RClust6 1 2+ 0.00-0.501.35 p=0.824 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.110.98 p=0.336 ns
Antigen Specific FHA 1 2+ 0.00-0.530.44 p=0.939 ns
Antigen Specific PRN 1 2+ 0.00-0.760.29 p=0.648 ns
Antigen Specific PT 1 2+ 0.00-1.110.14 p=0.336 ns
Antigen Specific TT 1 2+ 0.00-0.400.90 p=0.674 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.260.48 p=0.746 ns
Unsupervised RClust2 1 2+ 0.00-0.070.99 p=0.336 ns
Unsupervised RClust3 1 2+ 0.00-1.100.09 p=0.336 ns
Unsupervised RClust4 1 2+ 0.00-0.120.68 p=0.359 ns
Unsupervised RClust5 1 2+ 0.00-0.540.55 p=0.980 ns
Unsupervised RClust6 1 2+ 0.00-0.120.91 p=0.336 ns
Unsupervised RClust7 1 2+ 0.00-0.490.41 p=0.939 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-1.140.57 p=0.720 ns
Antigen Specific FHA 1 2+ 0.00-1.940.18 p=0.720 ns
Antigen Specific PRN 1 2+ 0.00-0.961.11 p=0.887 ns
Antigen Specific PT 1 2+ 0.00-0.571.34 p=0.720 ns
Antigen Specific TT 1 2+ 0.00-0.551.09 p=0.720 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.990.76 p=0.865 ns
Unsupervised RClust2 1 2+ 0.00-0.940.46 p=0.720 ns
Unsupervised RClust3 1 2+ 0.00-1.510.79 p=0.720 ns
Unsupervised RClust4 1 2+ 0.00-0.501.29 p=0.720 ns
Unsupervised RClust5 1 2+ 0.00-0.630.95 p=0.827 ns
Unsupervised RClust6 1 2+ 0.00-0.261.17 p=0.720 ns
Unsupervised RClust7 1 2+ 0.00-1.920.31 p=0.720 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.110.98 p=0.385 ns
Antigen Specific FHA 1 2+ 0.00-0.530.44 p=0.947 ns
Antigen Specific PRN 1 2+ 0.00-0.760.29 p=0.610 ns
Antigen Specific PT 1 2+ 0.00-1.110.14 p=0.385 ns
Antigen Specific TT 1 2+ 0.00-0.400.90 p=0.618 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.260.48 p=0.684 ns
Unsupervised RClust2 1 2+ 0.00-0.070.99 p=0.385 ns
Unsupervised RClust3 1 2+ 0.00-1.210.47 p=0.610 ns
Unsupervised RClust4 1 2+ 0.00-0.120.68 p=0.395 ns
Unsupervised RClust5 1 2+ 0.00-0.540.55 p=0.980 ns
Unsupervised RClust6 1 2+ 0.00-0.120.91 p=0.385 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-1.140.57 p=0.720 ns
Antigen Specific FHA 1 2+ 0.00-1.940.18 p=0.720 ns
Antigen Specific PRN 1 2+ 0.00-0.961.11 p=0.887 ns
Antigen Specific PT 1 2+ 0.00-0.571.34 p=0.720 ns
Antigen Specific TT 1 2+ 0.00-0.551.09 p=0.720 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.990.76 p=0.872 ns
Unsupervised RClust2 1 2+ 0.00-0.940.46 p=0.720 ns
Unsupervised RClust3 1 2+ 0.00-2.220.55 p=0.720 ns
Unsupervised RClust4 1 2+ 0.00-0.501.29 p=0.720 ns
Unsupervised RClust5 1 2+ 0.00-0.630.95 p=0.842 ns
Unsupervised RClust6 1 2+ 0.00-0.261.17 p=0.720 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-1.060.11 p=0.607 ns
Antigen Specific FHA 1 2+ 0.00-0.810.28 p=0.607 ns
Antigen Specific PRN 1 2+ 0.00-0.820.46 p=0.698 ns
Antigen Specific PT 1 2+ 0.00-0.870.39 p=0.607 ns
Antigen Specific TT 1 2+ 0.00-0.770.33 p=0.607 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.720.08 p=0.607 ns
Unsupervised RClust2 1 2+ 0.00-0.550.51 p=0.949 ns
Unsupervised RClust3 1 2+ 0.00-0.910.31 p=0.607 ns
Unsupervised RClust4 1 2+ 0.00-0.490.40 p=0.911 ns
Unsupervised RClust5 1 2+ 0.00-0.540.22 p=0.607 ns
Unsupervised RClust6 1 2+ 0.00-0.200.79 p=0.607 ns
Unsupervised RClust7 1 2+ 0.00-0.620.12 p=0.607 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.470.86 p=0.815 ns
Antigen Specific FHA 1 2+ 0.00-0.850.88 p=0.968 ns
Antigen Specific PRN 1 2+ 0.00-0.081.36 p=0.336 ns
Antigen Specific PT 1 2+ 0.00-1.360.30 p=0.610 ns
Antigen Specific TT 1 2+ 0.00-0.760.81 p=0.968 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.880.95 p=0.968 ns
Unsupervised RClust2 1 2+ 0.000.381.86 p=0.051 **
Unsupervised RClust3 1 2+ 0.00-1.680.68 p=0.815 ns
Unsupervised RClust4 1 2+ 0.00-1.670.43 p=0.610 ns
Unsupervised RClust5 1 2+ 0.00-0.051.29 p=0.336 ns
Unsupervised RClust6 1 2+ 0.00-0.530.91 p=0.815 ns
Unsupervised RClust7 1 2+ 0.00-0.440.82 p=0.815 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.111.06 p=0.716 ns
Antigen Specific FHA 1 2+ 0.00-0.280.81 p=0.716 ns
Antigen Specific PRN 1 2+ 0.00-0.820.46 p=0.731 ns
Antigen Specific PT 1 2+ 0.00-0.870.39 p=0.716 ns
Antigen Specific TT 1 2+ 0.00-0.770.33 p=0.716 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.930.54 p=0.731 ns
Unsupervised RClust2 1 2+ 0.00-0.550.51 p=0.949 ns
Unsupervised RClust3 1 2+ 0.00-0.910.31 p=0.716 ns
Unsupervised RClust4 1 2+ 0.00-0.490.40 p=0.918 ns
Unsupervised RClust5 1 2+ 0.00-0.540.22 p=0.716 ns
Unsupervised RClust6 1 2+ 0.00-0.620.12 p=0.716 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.470.86 p=0.779 ns
Antigen Specific FHA 1 2+ 0.00-0.850.88 p=0.968 ns
Antigen Specific PRN 1 2+ 0.00-0.081.36 p=0.308 ns
Antigen Specific PT 1 2+ 0.00-1.360.30 p=0.559 ns
Antigen Specific TT 1 2+ 0.00-0.760.81 p=0.968 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.91 p=0.968 ns
Unsupervised RClust2 1 2+ 0.000.381.86 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-1.680.68 p=0.753 ns
Unsupervised RClust4 1 2+ 0.00-1.670.43 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.051.29 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.440.82 p=0.779 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.051.09 p=0.699 ns
Antigen Specific FHA 1 2+ 0.00-0.390.70 p=0.699 ns
Antigen Specific PRN 1 2+ 0.00-0.840.44 p=0.699 ns
Antigen Specific PT 1 2+ 0.00-0.900.34 p=0.699 ns
Antigen Specific TT 1 2+ 0.00-0.380.70 p=0.699 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.720.08 p=0.699 ns
Unsupervised RClust2 1 2+ 0.00-0.510.55 p=0.949 ns
Unsupervised RClust3 1 2+ 0.00-0.770.36 p=0.699 ns
Unsupervised RClust4 1 2+ 0.00-0.490.40 p=0.911 ns
Unsupervised RClust5 1 2+ 0.00-0.220.54 p=0.699 ns
Unsupervised RClust6 1 2+ 0.00-0.120.62 p=0.699 ns
Unsupervised RClust7 1 2+ 0.00-0.340.77 p=0.699 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.810.51 p=0.985 ns
Antigen Specific FHA 1 2+ 0.00-0.810.92 p=0.993 ns
Antigen Specific PRN 1 2+ 0.00-1.340.08 p=0.341 ns
Antigen Specific PT 1 2+ 0.00-0.271.37 p=0.575 ns
Antigen Specific TT 1 2+ 0.00-0.790.78 p=0.993 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.993 ns
Unsupervised RClust2 1 2+ 0.000.381.86 p=0.051 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.993 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.610 ns
Unsupervised RClust5 1 2+ 0.00-0.051.29 p=0.341 ns
Unsupervised RClust6 1 2+ 0.00-0.820.44 p=0.955 ns
Unsupervised RClust7 1 2+ 0.00-0.671.32 p=0.955 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-1.060.11 p=0.664 ns
Antigen Specific FHA 1 2+ 0.00-0.810.28 p=0.764 ns
Antigen Specific PRN 1 2+ 0.00-0.820.46 p=0.800 ns
Antigen Specific PT 1 2+ 0.00-0.870.39 p=0.764 ns
Antigen Specific TT 1 2+ 0.00-0.770.33 p=0.764 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.720.08 p=0.664 ns
Unsupervised RClust2 1 2+ 0.00-0.550.51 p=0.949 ns
Unsupervised RClust3 1 2+ 0.00-0.360.77 p=0.764 ns
Unsupervised RClust4 1 2+ 0.00-0.490.40 p=0.918 ns
Unsupervised RClust5 1 2+ 0.00-0.720.51 p=0.897 ns
Unsupervised RClust6 1 2+ 0.00-0.770.34 p=0.764 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.860.47 p=0.890 ns
Antigen Specific FHA 1 2+ 0.00-0.880.85 p=0.968 ns
Antigen Specific PRN 1 2+ 0.00-1.360.08 p=0.308 ns
Antigen Specific PT 1 2+ 0.00-1.360.30 p=0.559 ns
Antigen Specific TT 1 2+ 0.00-0.760.81 p=0.968 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

gestational_age_at_vaccine

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.20 p=0.479 ns
Antigen Specific FHA continuous 0.00-0.180.01 p=0.479 ns
Antigen Specific PRN continuous 0.00-0.050.15 p=0.523 ns
Antigen Specific PT continuous 0.00-0.160.05 p=0.523 ns
Antigen Specific TT continuous 0.00-0.190.04 p=0.479 ns
Unsupervised RClust1 continuous 0.00-0.160.02 p=0.479 ns
Unsupervised RClust2 continuous 0.00-0.090.16 p=0.733 ns
Unsupervised RClust3 continuous 0.00-0.130.02 p=0.479 ns
Unsupervised RClust4 continuous 0.00-0.090.08 p=0.863 ns
Unsupervised RClust5 continuous 0.00-0.050.08 p=0.733 ns
Unsupervised RClust6 continuous 0.00-0.050.09 p=0.733 ns
Unsupervised RClust7 continuous 0.00-0.140.03 p=0.479 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.37-0.03 p=0.078 *
Antigen Specific FHA continuous 0.00-0.380.03 p=0.193 ns
Antigen Specific PRN continuous 0.00-0.080.33 p=0.314 ns
Antigen Specific PT continuous 0.000.050.45 p=0.078 *
Antigen Specific TT continuous 0.00-0.300.09 p=0.314 ns
Unsupervised RClust1 continuous 0.00-0.070.22 p=0.329 ns
Unsupervised RClust2 continuous 0.00-0.45-0.04 p=0.078 *
Unsupervised RClust3 continuous 0.00-0.310.04 p=0.230 ns
Unsupervised RClust4 continuous 0.00-0.280.07 p=0.314 ns
Unsupervised RClust5 continuous 0.00-0.080.28 p=0.314 ns
Unsupervised RClust6 continuous 0.000.000.29 p=0.116 *
Unsupervised RClust7 continuous 0.000.030.44 p=0.078 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.20 p=0.441 ns
Antigen Specific FHA continuous 0.00-0.180.01 p=0.441 ns
Antigen Specific PRN continuous 0.00-0.050.15 p=0.548 ns
Antigen Specific PT continuous 0.00-0.160.05 p=0.548 ns
Antigen Specific TT continuous 0.00-0.190.04 p=0.487 ns
Unsupervised RClust1 continuous 0.00-0.160.02 p=0.441 ns
Unsupervised RClust2 continuous 0.00-0.090.16 p=0.672 ns
Unsupervised RClust3 continuous 0.00-0.130.02 p=0.441 ns
Unsupervised RClust4 continuous 0.00-0.190.08 p=0.564 ns
Unsupervised RClust5 continuous 0.00-0.050.08 p=0.672 ns
Unsupervised RClust6 continuous 0.00-0.050.09 p=0.672 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.37-0.03 p=0.088 *
Antigen Specific FHA continuous 0.00-0.380.03 p=0.177 ns
Antigen Specific PRN continuous 0.00-0.080.33 p=0.312 ns
Antigen Specific PT continuous 0.000.050.45 p=0.088 *
Antigen Specific TT continuous 0.00-0.300.09 p=0.317 ns
Unsupervised RClust1 continuous 0.00-0.070.22 p=0.329 ns
Unsupervised RClust2 continuous 0.00-0.45-0.04 p=0.088 *
Unsupervised RClust3 continuous 0.00-0.310.04 p=0.211 ns
Unsupervised RClust4 continuous 0.000.020.49 p=0.106 *
Unsupervised RClust5 continuous 0.00-0.080.28 p=0.317 ns
Unsupervised RClust6 continuous 0.000.000.29 p=0.106 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.26-0.05 p=0.046 **
Antigen Specific FHA continuous 0.00-0.26-0.03 p=0.048 *
Antigen Specific PRN continuous 0.00-0.090.13 p=0.877 ns
Antigen Specific PT continuous 0.000.000.22 p=0.153 ns
Antigen Specific TT continuous 0.00-0.190.03 p=0.314 ns
Unsupervised RClust1 continuous 0.00-0.130.07 p=0.721 ns
Unsupervised RClust2 continuous 0.000.030.19 p=0.046 **
Unsupervised RClust3 continuous 0.00-0.070.09 p=0.877 ns
Unsupervised RClust4 continuous 0.00-0.210.00 p=0.153 ns
Unsupervised RClust5 continuous 0.00-0.070.07 p=0.974 ns
Unsupervised RClust6 continuous 0.00-0.040.14 p=0.449 ns
Unsupervised RClust7 continuous 0.00-0.070.15 p=0.721 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.210.08 p=0.731 ns
Antigen Specific FHA continuous 0.00-0.130.19 p=0.793 ns
Antigen Specific PRN continuous 0.00-0.160.12 p=0.793 ns
Antigen Specific PT continuous 0.00-0.080.27 p=0.731 ns
Antigen Specific TT continuous 0.00-0.200.14 p=0.793 ns
Unsupervised RClust1 continuous 0.00-0.140.26 p=0.731 ns
Unsupervised RClust2 continuous 0.00-0.020.16 p=0.671 ns
Unsupervised RClust3 continuous 0.00-0.090.16 p=0.731 ns
Unsupervised RClust4 continuous 0.00-0.270.12 p=0.731 ns
Unsupervised RClust5 continuous 0.00-0.210.07 p=0.731 ns
Unsupervised RClust6 continuous 0.000.010.40 p=0.532 *
Unsupervised RClust7 continuous 0.00-0.100.27 p=0.731 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.26-0.05 p=0.066 **
Antigen Specific FHA continuous 0.00-0.26-0.03 p=0.066 *
Antigen Specific PRN continuous 0.00-0.130.09 p=0.813 ns
Antigen Specific PT continuous 0.000.000.22 p=0.140 ns
Antigen Specific TT continuous 0.00-0.190.03 p=0.288 ns
Unsupervised RClust1 continuous 0.00-0.130.07 p=0.661 ns
Unsupervised RClust2 continuous 0.000.010.20 p=0.136 *
Unsupervised RClust3 continuous 0.00-0.210.00 p=0.140 ns
Unsupervised RClust4 continuous 0.00-0.070.07 p=0.974 ns
Unsupervised RClust5 continuous 0.00-0.040.14 p=0.411 ns
Unsupervised RClust6 continuous 0.00-0.070.15 p=0.661 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.210.08 p=0.793 ns
Antigen Specific FHA continuous 0.00-0.130.19 p=0.793 ns
Antigen Specific PRN continuous 0.00-0.160.12 p=0.793 ns
Antigen Specific PT continuous 0.00-0.080.27 p=0.793 ns
Antigen Specific TT continuous 0.00-0.200.14 p=0.793 ns
Unsupervised RClust1 continuous 0.00-0.140.26 p=0.793 ns
Unsupervised RClust2 continuous 0.00-0.160.10 p=0.793 ns
Unsupervised RClust3 continuous 0.00-0.270.12 p=0.793 ns
Unsupervised RClust4 continuous 0.00-0.210.07 p=0.793 ns
Unsupervised RClust5 continuous 0.000.010.40 p=0.488 *
Unsupervised RClust6 continuous 0.00-0.100.27 p=0.793 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.040.24 p=0.115 **
Antigen Specific FHA continuous 0.00-0.22-0.01 p=0.241 *
Antigen Specific PRN continuous 0.00-0.130.09 p=0.953 ns
Antigen Specific PT continuous 0.00-0.030.19 p=0.358 ns
Antigen Specific TT continuous 0.00-0.040.18 p=0.406 ns
Unsupervised RClust1 continuous 0.00-0.020.15 p=0.358 ns
Unsupervised RClust2 continuous 0.00-0.090.07 p=0.965 ns
Unsupervised RClust3 continuous 0.00-0.150.02 p=0.358 ns
Unsupervised RClust4 continuous 0.00-0.070.07 p=0.995 ns
Unsupervised RClust5 continuous 0.00-0.140.04 p=0.406 ns
Unsupervised RClust6 continuous 0.00-0.110.03 p=0.406 ns
Unsupervised RClust7 continuous 0.00-0.090.09 p=0.995 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.080.21 p=0.881 ns
Antigen Specific FHA continuous 0.00-0.180.14 p=0.941 ns
Antigen Specific PRN continuous 0.00-0.140.14 p=0.958 ns
Antigen Specific PT continuous 0.00-0.080.26 p=0.881 ns
Antigen Specific TT continuous 0.00-0.210.13 p=0.941 ns
Unsupervised RClust1 continuous 0.00-0.240.07 p=0.881 ns
Unsupervised RClust2 continuous 0.00-0.090.16 p=0.925 ns
Unsupervised RClust3 continuous 0.00-0.130.27 p=0.925 ns
Unsupervised RClust4 continuous 0.00-0.070.21 p=0.881 ns
Unsupervised RClust5 continuous 0.000.010.40 p=0.532 *
Unsupervised RClust6 continuous 0.00-0.130.18 p=0.941 ns
Unsupervised RClust7 continuous 0.00-0.170.19 p=0.958 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.050.26 p=0.066 **
Antigen Specific FHA continuous 0.00-0.26-0.03 p=0.066 *
Antigen Specific PRN continuous 0.00-0.130.09 p=0.995 ns
Antigen Specific PT continuous 0.000.000.22 p=0.233 ns
Antigen Specific TT continuous 0.00-0.030.19 p=0.345 ns
Unsupervised RClust1 continuous 0.00-0.020.15 p=0.345 ns
Unsupervised RClust2 continuous 0.00-0.090.07 p=0.995 ns
Unsupervised RClust3 continuous 0.00-0.120.13 p=0.995 ns
Unsupervised RClust4 continuous 0.00-0.070.07 p=0.995 ns
Unsupervised RClust5 continuous 0.00-0.140.04 p=0.480 ns
Unsupervised RClust6 continuous 0.00-0.090.09 p=0.995 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.210.08 p=0.848 ns
Antigen Specific FHA continuous 0.00-0.190.13 p=0.873 ns
Antigen Specific PRN continuous 0.00-0.160.12 p=0.873 ns
Antigen Specific PT continuous 0.00-0.080.27 p=0.848 ns
Antigen Specific TT continuous 0.00-0.200.14 p=0.873 ns
Unsupervised RClust1 continuous 0.00-0.070.24 p=0.848 ns
Unsupervised RClust2 continuous 0.00-0.160.09 p=0.848 ns
Unsupervised RClust3 continuous 0.00-0.140.29 p=0.848 ns
Unsupervised RClust4 continuous 0.00-0.070.21 p=0.848 ns
Unsupervised RClust5 continuous 0.000.010.40 p=0.488 *
Unsupervised RClust6 continuous 0.00-0.170.19 p=0.906 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.150.06 p=0.841 ns
Antigen Specific FHA continuous 0.00-0.130.05 p=0.841 ns
Antigen Specific PRN continuous 0.00-0.050.15 p=0.841 ns
Antigen Specific PT continuous 0.00-0.090.15 p=0.841 ns
Antigen Specific TT continuous 0.00-0.180.07 p=0.841 ns
Unsupervised RClust1 continuous 0.00-0.090.06 p=0.841 ns
Unsupervised RClust2 continuous 0.00-0.120.08 p=0.841 ns
Unsupervised RClust3 continuous 0.00-0.040.19 p=0.841 ns
Unsupervised RClust4 continuous 0.00-0.060.09 p=0.841 ns
Unsupervised RClust5 continuous 0.00-0.090.12 p=0.841 ns
Unsupervised RClust6 continuous 0.00-0.130.07 p=0.841 ns
Unsupervised RClust7 continuous 0.00-0.100.08 p=0.841 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.130.20 p=0.844 ns
Antigen Specific FHA continuous 0.00-0.050.36 p=0.427 ns
Antigen Specific PRN continuous 0.00-0.210.18 p=0.913 ns
Antigen Specific PT continuous 0.00-0.130.24 p=0.818 ns
Antigen Specific TT continuous 0.00-0.030.28 p=0.427 ns
Unsupervised RClust1 continuous 0.00-0.310.02 p=0.427 ns
Unsupervised RClust2 continuous 0.00-0.240.03 p=0.427 ns
Unsupervised RClust3 continuous 0.00-0.080.36 p=0.517 ns
Unsupervised RClust4 continuous 0.00-0.090.25 p=0.650 ns
Unsupervised RClust5 continuous 0.00-0.180.12 p=0.844 ns
Unsupervised RClust6 continuous 0.00-0.130.15 p=0.913 ns
Unsupervised RClust7 continuous 0.00-0.100.33 p=0.636 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.150.06 p=0.869 ns
Antigen Specific FHA continuous 0.00-0.130.05 p=0.869 ns
Antigen Specific PRN continuous 0.00-0.050.15 p=0.869 ns
Antigen Specific PT continuous 0.00-0.090.15 p=0.869 ns
Antigen Specific TT continuous 0.00-0.180.07 p=0.869 ns
Unsupervised RClust1 continuous 0.00-0.090.06 p=0.869 ns
Unsupervised RClust2 continuous 0.00-0.120.08 p=0.869 ns
Unsupervised RClust3 continuous 0.00-0.170.15 p=0.869 ns
Unsupervised RClust4 continuous 0.00-0.060.09 p=0.869 ns
Unsupervised RClust5 continuous 0.00-0.090.12 p=0.869 ns
Unsupervised RClust6 continuous 0.00-0.130.07 p=0.869 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.130.20 p=0.860 ns
Antigen Specific FHA continuous 0.00-0.050.36 p=0.392 ns
Antigen Specific PRN continuous 0.00-0.210.18 p=0.913 ns
Antigen Specific PT continuous 0.00-0.130.24 p=0.857 ns
Antigen Specific TT continuous 0.00-0.030.28 p=0.392 ns
Unsupervised RClust1 continuous 0.00-0.310.02 p=0.392 ns
Unsupervised RClust2 continuous 0.00-0.240.03 p=0.392 ns
Unsupervised RClust3 continuous 0.00-0.090.44 p=0.437 ns
Unsupervised RClust4 continuous 0.00-0.090.25 p=0.695 ns
Unsupervised RClust5 continuous 0.00-0.180.12 p=0.860 ns
Unsupervised RClust6 continuous 0.00-0.130.15 p=0.913 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.130.10 p=0.955 ns
Antigen Specific FHA continuous 0.00-0.100.11 p=0.955 ns
Antigen Specific PRN continuous 0.00-0.130.11 p=0.955 ns
Antigen Specific PT continuous 0.00-0.070.17 p=0.955 ns
Antigen Specific TT continuous 0.00-0.070.14 p=0.955 ns
Unsupervised RClust1 continuous 0.00-0.110.04 p=0.955 ns
Unsupervised RClust2 continuous 0.00-0.200.00 p=0.295 ns
Unsupervised RClust3 continuous 0.00-0.140.09 p=0.955 ns
Unsupervised RClust4 continuous 0.00-0.010.16 p=0.295 ns
Unsupervised RClust5 continuous 0.00-0.070.08 p=0.955 ns
Unsupervised RClust6 continuous 0.00-0.090.10 p=0.955 ns
Unsupervised RClust7 continuous 0.00-0.140.00 p=0.295 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.19 p=0.624 ns
Antigen Specific FHA continuous 0.00-0.320.00 p=0.269 ns
Antigen Specific PRN continuous 0.00-0.140.14 p=0.980 ns
Antigen Specific PT continuous 0.00-0.180.14 p=0.876 ns
Antigen Specific TT continuous 0.00-0.250.05 p=0.454 ns
Unsupervised RClust1 continuous 0.00-0.320.02 p=0.269 ns
Unsupervised RClust2 continuous 0.00-0.020.28 p=0.269 ns
Unsupervised RClust3 continuous 0.00-0.270.19 p=0.867 ns
Unsupervised RClust4 continuous 0.00-0.100.30 p=0.624 ns
Unsupervised RClust5 continuous 0.00-0.160.11 p=0.867 ns
Unsupervised RClust6 continuous 0.00-0.260.01 p=0.269 ns
Unsupervised RClust7 continuous 0.00-0.090.15 p=0.867 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.100.13 p=0.955 ns
Antigen Specific FHA continuous 0.00-0.110.10 p=0.955 ns
Antigen Specific PRN continuous 0.00-0.130.11 p=0.955 ns
Antigen Specific PT continuous 0.00-0.070.17 p=0.928 ns
Antigen Specific TT continuous 0.00-0.070.14 p=0.928 ns
Unsupervised RClust1 continuous 0.000.030.30 p=0.202 *
Unsupervised RClust2 continuous 0.00-0.200.00 p=0.203 ns
Unsupervised RClust3 continuous 0.00-0.140.09 p=0.955 ns
Unsupervised RClust4 continuous 0.00-0.010.16 p=0.203 ns
Unsupervised RClust5 continuous 0.00-0.070.08 p=0.955 ns
Unsupervised RClust6 continuous 0.00-0.140.00 p=0.203 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.19 p=0.667 ns
Antigen Specific FHA continuous 0.00-0.320.00 p=0.493 ns
Antigen Specific PRN continuous 0.00-0.140.14 p=0.980 ns
Antigen Specific PT continuous 0.00-0.180.14 p=0.883 ns
Antigen Specific TT continuous 0.00-0.250.05 p=0.529 ns
Unsupervised RClust1 continuous 0.00-0.290.06 p=0.529 ns
Unsupervised RClust2 continuous 0.00-0.020.28 p=0.493 ns
Unsupervised RClust3 continuous 0.00-0.270.19 p=0.883 ns
Unsupervised RClust4 continuous 0.00-0.100.30 p=0.667 ns
Unsupervised RClust5 continuous 0.00-0.160.11 p=0.883 ns
Unsupervised RClust6 continuous 0.00-0.090.15 p=0.883 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.130.09 p=0.983 ns
Antigen Specific FHA continuous 0.00-0.100.10 p=0.994 ns
Antigen Specific PRN continuous 0.00-0.130.11 p=0.994 ns
Antigen Specific PT continuous 0.00-0.070.16 p=0.793 ns
Antigen Specific TT continuous 0.00-0.200.01 p=0.221 ns
Unsupervised RClust1 continuous 0.00-0.110.04 p=0.786 ns
Unsupervised RClust2 continuous 0.000.000.20 p=0.221 ns
Unsupervised RClust3 continuous 0.00-0.130.09 p=0.983 ns
Unsupervised RClust4 continuous 0.00-0.010.16 p=0.221 ns
Unsupervised RClust5 continuous 0.00-0.080.07 p=0.994 ns
Unsupervised RClust6 continuous 0.000.000.14 p=0.221 ns
Unsupervised RClust7 continuous 0.00-0.160.06 p=0.786 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.180.07 p=0.702 ns
Antigen Specific FHA continuous 0.00-0.320.00 p=0.358 ns
Antigen Specific PRN continuous 0.00-0.140.14 p=0.963 ns
Antigen Specific PT continuous 0.00-0.130.18 p=0.919 ns
Antigen Specific TT continuous 0.00-0.260.04 p=0.467 ns
Unsupervised RClust1 continuous 0.00-0.020.32 p=0.358 ns
Unsupervised RClust2 continuous 0.00-0.020.28 p=0.358 ns
Unsupervised RClust3 continuous 0.00-0.120.14 p=0.963 ns
Unsupervised RClust4 continuous 0.00-0.300.10 p=0.697 ns
Unsupervised RClust5 continuous 0.00-0.160.11 p=0.919 ns
Unsupervised RClust6 continuous 0.00-0.150.09 p=0.919 ns
Unsupervised RClust7 continuous 0.00-0.090.29 p=0.697 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.130.10 p=0.955 ns
Antigen Specific FHA continuous 0.00-0.100.11 p=0.955 ns
Antigen Specific PRN continuous 0.00-0.130.11 p=0.955 ns
Antigen Specific PT continuous 0.00-0.070.17 p=0.795 ns
Antigen Specific TT continuous 0.00-0.070.14 p=0.795 ns
Unsupervised RClust1 continuous 0.00-0.110.04 p=0.795 ns
Unsupervised RClust2 continuous 0.00-0.200.00 p=0.405 ns
Unsupervised RClust3 continuous 0.00-0.090.13 p=0.955 ns
Unsupervised RClust4 continuous 0.00-0.010.16 p=0.405 ns
Unsupervised RClust5 continuous 0.00-0.070.16 p=0.795 ns
Unsupervised RClust6 continuous 0.00-0.060.16 p=0.795 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.190.07 p=0.572 ns
Antigen Specific FHA continuous 0.000.000.32 p=0.329 ns
Antigen Specific PRN continuous 0.00-0.140.14 p=0.980 ns
Antigen Specific PT continuous 0.00-0.180.14 p=0.980 ns
Antigen Specific TT continuous 0.00-0.250.05 p=0.520 ns
Unsupervised RClust1 continuous 0.00-0.020.32 p=0.329 ns
Unsupervised RClust2 continuous 0.00-0.280.02 p=0.329 ns
Unsupervised RClust3 continuous 0.00-0.120.14 p=0.980 ns
Unsupervised RClust4 continuous 0.00-0.300.10 p=0.572 ns
Unsupervised RClust5 continuous 0.00-0.140.13 p=0.980 ns
Unsupervised RClust6 continuous 0.00-0.090.29 p=0.572 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

infant_interval_between_vaccination_and_delivery_days

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.02 p=0.854 ns
Antigen Specific FHA continuous 0.00-0.010.02 p=0.861 ns
Antigen Specific PRN continuous 0.00-0.010.02 p=0.854 ns
Antigen Specific PT continuous 0.00-0.020.01 p=0.745 ns
Antigen Specific TT continuous 0.00-0.030.00 p=0.745 ns
Unsupervised RClust1 continuous 0.000.000.02 p=0.745 ns
Unsupervised RClust2 continuous 0.00-0.030.00 p=0.745 ns
Unsupervised RClust3 continuous 0.00-0.010.01 p=0.919 ns
Unsupervised RClust4 continuous 0.00-0.010.01 p=0.919 ns
Unsupervised RClust5 continuous 0.00-0.010.01 p=0.854 ns
Unsupervised RClust6 continuous 0.00-0.010.01 p=0.854 ns
Unsupervised RClust7 continuous 0.00-0.010.01 p=0.854 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.01 p=0.446 ns
Antigen Specific FHA continuous 0.00-0.050.01 p=0.262 ns
Antigen Specific PRN continuous 0.000.000.06 p=0.182 *
Antigen Specific PT continuous 0.00-0.050.01 p=0.262 ns
Antigen Specific TT continuous 0.00-0.010.05 p=0.262 ns
Unsupervised RClust1 continuous 0.00-0.030.02 p=0.599 ns
Unsupervised RClust2 continuous 0.00-0.010.05 p=0.356 ns
Unsupervised RClust3 continuous 0.00-0.040.01 p=0.262 ns
Unsupervised RClust4 continuous 0.00-0.050.00 p=0.182 *
Unsupervised RClust5 continuous 0.00-0.040.01 p=0.262 ns
Unsupervised RClust6 continuous 0.00-0.010.03 p=0.418 ns
Unsupervised RClust7 continuous 0.00-0.010.05 p=0.262 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.02 p=0.722 ns
Antigen Specific FHA continuous 0.00-0.010.02 p=0.789 ns
Antigen Specific PRN continuous 0.00-0.010.02 p=0.717 ns
Antigen Specific PT continuous 0.00-0.020.01 p=0.546 ns
Antigen Specific TT continuous 0.00-0.030.00 p=0.546 ns
Unsupervised RClust1 continuous 0.000.000.02 p=0.546 ns
Unsupervised RClust2 continuous 0.00-0.030.00 p=0.546 ns
Unsupervised RClust3 continuous 0.00-0.010.01 p=0.890 ns
Unsupervised RClust4 continuous 0.00-0.010.03 p=0.546 ns
Unsupervised RClust5 continuous 0.00-0.010.01 p=0.726 ns
Unsupervised RClust6 continuous 0.00-0.010.01 p=0.722 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.01 p=0.450 ns
Antigen Specific FHA continuous 0.00-0.050.01 p=0.274 ns
Antigen Specific PRN continuous 0.000.000.06 p=0.268 *
Antigen Specific PT continuous 0.00-0.050.01 p=0.274 ns
Antigen Specific TT continuous 0.00-0.010.05 p=0.274 ns
Unsupervised RClust1 continuous 0.00-0.030.02 p=0.599 ns
Unsupervised RClust2 continuous 0.00-0.010.05 p=0.367 ns
Unsupervised RClust3 continuous 0.00-0.040.01 p=0.274 ns
Unsupervised RClust4 continuous 0.000.000.07 p=0.268 *
Unsupervised RClust5 continuous 0.00-0.040.01 p=0.274 ns
Unsupervised RClust6 continuous 0.00-0.010.03 p=0.426 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.01 p=0.661 ns
Antigen Specific FHA continuous 0.00-0.020.01 p=0.661 ns
Antigen Specific PRN continuous 0.00-0.020.01 p=0.661 ns
Antigen Specific PT continuous 0.00-0.010.02 p=0.661 ns
Antigen Specific TT continuous 0.00-0.020.01 p=0.661 ns
Unsupervised RClust1 continuous 0.00-0.020.01 p=0.899 ns
Unsupervised RClust2 continuous 0.00-0.020.00 p=0.661 ns
Unsupervised RClust3 continuous 0.00-0.010.01 p=0.951 ns
Unsupervised RClust4 continuous 0.00-0.030.00 p=0.661 ns
Unsupervised RClust5 continuous 0.000.000.02 p=0.661 ns
Unsupervised RClust6 continuous 0.00-0.010.02 p=0.661 ns
Unsupervised RClust7 continuous 0.00-0.020.01 p=0.661 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.884 ns
Antigen Specific FHA continuous 0.00-0.030.02 p=0.884 ns
Antigen Specific PRN continuous 0.00-0.030.01 p=0.595 ns
Antigen Specific PT continuous 0.00-0.040.00 p=0.595 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.884 ns
Unsupervised RClust1 continuous 0.00-0.030.03 p=0.884 ns
Unsupervised RClust2 continuous 0.00-0.020.00 p=0.595 ns
Unsupervised RClust3 continuous 0.00-0.020.01 p=0.884 ns
Unsupervised RClust4 continuous 0.00-0.040.01 p=0.685 ns
Unsupervised RClust5 continuous 0.00-0.020.02 p=0.884 ns
Unsupervised RClust6 continuous 0.00-0.010.04 p=0.686 ns
Unsupervised RClust7 continuous 0.00-0.040.01 p=0.595 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.01 p=0.606 ns
Antigen Specific FHA continuous 0.00-0.020.01 p=0.606 ns
Antigen Specific PRN continuous 0.00-0.010.02 p=0.606 ns
Antigen Specific PT continuous 0.00-0.010.02 p=0.606 ns
Antigen Specific TT continuous 0.00-0.020.01 p=0.606 ns
Unsupervised RClust1 continuous 0.00-0.020.01 p=0.824 ns
Unsupervised RClust2 continuous 0.00-0.020.00 p=0.606 ns
Unsupervised RClust3 continuous 0.00-0.030.00 p=0.606 ns
Unsupervised RClust4 continuous 0.000.000.02 p=0.606 ns
Unsupervised RClust5 continuous 0.00-0.010.02 p=0.606 ns
Unsupervised RClust6 continuous 0.00-0.020.01 p=0.606 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.884 ns
Antigen Specific FHA continuous 0.00-0.030.02 p=0.884 ns
Antigen Specific PRN continuous 0.00-0.030.01 p=0.727 ns
Antigen Specific PT continuous 0.00-0.040.00 p=0.727 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.884 ns
Unsupervised RClust1 continuous 0.00-0.030.03 p=0.884 ns
Unsupervised RClust2 continuous 0.00-0.010.02 p=0.884 ns
Unsupervised RClust3 continuous 0.00-0.040.01 p=0.755 ns
Unsupervised RClust4 continuous 0.00-0.020.02 p=0.884 ns
Unsupervised RClust5 continuous 0.00-0.010.04 p=0.755 ns
Unsupervised RClust6 continuous 0.00-0.040.01 p=0.727 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.02 p=0.955 ns
Antigen Specific FHA continuous 0.00-0.020.02 p=0.997 ns
Antigen Specific PRN continuous 0.00-0.010.02 p=0.921 ns
Antigen Specific PT continuous 0.00-0.010.02 p=0.858 ns
Antigen Specific TT continuous 0.00-0.010.02 p=0.858 ns
Unsupervised RClust1 continuous 0.00-0.020.00 p=0.514 ns
Unsupervised RClust2 continuous 0.00-0.010.01 p=0.997 ns
Unsupervised RClust3 continuous 0.000.000.02 p=0.514 ns
Unsupervised RClust4 continuous 0.000.000.02 p=0.814 ns
Unsupervised RClust5 continuous 0.00-0.020.01 p=0.921 ns
Unsupervised RClust6 continuous 0.00-0.010.01 p=0.997 ns
Unsupervised RClust7 continuous 0.00-0.010.01 p=0.997 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.03 p=0.887 ns
Antigen Specific FHA continuous 0.00-0.020.03 p=0.887 ns
Antigen Specific PRN continuous 0.00-0.010.03 p=0.887 ns
Antigen Specific PT continuous 0.00-0.040.01 p=0.887 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.887 ns
Unsupervised RClust1 continuous 0.00-0.020.02 p=0.944 ns
Unsupervised RClust2 continuous 0.00-0.020.01 p=0.887 ns
Unsupervised RClust3 continuous 0.00-0.040.01 p=0.887 ns
Unsupervised RClust4 continuous 0.00-0.020.02 p=0.944 ns
Unsupervised RClust5 continuous 0.00-0.010.04 p=0.887 ns
Unsupervised RClust6 continuous 0.00-0.030.01 p=0.887 ns
Unsupervised RClust7 continuous 0.00-0.020.03 p=0.887 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.02 p=0.757 ns
Antigen Specific FHA continuous 0.00-0.020.01 p=0.757 ns
Antigen Specific PRN continuous 0.00-0.010.02 p=0.757 ns
Antigen Specific PT continuous 0.00-0.010.02 p=0.757 ns
Antigen Specific TT continuous 0.00-0.010.02 p=0.757 ns
Unsupervised RClust1 continuous 0.00-0.020.00 p=0.757 ns
Unsupervised RClust2 continuous 0.00-0.010.01 p=0.951 ns
Unsupervised RClust3 continuous 0.00-0.020.02 p=0.881 ns
Unsupervised RClust4 continuous 0.000.000.02 p=0.757 ns
Unsupervised RClust5 continuous 0.00-0.020.01 p=0.757 ns
Unsupervised RClust6 continuous 0.00-0.010.01 p=0.881 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.937 ns
Antigen Specific FHA continuous 0.00-0.020.03 p=0.944 ns
Antigen Specific PRN continuous 0.00-0.030.01 p=0.885 ns
Antigen Specific PT continuous 0.00-0.040.00 p=0.885 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.937 ns
Unsupervised RClust1 continuous 0.00-0.020.02 p=0.944 ns
Unsupervised RClust2 continuous 0.00-0.010.02 p=0.937 ns
Unsupervised RClust3 continuous 0.00-0.050.01 p=0.937 ns
Unsupervised RClust4 continuous 0.00-0.020.02 p=0.944 ns
Unsupervised RClust5 continuous 0.00-0.010.04 p=0.937 ns
Unsupervised RClust6 continuous 0.00-0.020.03 p=0.937 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.01 p=0.836 ns
Antigen Specific FHA continuous 0.00-0.020.01 p=0.651 ns
Antigen Specific PRN continuous 0.000.000.03 p=0.651 ns
Antigen Specific PT continuous 0.00-0.010.02 p=0.651 ns
Antigen Specific TT continuous 0.00-0.030.01 p=0.651 ns
Unsupervised RClust1 continuous 0.00-0.010.01 p=0.651 ns
Unsupervised RClust2 continuous 0.00-0.020.01 p=0.815 ns
Unsupervised RClust3 continuous 0.00-0.030.01 p=0.651 ns
Unsupervised RClust4 continuous 0.00-0.020.01 p=0.651 ns
Unsupervised RClust5 continuous 0.00-0.010.02 p=0.836 ns
Unsupervised RClust6 continuous 0.00-0.010.02 p=0.651 ns
Unsupervised RClust7 continuous 0.00-0.010.02 p=0.651 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.04 p=0.522 ns
Antigen Specific FHA continuous 0.00-0.030.03 p=0.985 ns
Antigen Specific PRN continuous 0.00-0.050.01 p=0.410 ns
Antigen Specific PT continuous 0.00-0.050.00 p=0.311 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.763 ns
Unsupervised RClust1 continuous 0.00-0.030.02 p=0.763 ns
Unsupervised RClust2 continuous 0.00-0.010.03 p=0.717 ns
Unsupervised RClust3 continuous 0.00-0.020.04 p=0.745 ns
Unsupervised RClust4 continuous 0.00-0.050.00 p=0.311 *
Unsupervised RClust5 continuous 0.00-0.030.01 p=0.574 ns
Unsupervised RClust6 continuous 0.00-0.020.02 p=0.920 ns
Unsupervised RClust7 continuous 0.00-0.010.05 p=0.410 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.01 p=0.836 ns
Antigen Specific FHA continuous 0.00-0.020.01 p=0.686 ns
Antigen Specific PRN continuous 0.000.000.03 p=0.686 ns
Antigen Specific PT continuous 0.00-0.010.02 p=0.686 ns
Antigen Specific TT continuous 0.00-0.030.01 p=0.686 ns
Unsupervised RClust1 continuous 0.00-0.010.01 p=0.686 ns
Unsupervised RClust2 continuous 0.00-0.020.01 p=0.830 ns
Unsupervised RClust3 continuous 0.00-0.020.03 p=0.686 ns
Unsupervised RClust4 continuous 0.00-0.020.01 p=0.686 ns
Unsupervised RClust5 continuous 0.00-0.010.02 p=0.836 ns
Unsupervised RClust6 continuous 0.00-0.010.02 p=0.686 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.04 p=0.492 ns
Antigen Specific FHA continuous 0.00-0.030.03 p=0.985 ns
Antigen Specific PRN continuous 0.00-0.050.01 p=0.445 ns
Antigen Specific PT continuous 0.00-0.050.00 p=0.285 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.778 ns
Unsupervised RClust1 continuous 0.00-0.030.02 p=0.778 ns
Unsupervised RClust2 continuous 0.00-0.010.03 p=0.657 ns
Unsupervised RClust3 continuous 0.00-0.010.06 p=0.492 ns
Unsupervised RClust4 continuous 0.00-0.050.00 p=0.285 *
Unsupervised RClust5 continuous 0.00-0.030.01 p=0.526 ns
Unsupervised RClust6 continuous 0.00-0.020.02 p=0.927 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.02 p=0.671 ns
Antigen Specific FHA continuous 0.00-0.010.02 p=0.855 ns
Antigen Specific PRN continuous 0.000.000.03 p=0.671 ns
Antigen Specific PT continuous 0.00-0.020.01 p=0.855 ns
Antigen Specific TT continuous 0.000.000.03 p=0.671 ns
Unsupervised RClust1 continuous 0.00-0.010.02 p=0.671 ns
Unsupervised RClust2 continuous 0.00-0.010.02 p=0.959 ns
Unsupervised RClust3 continuous 0.00-0.010.03 p=0.671 ns
Unsupervised RClust4 continuous 0.00-0.010.02 p=0.855 ns
Unsupervised RClust5 continuous 0.000.000.02 p=0.671 ns
Unsupervised RClust6 continuous 0.00-0.020.01 p=0.855 ns
Unsupervised RClust7 continuous 0.00-0.010.01 p=0.897 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.03 p=0.995 ns
Antigen Specific FHA continuous 0.00-0.020.03 p=0.995 ns
Antigen Specific PRN continuous 0.00-0.020.02 p=0.995 ns
Antigen Specific PT continuous 0.00-0.010.03 p=0.995 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.995 ns
Unsupervised RClust1 continuous 0.00-0.030.02 p=0.995 ns
Unsupervised RClust2 continuous 0.00-0.020.02 p=0.995 ns
Unsupervised RClust3 continuous 0.00-0.030.04 p=0.995 ns
Unsupervised RClust4 continuous 0.00-0.010.05 p=0.995 ns
Unsupervised RClust5 continuous 0.00-0.020.02 p=0.995 ns
Unsupervised RClust6 continuous 0.00-0.020.02 p=0.995 ns
Unsupervised RClust7 continuous 0.00-0.010.03 p=0.995 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.01 p=0.738 ns
Antigen Specific FHA continuous 0.00-0.020.01 p=0.959 ns
Antigen Specific PRN continuous 0.000.000.03 p=0.738 ns
Antigen Specific PT continuous 0.00-0.020.01 p=0.959 ns
Antigen Specific TT continuous 0.000.000.03 p=0.738 ns
Unsupervised RClust1 continuous 0.00-0.020.02 p=0.959 ns
Unsupervised RClust2 continuous 0.00-0.010.02 p=0.959 ns
Unsupervised RClust3 continuous 0.00-0.010.03 p=0.738 ns
Unsupervised RClust4 continuous 0.00-0.010.02 p=0.959 ns
Unsupervised RClust5 continuous 0.000.000.02 p=0.738 ns
Unsupervised RClust6 continuous 0.00-0.010.01 p=0.959 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.03 p=0.965 ns
Antigen Specific FHA continuous 0.00-0.020.03 p=0.965 ns
Antigen Specific PRN continuous 0.00-0.020.02 p=0.965 ns
Antigen Specific PT continuous 0.00-0.010.03 p=0.965 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.965 ns
Unsupervised RClust1 continuous 0.00-0.030.02 p=0.965 ns
Unsupervised RClust2 continuous 0.00-0.020.02 p=0.987 ns
Unsupervised RClust3 continuous 0.00-0.030.04 p=0.965 ns
Unsupervised RClust4 continuous 0.00-0.010.05 p=0.965 ns
Unsupervised RClust5 continuous 0.00-0.020.02 p=0.965 ns
Unsupervised RClust6 continuous 0.00-0.010.03 p=0.965 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.01 p=0.889 ns
Antigen Specific FHA continuous 0.00-0.020.01 p=0.908 ns
Antigen Specific PRN continuous 0.000.000.03 p=0.889 ns
Antigen Specific PT continuous 0.00-0.020.02 p=0.959 ns
Antigen Specific TT continuous 0.00-0.020.01 p=0.889 ns
Unsupervised RClust1 continuous 0.00-0.010.02 p=0.889 ns
Unsupervised RClust2 continuous 0.00-0.020.01 p=0.959 ns
Unsupervised RClust3 continuous 0.00-0.010.02 p=0.959 ns
Unsupervised RClust4 continuous 0.00-0.010.02 p=0.959 ns
Unsupervised RClust5 continuous 0.00-0.020.00 p=0.889 ns
Unsupervised RClust6 continuous 0.00-0.010.01 p=0.959 ns
Unsupervised RClust7 continuous 0.00-0.020.01 p=0.908 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.921 ns
Antigen Specific FHA continuous 0.00-0.020.03 p=0.921 ns
Antigen Specific PRN continuous 0.00-0.020.02 p=0.921 ns
Antigen Specific PT continuous 0.00-0.040.01 p=0.921 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.921 ns
Unsupervised RClust1 continuous 0.00-0.020.03 p=0.921 ns
Unsupervised RClust2 continuous 0.00-0.020.02 p=0.987 ns
Unsupervised RClust3 continuous 0.00-0.010.02 p=0.921 ns
Unsupervised RClust4 continuous 0.00-0.050.01 p=0.921 ns
Unsupervised RClust5 continuous 0.00-0.020.02 p=0.921 ns
Unsupervised RClust6 continuous 0.00-0.030.01 p=0.921 ns
Unsupervised RClust7 continuous 0.00-0.030.02 p=0.921 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.02 p=0.871 ns
Antigen Specific FHA continuous 0.00-0.010.02 p=0.871 ns
Antigen Specific PRN continuous 0.000.000.03 p=0.840 ns
Antigen Specific PT continuous 0.00-0.020.01 p=0.871 ns
Antigen Specific TT continuous 0.000.000.03 p=0.871 ns
Unsupervised RClust1 continuous 0.00-0.010.02 p=0.871 ns
Unsupervised RClust2 continuous 0.00-0.010.02 p=0.959 ns
Unsupervised RClust3 continuous 0.00-0.020.01 p=0.896 ns
Unsupervised RClust4 continuous 0.00-0.010.02 p=0.871 ns
Unsupervised RClust5 continuous 0.00-0.010.02 p=0.871 ns
Unsupervised RClust6 continuous 0.00-0.010.02 p=0.871 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.923 ns
Antigen Specific FHA continuous 0.00-0.030.02 p=0.923 ns
Antigen Specific PRN continuous 0.00-0.020.02 p=0.923 ns
Antigen Specific PT continuous 0.00-0.010.03 p=0.923 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.923 ns
Unsupervised RClust1 continuous 0.00-0.020.03 p=0.923 ns
Unsupervised RClust2 continuous 0.00-0.020.02 p=0.987 ns
Unsupervised RClust3 continuous 0.00-0.010.02 p=0.923 ns
Unsupervised RClust4 continuous 0.00-0.050.01 p=0.923 ns
Unsupervised RClust5 continuous 0.00-0.010.03 p=0.923 ns
Unsupervised RClust6 continuous 0.00-0.030.02 p=0.923 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

gestational_age_at_delivery

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.360.13 p=0.907 ns
Antigen Specific FHA continuous 0.00-0.320.12 p=0.907 ns
Antigen Specific PRN continuous 0.00-0.200.27 p=0.907 ns
Antigen Specific PT continuous 0.00-0.370.13 p=0.907 ns
Antigen Specific TT continuous 0.00-0.380.15 p=0.907 ns
Unsupervised RClust1 continuous 0.00-0.300.13 p=0.907 ns
Unsupervised RClust2 continuous 0.00-0.350.23 p=0.907 ns
Unsupervised RClust3 continuous 0.00-0.190.17 p=0.907 ns
Unsupervised RClust4 continuous 0.00-0.150.23 p=0.907 ns
Unsupervised RClust5 continuous 0.00-0.150.17 p=0.907 ns
Unsupervised RClust6 continuous 0.00-0.180.15 p=0.907 ns
Unsupervised RClust7 continuous 0.00-0.170.22 p=0.907 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.710.10 p=0.691 ns
Antigen Specific FHA continuous 0.00-0.530.43 p=0.911 ns
Antigen Specific PRN continuous 0.00-0.400.54 p=0.911 ns
Antigen Specific PT continuous 0.00-0.720.24 p=0.691 ns
Antigen Specific TT continuous 0.00-0.530.36 p=0.911 ns
Unsupervised RClust1 continuous 0.00-0.530.15 p=0.691 ns
Unsupervised RClust2 continuous 0.00-0.260.74 p=0.691 ns
Unsupervised RClust3 continuous 0.00-0.360.45 p=0.911 ns
Unsupervised RClust4 continuous 0.00-0.420.39 p=0.952 ns
Unsupervised RClust5 continuous 0.00-0.330.49 p=0.911 ns
Unsupervised RClust6 continuous 0.00-0.110.58 p=0.691 ns
Unsupervised RClust7 continuous 0.00-0.220.75 p=0.691 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.360.13 p=0.776 ns
Antigen Specific FHA continuous 0.00-0.320.12 p=0.776 ns
Antigen Specific PRN continuous 0.00-0.200.27 p=0.907 ns
Antigen Specific PT continuous 0.00-0.370.13 p=0.776 ns
Antigen Specific TT continuous 0.00-0.380.15 p=0.776 ns
Unsupervised RClust1 continuous 0.00-0.300.13 p=0.776 ns
Unsupervised RClust2 continuous 0.00-0.350.23 p=0.907 ns
Unsupervised RClust3 continuous 0.00-0.190.17 p=0.907 ns
Unsupervised RClust4 continuous 0.00-0.460.16 p=0.776 ns
Unsupervised RClust5 continuous 0.00-0.150.17 p=0.907 ns
Unsupervised RClust6 continuous 0.00-0.180.15 p=0.907 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.710.10 p=0.760 ns
Antigen Specific FHA continuous 0.00-0.530.43 p=0.835 ns
Antigen Specific PRN continuous 0.00-0.400.54 p=0.835 ns
Antigen Specific PT continuous 0.00-0.720.24 p=0.760 ns
Antigen Specific TT continuous 0.00-0.530.36 p=0.835 ns
Unsupervised RClust1 continuous 0.00-0.530.15 p=0.760 ns
Unsupervised RClust2 continuous 0.00-0.260.74 p=0.760 ns
Unsupervised RClust3 continuous 0.00-0.360.45 p=0.835 ns
Unsupervised RClust4 continuous 0.00-0.330.78 p=0.785 ns
Unsupervised RClust5 continuous 0.00-0.330.49 p=0.835 ns
Unsupervised RClust6 continuous 0.00-0.110.58 p=0.760 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.430.09 p=0.605 ns
Antigen Specific FHA continuous 0.00-0.390.14 p=0.759 ns
Antigen Specific PRN continuous 0.00-0.350.17 p=0.759 ns
Antigen Specific PT continuous 0.00-0.190.34 p=0.777 ns
Antigen Specific TT continuous 0.00-0.370.15 p=0.759 ns
Unsupervised RClust1 continuous 0.000.000.43 p=0.414 ns
Unsupervised RClust2 continuous 0.00-0.150.23 p=0.826 ns
Unsupervised RClust3 continuous 0.00-0.010.35 p=0.414 ns
Unsupervised RClust4 continuous 0.00-0.270.22 p=0.910 ns
Unsupervised RClust5 continuous 0.00-0.050.27 p=0.605 ns
Unsupervised RClust6 continuous 0.00-0.220.19 p=0.910 ns
Unsupervised RClust7 continuous 0.00-0.170.35 p=0.759 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.460.19 p=0.781 ns
Antigen Specific FHA continuous 0.00-0.290.45 p=0.816 ns
Antigen Specific PRN continuous 0.00-0.460.20 p=0.781 ns
Antigen Specific PT continuous 0.00-0.490.31 p=0.816 ns
Antigen Specific TT continuous 0.00-0.590.20 p=0.781 ns
Unsupervised RClust1 continuous 0.00-0.470.46 p=0.975 ns
Unsupervised RClust2 continuous 0.00-0.360.06 p=0.781 ns
Unsupervised RClust3 continuous 0.00-0.280.30 p=0.975 ns
Unsupervised RClust4 continuous 0.00-0.630.26 p=0.781 ns
Unsupervised RClust5 continuous 0.00-0.130.51 p=0.781 ns
Unsupervised RClust6 continuous 0.00-0.250.67 p=0.781 ns
Unsupervised RClust7 continuous 0.00-0.550.33 p=0.816 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.430.09 p=0.712 ns
Antigen Specific FHA continuous 0.00-0.390.14 p=0.712 ns
Antigen Specific PRN continuous 0.00-0.170.35 p=0.712 ns
Antigen Specific PT continuous 0.00-0.190.34 p=0.712 ns
Antigen Specific TT continuous 0.00-0.370.15 p=0.712 ns
Unsupervised RClust1 continuous 0.000.000.43 p=0.650 ns
Unsupervised RClust2 continuous 0.00-0.300.16 p=0.712 ns
Unsupervised RClust3 continuous 0.00-0.270.22 p=0.910 ns
Unsupervised RClust4 continuous 0.00-0.050.27 p=0.712 ns
Unsupervised RClust5 continuous 0.00-0.220.19 p=0.910 ns
Unsupervised RClust6 continuous 0.00-0.170.35 p=0.712 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.460.19 p=0.831 ns
Antigen Specific FHA continuous 0.00-0.290.45 p=0.831 ns
Antigen Specific PRN continuous 0.00-0.460.20 p=0.831 ns
Antigen Specific PT continuous 0.00-0.490.31 p=0.831 ns
Antigen Specific TT continuous 0.00-0.590.20 p=0.831 ns
Unsupervised RClust1 continuous 0.00-0.470.46 p=0.982 ns
Unsupervised RClust2 continuous 0.00-0.290.29 p=0.982 ns
Unsupervised RClust3 continuous 0.00-0.630.26 p=0.831 ns
Unsupervised RClust4 continuous 0.00-0.130.51 p=0.831 ns
Unsupervised RClust5 continuous 0.00-0.250.67 p=0.831 ns
Unsupervised RClust6 continuous 0.00-0.550.33 p=0.831 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.160.34 p=0.671 ns
Antigen Specific FHA continuous 0.00-0.390.12 p=0.671 ns
Antigen Specific PRN continuous 0.00-0.170.35 p=0.671 ns
Antigen Specific PT continuous 0.00-0.150.36 p=0.671 ns
Antigen Specific TT continuous 0.00-0.150.36 p=0.671 ns
Unsupervised RClust1 continuous 0.00-0.310.09 p=0.671 ns
Unsupervised RClust2 continuous 0.00-0.350.01 p=0.671 ns
Unsupervised RClust3 continuous 0.00-0.150.25 p=0.708 ns
Unsupervised RClust4 continuous 0.00-0.050.27 p=0.671 ns
Unsupervised RClust5 continuous 0.00-0.190.22 p=0.910 ns
Unsupervised RClust6 continuous 0.00-0.110.21 p=0.671 ns
Unsupervised RClust7 continuous 0.00-0.120.28 p=0.671 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.190.47 p=0.734 ns
Antigen Specific FHA continuous 0.00-0.440.30 p=0.838 ns
Antigen Specific PRN continuous 0.00-0.220.43 p=0.783 ns
Antigen Specific PT continuous 0.00-0.490.31 p=0.838 ns
Antigen Specific TT continuous 0.00-0.580.20 p=0.734 ns
Unsupervised RClust1 continuous 0.00-0.200.51 p=0.734 ns
Unsupervised RClust2 continuous 0.00-0.280.30 p=0.940 ns
Unsupervised RClust3 continuous 0.00-0.480.42 p=0.940 ns
Unsupervised RClust4 continuous 0.00-0.510.13 p=0.734 ns
Unsupervised RClust5 continuous 0.00-0.250.67 p=0.734 ns
Unsupervised RClust6 continuous 0.00-0.490.21 p=0.734 ns
Unsupervised RClust7 continuous 0.00-0.190.63 p=0.734 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.43 p=0.618 ns
Antigen Specific FHA continuous 0.00-0.390.14 p=0.618 ns
Antigen Specific PRN continuous 0.00-0.170.35 p=0.618 ns
Antigen Specific PT continuous 0.00-0.190.34 p=0.641 ns
Antigen Specific TT continuous 0.00-0.150.37 p=0.618 ns
Unsupervised RClust1 continuous 0.00-0.310.09 p=0.618 ns
Unsupervised RClust2 continuous 0.00-0.350.01 p=0.618 ns
Unsupervised RClust3 continuous 0.00-0.410.17 p=0.618 ns
Unsupervised RClust4 continuous 0.00-0.050.27 p=0.618 ns
Unsupervised RClust5 continuous 0.00-0.190.22 p=0.910 ns
Unsupervised RClust6 continuous 0.00-0.280.12 p=0.618 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.460.19 p=0.716 ns
Antigen Specific FHA continuous 0.00-0.450.29 p=0.794 ns
Antigen Specific PRN continuous 0.00-0.460.20 p=0.716 ns
Antigen Specific PT continuous 0.00-0.490.31 p=0.794 ns
Antigen Specific TT continuous 0.00-0.590.20 p=0.716 ns
Unsupervised RClust1 continuous 0.00-0.510.20 p=0.716 ns
Unsupervised RClust2 continuous 0.00-0.300.28 p=0.940 ns
Unsupervised RClust3 continuous 0.00-0.590.41 p=0.794 ns
Unsupervised RClust4 continuous 0.00-0.510.13 p=0.716 ns
Unsupervised RClust5 continuous 0.00-0.250.67 p=0.716 ns
Unsupervised RClust6 continuous 0.00-0.190.63 p=0.716 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.410.09 p=0.783 ns
Antigen Specific FHA continuous 0.00-0.340.10 p=0.783 ns
Antigen Specific PRN continuous 0.00-0.180.30 p=0.783 ns
Antigen Specific PT continuous 0.00-0.200.38 p=0.783 ns
Antigen Specific TT continuous 0.00-0.450.13 p=0.783 ns
Unsupervised RClust1 continuous 0.00-0.100.24 p=0.783 ns
Unsupervised RClust2 continuous 0.00-0.430.06 p=0.783 ns
Unsupervised RClust3 continuous 0.00-0.270.28 p=0.971 ns
Unsupervised RClust4 continuous 0.00-0.180.19 p=0.971 ns
Unsupervised RClust5 continuous 0.00-0.150.35 p=0.783 ns
Unsupervised RClust6 continuous 0.00-0.180.29 p=0.783 ns
Unsupervised RClust7 continuous 0.00-0.130.28 p=0.783 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.020.78 p=0.518 *
Antigen Specific FHA continuous 0.00-0.480.50 p=0.968 ns
Antigen Specific PRN continuous 0.00-0.540.40 p=0.968 ns
Antigen Specific PT continuous 0.00-0.470.40 p=0.968 ns
Antigen Specific TT continuous 0.00-0.330.42 p=0.968 ns
Unsupervised RClust1 continuous 0.00-0.110.67 p=0.656 ns
Unsupervised RClust2 continuous 0.00-0.420.22 p=0.968 ns
Unsupervised RClust3 continuous 0.00-0.560.48 p=0.968 ns
Unsupervised RClust4 continuous 0.00-0.510.30 p=0.968 ns
Unsupervised RClust5 continuous 0.00-0.630.08 p=0.656 ns
Unsupervised RClust6 continuous 0.00-0.310.34 p=0.968 ns
Unsupervised RClust7 continuous 0.00-0.230.79 p=0.868 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.410.09 p=0.640 ns
Antigen Specific FHA continuous 0.00-0.340.10 p=0.640 ns
Antigen Specific PRN continuous 0.00-0.180.30 p=0.717 ns
Antigen Specific PT continuous 0.00-0.200.38 p=0.717 ns
Antigen Specific TT continuous 0.00-0.450.13 p=0.640 ns
Unsupervised RClust1 continuous 0.00-0.100.24 p=0.675 ns
Unsupervised RClust2 continuous 0.00-0.430.06 p=0.640 ns
Unsupervised RClust3 continuous 0.00-0.130.62 p=0.640 ns
Unsupervised RClust4 continuous 0.00-0.180.19 p=0.927 ns
Unsupervised RClust5 continuous 0.00-0.150.35 p=0.675 ns
Unsupervised RClust6 continuous 0.00-0.180.29 p=0.717 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.020.78 p=0.475 *
Antigen Specific FHA continuous 0.00-0.480.50 p=0.968 ns
Antigen Specific PRN continuous 0.00-0.540.40 p=0.968 ns
Antigen Specific PT continuous 0.00-0.470.40 p=0.968 ns
Antigen Specific TT continuous 0.00-0.330.42 p=0.968 ns
Unsupervised RClust1 continuous 0.00-0.110.67 p=0.602 ns
Unsupervised RClust2 continuous 0.00-0.420.22 p=0.968 ns
Unsupervised RClust3 continuous 0.00-0.470.80 p=0.968 ns
Unsupervised RClust4 continuous 0.00-0.510.30 p=0.968 ns
Unsupervised RClust5 continuous 0.00-0.630.08 p=0.602 ns
Unsupervised RClust6 continuous 0.00-0.310.34 p=0.968 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.090.61 p=0.118 **
Antigen Specific FHA continuous 0.00-0.070.42 p=0.871 ns
Antigen Specific PRN continuous 0.00-0.240.34 p=0.880 ns
Antigen Specific PT continuous 0.00-0.130.44 p=0.871 ns
Antigen Specific TT continuous 0.00-0.220.28 p=0.880 ns
Unsupervised RClust1 continuous 0.00-0.130.24 p=0.880 ns
Unsupervised RClust2 continuous 0.00-0.340.14 p=0.871 ns
Unsupervised RClust3 continuous 0.00-0.120.44 p=0.871 ns
Unsupervised RClust4 continuous 0.00-0.250.15 p=0.880 ns
Unsupervised RClust5 continuous 0.00-0.180.17 p=0.939 ns
Unsupervised RClust6 continuous 0.00-0.270.19 p=0.880 ns
Unsupervised RClust7 continuous 0.00-0.250.09 p=0.871 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.340.27 p=0.950 ns
Antigen Specific FHA continuous 0.00-0.360.42 p=0.950 ns
Antigen Specific PRN continuous 0.00-0.480.19 p=0.950 ns
Antigen Specific PT continuous 0.00-0.470.29 p=0.950 ns
Antigen Specific TT continuous 0.00-0.490.22 p=0.950 ns
Unsupervised RClust1 continuous 0.00-0.160.67 p=0.950 ns
Unsupervised RClust2 continuous 0.00-0.530.17 p=0.950 ns
Unsupervised RClust3 continuous 0.00-0.430.65 p=0.950 ns
Unsupervised RClust4 continuous 0.00-0.250.71 p=0.950 ns
Unsupervised RClust5 continuous 0.00-0.240.38 p=0.950 ns
Unsupervised RClust6 continuous 0.00-0.300.36 p=0.950 ns
Unsupervised RClust7 continuous 0.00-0.280.29 p=0.982 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.61-0.09 p=0.108 **
Antigen Specific FHA continuous 0.00-0.420.07 p=0.762 ns
Antigen Specific PRN continuous 0.00-0.240.34 p=0.882 ns
Antigen Specific PT continuous 0.00-0.130.44 p=0.762 ns
Antigen Specific TT continuous 0.00-0.220.28 p=0.888 ns
Unsupervised RClust1 continuous 0.00-0.450.21 p=0.762 ns
Unsupervised RClust2 continuous 0.00-0.340.14 p=0.762 ns
Unsupervised RClust3 continuous 0.00-0.120.44 p=0.762 ns
Unsupervised RClust4 continuous 0.00-0.250.15 p=0.872 ns
Unsupervised RClust5 continuous 0.00-0.180.17 p=0.939 ns
Unsupervised RClust6 continuous 0.00-0.250.09 p=0.762 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.340.27 p=0.958 ns
Antigen Specific FHA continuous 0.00-0.360.42 p=0.958 ns
Antigen Specific PRN continuous 0.00-0.480.19 p=0.947 ns
Antigen Specific PT continuous 0.00-0.470.29 p=0.947 ns
Antigen Specific TT continuous 0.00-0.490.22 p=0.947 ns
Unsupervised RClust1 continuous 0.00-0.180.66 p=0.947 ns
Unsupervised RClust2 continuous 0.00-0.530.17 p=0.947 ns
Unsupervised RClust3 continuous 0.00-0.430.65 p=0.947 ns
Unsupervised RClust4 continuous 0.00-0.250.71 p=0.947 ns
Unsupervised RClust5 continuous 0.00-0.240.38 p=0.947 ns
Unsupervised RClust6 continuous 0.00-0.280.29 p=0.982 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.500.02 p=0.841 ns
Antigen Specific FHA continuous 0.00-0.420.07 p=0.864 ns
Antigen Specific PRN continuous 0.00-0.240.34 p=0.864 ns
Antigen Specific PT continuous 0.00-0.110.45 p=0.864 ns
Antigen Specific TT continuous 0.00-0.270.22 p=0.922 ns
Unsupervised RClust1 continuous 0.00-0.130.24 p=0.864 ns
Unsupervised RClust2 continuous 0.00-0.140.34 p=0.864 ns
Unsupervised RClust3 continuous 0.00-0.200.31 p=0.864 ns
Unsupervised RClust4 continuous 0.00-0.250.15 p=0.864 ns
Unsupervised RClust5 continuous 0.00-0.170.18 p=0.939 ns
Unsupervised RClust6 continuous 0.00-0.090.25 p=0.864 ns
Unsupervised RClust7 continuous 0.00-0.160.35 p=0.864 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.320.28 p=0.982 ns
Antigen Specific FHA continuous 0.00-0.360.42 p=0.982 ns
Antigen Specific PRN continuous 0.00-0.200.46 p=0.903 ns
Antigen Specific PT continuous 0.00-0.300.46 p=0.903 ns
Antigen Specific TT continuous 0.00-0.490.22 p=0.903 ns
Unsupervised RClust1 continuous 0.00-0.670.16 p=0.903 ns
Unsupervised RClust2 continuous 0.00-0.530.17 p=0.903 ns
Unsupervised RClust3 continuous 0.00-0.230.39 p=0.903 ns
Unsupervised RClust4 continuous 0.00-0.710.25 p=0.903 ns
Unsupervised RClust5 continuous 0.00-0.240.38 p=0.903 ns
Unsupervised RClust6 continuous 0.00-0.290.28 p=0.982 ns
Unsupervised RClust7 continuous 0.00-0.580.33 p=0.903 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.090.61 p=0.108 **
Antigen Specific FHA continuous 0.00-0.070.42 p=0.807 ns
Antigen Specific PRN continuous 0.00-0.240.34 p=0.807 ns
Antigen Specific PT continuous 0.00-0.130.44 p=0.807 ns
Antigen Specific TT continuous 0.00-0.220.28 p=0.807 ns
Unsupervised RClust1 continuous 0.00-0.130.24 p=0.807 ns
Unsupervised RClust2 continuous 0.00-0.340.14 p=0.807 ns
Unsupervised RClust3 continuous 0.00-0.310.20 p=0.807 ns
Unsupervised RClust4 continuous 0.00-0.250.15 p=0.807 ns
Unsupervised RClust5 continuous 0.00-0.330.23 p=0.807 ns
Unsupervised RClust6 continuous 0.00-0.350.16 p=0.807 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.270.34 p=0.871 ns
Antigen Specific FHA continuous 0.00-0.420.36 p=0.871 ns
Antigen Specific PRN continuous 0.00-0.190.48 p=0.871 ns
Antigen Specific PT continuous 0.00-0.470.29 p=0.871 ns
Antigen Specific TT continuous 0.00-0.490.22 p=0.871 ns
Unsupervised RClust1 continuous 0.00-0.670.16 p=0.871 ns
Unsupervised RClust2 continuous 0.00-0.170.53 p=0.871 ns
Unsupervised RClust3 continuous 0.00-0.230.39 p=0.871 ns
Unsupervised RClust4 continuous 0.00-0.710.25 p=0.871 ns
Unsupervised RClust5 continuous 0.00-0.260.38 p=0.871 ns
Unsupervised RClust6 continuous 0.00-0.580.33 p=0.871 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

maternal_age_at_delivery

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.01 p=0.344 ns
Antigen Specific FHA continuous 0.00-0.030.06 p=0.767 ns
Antigen Specific PRN continuous 0.00-0.070.04 p=0.767 ns
Antigen Specific PT continuous 0.00-0.050.05 p=0.987 ns
Antigen Specific TT continuous 0.00-0.060.05 p=0.987 ns
Unsupervised RClust1 continuous 0.00-0.020.07 p=0.704 ns
Unsupervised RClust2 continuous 0.000.020.14 p=0.086 *
Unsupervised RClust3 continuous 0.00-0.050.03 p=0.767 ns
Unsupervised RClust4 continuous 0.00-0.040.04 p=0.987 ns
Unsupervised RClust5 continuous 0.00-0.060.01 p=0.393 ns
Unsupervised RClust6 continuous 0.00-0.08-0.01 p=0.086 *
Unsupervised RClust7 continuous 0.000.000.08 p=0.226 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.09 p=0.984 ns
Antigen Specific FHA continuous 0.00-0.010.20 p=0.815 ns
Antigen Specific PRN continuous 0.00-0.130.07 p=0.850 ns
Antigen Specific PT continuous 0.00-0.130.08 p=0.850 ns
Antigen Specific TT continuous 0.00-0.140.05 p=0.850 ns
Unsupervised RClust1 continuous 0.00-0.090.06 p=0.850 ns
Unsupervised RClust2 continuous 0.00-0.050.16 p=0.850 ns
Unsupervised RClust3 continuous 0.00-0.020.15 p=0.850 ns
Unsupervised RClust4 continuous 0.00-0.070.11 p=0.850 ns
Unsupervised RClust5 continuous 0.00-0.070.11 p=0.850 ns
Unsupervised RClust6 continuous 0.00-0.060.08 p=0.850 ns
Unsupervised RClust7 continuous 0.00-0.150.06 p=0.850 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.01 p=0.420 ns
Antigen Specific FHA continuous 0.00-0.030.06 p=0.791 ns
Antigen Specific PRN continuous 0.00-0.070.04 p=0.791 ns
Antigen Specific PT continuous 0.00-0.050.05 p=0.987 ns
Antigen Specific TT continuous 0.00-0.060.05 p=0.911 ns
Unsupervised RClust1 continuous 0.00-0.020.07 p=0.774 ns
Unsupervised RClust2 continuous 0.000.020.14 p=0.079 *
Unsupervised RClust3 continuous 0.00-0.050.03 p=0.791 ns
Unsupervised RClust4 continuous 0.00-0.060.08 p=0.911 ns
Unsupervised RClust5 continuous 0.00-0.060.01 p=0.450 ns
Unsupervised RClust6 continuous 0.00-0.08-0.01 p=0.079 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, DT_ADCP, DT_ADNP
Cluster_2 PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_3 FHA_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_5 TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG, TT_IgG1
Cluster_6 DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.09 p=0.984 ns
Antigen Specific FHA continuous 0.00-0.010.20 p=0.747 ns
Antigen Specific PRN continuous 0.00-0.130.07 p=0.857 ns
Antigen Specific PT continuous 0.00-0.130.08 p=0.857 ns
Antigen Specific TT continuous 0.00-0.140.05 p=0.857 ns
Unsupervised RClust1 continuous 0.00-0.090.06 p=0.857 ns
Unsupervised RClust2 continuous 0.00-0.050.16 p=0.857 ns
Unsupervised RClust3 continuous 0.00-0.020.15 p=0.839 ns
Unsupervised RClust4 continuous 0.00-0.170.07 p=0.857 ns
Unsupervised RClust5 continuous 0.00-0.070.11 p=0.857 ns
Unsupervised RClust6 continuous 0.00-0.060.08 p=0.857 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.07 p=0.623 ns
Antigen Specific FHA continuous 0.000.000.11 p=0.383 ns
Antigen Specific PRN continuous 0.00-0.080.03 p=0.623 ns
Antigen Specific PT continuous 0.00-0.060.06 p=0.952 ns
Antigen Specific TT continuous 0.00-0.070.04 p=0.623 ns
Unsupervised RClust1 continuous 0.00-0.030.06 p=0.623 ns
Unsupervised RClust2 continuous 0.00-0.060.03 p=0.623 ns
Unsupervised RClust3 continuous 0.00-0.030.05 p=0.623 ns
Unsupervised RClust4 continuous 0.00-0.040.07 p=0.623 ns
Unsupervised RClust5 continuous 0.00-0.010.06 p=0.623 ns
Unsupervised RClust6 continuous 0.00-0.070.01 p=0.623 ns
Unsupervised RClust7 continuous 0.000.020.13 p=0.093 **

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, PRN_ADNP
Cluster_3 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_4 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.05 p=0.863 ns
Antigen Specific FHA continuous 0.00-0.010.15 p=0.575 ns
Antigen Specific PRN continuous 0.00-0.060.08 p=0.863 ns
Antigen Specific PT continuous 0.00-0.100.08 p=0.863 ns
Antigen Specific TT continuous 0.00-0.090.08 p=0.863 ns
Unsupervised RClust1 continuous 0.00-0.140.06 p=0.863 ns
Unsupervised RClust2 continuous 0.00-0.050.04 p=0.863 ns
Unsupervised RClust3 continuous 0.00-0.040.09 p=0.863 ns
Unsupervised RClust4 continuous 0.00-0.080.11 p=0.863 ns
Unsupervised RClust5 continuous 0.00-0.010.13 p=0.575 ns
Unsupervised RClust6 continuous 0.00-0.140.06 p=0.863 ns
Unsupervised RClust7 continuous 0.00-0.150.03 p=0.836 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.07 p=0.692 ns
Antigen Specific FHA continuous 0.000.000.11 p=0.351 ns
Antigen Specific PRN continuous 0.00-0.030.08 p=0.692 ns
Antigen Specific PT continuous 0.00-0.060.06 p=0.952 ns
Antigen Specific TT continuous 0.00-0.070.04 p=0.692 ns
Unsupervised RClust1 continuous 0.00-0.030.06 p=0.692 ns
Unsupervised RClust2 continuous 0.00-0.060.04 p=0.901 ns
Unsupervised RClust3 continuous 0.00-0.040.07 p=0.692 ns
Unsupervised RClust4 continuous 0.00-0.010.06 p=0.648 ns
Unsupervised RClust5 continuous 0.00-0.070.01 p=0.636 ns
Unsupervised RClust6 continuous 0.000.020.13 p=0.086 **

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, FHA_ADCD, PRN_ADCD, PT_IgG1, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP, PRN_ADNP
Cluster_3 DT_IgG, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_IgG, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.05 p=0.863 ns
Antigen Specific FHA continuous 0.00-0.010.15 p=0.527 ns
Antigen Specific PRN continuous 0.00-0.060.08 p=0.863 ns
Antigen Specific PT continuous 0.00-0.100.08 p=0.863 ns
Antigen Specific TT continuous 0.00-0.090.08 p=0.863 ns
Unsupervised RClust1 continuous 0.00-0.140.06 p=0.863 ns
Unsupervised RClust2 continuous 0.00-0.090.04 p=0.863 ns
Unsupervised RClust3 continuous 0.00-0.080.11 p=0.863 ns
Unsupervised RClust4 continuous 0.00-0.010.13 p=0.527 ns
Unsupervised RClust5 continuous 0.00-0.140.06 p=0.863 ns
Unsupervised RClust6 continuous 0.00-0.150.03 p=0.766 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.080.03 p=0.709 ns
Antigen Specific FHA continuous 0.00-0.010.09 p=0.707 ns
Antigen Specific PRN continuous 0.00-0.030.08 p=0.709 ns
Antigen Specific PT continuous 0.00-0.050.06 p=0.960 ns
Antigen Specific TT continuous 0.00-0.040.07 p=0.803 ns
Unsupervised RClust1 continuous 0.00-0.050.03 p=0.803 ns
Unsupervised RClust2 continuous 0.00-0.050.03 p=0.803 ns
Unsupervised RClust3 continuous 0.00-0.010.07 p=0.707 ns
Unsupervised RClust4 continuous 0.00-0.010.06 p=0.707 ns
Unsupervised RClust5 continuous 0.00-0.010.07 p=0.707 ns
Unsupervised RClust6 continuous 0.00-0.030.04 p=0.960 ns
Unsupervised RClust7 continuous 0.00-0.060.02 p=0.709 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, TT_FcgR2a
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.050.09 p=0.901 ns
Antigen Specific FHA continuous 0.00-0.150.00 p=0.383 ns
Antigen Specific PRN continuous 0.00-0.080.06 p=0.901 ns
Antigen Specific PT continuous 0.00-0.100.08 p=0.901 ns
Antigen Specific TT continuous 0.00-0.100.07 p=0.901 ns
Unsupervised RClust1 continuous 0.00-0.050.10 p=0.901 ns
Unsupervised RClust2 continuous 0.00-0.040.09 p=0.901 ns
Unsupervised RClust3 continuous 0.00-0.070.12 p=0.901 ns
Unsupervised RClust4 continuous 0.00-0.130.01 p=0.383 ns
Unsupervised RClust5 continuous 0.00-0.140.06 p=0.901 ns
Unsupervised RClust6 continuous 0.00-0.17-0.02 p=0.144 *
Unsupervised RClust7 continuous 0.00-0.100.08 p=0.901 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.04 p=0.693 ns
Antigen Specific FHA continuous 0.000.000.11 p=0.351 ns
Antigen Specific PRN continuous 0.00-0.030.08 p=0.693 ns
Antigen Specific PT continuous 0.00-0.060.06 p=0.952 ns
Antigen Specific TT continuous 0.00-0.040.07 p=0.693 ns
Unsupervised RClust1 continuous 0.00-0.050.03 p=0.693 ns
Unsupervised RClust2 continuous 0.00-0.050.03 p=0.693 ns
Unsupervised RClust3 continuous 0.00-0.16-0.04 p=0.013 **
Unsupervised RClust4 continuous 0.00-0.010.06 p=0.648 ns
Unsupervised RClust5 continuous 0.00-0.010.07 p=0.636 ns
Unsupervised RClust6 continuous 0.00-0.020.06 p=0.693 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_ADCP, FHA_ADCD, PRN_ADCD, PRN_ADNP, TT_ADCD
Cluster_2 DT_ADNP, FHA_ADCP, FHA_ADNP, PRN_ADCP
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_FcgR2a, TT_IgG3
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, TT_ADCP, TT_ADNP, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.05 p=0.901 ns
Antigen Specific FHA continuous 0.00-0.150.01 p=0.527 ns
Antigen Specific PRN continuous 0.00-0.060.08 p=0.901 ns
Antigen Specific PT continuous 0.00-0.100.08 p=0.901 ns
Antigen Specific TT continuous 0.00-0.090.08 p=0.901 ns
Unsupervised RClust1 continuous 0.00-0.100.05 p=0.901 ns
Unsupervised RClust2 continuous 0.00-0.090.04 p=0.901 ns
Unsupervised RClust3 continuous 0.00-0.130.08 p=0.901 ns
Unsupervised RClust4 continuous 0.00-0.130.01 p=0.527 ns
Unsupervised RClust5 continuous 0.00-0.140.06 p=0.901 ns
Unsupervised RClust6 continuous 0.00-0.100.08 p=0.901 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.050.05 p=0.976 ns
Antigen Specific FHA continuous 0.00-0.040.05 p=0.976 ns
Antigen Specific PRN continuous 0.00-0.060.05 p=0.976 ns
Antigen Specific PT continuous 0.00-0.080.04 p=0.976 ns
Antigen Specific TT continuous 0.00-0.070.05 p=0.976 ns
Unsupervised RClust1 continuous 0.00-0.030.05 p=0.976 ns
Unsupervised RClust2 continuous 0.00-0.040.06 p=0.976 ns
Unsupervised RClust3 continuous 0.00-0.090.03 p=0.976 ns
Unsupervised RClust4 continuous 0.00-0.050.03 p=0.976 ns
Unsupervised RClust5 continuous 0.00-0.050.06 p=0.976 ns
Unsupervised RClust6 continuous 0.000.010.11 p=0.279 *
Unsupervised RClust7 continuous 0.00-0.020.07 p=0.976 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_7 DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.09 p=0.973 ns
Antigen Specific FHA continuous 0.00-0.180.03 p=0.973 ns
Antigen Specific PRN continuous 0.00-0.080.12 p=0.973 ns
Antigen Specific PT continuous 0.00-0.090.10 p=0.973 ns
Antigen Specific TT continuous 0.00-0.090.07 p=0.973 ns
Unsupervised RClust1 continuous 0.00-0.040.12 p=0.973 ns
Unsupervised RClust2 continuous 0.00-0.070.07 p=0.973 ns
Unsupervised RClust3 continuous 0.00-0.160.06 p=0.973 ns
Unsupervised RClust4 continuous 0.00-0.090.08 p=0.973 ns
Unsupervised RClust5 continuous 0.00-0.070.08 p=0.973 ns
Unsupervised RClust6 continuous 0.00-0.040.10 p=0.973 ns
Unsupervised RClust7 continuous 0.00-0.140.08 p=0.973 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.050.05 p=0.976 ns
Antigen Specific FHA continuous 0.00-0.040.05 p=0.976 ns
Antigen Specific PRN continuous 0.00-0.060.05 p=0.976 ns
Antigen Specific PT continuous 0.00-0.080.04 p=0.976 ns
Antigen Specific TT continuous 0.00-0.070.05 p=0.976 ns
Unsupervised RClust1 continuous 0.00-0.030.05 p=0.976 ns
Unsupervised RClust2 continuous 0.00-0.040.06 p=0.976 ns
Unsupervised RClust3 continuous 0.00-0.060.10 p=0.976 ns
Unsupervised RClust4 continuous 0.00-0.050.03 p=0.976 ns
Unsupervised RClust5 continuous 0.00-0.050.06 p=0.976 ns
Unsupervised RClust6 continuous 0.000.010.11 p=0.256 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD
Cluster_2 DT_ADCP, TT_ADCP, DT_ADNP, TT_ADNP, TT_FcgR2a, TT_FcgR3b
Cluster_3 FHA_ADCP, PRN_ADCP, FHA_ADNP, FHA_FcgR2a, PRN_FcgR2a, FHA_FcgR3b, PRN_FcgR3b, FHA_IgG, PRN_IgG, FHA_IgG1, PRN_IgG1, DT_IgG2, FHA_IgG2, PRN_IgG2, PT_IgG2, TT_IgG2, DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_4 PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1, PT_IgG3
Cluster_5 PRN_ADNP, PT_ADNP, DT_FcgR2a, DT_FcgR3b, DT_IgG, DT_IgG1, DT_IgG3
Cluster_6 TT_IgG, TT_IgG1, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.09 p=0.973 ns
Antigen Specific FHA continuous 0.00-0.180.03 p=0.973 ns
Antigen Specific PRN continuous 0.00-0.080.12 p=0.973 ns
Antigen Specific PT continuous 0.00-0.090.10 p=0.973 ns
Antigen Specific TT continuous 0.00-0.090.07 p=0.973 ns
Unsupervised RClust1 continuous 0.00-0.040.12 p=0.973 ns
Unsupervised RClust2 continuous 0.00-0.070.07 p=0.973 ns
Unsupervised RClust3 continuous 0.00-0.190.07 p=0.973 ns
Unsupervised RClust4 continuous 0.00-0.090.08 p=0.973 ns
Unsupervised RClust5 continuous 0.00-0.070.08 p=0.973 ns
Unsupervised RClust6 continuous 0.00-0.040.10 p=0.973 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG included

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.08 p=0.892 ns
Antigen Specific FHA continuous 0.00-0.060.05 p=0.892 ns
Antigen Specific PRN continuous 0.00-0.080.04 p=0.892 ns
Antigen Specific PT continuous 0.00-0.070.05 p=0.892 ns
Antigen Specific TT continuous 0.00-0.060.05 p=0.892 ns
Unsupervised RClust1 continuous 0.00-0.050.03 p=0.892 ns
Unsupervised RClust2 continuous 0.00-0.030.07 p=0.892 ns
Unsupervised RClust3 continuous 0.00-0.060.05 p=0.892 ns
Unsupervised RClust4 continuous 0.00-0.030.05 p=0.892 ns
Unsupervised RClust5 continuous 0.00-0.020.05 p=0.892 ns
Unsupervised RClust6 continuous 0.00-0.070.03 p=0.892 ns
Unsupervised RClust7 continuous 0.00-0.050.03 p=0.892 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 DT_IgG4, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PT_IgG3
Cluster_7 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.080.04 p=0.944 ns
Antigen Specific FHA continuous 0.00-0.030.13 p=0.944 ns
Antigen Specific PRN continuous 0.00-0.070.07 p=0.944 ns
Antigen Specific PT continuous 0.00-0.090.07 p=0.944 ns
Antigen Specific TT continuous 0.00-0.080.07 p=0.944 ns
Unsupervised RClust1 continuous 0.00-0.040.14 p=0.944 ns
Unsupervised RClust2 continuous 0.00-0.080.07 p=0.944 ns
Unsupervised RClust3 continuous 0.00-0.090.14 p=0.944 ns
Unsupervised RClust4 continuous 0.00-0.130.07 p=0.944 ns
Unsupervised RClust5 continuous 0.000.000.13 p=0.574 *
Unsupervised RClust6 continuous 0.00-0.040.10 p=0.944 ns
Unsupervised RClust7 continuous 0.00-0.070.05 p=0.944 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.080.04 p=0.892 ns
Antigen Specific FHA continuous 0.00-0.050.06 p=0.892 ns
Antigen Specific PRN continuous 0.00-0.080.04 p=0.892 ns
Antigen Specific PT continuous 0.00-0.070.05 p=0.892 ns
Antigen Specific TT continuous 0.00-0.060.05 p=0.892 ns
Unsupervised RClust1 continuous 0.00-0.110.03 p=0.892 ns
Unsupervised RClust2 continuous 0.00-0.030.07 p=0.892 ns
Unsupervised RClust3 continuous 0.00-0.060.05 p=0.892 ns
Unsupervised RClust4 continuous 0.00-0.030.05 p=0.892 ns
Unsupervised RClust5 continuous 0.00-0.020.05 p=0.892 ns
Unsupervised RClust6 continuous 0.00-0.050.03 p=0.892 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_IgG4, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCD, PT_ADCD, PT_IgG3, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG, FHA_IgG, PRN_ADNP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, TT_ADNP, TT_FcgR3b, TT_IgG
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.080.04 p=0.944 ns
Antigen Specific FHA continuous 0.00-0.030.13 p=0.944 ns
Antigen Specific PRN continuous 0.00-0.070.07 p=0.944 ns
Antigen Specific PT continuous 0.00-0.090.07 p=0.944 ns
Antigen Specific TT continuous 0.00-0.080.07 p=0.944 ns
Unsupervised RClust1 continuous 0.00-0.050.13 p=0.944 ns
Unsupervised RClust2 continuous 0.00-0.080.07 p=0.944 ns
Unsupervised RClust3 continuous 0.00-0.090.14 p=0.944 ns
Unsupervised RClust4 continuous 0.00-0.130.07 p=0.944 ns
Unsupervised RClust5 continuous 0.000.000.13 p=0.526 *
Unsupervised RClust6 continuous 0.00-0.070.05 p=0.944 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.04 p=0.817 ns
Antigen Specific FHA continuous 0.00-0.050.05 p=0.976 ns
Antigen Specific PRN continuous 0.00-0.080.04 p=0.817 ns
Antigen Specific PT continuous 0.00-0.070.05 p=0.817 ns
Antigen Specific TT continuous 0.00-0.040.07 p=0.817 ns
Unsupervised RClust1 continuous 0.00-0.050.03 p=0.847 ns
Unsupervised RClust2 continuous 0.00-0.070.03 p=0.817 ns
Unsupervised RClust3 continuous 0.00-0.040.07 p=0.817 ns
Unsupervised RClust4 continuous 0.00-0.030.05 p=0.817 ns
Unsupervised RClust5 continuous 0.00-0.050.02 p=0.817 ns
Unsupervised RClust6 continuous 0.00-0.030.05 p=0.817 ns
Unsupervised RClust7 continuous 0.00-0.030.07 p=0.817 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_IgG3, PRN_IgG3, TT_IgG3
Cluster_6 FHA_ADCP, PRN_ADCP, TT_ADCP
Cluster_7 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.050.08 p=0.949 ns
Antigen Specific FHA continuous 0.00-0.030.13 p=0.949 ns
Antigen Specific PRN continuous 0.00-0.070.07 p=0.949 ns
Antigen Specific PT continuous 0.00-0.070.09 p=0.949 ns
Antigen Specific TT continuous 0.00-0.080.07 p=0.949 ns
Unsupervised RClust1 continuous 0.00-0.140.04 p=0.949 ns
Unsupervised RClust2 continuous 0.00-0.080.07 p=0.949 ns
Unsupervised RClust3 continuous 0.00-0.080.05 p=0.949 ns
Unsupervised RClust4 continuous 0.00-0.070.13 p=0.949 ns
Unsupervised RClust5 continuous 0.000.000.13 p=0.574 *
Unsupervised RClust6 continuous 0.00-0.050.07 p=0.949 ns
Unsupervised RClust7 continuous 0.00-0.130.06 p=0.949 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.08 p=0.879 ns
Antigen Specific FHA continuous 0.00-0.060.05 p=0.879 ns
Antigen Specific PRN continuous 0.00-0.080.04 p=0.879 ns
Antigen Specific PT continuous 0.00-0.070.05 p=0.879 ns
Antigen Specific TT continuous 0.00-0.060.05 p=0.879 ns
Unsupervised RClust1 continuous 0.00-0.050.03 p=0.879 ns
Unsupervised RClust2 continuous 0.00-0.030.07 p=0.879 ns
Unsupervised RClust3 continuous 0.00-0.070.04 p=0.879 ns
Unsupervised RClust4 continuous 0.00-0.030.05 p=0.879 ns
Unsupervised RClust5 continuous 0.00-0.100.02 p=0.879 ns
Unsupervised RClust6 continuous 0.00-0.070.03 p=0.879 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_3 DT_FcgR2a, DT_FcgR3b, DT_IgG4, PRN_ADNP, PT_ADNP, PT_IgG3, TT_ADNP
Cluster_4 DT_IgG2, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 DT_IgG3, FHA_ADCP, FHA_IgG3, PRN_ADCP, PRN_IgG3, TT_ADCP, TT_IgG3
Cluster_6 FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR2a, PT_FcgR3b, TT_FcgR3b
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.08 p=0.898 ns
Antigen Specific FHA continuous 0.00-0.130.03 p=0.898 ns
Antigen Specific PRN continuous 0.00-0.070.07 p=0.944 ns
Antigen Specific PT continuous 0.00-0.090.07 p=0.944 ns
Antigen Specific TT continuous 0.00-0.080.07 p=0.944 ns
Unsupervised RClust1 continuous 0.00-0.140.04 p=0.898 ns
Unsupervised RClust2 continuous 0.00-0.070.08 p=0.944 ns
Unsupervised RClust3 continuous 0.00-0.080.05 p=0.898 ns
Unsupervised RClust4 continuous 0.00-0.070.13 p=0.898 ns
Unsupervised RClust5 continuous 0.00-0.010.12 p=0.898 ns
Unsupervised RClust6 continuous 0.00-0.130.06 p=0.898 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.88 p=0.968 ns
Unsupervised RClust2 1 2+ 0.00-1.86-0.38 p=0.047 **
Unsupervised RClust3 1 2+ 0.00-0.780.59 p=0.968 ns
Unsupervised RClust4 1 2+ 0.00-0.431.67 p=0.559 ns
Unsupervised RClust5 1 2+ 0.00-0.041.34 p=0.308 ns
Unsupervised RClust6 1 2+ 0.00-0.671.32 p=0.890 ns
 

sessionInfo()
R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/New_York
tzcode source: internal

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] RColorBrewer_1.1-3 rstatix_0.7.2      lubridate_1.9.2    forcats_1.0.0     
 [5] purrr_1.0.1        readr_2.1.4        tidyverse_2.0.0    stringr_1.5.0     
 [9] tibble_3.2.1       tidyr_1.3.0        data.table_1.14.8  pBrackets_1.0.1   
[13] htmltools_0.5.8    plotly_4.10.4      cowplot_1.1.1      ggtext_0.1.2      
[17] ggridges_0.5.6     ggfortify_0.4.16   ggpubr_0.6.0       gtExtras_0.5.0    
[21] ggExtra_0.10.1     ggrepel_0.9.3      ggplot2_3.4.4      gt_0.10.1         
[25] gdata_2.19.0       tidyquery_0.2.4    DT_0.28            DBI_1.1.3         
[29] RPostgres_1.4.5    scales_1.3.0       dplyr_1.1.2        here_1.0.1        

loaded via a namespace (and not attached):
 [1] gridExtra_2.3     rematch2_2.1.2    rlang_1.1.1       magrittr_2.0.3   
 [5] git2r_0.32.0      compiler_4.3.1    systemfonts_1.0.5 vctrs_0.6.3      
 [9] pkgconfig_2.0.3   fastmap_1.1.1     backports_1.4.1   ellipsis_0.3.2   
[13] fontawesome_0.5.2 labeling_0.4.3    utf8_1.2.3        promises_1.2.0.1 
[17] rmarkdown_2.25    markdown_1.11     tzdb_0.4.0        ragg_1.2.6       
[21] bit_4.0.5         xfun_0.45         cachem_1.0.8      jsonlite_1.8.7   
[25] blob_1.2.4        highr_0.11        later_1.3.1       broom_1.0.5      
[29] R6_2.5.1          bslib_0.7.0       stringi_1.7.12    car_3.1-2        
[33] jquerylib_0.1.4   Rcpp_1.0.11       knitr_1.47        httpuv_1.6.11    
[37] timechange_0.2.0  tidyselect_1.2.0  rstudioapi_0.15.0 abind_1.4-5      
[41] yaml_2.3.7        miniUI_0.1.1.1    shiny_1.7.4.1     withr_3.0.0      
[45] evaluate_0.23     xml2_1.3.5        pillar_1.9.0      carData_3.0-5    
[49] generics_0.1.3    rprojroot_2.0.4   paletteer_1.6.0   hms_1.1.3        
[53] commonmark_1.9.0  munsell_0.5.0     gtools_3.9.4      xtable_1.8-4     
[57] glue_1.6.2        lazyeval_0.2.2    tools_4.3.1       ggsignif_0.6.4   
[61] fs_1.6.3          grid_4.3.1        colorspace_2.1-0  cli_3.6.1        
[65] queryparser_0.3.2 textshaping_0.3.7 workflowr_1.7.1   fansi_1.0.4      
[69] viridisLite_0.4.2 svglite_2.1.2     gtable_0.3.4      sass_0.4.9       
[73] digest_0.6.33     farver_2.1.1      htmlwidgets_1.6.2 lifecycle_1.0.4  
[77] httr_1.4.7        mime_0.12         gridtext_0.1.5    bit64_4.0.5