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Rmd b797383 Michael S. Zens 2024-10-03 latest sets of feature estimates and plots. 
cat(paste("# Covariate associations with PCA scores from clustering","{.tabset}"))

Covariate associations with PCA scores from clustering

cat("\n\n")
for (covarsel in covar_loop_list) {
  cat(paste("##", covarsel ,"{.tabset}" ))
  cat("\n\n")
  visit_list <- unique(as.character(stat.test.store[stat.test.store$aggtype %in% c("Dimension Reduction")
                                   & stat.test.store$covarname %in% covarsel,]$groupbyvar))
  for (visith in visit_list) {
    cat(paste("### Visit:", visith  ,"{.tabset}"))
    cat("\n\n")
    stand_list <- unique(as.character(stat.test.store[stat.test.store$aggtype %in% c("Dimension Reduction")
                                       & stat.test.store$covarname %in% covarsel
                                       & stat.test.store$groupbyvar == visith,]$stand))
    for (standtype in stand_list) {
      # cat(paste("#### Transformation Type:", standtype  ,"{.tabset}"))
      # cat("\n\n")
      IgG_list <- unique(as.character(stat.test.store[stat.test.store$aggtype == c("Dimension Reduction")
                                       & stat.test.store$covarname == covarsel
                                       & stat.test.store$stand == standtype
                                       & stat.test.store$groupbyvar == visith,]$clust_typ))
      for (igginclude in IgG_list) {
        cat(paste("#### ", standtype, "-", igginclude  ,"{.tabset}"))
        cat("\n\n")
        clust_num_list <- unique(as.character(stat.test.store[stat.test.store$aggtype == c("Dimension Reduction")
                                       & stat.test.store$covarname == covarsel
                                       & stat.test.store$stand == standtype
                                       & stat.test.store$groupbyvar == visith
                                       & stat.test.store$clust_typ == igginclude
                                       ,]$clust_num))
        for (nclust in clust_num_list) {
          # cat(paste("##### Number of Unsupervised Clusters:", nclust  ,"{.tabset}"))
          # cat("\n\n")
          dimension_list <- unique(as.character(stat.test.store[stat.test.store$aggtype == c("Dimension Reduction")
                                       & stat.test.store$covarname == covarsel
                                       & stat.test.store$stand == standtype
                                       & stat.test.store$groupbyvar == visith
                                       & stat.test.store$clust_typ == igginclude
                                       & stat.test.store$clust_num == nclust
                                       ,]$antigen))
          for (dimension in dimension_list) {
            cat(paste("#####", nclust, "-", dimension))
            cat("\n\n")
            if (visith == "both") {
              ## both visit covariate plot
            } else {
              ## create Forest Plot
              # filter indata on these variables
              features = "all"
              antigens = "all"
              covariates = covarsel
              # if dimension reduction, features are clusters so no further clustering
              clusters = NULL
              cluster_mapping = NULL
              # if individual features, clusters may be included with mapping dataframe
              # clusters = "all"
              # cluster_mapping <- selected_set[ , c("feature","cluster")]
              # dplyr::arrange forest plot table on these variable(s)
              ordering = c("Cluster_Type","Feature") # options: Feature, Group 1, Group 2, Fixed Factor, Transformation, Test, Estimate, P-Value, Significance, Antigen, Cluster
              # required only if clusters != "all", maps cluster to their features
              # cluster_mapping = list(
              #   `1` = c('PT_TotIgG', 'FHA_FcAR', 'FHA_FcGR2B'),
              #   `2` = c('FHA_IgM', 'PRN_IgM'),
              #   `3` = c('FHA_FcGR2A', 'TT_FcAR', 'PRN_FcGR3B', 'ALB_IgG4', 'FHA_IgG3'),
              #   `4` = c('TT_IgM', 'ALB_IgM', 'FIM2_FcGR2A', 'TT_FcGR2A'),
              #   `5` = c('FIM2_IgG3', 'PT_FcAR', 'FIM2_FcGR3B'),
              #   `6` = c('PT_FcGR3B', 'FHA_FcGR3B', 'DT_IgG3'),
              #   `7` = c('ALB_IgA1', 'FHA_ADCP', 'DT_IgG1', 'PRN_IgG1')
              # )
              
              
              selected_set <- as.data.frame(cstackstorec[cstackstorec$stand == standtype 
               & cstackstorec$clust_typ == igginclude
               & cstackstorec$clust_num == nclust
               & cstackstorec$by_group == visith
               , ])
                clusters_wide <- pivot_wider(selected_set[ , c("Cluster_Name","feature")], 
                                             names_from = "Cluster_Name", 
                                             values_from = "feature", 
                                             values_fn = list)
                clusters_long <- as.data.frame(pivot_longer(clusters_wide, 
                                                            cols = everything(), 
                                                            values_to = "contents"
                                                            )
                                               )
                cluster_mapping <- as.list(clusters_long)
              
              forestdata <- stat.test.store[stat.test.store$aggtype %in% c("Dimension Reduction")
                                       & stat.test.store$antigen %in% dimension
                                       & stat.test.store$covarname == covarsel
                                       & stat.test.store$groupbyvar == visith 
                                       & stat.test.store$param == "parametric" 
                                       & stat.test.store$stand == standtype
                                       & stat.test.store$clust_typ == igginclude
                                       & stat.test.store$clust_num == nclust
                                      , ]
              forestdata$estimate = -1 * forestdata$estimate
              forestdata$conf.low = -1 * forestdata$conf.low
              forestdata$conf.high = -1 * forestdata$conf.high
              forestdata$Cluster_Type <- ifelse(forestdata$feature %in% c("PT","PRN","FHA","FIM-2","DT","TT"), "Antigen Specific","Unsupervised")
              if (nrow(forestdata)> 8) {
                ## FDR adjust pvalues - needs to be done here to get the correct number of comparisions
                forestdata$p.adj_arch <- p.adjust(forestdata$p, method = "fdr")
                forestdata <- forestdata %>% add_significance(p.col = "p.adj_arch")
                forestdata$p.adj <- paste(scales::pvalue(forestdata$p.adj_arch,
                                                         accuracy = 0.001, 
                                                         decimal.mark = ".", 
                                                         add_p = TRUE
                                                         ), forestdata$p.adj.signif
                                          )
                captiontxt=unique(forestdata$testname)

                covar_type <- ifelse(unique(forestdata$covarname) %in% covar_cat_list, "Categorical", "Continuous")
                effect_label <- ifelse(covar_type == "Categorical", "Effect Size", "Regression Slope")
                  
                # fp = forest_plot(indata = as.data.frame(forestdata), 
                #                  features = features, 
                #                  antigens = antigens, 
                #                  covariates = covariates, 
                #                  clusters = clusters, 
                #                  cluster_mapping = , 
                #                  ordering = ordering)
                
                if(covar_type == "Categorical") {
                   fp = forest_plot_dimreduc(indata = as.data.frame(forestdata[forestdata$Cluster_Type=="Antigen Specific", ]), 
                   features = features, 
                   covariates = covariates, 
                   clusters = clusters, 
                   cluster_mapping = NULL, 
                   ordering = ordering,
                   hidecols = c("Fixed Factor", "Transformation", "conf.low", "conf.high", "Cluster", "Test", "Significance"),
                   color_vector = dimrec.color.mapping,
                   conf_int_palette = c("darkgreen", "darkblue", color.forest.fill, "black")
                    )
                   fq = forest_plot_dimreduc(indata = as.data.frame(forestdata[forestdata$Cluster_Type=="Unsupervised", ]), 
                   features = features, 
                   covariates = covariates, 
                   clusters = clusters, 
                   cluster_mapping = NULL, 
                   ordering = ordering,
                   hidecols = c("Fixed Factor", "Transformation", "conf.low", "conf.high", "Cluster", "Test", "Significance"),
                   color_vector = dimrec.color.mapping,
                   conf_int_palette = c("darkgreen", "darkblue", color.forest.fill, "black")
                    )
                } else {
                   fp = forest_plot_dimreduc(indata = as.data.frame(forestdata), 
                   features = features, 
                   covariates = covariates, 
                   clusters = clusters, 
                   cluster_mapping = NULL, 
                   ordering = ordering,
                   hidecols = c("Fixed Factor", "Transformation", "conf.low", "conf.high", "Cluster", "Test", "Significance", "Contrast"),
                   color_vector = dimrec.color.mapping,
                   conf_int_palette = c("darkgreen", "darkblue", color.forest.fill, "black")
                    )
                }

              
              ## create Volcano Plot
              volcanodata <- forestdata
           
              h=-log10(0.05)
              volcanodata$Neglog10PV<- -log10(volcanodata$p.adj_arch)
              if(covar_type == "Categorical") {
                group1_label<-unique(volcanodata$group1)
                group2_label<-unique(volcanodata$group2)
                titletxt=paste(unique(volcanodata$group2),"Vs.", unique(volcanodata$group1), "(referent)")
                effecttxt_low <- paste(" Higher in", group1_label)
                effecttxt_high <- paste(" Higher in", group2_label)
              } else {
                titletxt=paste(unique(volcanodata$covarname), "(continuous)")
                effecttxt_low <- paste("Decreasing with", unique(volcanodata$covarname))
                effecttxt_high <- paste("Increasing with", unique(volcanodata$covarname))
              }
              
              ymax=max(volcanodata$Neglog10PV)*0.90
              ylabel='Neglog[10](Pvalue)'
              xlabel= effect_label

              volcano_plota<-ggplot(data=volcanodata[volcanodata$Cluster_Type=="Antigen Specific", ], aes(x=estimate, 
                                        y=Neglog10PV, 
                                        color=feature,
                                        shape=Cluster_Type,
                                        label=feature
                                        ) )+ 
                geom_text_repel(size = 3, max.overlaps = 50,segment.colour = NA) +
                geom_point(size = 3)+
                scale_shape_manual(values = c(15,16))+ 
                scale_color_manual(values=dimrec.color.mapping)+
                geom_hline(yintercept=h,linetype="dashed")+
                geom_vline(xintercept=0,linetype="dashed")+
                theme_classic()+
                theme(legend.title = element_text(size = 8), 
                      legend.text = element_text(size = 8),
                      legend.position = 'bottom', legend.box="vertical")+
                geom_text(aes(-Inf,ymax,label = effecttxt_low, hjust = 0),show.legend = FALSE)+
                geom_text(aes( Inf,ymax,label = effecttxt_high, hjust = 1),show.legend = FALSE)+
                labs(y = ylabel, x = xlabel, title = titletxt, caption = captiontxt)
              
                volcano_plotb<-ggplot(data=volcanodata[volcanodata$Cluster_Type=="Unsupervised", ], aes(x=estimate, 
                                        y=Neglog10PV, 
                                        color=feature,
                                        shape=Cluster_Type,
                                        label=feature
                                        ) )+ 
                geom_text_repel(size = 3, max.overlaps = 50,segment.colour = NA) +
                geom_point(size = 3)+
                scale_shape_manual(values = c(15,16))+ 
                scale_color_manual(values=dimrec.color.mapping)+
                geom_hline(yintercept=h,linetype="dashed")+
                geom_vline(xintercept=0,linetype="dashed")+
                theme_classic()+
                theme(legend.title = element_text(size = 8), 
                      legend.text = element_text(size = 8),
                      legend.position = 'bottom')+
                geom_text(aes(-Inf,ymax,label = effecttxt_low, hjust = 0),show.legend = FALSE)+
                geom_text(aes( Inf,ymax,label = effecttxt_high, hjust = 1),show.legend = FALSE)+
                labs(y = ylabel, x = xlabel, title = titletxt, caption = captiontxt)

                # cat(paste("Volcano"))
                cat("\n\n")
                plot(volcano_plota)   
                cat("\n\n")
                cat("\n\n")
                
                cat("\n\n")
                plot(volcano_plotb)   
                cat("\n\n")
                cat("\n\n")
                
                cat(knitr::knit_print(gt(data = clusters_long[ , c("name","contents")]) |>
  tab_header(
    title = md("Unsupervised Cluster Contents")
  )))
                cat("\n\n")  
                cat("\n\n")
                
                # cat(paste("Forest"))
                cat("\n\n")
                cat(knitr::knit_print(fp))
                cat("\n\n")
                cat("\n\n")
                
                cat("\n\n")
                cat(knitr::knit_print(fq))
                cat("\n\n")
                cat("\n\n")
                
                # gt:::as.tags.gt_tbl(fp)
                # knitr::knit_print(fp)
                
              } # end check nrows
            } # end if visith == both
          } # end dimension
        } # end nclust
      } # end igginclude
    } # end standtype
  } # end visith
} # end covariates loop

arm_name

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.621.01 p=0.659 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-1.180.73 p=0.659 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-1.460.50 p=0.582 ns
Antigen Specific PT mTdap- mTdap+ 0.00-1.470.57 p=0.582 ns
Antigen Specific TT mTdap- mTdap+ 0.000.592.50 p=0.013 **

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.231.64 p=0.353 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-1.620.23 p=0.353 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-1.72-0.60 p=0.001 ***
Unsupervised RClust4 mTdap- mTdap+ 0.00-1.200.57 p=0.646 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-2.75-0.40 p=0.041 *
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.360.57 p=0.659 ns
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.241.13 p=0.415 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-1.32-0.31 p=0.009 **
Antigen Specific FHA mTdap- mTdap+ 0.000.831.70 p<0.001 ****
Antigen Specific PRN mTdap- mTdap+ 0.00-0.720.16 p=0.439 ns
Antigen Specific PT mTdap- mTdap+ 0.00-1.13-0.24 p=0.011 **
Antigen Specific TT mTdap- mTdap+ 0.00-0.380.60 p=0.740 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.840.32 p=0.545 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-1.13-0.63 p<0.001 ****
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.630.41 p=0.740 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.360.37 p=0.974 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.290.72 p=0.545 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.170.57 p=0.503 ns
Unsupervised RClust7 mTdap- mTdap+ 0.000.090.88 p=0.042 *
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.621.01 p=0.659 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-1.180.73 p=0.659 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-1.460.50 p=0.610 ns
Antigen Specific PT mTdap- mTdap+ 0.00-1.470.57 p=0.610 ns
Antigen Specific TT mTdap- mTdap+ 0.000.592.50 p=0.012 **

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.000.233.06 p=0.092 *
Unsupervised RClust2 mTdap- mTdap+ 0.00-1.620.23 p=0.405 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-1.72-0.60 p=0.001 ***
Unsupervised RClust4 mTdap- mTdap+ 0.00-1.200.57 p=0.659 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.360.57 p=0.659 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.241.13 p=0.456 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.000.311.32 p=0.008 **
Antigen Specific FHA mTdap- mTdap+ 0.000.831.70 p<0.001 ****
Antigen Specific PRN mTdap- mTdap+ 0.00-0.720.16 p=0.402 ns
Antigen Specific PT mTdap- mTdap+ 0.000.241.13 p=0.010 **
Antigen Specific TT mTdap- mTdap+ 0.00-0.600.38 p=0.829 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.750.60 p=0.903 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-1.13-0.63 p<0.001 ****
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.630.41 p=0.829 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.360.37 p=0.974 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.170.57 p=0.461 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.090.88 p=0.039 *

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-2.03-0.75 p<0.001 ****
Antigen Specific FHA mTdap- mTdap+ 0.00-2.16-0.63 p=0.001 ***
Antigen Specific PRN mTdap- mTdap+ 0.00-2.27-0.99 p<0.001 ****
Antigen Specific PT mTdap- mTdap+ 0.000.802.49 p<0.001 ***
Antigen Specific TT mTdap- mTdap+ 0.000.872.40 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-4.85-1.91 p<0.001 ****
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.570.36 p=0.659 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.381.08 p=0.432 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.700.32 p=0.514 ns
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.95-0.04 p=0.051 *
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.300.76 p=0.582 ns
Antigen Specific FHA mTdap- mTdap+ 0.000.311.30 p=0.020 **
Antigen Specific PRN mTdap- mTdap+ 0.00-0.050.96 p=0.298 ns
Antigen Specific PT mTdap- mTdap+ 0.00-0.400.55 p=0.794 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.440.58 p=0.794 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.410.89 p=0.582 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.570.17 p=0.582 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.840.06 p=0.298 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.470.17 p=0.582 ns
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.220.53 p=0.582 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-2.03-0.75 p<0.001 ****
Antigen Specific FHA mTdap- mTdap+ 0.00-2.16-0.63 p=0.001 ***
Antigen Specific PRN mTdap- mTdap+ 0.00-2.27-0.99 p<0.001 ****
Antigen Specific PT mTdap- mTdap+ 0.000.802.49 p<0.001 ***
Antigen Specific TT mTdap- mTdap+ 0.000.872.40 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-4.85-1.91 p<0.001 ****
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.320.72 p=0.508 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.570.36 p=0.659 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.381.08 p=0.432 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.95-0.04 p=0.051 *
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.300.76 p=0.665 ns
Antigen Specific FHA mTdap- mTdap+ 0.000.311.30 p=0.020 **
Antigen Specific PRN mTdap- mTdap+ 0.00-0.050.96 p=0.298 ns
Antigen Specific PT mTdap- mTdap+ 0.00-0.400.55 p=0.812 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.440.58 p=0.812 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.410.89 p=0.665 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.370.47 p=0.812 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.570.17 p=0.665 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.840.06 p=0.298 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.220.53 p=0.665 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-2.02-0.73 p<0.001 ****
Antigen Specific FHA mTdap- mTdap+ 0.000.632.16 p<0.001 ***
Antigen Specific PRN mTdap- mTdap+ 0.000.992.27 p<0.001 ****
Antigen Specific PT mTdap- mTdap+ 0.00-2.49-0.80 p<0.001 ***
Antigen Specific TT mTdap- mTdap+ 0.00-2.40-0.88 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-4.85-1.91 p<0.001 ****
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.320.72 p=0.503 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.360.57 p=0.659 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-1.38-0.06 p=0.048 *
Unsupervised RClust5 mTdap- mTdap+ 0.00-1.080.38 p=0.422 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.531.39 p<0.001 ****
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.770.29 p=0.698 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-1.30-0.31 p=0.023 **
Antigen Specific PRN mTdap- mTdap+ 0.00-0.070.94 p=0.338 ns
Antigen Specific PT mTdap- mTdap+ 0.00-0.420.53 p=0.898 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.590.43 p=0.898 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.890.41 p=0.732 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.470.37 p=0.898 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.570.17 p=0.645 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.190.65 p=0.645 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.840.06 p=0.338 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.450.39 p=0.901 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-2.02-0.73 p<0.001 ****
Antigen Specific FHA mTdap- mTdap+ 0.000.632.16 p<0.001 ***
Antigen Specific PRN mTdap- mTdap+ 0.000.992.27 p<0.001 ****
Antigen Specific PT mTdap- mTdap+ 0.00-2.49-0.80 p<0.001 ***
Antigen Specific TT mTdap- mTdap+ 0.00-2.40-0.88 p<0.001 ****

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-4.85-1.91 p<0.001 ****
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.320.72 p=0.503 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.360.57 p=0.659 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-1.38-0.06 p=0.048 *
Unsupervised RClust5 mTdap- mTdap+ 0.00-1.080.38 p=0.422 ns
Unsupervised RClust7 mTdap- mTdap+ 0.000.491.35 p<0.001 ****
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.770.29 p=0.598 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-1.30-0.31 p=0.023 **
Antigen Specific PRN mTdap- mTdap+ 0.00-0.070.94 p=0.338 ns
Antigen Specific PT mTdap- mTdap+ 0.00-0.420.53 p=0.817 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.590.43 p=0.817 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.890.41 p=0.640 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.470.37 p=0.817 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.570.17 p=0.538 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.190.65 p=0.538 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.840.06 p=0.338 ns
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.090.64 p=0.398 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.331.17 p=0.464 ns
Antigen Specific FHA mTdap- mTdap+ 0.000.162.03 p=0.290 *
Antigen Specific PRN mTdap- mTdap+ 0.00-0.721.20 p=0.654 ns
Antigen Specific PT mTdap- mTdap+ 0.00-1.540.18 p=0.375 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.860.54 p=0.654 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.381.33 p=0.464 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.970.29 p=0.464 ns
Unsupervised RClust3 mTdap- mTdap+ 0.000.021.73 p=0.296 *
Unsupervised RClust4 mTdap- mTdap+ 0.00-1.280.47 p=0.493 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-1.510.11 p=0.375 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.980.47 p=0.600 ns
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.371.17 p=0.464 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.470.59 p=0.910 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-0.470.46 p=0.989 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-0.690.27 p=0.593 ns
Antigen Specific PT mTdap- mTdap+ 0.000.161.15 p=0.134 *
Antigen Specific TT mTdap- mTdap+ 0.00-0.360.71 p=0.692 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.540.38 p=0.885 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.900.08 p=0.514 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.700.15 p=0.514 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.260.66 p=0.593 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.580.22 p=0.593 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.140.85 p=0.514 ns
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.180.82 p=0.514 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.331.17 p=0.468 ns
Antigen Specific FHA mTdap- mTdap+ 0.000.162.03 p=0.266 *
Antigen Specific PRN mTdap- mTdap+ 0.00-0.721.20 p=0.654 ns
Antigen Specific PT mTdap- mTdap+ 0.00-1.540.18 p=0.344 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.860.54 p=0.654 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.381.33 p=0.468 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.970.29 p=0.468 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.021.99 p=0.318 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-1.280.47 p=0.508 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-1.510.11 p=0.344 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.980.47 p=0.611 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.470.59 p=0.917 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-0.470.46 p=0.989 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-0.690.27 p=0.724 ns
Antigen Specific PT mTdap- mTdap+ 0.000.161.15 p=0.123 *
Antigen Specific TT mTdap- mTdap+ 0.00-0.360.71 p=0.816 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.540.38 p=0.901 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.900.08 p=0.567 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.800.47 p=0.840 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.260.66 p=0.724 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.580.22 p=0.724 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.140.85 p=0.592 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.700.43 p=0.903 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-0.311.17 p=0.903 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-0.700.63 p=0.919 ns
Antigen Specific PT mTdap- mTdap+ 0.00-0.580.74 p=0.903 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.640.51 p=0.903 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-1.340.54 p=0.903 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.540.77 p=0.903 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.471.31 p=0.903 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-1.250.27 p=0.903 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.450.59 p=0.903 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.830.50 p=0.903 ns
Unsupervised RClust7 mTdap- mTdap+ 0.00-1.050.39 p=0.903 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.600.51 p=0.973 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-0.170.87 p=0.397 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-0.550.53 p=0.973 ns
Antigen Specific PT mTdap- mTdap+ 0.00-1.11-0.08 p=0.314 *
Antigen Specific TT mTdap- mTdap+ 0.00-0.180.88 p=0.397 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.397 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.240.65 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.840.30 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.710.05 p=0.388 ns
Unsupervised RClust5 mTdap- mTdap+ 0.000.000.62 p=0.317 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.370.41 p=0.973 ns
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.170.74 p=0.397 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.700.43 p=0.911 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-0.311.17 p=0.911 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-0.700.63 p=0.919 ns
Antigen Specific PT mTdap- mTdap+ 0.00-0.580.74 p=0.911 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.640.51 p=0.911 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-1.340.54 p=0.911 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.540.77 p=0.911 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.471.31 p=0.911 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-1.250.27 p=0.911 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-1.030.52 p=0.911 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.830.50 p=0.911 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.600.51 p=0.973 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-0.170.87 p=0.425 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-0.550.53 p=0.973 ns
Antigen Specific PT mTdap- mTdap+ 0.00-1.11-0.08 p=0.144 *
Antigen Specific TT mTdap- mTdap+ 0.00-0.180.88 p=0.425 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.425 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.240.65 p=0.513 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.840.30 p=0.513 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.710.05 p=0.356 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-1.03-0.09 p=0.144 *
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.370.41 p=0.973 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.330.83 p=0.851 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-0.321.16 p=0.851 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-0.700.63 p=0.923 ns
Antigen Specific PT mTdap- mTdap+ 0.00-0.760.56 p=0.851 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.740.43 p=0.851 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.411.52 p=0.851 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.770.54 p=0.851 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.471.31 p=0.851 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.331.23 p=0.851 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-1.030.52 p=0.851 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.500.83 p=0.851 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.610.50 p=0.978 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-0.930.13 p=0.385 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-0.550.54 p=0.978 ns
Antigen Specific PT mTdap- mTdap+ 0.00-1.04-0.01 p=0.280 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.280.82 p=0.586 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.521.01 p=0.723 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.586 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.586 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.296 ns
Unsupervised RClust5 mTdap- mTdap+ 0.000.091.03 p=0.251 *
Unsupervised RClust6 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.330.83 p=0.807 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-0.321.16 p=0.807 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-0.700.63 p=0.923 ns
Antigen Specific PT mTdap- mTdap+ 0.00-0.760.56 p=0.844 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.740.43 p=0.837 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.541.34 p=0.807 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.770.54 p=0.844 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.471.31 p=0.807 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.331.23 p=0.807 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.271.25 p=0.807 ns
Unsupervised RClust6 mTdap- mTdap+ 0.00-1.030.52 p=0.837 ns
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.500.83 p=0.837 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT mTdap- mTdap+ 0.00-0.610.50 p=0.978 ns
Antigen Specific FHA mTdap- mTdap+ 0.00-0.130.93 p=0.336 ns
Antigen Specific PRN mTdap- mTdap+ 0.00-0.550.54 p=0.978 ns
Antigen Specific PT mTdap- mTdap+ 0.00-1.04-0.01 p=0.291 ns
Antigen Specific TT mTdap- mTdap+ 0.00-0.280.82 p=0.497 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns

birth_weight

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.664 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.893 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.664 ns
Antigen Specific PT continuous 0.000.000.00 p=0.893 ns
Antigen Specific TT continuous 0.000.000.00 p=0.664 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.981 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.893 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.981 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.664 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.664 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.664 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.665 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.931 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.931 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.931 ns
Antigen Specific PT continuous 0.000.000.00 p=0.931 ns
Antigen Specific TT continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.931 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.709 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.819 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.623 ns
Antigen Specific PT continuous 0.000.000.00 p=0.819 ns
Antigen Specific TT continuous 0.000.000.00 p=0.623 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.709 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.819 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.623 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.623 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.709 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.931 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.931 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.931 ns
Antigen Specific PT continuous 0.000.000.00 p=0.931 ns
Antigen Specific TT continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.650 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.881 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.931 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.931 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.750 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.747 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.750 ns
Antigen Specific PT continuous 0.000.000.00 p=0.747 ns
Antigen Specific TT continuous 0.000.000.00 p=0.747 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.747 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.747 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.747 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.747 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.747 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.864 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.864 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.288 ns
Antigen Specific PT continuous 0.000.000.00 p=0.864 ns
Antigen Specific TT continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.454 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.288 *
Unsupervised RClust7 continuous 0.000.000.00 p=0.864 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.750 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.750 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.750 ns
Antigen Specific PT continuous 0.000.000.00 p=0.750 ns
Antigen Specific TT continuous 0.000.000.00 p=0.750 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.750 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.750 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.750 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.750 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.750 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.864 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.864 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.575 ns
Antigen Specific PT continuous 0.000.000.00 p=0.864 ns
Antigen Specific TT continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.681 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.864 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.766 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.766 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.766 ns
Antigen Specific PT continuous 0.000.000.00 p=0.766 ns
Antigen Specific TT continuous 0.000.000.00 p=0.766 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.766 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.766 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.577 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.577 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.766 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.764 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.864 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.864 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.749 ns
Antigen Specific PT continuous 0.000.000.00 p=0.864 ns
Antigen Specific TT continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.749 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.864 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.766 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.766 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.766 ns
Antigen Specific PT continuous 0.000.000.00 p=0.766 ns
Antigen Specific TT continuous 0.000.000.00 p=0.766 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.766 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.766 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.577 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.577 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.766 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.766 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.864 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.864 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.749 ns
Antigen Specific PT continuous 0.000.000.00 p=0.864 ns
Antigen Specific TT continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.864 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.749 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.864 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.636 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.835 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.636 ns
Antigen Specific PT continuous 0.000.000.00 p=0.636 ns
Antigen Specific TT continuous 0.000.000.00 p=0.720 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.720 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.678 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.835 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.636 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.676 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.720 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.636 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.486 *
Antigen Specific FHA continuous 0.000.000.00 p=0.997 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.997 ns
Antigen Specific PT continuous 0.000.000.00 p=0.730 ns
Antigen Specific TT continuous 0.000.000.00 p=0.997 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.997 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.997 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.997 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.897 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.997 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.730 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.757 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.660 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.835 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.660 ns
Antigen Specific PT continuous 0.000.000.00 p=0.660 ns
Antigen Specific TT continuous 0.000.000.00 p=0.660 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.660 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.660 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.660 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.660 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.660 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.660 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.446 *
Antigen Specific FHA continuous 0.000.000.00 p=0.997 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.997 ns
Antigen Specific PT continuous 0.000.000.00 p=0.502 ns
Antigen Specific TT continuous 0.000.000.00 p=0.997 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.997 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.997 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.502 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.822 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.997 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.502 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.569 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.583 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.569 ns
Antigen Specific PT continuous 0.000.000.00 p=0.912 ns
Antigen Specific TT continuous 0.000.000.00 p=0.912 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.912 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.569 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.767 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.912 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.569 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.569 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.912 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.908 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.908 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.908 ns
Antigen Specific PT continuous 0.000.000.00 p=0.908 ns
Antigen Specific TT continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.908 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.641 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.641 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.641 ns
Antigen Specific PT continuous 0.000.000.00 p=0.912 ns
Antigen Specific TT continuous 0.000.000.00 p=0.912 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.912 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.641 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.704 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.912 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.704 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.641 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.845 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.908 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.908 ns
Antigen Specific PT continuous 0.000.000.00 p=0.845 ns
Antigen Specific TT continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.716 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.908 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.594 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.594 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.594 ns
Antigen Specific PT continuous 0.000.000.00 p=0.861 ns
Antigen Specific TT continuous 0.000.000.00 p=0.861 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.861 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.594 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.616 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.594 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.616 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.594 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.974 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.974 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.974 ns
Antigen Specific PT continuous 0.000.000.00 p=0.846 ns
Antigen Specific TT continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.716 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.974 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.648 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.648 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.648 ns
Antigen Specific PT continuous 0.000.000.00 p=0.908 ns
Antigen Specific TT continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.912 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.648 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.672 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.648 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.908 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.672 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.648 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.00 p=0.974 ns
Antigen Specific FHA continuous 0.000.000.00 p=0.974 ns
Antigen Specific PRN continuous 0.000.000.00 p=0.974 ns
Antigen Specific PT continuous 0.000.000.00 p=0.923 ns
Antigen Specific TT continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust1 continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust2 continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust3 continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust4 continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust5 continuous 0.000.000.00 p=0.974 ns
Unsupervised RClust6 continuous 0.000.000.00 p=0.781 ns
Unsupervised RClust7 continuous 0.000.000.00 p=0.974 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 mTdap- mTdap+ 0.00-0.770.18 p=0.463 ns
Unsupervised RClust2 mTdap- mTdap+ 0.00-0.650.24 p=0.497 ns
Unsupervised RClust3 mTdap- mTdap+ 0.00-0.300.84 p=0.497 ns
Unsupervised RClust4 mTdap- mTdap+ 0.00-0.030.64 p=0.291 ns
Unsupervised RClust5 mTdap- mTdap+ 0.00-0.710.05 p=0.291 ns
Unsupervised RClust6 mTdap- mTdap+ 0.000.091.03 p=0.274 *
Unsupervised RClust7 mTdap- mTdap+ 0.00-0.370.41 p=0.978 ns

infant_sex

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.220.41 p=0.741 ns
Antigen Specific FHA Male Female 0.00-1.000.92 p=0.940 ns
Antigen Specific PRN Male Female 0.00-0.581.39 p=0.741 ns
Antigen Specific PT Male Female 0.00-1.370.68 p=0.741 ns
Antigen Specific TT Male Female 0.00-1.230.80 p=0.741 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.751.15 p=0.741 ns
Unsupervised RClust2 Male Female 0.00-1.180.70 p=0.741 ns
Unsupervised RClust3 Male Female 0.00-1.000.21 p=0.741 ns
Unsupervised RClust4 Male Female 0.00-0.431.33 p=0.741 ns
Unsupervised RClust5 Male Female 0.00-0.771.67 p=0.741 ns
Unsupervised RClust6 Male Female 0.00-0.560.36 p=0.741 ns
Unsupervised RClust7 Male Female 0.00-0.950.43 p=0.741 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.720.34 p=0.917 ns
Antigen Specific FHA Male Female 0.00-0.380.65 p=0.917 ns
Antigen Specific PRN Male Female 0.00-0.490.40 p=0.934 ns
Antigen Specific PT Male Female 0.00-0.600.35 p=0.917 ns
Antigen Specific TT Male Female 0.00-0.550.44 p=0.934 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.060.10 p=0.424 ns
Unsupervised RClust2 Male Female 0.00-0.590.02 p=0.424 ns
Unsupervised RClust3 Male Female 0.00-0.180.86 p=0.493 ns
Unsupervised RClust4 Male Female 0.00-0.320.42 p=0.934 ns
Unsupervised RClust5 Male Female 0.00-0.520.49 p=0.959 ns
Unsupervised RClust6 Male Female 0.000.010.74 p=0.424 *
Unsupervised RClust7 Male Female 0.00-0.110.69 p=0.489 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.220.41 p=0.746 ns
Antigen Specific FHA Male Female 0.00-1.000.92 p=0.940 ns
Antigen Specific PRN Male Female 0.00-0.581.39 p=0.746 ns
Antigen Specific PT Male Female 0.00-1.370.68 p=0.746 ns
Antigen Specific TT Male Female 0.00-1.230.80 p=0.746 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.771.15 p=0.746 ns
Unsupervised RClust2 Male Female 0.00-1.180.70 p=0.746 ns
Unsupervised RClust3 Male Female 0.00-1.000.21 p=0.746 ns
Unsupervised RClust4 Male Female 0.00-0.431.33 p=0.746 ns
Unsupervised RClust5 Male Female 0.00-0.560.36 p=0.746 ns
Unsupervised RClust6 Male Female 0.00-0.950.43 p=0.746 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.340.72 p=0.841 ns
Antigen Specific FHA Male Female 0.00-0.380.65 p=0.841 ns
Antigen Specific PRN Male Female 0.00-0.490.40 p=0.856 ns
Antigen Specific PT Male Female 0.00-0.350.60 p=0.841 ns
Antigen Specific TT Male Female 0.00-0.440.55 p=0.856 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.000.071.38 p=0.269 *
Unsupervised RClust2 Male Female 0.00-0.590.02 p=0.271 ns
Unsupervised RClust3 Male Female 0.00-0.180.86 p=0.452 ns
Unsupervised RClust4 Male Female 0.00-0.320.42 p=0.856 ns
Unsupervised RClust5 Male Female 0.000.010.74 p=0.269 *
Unsupervised RClust6 Male Female 0.00-0.110.69 p=0.448 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.200.20 p=0.711 ns
Antigen Specific FHA Male Female 0.00-1.230.41 p=0.711 ns
Antigen Specific PRN Male Female 0.00-0.940.52 p=0.711 ns
Antigen Specific PT Male Female 0.00-0.651.18 p=0.711 ns
Antigen Specific TT Male Female 0.00-0.031.62 p=0.613 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-2.510.74 p=0.711 ns
Unsupervised RClust3 Male Female 0.00-0.360.56 p=0.711 ns
Unsupervised RClust4 Male Female 0.00-0.910.56 p=0.711 ns
Unsupervised RClust5 Male Female 0.00-0.600.41 p=0.711 ns
Unsupervised RClust7 Male Female 0.00-0.670.26 p=0.711 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.640.43 p=0.872 ns
Antigen Specific FHA Male Female 0.00-0.600.45 p=0.879 ns
Antigen Specific PRN Male Female 0.00-0.260.76 p=0.872 ns
Antigen Specific PT Male Female 0.00-0.570.37 p=0.872 ns
Antigen Specific TT Male Female 0.00-0.340.68 p=0.872 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.37-0.10 p=0.245 *
Unsupervised RClust3 Male Female 0.00-0.74-0.01 p=0.245 *
Unsupervised RClust4 Male Female 0.00-0.450.46 p=0.988 ns
Unsupervised RClust5 Male Female 0.00-0.190.46 p=0.872 ns
Unsupervised RClust7 Male Female 0.00-0.470.28 p=0.872 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.200.20 p=0.677 ns
Antigen Specific FHA Male Female 0.00-1.230.41 p=0.677 ns
Antigen Specific PRN Male Female 0.00-0.940.52 p=0.677 ns
Antigen Specific PT Male Female 0.00-0.651.18 p=0.677 ns
Antigen Specific TT Male Female 0.00-0.031.62 p=0.613 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-2.510.74 p=0.677 ns
Unsupervised RClust2 Male Female 0.00-0.350.69 p=0.677 ns
Unsupervised RClust3 Male Female 0.00-0.360.56 p=0.677 ns
Unsupervised RClust4 Male Female 0.00-0.910.56 p=0.677 ns
Unsupervised RClust6 Male Female 0.00-0.670.26 p=0.677 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.640.43 p=0.872 ns
Antigen Specific FHA Male Female 0.00-0.600.45 p=0.879 ns
Antigen Specific PRN Male Female 0.00-0.260.76 p=0.872 ns
Antigen Specific PT Male Female 0.00-0.570.37 p=0.872 ns
Antigen Specific TT Male Female 0.00-0.340.68 p=0.872 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.37-0.10 p=0.245 *
Unsupervised RClust2 Male Female 0.00-0.590.25 p=0.872 ns
Unsupervised RClust3 Male Female 0.00-0.74-0.01 p=0.245 *
Unsupervised RClust4 Male Female 0.00-0.450.46 p=0.988 ns
Unsupervised RClust6 Male Female 0.00-0.470.28 p=0.872 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.190.21 p=0.644 ns
Antigen Specific FHA Male Female 0.00-0.411.23 p=0.677 ns
Antigen Specific PRN Male Female 0.00-0.510.94 p=0.677 ns
Antigen Specific PT Male Female 0.00-1.180.65 p=0.677 ns
Antigen Specific TT Male Female 0.00-1.610.03 p=0.351 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-2.510.74 p=0.677 ns
Unsupervised RClust2 Male Female 0.00-0.350.69 p=0.677 ns
Unsupervised RClust3 Male Female 0.00-0.560.36 p=0.677 ns
Unsupervised RClust4 Male Female 0.00-1.38-0.06 p=0.351 *
Unsupervised RClust5 Male Female 0.00-0.560.91 p=0.677 ns
Unsupervised RClust6 Male Female 0.00-0.290.65 p=0.677 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.430.64 p=0.861 ns
Antigen Specific FHA Male Female 0.00-0.450.60 p=0.866 ns
Antigen Specific PRN Male Female 0.00-0.270.74 p=0.861 ns
Antigen Specific PT Male Female 0.00-0.580.37 p=0.861 ns
Antigen Specific TT Male Female 0.00-0.660.37 p=0.861 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.000.101.37 p=0.269 *
Unsupervised RClust2 Male Female 0.00-0.250.59 p=0.861 ns
Unsupervised RClust3 Male Female 0.00-0.74-0.01 p=0.269 *
Unsupervised RClust4 Male Female 0.00-0.300.55 p=0.861 ns
Unsupervised RClust5 Male Female 0.00-0.450.46 p=0.988 ns
Unsupervised RClust6 Male Female 0.00-0.190.64 p=0.861 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-1.190.21 p=0.598 ns
Antigen Specific FHA Male Female 0.00-0.411.23 p=0.598 ns
Antigen Specific PRN Male Female 0.00-0.510.94 p=0.677 ns
Antigen Specific PT Male Female 0.00-1.180.65 p=0.677 ns
Antigen Specific TT Male Female 0.00-1.610.03 p=0.351 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-2.510.74 p=0.598 ns
Unsupervised RClust2 Male Female 0.00-0.350.69 p=0.677 ns
Unsupervised RClust3 Male Female 0.00-0.560.36 p=0.677 ns
Unsupervised RClust4 Male Female 0.00-1.38-0.06 p=0.351 *
Unsupervised RClust5 Male Female 0.00-0.560.91 p=0.677 ns
Unsupervised RClust7 Male Female 0.00-0.230.71 p=0.598 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.430.64 p=0.861 ns
Antigen Specific FHA Male Female 0.00-0.450.60 p=0.866 ns
Antigen Specific PRN Male Female 0.00-0.270.74 p=0.861 ns
Antigen Specific PT Male Female 0.00-0.580.37 p=0.861 ns
Antigen Specific TT Male Female 0.00-0.660.37 p=0.861 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.000.101.37 p=0.269 *
Unsupervised RClust2 Male Female 0.00-0.250.59 p=0.861 ns
Unsupervised RClust3 Male Female 0.00-0.74-0.01 p=0.269 *
Unsupervised RClust4 Male Female 0.00-0.300.55 p=0.861 ns
Unsupervised RClust5 Male Female 0.00-0.450.46 p=0.988 ns
Unsupervised RClust7 Male Female 0.00-0.240.50 p=0.861 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.000.051.53 p=0.183 *
Antigen Specific FHA Male Female 0.00-0.581.34 p=0.811 ns
Antigen Specific PRN Male Female 0.00-1.690.20 p=0.381 ns
Antigen Specific PT Male Female 0.00-0.860.89 p=0.967 ns
Antigen Specific TT Male Female 0.00-0.450.96 p=0.811 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.000.72 p=0.812 ns
Unsupervised RClust2 Male Female 0.00-0.530.74 p=0.812 ns
Unsupervised RClust3 Male Female 0.00-0.601.15 p=0.811 ns
Unsupervised RClust4 Male Female 0.00-0.251.49 p=0.398 ns
Unsupervised RClust5 Male Female 0.00-0.641.02 p=0.812 ns
Unsupervised RClust6 Male Female 0.00-1.63-0.23 p=0.134 *
Unsupervised RClust7 Male Female 0.000.031.55 p=0.183 *
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.610.45 p=0.952 ns
Antigen Specific FHA Male Female 0.00-0.93-0.02 p=0.526 *
Antigen Specific PRN Male Female 0.00-0.480.48 p=0.997 ns
Antigen Specific PT Male Female 0.00-0.890.13 p=0.601 ns
Antigen Specific TT Male Female 0.00-0.820.25 p=0.895 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.610.32 p=0.952 ns
Unsupervised RClust2 Male Female 0.00-0.440.56 p=0.952 ns
Unsupervised RClust3 Male Female 0.00-0.300.56 p=0.952 ns
Unsupervised RClust4 Male Female 0.00-0.590.34 p=0.952 ns
Unsupervised RClust5 Male Female 0.00-0.730.06 p=0.584 ns
Unsupervised RClust6 Male Female 0.00-0.410.60 p=0.952 ns
Unsupervised RClust7 Male Female 0.00-0.460.55 p=0.952 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.000.051.53 p=0.218 *
Antigen Specific FHA Male Female 0.00-0.581.34 p=0.744 ns
Antigen Specific PRN Male Female 0.00-1.690.20 p=0.366 ns
Antigen Specific PT Male Female 0.00-0.860.89 p=0.967 ns
Antigen Specific TT Male Female 0.00-0.450.96 p=0.744 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.000.72 p=0.819 ns
Unsupervised RClust2 Male Female 0.00-0.530.74 p=0.819 ns
Unsupervised RClust3 Male Female 0.00-0.291.74 p=0.366 ns
Unsupervised RClust4 Male Female 0.00-0.251.49 p=0.366 ns
Unsupervised RClust5 Male Female 0.00-0.641.02 p=0.819 ns
Unsupervised RClust6 Male Female 0.00-1.63-0.23 p=0.123 *
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.610.45 p=0.906 ns
Antigen Specific FHA Male Female 0.00-0.93-0.02 p=0.482 *
Antigen Specific PRN Male Female 0.00-0.480.48 p=0.997 ns
Antigen Specific PT Male Female 0.00-0.890.13 p=0.523 ns
Antigen Specific TT Male Female 0.00-0.820.25 p=0.656 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.610.32 p=0.906 ns
Unsupervised RClust2 Male Female 0.00-0.440.56 p=0.906 ns
Unsupervised RClust3 Male Female 0.00-0.211.06 p=0.523 ns
Unsupervised RClust4 Male Female 0.00-0.590.34 p=0.906 ns
Unsupervised RClust5 Male Female 0.00-0.730.06 p=0.523 ns
Unsupervised RClust6 Male Female 0.00-0.410.60 p=0.906 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.240.89 p=0.554 ns
Antigen Specific FHA Male Female 0.00-0.860.64 p=0.904 ns
Antigen Specific PRN Male Female 0.00-0.620.71 p=0.904 ns
Antigen Specific PT Male Female 0.00-0.330.99 p=0.554 ns
Antigen Specific TT Male Female 0.00-0.180.96 p=0.554 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.451.42 p=0.554 ns
Unsupervised RClust2 Male Female 0.00-1.120.18 p=0.554 ns
Unsupervised RClust3 Male Female 0.00-0.970.82 p=0.904 ns
Unsupervised RClust4 Male Female 0.00-0.940.60 p=0.887 ns
Unsupervised RClust5 Male Female 0.00-0.190.83 p=0.554 ns
Unsupervised RClust6 Male Female 0.00-1.150.16 p=0.554 ns
Unsupervised RClust7 Male Female 0.00-0.391.06 p=0.554 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.190.91 p=0.594 ns
Antigen Specific FHA Male Female 0.00-0.060.98 p=0.551 ns
Antigen Specific PRN Male Female 0.00-0.330.76 p=0.664 ns
Antigen Specific PT Male Female 0.00-0.120.92 p=0.551 ns
Antigen Specific TT Male Female 0.00-0.750.31 p=0.664 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.420.54 p=0.880 ns
Unsupervised RClust2 Male Female 0.00-0.600.30 p=0.687 ns
Unsupervised RClust3 Male Female 0.00-0.290.85 p=0.662 ns
Unsupervised RClust4 Male Female 0.00-0.160.61 p=0.594 ns
Unsupervised RClust5 Male Female 0.00-0.370.27 p=0.880 ns
Unsupervised RClust6 Male Female 0.00-0.090.68 p=0.551 ns
Unsupervised RClust7 Male Female 0.00-0.460.45 p=0.981 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.240.89 p=0.521 ns
Antigen Specific FHA Male Female 0.00-0.860.64 p=0.904 ns
Antigen Specific PRN Male Female 0.00-0.620.71 p=0.904 ns
Antigen Specific PT Male Female 0.00-0.330.99 p=0.521 ns
Antigen Specific TT Male Female 0.00-0.180.96 p=0.521 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.451.42 p=0.521 ns
Unsupervised RClust2 Male Female 0.00-1.120.18 p=0.521 ns
Unsupervised RClust3 Male Female 0.00-0.970.82 p=0.904 ns
Unsupervised RClust4 Male Female 0.00-0.940.60 p=0.904 ns
Unsupervised RClust5 Male Female 0.00-0.341.20 p=0.521 ns
Unsupervised RClust6 Male Female 0.00-1.150.16 p=0.521 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.190.91 p=0.544 ns
Antigen Specific FHA Male Female 0.00-0.060.98 p=0.505 ns
Antigen Specific PRN Male Female 0.00-0.330.76 p=0.608 ns
Antigen Specific PT Male Female 0.00-0.120.92 p=0.505 ns
Antigen Specific TT Male Female 0.00-0.750.31 p=0.608 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.420.54 p=0.807 ns
Unsupervised RClust2 Male Female 0.00-0.600.30 p=0.630 ns
Unsupervised RClust3 Male Female 0.00-0.290.85 p=0.607 ns
Unsupervised RClust4 Male Female 0.00-0.160.61 p=0.544 ns
Unsupervised RClust5 Male Female 0.00-0.630.35 p=0.637 ns
Unsupervised RClust6 Male Female 0.00-0.090.68 p=0.505 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.620.54 p=0.920 ns
Antigen Specific FHA Male Female 0.00-0.860.63 p=0.920 ns
Antigen Specific PRN Male Female 0.00-0.630.70 p=0.920 ns
Antigen Specific PT Male Female 0.00-0.990.33 p=0.586 ns
Antigen Specific TT Male Female 0.00-0.141.03 p=0.586 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.410.53 p=0.586 ns
Unsupervised RClust2 Male Female 0.00-0.181.12 p=0.586 ns
Unsupervised RClust3 Male Female 0.00-0.970.82 p=0.920 ns
Unsupervised RClust4 Male Female 0.00-0.321.24 p=0.586 ns
Unsupervised RClust5 Male Female 0.00-0.341.20 p=0.586 ns
Unsupervised RClust6 Male Female 0.00-0.161.15 p=0.586 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.071.03 p=0.379 ns
Antigen Specific FHA Male Female 0.00-1.06-0.02 p=0.379 *
Antigen Specific PRN Male Female 0.00-0.340.75 p=0.630 ns
Antigen Specific PT Male Female 0.00-0.120.93 p=0.379 ns
Antigen Specific TT Male Female 0.00-0.610.50 p=0.842 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.421.11 p=0.595 ns
Unsupervised RClust2 Male Female 0.00-0.300.60 p=0.630 ns
Unsupervised RClust3 Male Female 0.00-0.850.29 p=0.595 ns
Unsupervised RClust4 Male Female 0.00-0.500.19 p=0.595 ns
Unsupervised RClust5 Male Female 0.00-0.350.63 p=0.637 ns
Unsupervised RClust6 Male Female 0.00-0.090.68 p=0.379 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.620.54 p=0.920 ns
Antigen Specific FHA Male Female 0.00-0.860.63 p=0.920 ns
Antigen Specific PRN Male Female 0.00-0.630.70 p=0.920 ns
Antigen Specific PT Male Female 0.00-0.990.33 p=0.557 ns
Antigen Specific TT Male Female 0.00-0.141.03 p=0.557 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-1.420.45 p=0.557 ns
Unsupervised RClust2 Male Female 0.00-0.181.12 p=0.557 ns
Unsupervised RClust3 Male Female 0.00-0.970.82 p=0.920 ns
Unsupervised RClust4 Male Female 0.00-0.321.24 p=0.557 ns
Unsupervised RClust5 Male Female 0.00-0.600.94 p=0.920 ns
Unsupervised RClust6 Male Female 0.00-0.341.20 p=0.557 ns
Unsupervised RClust7 Male Female 0.00-0.161.15 p=0.557 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Male Female 0.00-0.071.03 p=0.413 ns
Antigen Specific FHA Male Female 0.000.021.06 p=0.413 *
Antigen Specific PRN Male Female 0.00-0.340.75 p=0.687 ns
Antigen Specific PT Male Female 0.00-0.120.93 p=0.413 ns
Antigen Specific TT Male Female 0.00-0.610.50 p=0.842 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Male Female 0.00-0.420.54 p=0.842 ns
Unsupervised RClust2 Male Female 0.00-0.300.60 p=0.687 ns
Unsupervised RClust3 Male Female 0.00-0.850.29 p=0.649 ns
Unsupervised RClust4 Male Female 0.00-0.500.19 p=0.649 ns
Unsupervised RClust5 Male Female 0.00-0.160.61 p=0.594 ns
Unsupervised RClust6 Male Female 0.00-0.350.63 p=0.695 ns
Unsupervised RClust7 Male Female 0.00-0.090.68 p=0.413 ns

delivery_mode

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.631.01 p=0.836 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.621.30 p=0.836 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.170.82 p=0.836 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.620.43 p=0.836 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-1.001.04 p=0.970 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.591.31 p=0.836 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-1.550.32 p=0.836 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.500.73 p=0.836 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-1.050.73 p=0.836 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-1.421.03 p=0.836 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.260.67 p=0.836 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.590.80 p=0.836 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.750.33 p=0.891 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.520.51 p=0.992 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.750.14 p=0.711 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.710.23 p=0.774 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.100.87 p=0.711 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.600.58 p=0.992 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.250.37 p=0.992 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.120.92 p=0.711 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.410.33 p=0.992 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.540.47 p=0.992 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.280.47 p=0.992 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.640.17 p=0.774 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.631.01 p=0.843 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.621.30 p=0.843 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.170.82 p=0.843 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.620.43 p=0.843 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-1.001.04 p=0.970 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.101.83 p=0.843 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-1.550.32 p=0.843 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.500.73 p=0.843 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-1.050.73 p=0.843 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.260.67 p=0.843 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.590.80 p=0.843 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.330.75 p=0.816 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.520.51 p=0.992 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.750.14 p=0.652 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.230.71 p=0.710 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.870.10 p=0.652 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.470.88 p=0.855 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.250.37 p=0.866 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.120.92 p=0.652 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.410.33 p=0.918 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.280.47 p=0.855 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.640.17 p=0.710 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.910.51 p=0.939 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.000.65 p=0.939 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.870.60 p=0.939 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.940.90 p=0.962 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.611.07 p=0.939 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.851.44 p=0.939 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.670.26 p=0.939 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.550.92 p=0.939 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.320.70 p=0.939 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.520.42 p=0.939 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.390.68 p=0.839 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.530.53 p=0.995 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.630.40 p=0.839 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.610.34 p=0.839 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.890.14 p=0.769 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.690.62 p=0.995 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.470.28 p=0.839 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.060.84 p=0.769 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.410.25 p=0.839 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.230.53 p=0.839 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.910.51 p=0.939 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.000.65 p=0.939 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.870.60 p=0.939 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.940.90 p=0.962 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.611.07 p=0.939 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.851.44 p=0.939 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.740.30 p=0.939 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.670.26 p=0.939 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.550.92 p=0.939 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.520.42 p=0.939 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.390.68 p=0.959 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.530.53 p=0.995 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.630.40 p=0.959 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.610.34 p=0.959 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.890.14 p=0.769 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.690.62 p=0.995 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.380.46 p=0.995 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.470.28 p=0.959 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.060.84 p=0.769 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.230.53 p=0.959 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.910.51 p=0.963 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.651.00 p=0.963 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.600.87 p=0.963 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.900.94 p=0.963 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-1.070.61 p=0.963 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.851.44 p=0.963 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.740.30 p=0.963 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.260.67 p=0.963 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.630.73 p=0.963 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.920.55 p=0.963 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.140.81 p=0.963 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.680.39 p=0.987 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.530.53 p=0.997 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.630.40 p=0.987 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.610.34 p=0.987 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.130.89 p=0.827 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.620.69 p=0.997 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.460.38 p=0.997 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.470.28 p=0.987 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.510.35 p=0.987 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.060.84 p=0.827 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.520.33 p=0.987 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.910.51 p=0.963 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.651.00 p=0.963 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.600.87 p=0.963 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.900.94 p=0.963 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-1.070.61 p=0.963 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.851.44 p=0.963 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.740.30 p=0.963 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.260.67 p=0.963 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.630.73 p=0.963 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.920.55 p=0.963 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.170.76 p=0.963 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.680.39 p=0.987 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.530.53 p=0.997 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.630.40 p=0.987 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.610.34 p=0.987 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.130.89 p=0.827 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.620.69 p=0.997 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.460.38 p=0.997 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.470.28 p=0.987 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.510.35 p=0.987 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.060.84 p=0.827 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.270.47 p=0.987 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.720.81 p=0.906 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.140.79 p=0.906 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.411.50 p=0.906 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.000.76 p=0.906 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.630.78 p=0.906 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.110.62 p=0.906 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.510.77 p=0.906 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-1.160.60 p=0.906 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-1.460.29 p=0.906 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.990.67 p=0.906 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.910.55 p=0.906 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.730.84 p=0.906 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.720.35 p=0.849 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.810.12 p=0.659 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.140.82 p=0.659 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.530.50 p=0.958 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.750.33 p=0.849 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.210.72 p=0.750 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.110.88 p=0.659 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.470.40 p=0.958 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.420.51 p=0.958 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.310.50 p=0.956 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.490.52 p=0.958 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.760.24 p=0.750 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.720.81 p=0.906 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-1.140.79 p=0.906 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.411.50 p=0.906 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-1.000.76 p=0.906 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.630.78 p=0.906 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-1.110.62 p=0.906 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.510.77 p=0.906 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-1.220.84 p=0.906 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-1.460.29 p=0.906 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.990.67 p=0.906 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.910.55 p=0.906 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.720.35 p=0.876 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.810.12 p=0.604 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.140.82 p=0.604 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.530.50 p=0.958 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.750.33 p=0.876 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.210.72 p=0.791 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.110.88 p=0.604 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.480.80 p=0.876 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.420.51 p=0.958 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.310.50 p=0.876 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.490.52 p=0.958 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.450.68 p=0.891 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.660.84 p=0.891 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.150.17 p=0.891 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.750.58 p=0.891 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.370.79 p=0.891 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.980.91 p=0.936 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.530.79 p=0.891 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.481.31 p=0.891 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-1.210.33 p=0.891 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.350.69 p=0.891 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.530.80 p=0.891 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.331.11 p=0.891 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.260.84 p=0.457 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.200.85 p=0.457 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.180.90 p=0.457 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.550.51 p=0.934 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.850.21 p=0.457 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.250.71 p=0.478 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.190.70 p=0.457 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.640.51 p=0.900 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.030.73 p=0.457 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.080.55 p=0.457 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.660.11 p=0.457 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.300.61 p=0.609 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.450.68 p=0.898 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.660.84 p=0.898 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.150.17 p=0.898 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.750.58 p=0.898 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.370.79 p=0.898 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.980.91 p=0.936 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.530.79 p=0.898 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.481.31 p=0.898 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-1.210.33 p=0.898 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.371.18 p=0.898 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.530.80 p=0.898 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.260.84 p=0.479 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.200.85 p=0.479 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.180.90 p=0.479 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.550.51 p=0.941 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.850.21 p=0.479 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.250.71 p=0.493 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.190.70 p=0.479 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.640.51 p=0.941 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.030.73 p=0.479 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.510.47 p=0.941 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.660.11 p=0.479 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.630.53 p=0.871 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.660.84 p=0.871 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.140.18 p=0.871 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.580.75 p=0.871 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.330.85 p=0.871 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.851.10 p=0.871 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.790.53 p=0.871 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.481.31 p=0.871 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-1.030.55 p=0.871 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.371.18 p=0.871 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.800.53 p=0.871 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.290.83 p=0.644 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.790.28 p=0.644 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.170.91 p=0.644 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.540.52 p=0.970 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.720.39 p=0.788 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.281.25 p=0.644 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.700.19 p=0.644 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.510.64 p=0.970 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.240.45 p=0.788 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.470.51 p=0.970 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.660.11 p=0.644 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.630.53 p=0.936 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.660.84 p=0.936 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-1.140.18 p=0.936 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.580.75 p=0.936 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.330.85 p=0.936 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.910.98 p=0.936 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.790.53 p=0.936 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.481.31 p=0.936 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-1.030.55 p=0.936 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.331.21 p=0.936 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.371.18 p=0.936 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.800.53 p=0.936 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT Vaginal Delivery Caesarian Section 0.00-0.290.83 p=0.615 ns
Antigen Specific FHA Vaginal Delivery Caesarian Section 0.00-0.280.79 p=0.615 ns
Antigen Specific PRN Vaginal Delivery Caesarian Section 0.00-0.170.91 p=0.615 ns
Antigen Specific PT Vaginal Delivery Caesarian Section 0.00-0.540.52 p=0.970 ns
Antigen Specific TT Vaginal Delivery Caesarian Section 0.00-0.720.39 p=0.764 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 Vaginal Delivery Caesarian Section 0.00-0.250.71 p=0.615 ns
Unsupervised RClust2 Vaginal Delivery Caesarian Section 0.00-0.700.19 p=0.615 ns
Unsupervised RClust3 Vaginal Delivery Caesarian Section 0.00-0.510.64 p=0.970 ns
Unsupervised RClust4 Vaginal Delivery Caesarian Section 0.00-0.240.45 p=0.764 ns
Unsupervised RClust5 Vaginal Delivery Caesarian Section 0.00-0.030.73 p=0.615 ns
Unsupervised RClust6 Vaginal Delivery Caesarian Section 0.00-0.470.51 p=0.970 ns
Unsupervised RClust7 Vaginal Delivery Caesarian Section 0.00-0.660.11 p=0.615 ns

parity

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.391.23 p=0.987 ns
Antigen Specific FHA 1 2+ 0.00-0.781.13 p=0.987 ns
Antigen Specific PRN 1 2+ 0.00-1.200.77 p=0.987 ns
Antigen Specific PT 1 2+ 0.00-0.921.13 p=0.987 ns
Antigen Specific TT 1 2+ 0.00-0.591.43 p=0.987 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.970.92 p=0.987 ns
Unsupervised RClust2 1 2+ 0.00-0.940.93 p=0.987 ns
Unsupervised RClust3 1 2+ 0.00-0.530.68 p=0.987 ns
Unsupervised RClust4 1 2+ 0.00-1.090.67 p=0.987 ns
Unsupervised RClust5 1 2+ 0.00-1.950.46 p=0.987 ns
Unsupervised RClust6 1 2+ 0.00-0.160.76 p=0.987 ns
Unsupervised RClust7 1 2+ 0.00-0.410.97 p=0.987 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.590.48 p=0.941 ns
Antigen Specific FHA 1 2+ 0.00-0.340.68 p=0.941 ns
Antigen Specific PRN 1 2+ 0.00-0.400.49 p=0.941 ns
Antigen Specific PT 1 2+ 0.00-0.780.16 p=0.941 ns
Antigen Specific TT 1 2+ 0.00-0.240.74 p=0.941 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.260.90 p=0.941 ns
Unsupervised RClust2 1 2+ 0.00-0.240.38 p=0.941 ns
Unsupervised RClust3 1 2+ 0.00-0.420.62 p=0.941 ns
Unsupervised RClust4 1 2+ 0.00-0.380.35 p=0.941 ns
Unsupervised RClust5 1 2+ 0.00-0.570.44 p=0.941 ns
Unsupervised RClust6 1 2+ 0.00-0.360.39 p=0.941 ns
Unsupervised RClust7 1 2+ 0.00-0.590.22 p=0.941 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.391.23 p=0.918 ns
Antigen Specific FHA 1 2+ 0.00-0.781.13 p=0.918 ns
Antigen Specific PRN 1 2+ 0.00-1.200.77 p=0.918 ns
Antigen Specific PT 1 2+ 0.00-0.921.13 p=0.918 ns
Antigen Specific TT 1 2+ 0.00-0.591.43 p=0.918 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.822.08 p=0.918 ns
Unsupervised RClust2 1 2+ 0.00-0.940.93 p=0.987 ns
Unsupervised RClust3 1 2+ 0.00-0.530.68 p=0.918 ns
Unsupervised RClust4 1 2+ 0.00-1.090.67 p=0.918 ns
Unsupervised RClust5 1 2+ 0.00-0.160.76 p=0.918 ns
Unsupervised RClust6 1 2+ 0.00-0.410.97 p=0.918 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.480.59 p=0.941 ns
Antigen Specific FHA 1 2+ 0.00-0.340.68 p=0.941 ns
Antigen Specific PRN 1 2+ 0.00-0.400.49 p=0.941 ns
Antigen Specific PT 1 2+ 0.00-0.160.78 p=0.941 ns
Antigen Specific TT 1 2+ 0.00-0.740.24 p=0.941 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.120.21 p=0.941 ns
Unsupervised RClust2 1 2+ 0.00-0.240.38 p=0.941 ns
Unsupervised RClust3 1 2+ 0.00-0.420.62 p=0.941 ns
Unsupervised RClust4 1 2+ 0.00-0.380.35 p=0.941 ns
Unsupervised RClust5 1 2+ 0.00-0.360.39 p=0.941 ns
Unsupervised RClust6 1 2+ 0.00-0.590.22 p=0.941 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.850.57 p=0.831 ns
Antigen Specific FHA 1 2+ 0.00-0.561.07 p=0.831 ns
Antigen Specific PRN 1 2+ 0.00-0.610.85 p=0.831 ns
Antigen Specific PT 1 2+ 0.00-1.010.81 p=0.831 ns
Antigen Specific TT 1 2+ 0.00-1.120.55 p=0.831 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.431.84 p=0.831 ns
Unsupervised RClust3 1 2+ 0.00-0.760.16 p=0.831 ns
Unsupervised RClust4 1 2+ 0.00-0.331.13 p=0.831 ns
Unsupervised RClust5 1 2+ 0.00-0.650.36 p=0.831 ns
Unsupervised RClust7 1 2+ 0.00-0.200.73 p=0.831 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.510.56 p=0.941 ns
Antigen Specific FHA 1 2+ 0.00-0.160.88 p=0.527 ns
Antigen Specific PRN 1 2+ 0.00-0.700.32 p=0.774 ns
Antigen Specific PT 1 2+ 0.00-0.710.23 p=0.626 ns
Antigen Specific TT 1 2+ 0.00-0.840.18 p=0.527 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.111.17 p=0.527 ns
Unsupervised RClust3 1 2+ 0.00-0.390.36 p=0.941 ns
Unsupervised RClust4 1 2+ 0.00-0.350.56 p=0.928 ns
Unsupervised RClust5 1 2+ 0.00-0.530.11 p=0.527 ns
Unsupervised RClust7 1 2+ 0.00-0.350.41 p=0.941 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.850.57 p=0.831 ns
Antigen Specific FHA 1 2+ 0.00-0.561.07 p=0.831 ns
Antigen Specific PRN 1 2+ 0.00-0.610.85 p=0.831 ns
Antigen Specific PT 1 2+ 0.00-1.010.81 p=0.831 ns
Antigen Specific TT 1 2+ 0.00-1.120.55 p=0.831 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.431.84 p=0.831 ns
Unsupervised RClust2 1 2+ 0.00-0.340.70 p=0.831 ns
Unsupervised RClust3 1 2+ 0.00-0.760.16 p=0.831 ns
Unsupervised RClust4 1 2+ 0.00-0.331.13 p=0.831 ns
Unsupervised RClust6 1 2+ 0.00-0.200.73 p=0.831 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.510.56 p=0.987 ns
Antigen Specific FHA 1 2+ 0.00-0.160.88 p=0.703 ns
Antigen Specific PRN 1 2+ 0.00-0.700.32 p=0.928 ns
Antigen Specific PT 1 2+ 0.00-0.710.23 p=0.783 ns
Antigen Specific TT 1 2+ 0.00-0.840.18 p=0.703 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.111.17 p=0.703 ns
Unsupervised RClust2 1 2+ 0.00-0.420.42 p=0.987 ns
Unsupervised RClust3 1 2+ 0.00-0.390.36 p=0.987 ns
Unsupervised RClust4 1 2+ 0.00-0.350.56 p=0.987 ns
Unsupervised RClust6 1 2+ 0.00-0.350.41 p=0.987 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.850.57 p=0.831 ns
Antigen Specific FHA 1 2+ 0.00-1.080.56 p=0.831 ns
Antigen Specific PRN 1 2+ 0.00-0.850.60 p=0.831 ns
Antigen Specific PT 1 2+ 0.00-0.811.01 p=0.831 ns
Antigen Specific TT 1 2+ 0.00-0.561.11 p=0.831 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.431.84 p=0.831 ns
Unsupervised RClust2 1 2+ 0.00-0.340.70 p=0.831 ns
Unsupervised RClust3 1 2+ 0.00-0.160.76 p=0.831 ns
Unsupervised RClust4 1 2+ 0.00-0.171.17 p=0.831 ns
Unsupervised RClust5 1 2+ 0.00-1.130.33 p=0.831 ns
Unsupervised RClust6 1 2+ 0.00-0.670.27 p=0.831 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.560.50 p=0.987 ns
Antigen Specific FHA 1 2+ 0.00-0.880.16 p=0.869 ns
Antigen Specific PRN 1 2+ 0.00-0.690.33 p=0.900 ns
Antigen Specific PT 1 2+ 0.00-0.710.23 p=0.869 ns
Antigen Specific TT 1 2+ 0.00-0.210.81 p=0.869 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.170.11 p=0.869 ns
Unsupervised RClust2 1 2+ 0.00-0.420.42 p=0.987 ns
Unsupervised RClust3 1 2+ 0.00-0.390.36 p=0.987 ns
Unsupervised RClust4 1 2+ 0.00-0.600.24 p=0.896 ns
Unsupervised RClust5 1 2+ 0.00-0.350.56 p=0.987 ns
Unsupervised RClust6 1 2+ 0.00-0.390.45 p=0.987 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.850.57 p=0.831 ns
Antigen Specific FHA 1 2+ 0.00-1.080.56 p=0.831 ns
Antigen Specific PRN 1 2+ 0.00-0.850.60 p=0.831 ns
Antigen Specific PT 1 2+ 0.00-0.811.01 p=0.831 ns
Antigen Specific TT 1 2+ 0.00-0.561.11 p=0.831 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.431.84 p=0.831 ns
Unsupervised RClust2 1 2+ 0.00-0.340.70 p=0.831 ns
Unsupervised RClust3 1 2+ 0.00-0.160.76 p=0.831 ns
Unsupervised RClust4 1 2+ 0.00-0.171.17 p=0.831 ns
Unsupervised RClust5 1 2+ 0.00-1.130.33 p=0.831 ns
Unsupervised RClust7 1 2+ 0.00-0.650.29 p=0.831 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.560.50 p=0.987 ns
Antigen Specific FHA 1 2+ 0.00-0.880.16 p=0.869 ns
Antigen Specific PRN 1 2+ 0.00-0.690.33 p=0.900 ns
Antigen Specific PT 1 2+ 0.00-0.710.23 p=0.869 ns
Antigen Specific TT 1 2+ 0.00-0.210.81 p=0.869 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.170.11 p=0.869 ns
Unsupervised RClust2 1 2+ 0.00-0.420.42 p=0.987 ns
Unsupervised RClust3 1 2+ 0.00-0.390.36 p=0.987 ns
Unsupervised RClust4 1 2+ 0.00-0.600.24 p=0.896 ns
Unsupervised RClust5 1 2+ 0.00-0.350.56 p=0.987 ns
Unsupervised RClust7 1 2+ 0.00-0.310.43 p=0.987 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.680.83 p=0.929 ns
Antigen Specific FHA 1 2+ 0.00-0.661.25 p=0.929 ns
Antigen Specific PRN 1 2+ 0.00-0.751.16 p=0.929 ns
Antigen Specific PT 1 2+ 0.00-1.030.71 p=0.929 ns
Antigen Specific TT 1 2+ 0.00-0.430.96 p=0.929 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.521.18 p=0.929 ns
Unsupervised RClust2 1 2+ 0.00-0.520.74 p=0.929 ns
Unsupervised RClust3 1 2+ 0.00-0.621.12 p=0.929 ns
Unsupervised RClust4 1 2+ 0.00-0.920.84 p=0.929 ns
Unsupervised RClust5 1 2+ 0.00-0.970.67 p=0.929 ns
Unsupervised RClust6 1 2+ 0.00-0.530.91 p=0.929 ns
Unsupervised RClust7 1 2+ 0.00-0.700.85 p=0.929 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.380.67 p=0.964 ns
Antigen Specific FHA 1 2+ 0.00-0.350.57 p=0.964 ns
Antigen Specific PRN 1 2+ 0.00-0.670.29 p=0.964 ns
Antigen Specific PT 1 2+ 0.00-0.770.25 p=0.964 ns
Antigen Specific TT 1 2+ 0.00-0.340.72 p=0.964 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.450.48 p=0.987 ns
Unsupervised RClust2 1 2+ 0.00-0.280.71 p=0.964 ns
Unsupervised RClust3 1 2+ 0.00-0.430.43 p=0.987 ns
Unsupervised RClust4 1 2+ 0.00-0.670.24 p=0.964 ns
Unsupervised RClust5 1 2+ 0.00-0.330.47 p=0.987 ns
Unsupervised RClust6 1 2+ 0.00-0.200.79 p=0.964 ns
Unsupervised RClust7 1 2+ 0.00-0.530.47 p=0.987 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.680.83 p=0.929 ns
Antigen Specific FHA 1 2+ 0.00-0.661.25 p=0.888 ns
Antigen Specific PRN 1 2+ 0.00-0.751.16 p=0.888 ns
Antigen Specific PT 1 2+ 0.00-1.030.71 p=0.888 ns
Antigen Specific TT 1 2+ 0.00-0.430.96 p=0.888 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.521.18 p=0.888 ns
Unsupervised RClust2 1 2+ 0.00-0.520.74 p=0.888 ns
Unsupervised RClust3 1 2+ 0.00-0.761.28 p=0.888 ns
Unsupervised RClust4 1 2+ 0.00-0.920.84 p=0.929 ns
Unsupervised RClust5 1 2+ 0.00-0.970.67 p=0.888 ns
Unsupervised RClust6 1 2+ 0.00-0.530.91 p=0.888 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.380.67 p=0.873 ns
Antigen Specific FHA 1 2+ 0.00-0.350.57 p=0.873 ns
Antigen Specific PRN 1 2+ 0.00-0.670.29 p=0.873 ns
Antigen Specific PT 1 2+ 0.00-0.770.25 p=0.873 ns
Antigen Specific TT 1 2+ 0.00-0.340.72 p=0.873 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.450.48 p=0.943 ns
Unsupervised RClust2 1 2+ 0.00-0.280.71 p=0.873 ns
Unsupervised RClust3 1 2+ 0.00-0.720.55 p=0.873 ns
Unsupervised RClust4 1 2+ 0.00-0.670.24 p=0.873 ns
Unsupervised RClust5 1 2+ 0.00-0.330.47 p=0.873 ns
Unsupervised RClust6 1 2+ 0.00-0.200.79 p=0.873 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.740.38 p=0.882 ns
Antigen Specific FHA 1 2+ 0.00-0.990.50 p=0.882 ns
Antigen Specific PRN 1 2+ 0.00-1.240.06 p=0.882 ns
Antigen Specific PT 1 2+ 0.00-0.590.73 p=0.983 ns
Antigen Specific TT 1 2+ 0.00-0.790.35 p=0.882 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.930.95 p=0.983 ns
Unsupervised RClust2 1 2+ 0.00-0.470.83 p=0.882 ns
Unsupervised RClust3 1 2+ 0.00-0.481.29 p=0.882 ns
Unsupervised RClust4 1 2+ 0.00-0.281.24 p=0.882 ns
Unsupervised RClust5 1 2+ 0.00-0.690.34 p=0.882 ns
Unsupervised RClust6 1 2+ 0.00-0.600.72 p=0.983 ns
Unsupervised RClust7 1 2+ 0.00-0.740.71 p=0.983 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.790.31 p=0.984 ns
Antigen Specific FHA 1 2+ 0.00-0.550.50 p=0.984 ns
Antigen Specific PRN 1 2+ 0.00-0.970.09 p=0.984 ns
Antigen Specific PT 1 2+ 0.00-0.280.77 p=0.984 ns
Antigen Specific TT 1 2+ 0.00-0.540.53 p=0.984 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.500.46 p=0.984 ns
Unsupervised RClust2 1 2+ 0.00-0.470.42 p=0.984 ns
Unsupervised RClust3 1 2+ 0.00-0.400.73 p=0.984 ns
Unsupervised RClust4 1 2+ 0.00-0.550.21 p=0.984 ns
Unsupervised RClust5 1 2+ 0.00-0.380.25 p=0.984 ns
Unsupervised RClust6 1 2+ 0.00-0.450.33 p=0.984 ns
Unsupervised RClust7 1 2+ 0.00-0.310.60 p=0.984 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.740.38 p=0.924 ns
Antigen Specific FHA 1 2+ 0.00-0.990.50 p=0.924 ns
Antigen Specific PRN 1 2+ 0.00-1.240.06 p=0.884 ns
Antigen Specific PT 1 2+ 0.00-0.590.73 p=0.948 ns
Antigen Specific TT 1 2+ 0.00-0.790.35 p=0.924 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.930.95 p=0.983 ns
Unsupervised RClust2 1 2+ 0.00-0.470.83 p=0.924 ns
Unsupervised RClust3 1 2+ 0.00-0.481.29 p=0.924 ns
Unsupervised RClust4 1 2+ 0.00-0.281.24 p=0.924 ns
Unsupervised RClust5 1 2+ 0.00-0.870.68 p=0.948 ns
Unsupervised RClust6 1 2+ 0.00-0.600.72 p=0.948 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.790.31 p=0.857 ns
Antigen Specific FHA 1 2+ 0.00-0.550.50 p=0.984 ns
Antigen Specific PRN 1 2+ 0.00-0.970.09 p=0.857 ns
Antigen Specific PT 1 2+ 0.00-0.280.77 p=0.857 ns
Antigen Specific TT 1 2+ 0.00-0.540.53 p=0.984 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.500.46 p=0.984 ns
Unsupervised RClust2 1 2+ 0.00-0.470.42 p=0.984 ns
Unsupervised RClust3 1 2+ 0.00-0.400.73 p=0.984 ns
Unsupervised RClust4 1 2+ 0.00-0.550.21 p=0.857 ns
Unsupervised RClust5 1 2+ 0.00-0.160.81 p=0.857 ns
Unsupervised RClust6 1 2+ 0.00-0.450.33 p=0.984 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.410.74 p=0.862 ns
Antigen Specific FHA 1 2+ 0.00-0.990.49 p=0.862 ns
Antigen Specific PRN 1 2+ 0.00-1.240.06 p=0.862 ns
Antigen Specific PT 1 2+ 0.00-0.740.58 p=0.862 ns
Antigen Specific TT 1 2+ 0.00-0.690.48 p=0.862 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.100.83 p=0.862 ns
Unsupervised RClust2 1 2+ 0.00-0.830.47 p=0.862 ns
Unsupervised RClust3 1 2+ 0.00-0.481.29 p=0.862 ns
Unsupervised RClust4 1 2+ 0.00-0.351.20 p=0.862 ns
Unsupervised RClust5 1 2+ 0.00-0.870.68 p=0.862 ns
Unsupervised RClust6 1 2+ 0.00-0.720.60 p=0.862 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.800.30 p=0.841 ns
Antigen Specific FHA 1 2+ 0.00-0.570.49 p=0.993 ns
Antigen Specific PRN 1 2+ 0.00-0.970.09 p=0.764 ns
Antigen Specific PT 1 2+ 0.00-0.260.79 p=0.841 ns
Antigen Specific TT 1 2+ 0.00-0.740.36 p=0.895 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.240.27 p=0.764 ns
Unsupervised RClust2 1 2+ 0.00-0.420.47 p=0.993 ns
Unsupervised RClust3 1 2+ 0.00-0.730.40 p=0.895 ns
Unsupervised RClust4 1 2+ 0.00-0.340.34 p=0.998 ns
Unsupervised RClust5 1 2+ 0.00-0.810.16 p=0.764 ns
Unsupervised RClust6 1 2+ 0.00-0.450.33 p=0.993 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.410.74 p=0.940 ns
Antigen Specific FHA 1 2+ 0.00-0.990.49 p=0.940 ns
Antigen Specific PRN 1 2+ 0.00-1.240.06 p=0.940 ns
Antigen Specific PT 1 2+ 0.00-0.740.58 p=0.940 ns
Antigen Specific TT 1 2+ 0.00-0.690.48 p=0.940 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.950.93 p=0.983 ns
Unsupervised RClust2 1 2+ 0.00-0.830.47 p=0.940 ns
Unsupervised RClust3 1 2+ 0.00-0.481.29 p=0.940 ns
Unsupervised RClust4 1 2+ 0.00-0.351.20 p=0.940 ns
Unsupervised RClust5 1 2+ 0.00-1.240.28 p=0.940 ns
Unsupervised RClust6 1 2+ 0.00-0.870.68 p=0.940 ns
Unsupervised RClust7 1 2+ 0.00-0.720.60 p=0.940 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.800.30 p=0.924 ns
Antigen Specific FHA 1 2+ 0.00-0.490.57 p=0.998 ns
Antigen Specific PRN 1 2+ 0.00-0.970.09 p=0.924 ns
Antigen Specific PT 1 2+ 0.00-0.260.79 p=0.924 ns
Antigen Specific TT 1 2+ 0.00-0.740.36 p=0.976 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.500.46 p=0.998 ns
Unsupervised RClust2 1 2+ 0.00-0.420.47 p=0.998 ns
Unsupervised RClust3 1 2+ 0.00-0.730.40 p=0.976 ns
Unsupervised RClust4 1 2+ 0.00-0.340.34 p=0.998 ns
Unsupervised RClust5 1 2+ 0.00-0.550.21 p=0.924 ns
Unsupervised RClust6 1 2+ 0.00-0.810.16 p=0.924 ns
Unsupervised RClust7 1 2+ 0.00-0.450.33 p=0.998 ns

gravidity

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.641.01 p=0.890 ns
Antigen Specific FHA 1 2+ 0.00-1.130.80 p=0.890 ns
Antigen Specific PRN 1 2+ 0.00-1.090.91 p=0.939 ns
Antigen Specific PT 1 2+ 0.00-1.270.80 p=0.890 ns
Antigen Specific TT 1 2+ 0.00-0.701.34 p=0.890 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.250.65 p=0.890 ns
Unsupervised RClust2 1 2+ 0.00-1.260.63 p=0.890 ns
Unsupervised RClust3 1 2+ 0.00-0.760.47 p=0.890 ns
Unsupervised RClust4 1 2+ 0.00-0.910.88 p=0.972 ns
Unsupervised RClust5 1 2+ 0.00-1.750.70 p=0.890 ns
Unsupervised RClust6 1 2+ 0.00-0.210.72 p=0.890 ns
Unsupervised RClust7 1 2+ 0.00-0.580.81 p=0.890 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.600.48 p=0.859 ns
Antigen Specific FHA 1 2+ 0.00-0.460.57 p=0.859 ns
Antigen Specific PRN 1 2+ 0.00-0.160.73 p=0.859 ns
Antigen Specific PT 1 2+ 0.00-0.820.12 p=0.859 ns
Antigen Specific TT 1 2+ 0.00-0.260.73 p=0.859 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.460.72 p=0.859 ns
Unsupervised RClust2 1 2+ 0.00-0.240.39 p=0.859 ns
Unsupervised RClust3 1 2+ 0.00-0.460.60 p=0.859 ns
Unsupervised RClust4 1 2+ 0.00-0.330.41 p=0.859 ns
Unsupervised RClust5 1 2+ 0.00-0.560.46 p=0.859 ns
Unsupervised RClust6 1 2+ 0.00-0.320.43 p=0.859 ns
Unsupervised RClust7 1 2+ 0.00-0.370.45 p=0.859 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.641.01 p=0.906 ns
Antigen Specific FHA 1 2+ 0.00-1.130.80 p=0.906 ns
Antigen Specific PRN 1 2+ 0.00-1.090.91 p=0.947 ns
Antigen Specific PT 1 2+ 0.00-1.270.80 p=0.906 ns
Antigen Specific TT 1 2+ 0.00-0.701.34 p=0.906 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.181.75 p=0.906 ns
Unsupervised RClust2 1 2+ 0.00-1.260.63 p=0.906 ns
Unsupervised RClust3 1 2+ 0.00-0.760.47 p=0.906 ns
Unsupervised RClust4 1 2+ 0.00-0.910.88 p=0.972 ns
Unsupervised RClust5 1 2+ 0.00-0.210.72 p=0.906 ns
Unsupervised RClust6 1 2+ 0.00-0.580.81 p=0.906 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.480.60 p=0.857 ns
Antigen Specific FHA 1 2+ 0.00-0.460.57 p=0.857 ns
Antigen Specific PRN 1 2+ 0.00-0.160.73 p=0.780 ns
Antigen Specific PT 1 2+ 0.00-0.120.82 p=0.780 ns
Antigen Specific TT 1 2+ 0.00-0.730.26 p=0.857 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.190.16 p=0.780 ns
Unsupervised RClust2 1 2+ 0.00-0.240.39 p=0.857 ns
Unsupervised RClust3 1 2+ 0.00-0.460.60 p=0.857 ns
Unsupervised RClust4 1 2+ 0.00-0.330.41 p=0.857 ns
Unsupervised RClust5 1 2+ 0.00-0.320.43 p=0.857 ns
Unsupervised RClust6 1 2+ 0.00-0.370.45 p=0.857 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.760.67 p=0.994 ns
Antigen Specific FHA 1 2+ 0.00-0.491.16 p=0.790 ns
Antigen Specific PRN 1 2+ 0.00-0.550.92 p=0.790 ns
Antigen Specific PT 1 2+ 0.00-1.160.68 p=0.790 ns
Antigen Specific TT 1 2+ 0.00-1.140.54 p=0.790 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.242.05 p=0.790 ns
Unsupervised RClust3 1 2+ 0.00-0.720.21 p=0.790 ns
Unsupervised RClust4 1 2+ 0.00-0.451.03 p=0.790 ns
Unsupervised RClust5 1 2+ 0.00-0.700.32 p=0.790 ns
Unsupervised RClust7 1 2+ 0.00-0.470.47 p=0.994 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.530.54 p=0.982 ns
Antigen Specific FHA 1 2+ 0.00-0.350.71 p=0.712 ns
Antigen Specific PRN 1 2+ 0.00-0.470.57 p=0.949 ns
Antigen Specific PT 1 2+ 0.00-0.770.18 p=0.668 ns
Antigen Specific TT 1 2+ 0.00-0.810.22 p=0.668 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.181.12 p=0.668 ns
Unsupervised RClust3 1 2+ 0.00-0.430.32 p=0.949 ns
Unsupervised RClust4 1 2+ 0.00-0.290.63 p=0.712 ns
Unsupervised RClust5 1 2+ 0.00-0.480.17 p=0.708 ns
Unsupervised RClust7 1 2+ 0.00-0.610.14 p=0.668 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.760.67 p=0.994 ns
Antigen Specific FHA 1 2+ 0.00-0.491.16 p=0.790 ns
Antigen Specific PRN 1 2+ 0.00-0.550.92 p=0.790 ns
Antigen Specific PT 1 2+ 0.00-1.160.68 p=0.790 ns
Antigen Specific TT 1 2+ 0.00-1.140.54 p=0.790 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.242.05 p=0.790 ns
Unsupervised RClust2 1 2+ 0.00-0.240.81 p=0.790 ns
Unsupervised RClust3 1 2+ 0.00-0.720.21 p=0.790 ns
Unsupervised RClust4 1 2+ 0.00-0.451.03 p=0.790 ns
Unsupervised RClust6 1 2+ 0.00-0.470.47 p=0.994 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.530.54 p=0.982 ns
Antigen Specific FHA 1 2+ 0.00-0.350.71 p=0.762 ns
Antigen Specific PRN 1 2+ 0.00-0.470.57 p=0.949 ns
Antigen Specific PT 1 2+ 0.00-0.770.18 p=0.668 ns
Antigen Specific TT 1 2+ 0.00-0.810.22 p=0.668 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.181.12 p=0.668 ns
Unsupervised RClust2 1 2+ 0.00-0.560.29 p=0.762 ns
Unsupervised RClust3 1 2+ 0.00-0.430.32 p=0.949 ns
Unsupervised RClust4 1 2+ 0.00-0.290.63 p=0.762 ns
Unsupervised RClust6 1 2+ 0.00-0.610.14 p=0.668 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.770.67 p=0.893 ns
Antigen Specific FHA 1 2+ 0.00-1.160.49 p=0.695 ns
Antigen Specific PRN 1 2+ 0.00-0.920.55 p=0.695 ns
Antigen Specific PT 1 2+ 0.00-0.681.16 p=0.695 ns
Antigen Specific TT 1 2+ 0.00-0.551.14 p=0.695 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.242.05 p=0.695 ns
Unsupervised RClust2 1 2+ 0.00-0.240.81 p=0.695 ns
Unsupervised RClust3 1 2+ 0.00-0.210.72 p=0.695 ns
Unsupervised RClust4 1 2+ 0.00-0.420.94 p=0.695 ns
Unsupervised RClust5 1 2+ 0.00-1.030.45 p=0.695 ns
Unsupervised RClust6 1 2+ 0.00-0.620.33 p=0.695 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.550.53 p=0.968 ns
Antigen Specific FHA 1 2+ 0.00-0.710.34 p=0.733 ns
Antigen Specific PRN 1 2+ 0.00-0.460.57 p=0.925 ns
Antigen Specific PT 1 2+ 0.00-0.770.18 p=0.733 ns
Antigen Specific TT 1 2+ 0.00-0.250.79 p=0.733 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.120.18 p=0.733 ns
Unsupervised RClust2 1 2+ 0.00-0.290.56 p=0.733 ns
Unsupervised RClust3 1 2+ 0.00-0.430.32 p=0.925 ns
Unsupervised RClust4 1 2+ 0.00-0.240.62 p=0.733 ns
Unsupervised RClust5 1 2+ 0.00-0.290.63 p=0.733 ns
Unsupervised RClust6 1 2+ 0.00-0.270.58 p=0.733 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.770.67 p=0.893 ns
Antigen Specific FHA 1 2+ 0.00-1.160.49 p=0.772 ns
Antigen Specific PRN 1 2+ 0.00-0.920.55 p=0.772 ns
Antigen Specific PT 1 2+ 0.00-0.681.16 p=0.772 ns
Antigen Specific TT 1 2+ 0.00-0.551.14 p=0.772 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.242.05 p=0.772 ns
Unsupervised RClust2 1 2+ 0.00-0.240.81 p=0.772 ns
Unsupervised RClust3 1 2+ 0.00-0.210.72 p=0.772 ns
Unsupervised RClust4 1 2+ 0.00-0.420.94 p=0.772 ns
Unsupervised RClust5 1 2+ 0.00-1.030.45 p=0.772 ns
Unsupervised RClust7 1 2+ 0.00-0.560.38 p=0.783 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.550.53 p=0.968 ns
Antigen Specific FHA 1 2+ 0.00-0.710.34 p=0.733 ns
Antigen Specific PRN 1 2+ 0.00-0.460.57 p=0.925 ns
Antigen Specific PT 1 2+ 0.00-0.770.18 p=0.733 ns
Antigen Specific TT 1 2+ 0.00-0.250.79 p=0.733 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.120.18 p=0.733 ns
Unsupervised RClust2 1 2+ 0.00-0.290.56 p=0.733 ns
Unsupervised RClust3 1 2+ 0.00-0.430.32 p=0.925 ns
Unsupervised RClust4 1 2+ 0.00-0.240.62 p=0.733 ns
Unsupervised RClust5 1 2+ 0.00-0.290.63 p=0.733 ns
Unsupervised RClust7 1 2+ 0.00-0.230.52 p=0.733 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.580.96 p=0.912 ns
Antigen Specific FHA 1 2+ 0.00-0.261.67 p=0.551 ns
Antigen Specific PRN 1 2+ 0.00-0.960.98 p=0.987 ns
Antigen Specific PT 1 2+ 0.00-1.420.33 p=0.551 ns
Antigen Specific TT 1 2+ 0.00-0.271.15 p=0.551 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.571.17 p=0.912 ns
Unsupervised RClust2 1 2+ 0.00-0.710.58 p=0.918 ns
Unsupervised RClust3 1 2+ 0.00-0.151.60 p=0.551 ns
Unsupervised RClust4 1 2+ 0.00-0.711.08 p=0.912 ns
Unsupervised RClust5 1 2+ 0.00-1.340.32 p=0.551 ns
Unsupervised RClust6 1 2+ 0.00-0.640.83 p=0.918 ns
Unsupervised RClust7 1 2+ 0.00-0.541.03 p=0.912 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.550.53 p=0.965 ns
Antigen Specific FHA 1 2+ 0.00-0.270.68 p=0.761 ns
Antigen Specific PRN 1 2+ 0.00-0.710.26 p=0.761 ns
Antigen Specific PT 1 2+ 0.00-0.700.34 p=0.761 ns
Antigen Specific TT 1 2+ 0.00-0.420.67 p=0.779 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.540.40 p=0.843 ns
Unsupervised RClust2 1 2+ 0.00-0.270.74 p=0.761 ns
Unsupervised RClust3 1 2+ 0.00-0.210.66 p=0.761 ns
Unsupervised RClust4 1 2+ 0.00-0.750.18 p=0.761 ns
Unsupervised RClust5 1 2+ 0.00-0.250.56 p=0.761 ns
Unsupervised RClust6 1 2+ 0.00-0.200.81 p=0.761 ns
Unsupervised RClust7 1 2+ 0.00-0.630.39 p=0.779 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.580.96 p=0.926 ns
Antigen Specific FHA 1 2+ 0.00-0.261.67 p=0.505 ns
Antigen Specific PRN 1 2+ 0.00-0.960.98 p=0.987 ns
Antigen Specific PT 1 2+ 0.00-1.420.33 p=0.505 ns
Antigen Specific TT 1 2+ 0.00-0.271.15 p=0.505 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.571.17 p=0.919 ns
Unsupervised RClust2 1 2+ 0.00-0.710.58 p=0.926 ns
Unsupervised RClust3 1 2+ 0.00-0.311.75 p=0.505 ns
Unsupervised RClust4 1 2+ 0.00-0.711.08 p=0.926 ns
Unsupervised RClust5 1 2+ 0.00-1.340.32 p=0.505 ns
Unsupervised RClust6 1 2+ 0.00-0.640.83 p=0.926 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.550.53 p=0.965 ns
Antigen Specific FHA 1 2+ 0.00-0.270.68 p=0.762 ns
Antigen Specific PRN 1 2+ 0.00-0.710.26 p=0.762 ns
Antigen Specific PT 1 2+ 0.00-0.700.34 p=0.762 ns
Antigen Specific TT 1 2+ 0.00-0.420.67 p=0.794 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.540.40 p=0.850 ns
Unsupervised RClust2 1 2+ 0.00-0.270.74 p=0.762 ns
Unsupervised RClust3 1 2+ 0.00-0.840.45 p=0.762 ns
Unsupervised RClust4 1 2+ 0.00-0.750.18 p=0.762 ns
Unsupervised RClust5 1 2+ 0.00-0.250.56 p=0.762 ns
Unsupervised RClust6 1 2+ 0.00-0.200.81 p=0.762 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.700.44 p>0.999 ns
Antigen Specific FHA 1 2+ 0.00-0.840.68 p>0.999 ns
Antigen Specific PRN 1 2+ 0.00-1.100.23 p>0.999 ns
Antigen Specific PT 1 2+ 0.00-0.900.44 p>0.999 ns
Antigen Specific TT 1 2+ 0.00-0.700.47 p>0.999 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.901.01 p>0.999 ns
Unsupervised RClust2 1 2+ 0.00-0.390.94 p>0.999 ns
Unsupervised RClust3 1 2+ 0.00-0.910.91 p>0.999 ns
Unsupervised RClust4 1 2+ 0.00-0.481.08 p>0.999 ns
Unsupervised RClust5 1 2+ 0.00-0.590.46 p>0.999 ns
Unsupervised RClust6 1 2+ 0.00-0.640.71 p>0.999 ns
Unsupervised RClust7 1 2+ 0.00-0.890.57 p>0.999 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.570.55 p=0.995 ns
Antigen Specific FHA 1 2+ 0.00-0.700.36 p=0.791 ns
Antigen Specific PRN 1 2+ 0.00-1.020.07 p=0.791 ns
Antigen Specific PT 1 2+ 0.00-0.300.77 p=0.791 ns
Antigen Specific TT 1 2+ 0.00-0.760.32 p=0.791 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.791 ns
Unsupervised RClust2 1 2+ 0.00-0.620.29 p=0.791 ns
Unsupervised RClust3 1 2+ 0.00-0.390.77 p=0.791 ns
Unsupervised RClust4 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.390.25 p=0.874 ns
Unsupervised RClust6 1 2+ 0.00-0.400.40 p=0.995 ns
Unsupervised RClust7 1 2+ 0.00-0.300.62 p=0.791 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.700.44 p>0.999 ns
Antigen Specific FHA 1 2+ 0.00-0.840.68 p>0.999 ns
Antigen Specific PRN 1 2+ 0.00-1.100.23 p>0.999 ns
Antigen Specific PT 1 2+ 0.00-0.900.44 p>0.999 ns
Antigen Specific TT 1 2+ 0.00-0.700.47 p>0.999 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.901.01 p>0.999 ns
Unsupervised RClust2 1 2+ 0.00-0.390.94 p>0.999 ns
Unsupervised RClust3 1 2+ 0.00-0.910.91 p>0.999 ns
Unsupervised RClust4 1 2+ 0.00-0.481.08 p>0.999 ns
Unsupervised RClust5 1 2+ 0.00-0.970.61 p>0.999 ns
Unsupervised RClust6 1 2+ 0.00-0.640.71 p>0.999 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.570.55 p=0.995 ns
Antigen Specific FHA 1 2+ 0.00-0.700.36 p=0.725 ns
Antigen Specific PRN 1 2+ 0.00-1.020.07 p=0.725 ns
Antigen Specific PT 1 2+ 0.00-0.300.77 p=0.725 ns
Antigen Specific TT 1 2+ 0.00-0.760.32 p=0.725 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.725 ns
Unsupervised RClust2 1 2+ 0.00-0.620.29 p=0.725 ns
Unsupervised RClust3 1 2+ 0.00-0.390.77 p=0.725 ns
Unsupervised RClust4 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.300.69 p=0.725 ns
Unsupervised RClust6 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.380.79 p>0.999 ns
Antigen Specific FHA 1 2+ 0.00-0.850.67 p>0.999 ns
Antigen Specific PRN 1 2+ 0.00-1.110.23 p>0.999 ns
Antigen Specific PT 1 2+ 0.00-0.450.89 p>0.999 ns
Antigen Specific TT 1 2+ 0.00-0.550.64 p>0.999 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.120.85 p>0.999 ns
Unsupervised RClust2 1 2+ 0.00-0.940.39 p>0.999 ns
Unsupervised RClust3 1 2+ 0.00-0.910.91 p>0.999 ns
Unsupervised RClust4 1 2+ 0.00-0.221.35 p>0.999 ns
Unsupervised RClust5 1 2+ 0.00-0.970.61 p>0.999 ns
Unsupervised RClust6 1 2+ 0.00-0.710.64 p>0.999 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.610.52 p=0.995 ns
Antigen Specific FHA 1 2+ 0.00-0.530.55 p=0.995 ns
Antigen Specific PRN 1 2+ 0.00-1.020.06 p=0.910 ns
Antigen Specific PT 1 2+ 0.00-0.270.80 p=0.910 ns
Antigen Specific TT 1 2+ 0.00-0.880.24 p=0.910 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.990.55 p=0.910 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.910 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.910 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.977 ns
Unsupervised RClust5 1 2+ 0.00-0.690.30 p=0.910 ns
Unsupervised RClust6 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.380.79 p>0.999 ns
Antigen Specific FHA 1 2+ 0.00-0.850.67 p>0.999 ns
Antigen Specific PRN 1 2+ 0.00-1.110.23 p>0.999 ns
Antigen Specific PT 1 2+ 0.00-0.450.89 p>0.999 ns
Antigen Specific TT 1 2+ 0.00-0.550.64 p>0.999 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-1.010.90 p>0.999 ns
Unsupervised RClust2 1 2+ 0.00-0.940.39 p>0.999 ns
Unsupervised RClust3 1 2+ 0.00-0.910.91 p>0.999 ns
Unsupervised RClust4 1 2+ 0.00-0.221.35 p>0.999 ns
Unsupervised RClust5 1 2+ 0.00-1.080.48 p>0.999 ns
Unsupervised RClust6 1 2+ 0.00-0.970.61 p>0.999 ns
Unsupervised RClust7 1 2+ 0.00-0.710.64 p>0.999 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent Contrast estimate P-Value
Antigen Specific DT 1 2+ 0.00-0.610.52 p=0.995 ns
Antigen Specific FHA 1 2+ 0.00-0.550.53 p=0.995 ns
Antigen Specific PRN 1 2+ 0.00-1.020.06 p=0.904 ns
Antigen Specific PT 1 2+ 0.00-0.270.80 p=0.904 ns
Antigen Specific TT 1 2+ 0.00-0.880.24 p=0.904 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

gestational_age_at_vaccine

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.010.36 p=0.236 *
Antigen Specific FHA continuous 0.00-0.110.35 p=0.518 ns
Antigen Specific PRN continuous 0.00-0.210.30 p=0.876 ns
Antigen Specific PT continuous 0.000.000.45 p=0.236 ns
Antigen Specific TT continuous 0.00-0.330.06 p=0.369 ns
Unsupervised RClust1 continuous 0.00-0.120.25 p=0.736 ns
Unsupervised RClust2 continuous 0.000.010.41 p=0.236 ns
Unsupervised RClust3 continuous 0.00-0.030.31 p=0.369 ns
Unsupervised RClust4 continuous 0.00-0.190.27 p=0.876 ns
Unsupervised RClust5 continuous 0.00-0.200.23 p=0.884 ns
Unsupervised RClust6 continuous 0.00-0.120.14 p=0.884 ns
Unsupervised RClust7 continuous 0.00-0.290.05 p=0.369 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.21 p=0.446 ns
Antigen Specific FHA continuous 0.00-0.160.06 p=0.786 ns
Antigen Specific PRN continuous 0.00-0.110.12 p=0.921 ns
Antigen Specific PT continuous 0.00-0.070.14 p=0.795 ns
Antigen Specific TT continuous 0.00-0.180.14 p=0.912 ns
Unsupervised RClust1 continuous 0.00-0.110.17 p=0.872 ns
Unsupervised RClust2 continuous 0.00-0.080.03 p=0.786 ns
Unsupervised RClust3 continuous 0.00-0.200.08 p=0.786 ns
Unsupervised RClust4 continuous 0.00-0.200.02 p=0.446 ns
Unsupervised RClust5 continuous 0.00-0.29-0.05 p=0.084 **
Unsupervised RClust6 continuous 0.00-0.110.09 p=0.912 ns
Unsupervised RClust7 continuous 0.00-0.150.06 p=0.786 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.010.36 p=0.216 *
Antigen Specific FHA continuous 0.00-0.110.35 p=0.475 ns
Antigen Specific PRN continuous 0.00-0.210.30 p=0.869 ns
Antigen Specific PT continuous 0.000.000.45 p=0.216 ns
Antigen Specific TT continuous 0.00-0.330.06 p=0.339 ns
Unsupervised RClust1 continuous 0.00-0.210.27 p=0.869 ns
Unsupervised RClust2 continuous 0.000.010.41 p=0.216 ns
Unsupervised RClust3 continuous 0.00-0.030.31 p=0.339 ns
Unsupervised RClust4 continuous 0.00-0.190.27 p=0.869 ns
Unsupervised RClust5 continuous 0.00-0.120.14 p=0.872 ns
Unsupervised RClust6 continuous 0.00-0.290.05 p=0.339 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.210.02 p=0.614 ns
Antigen Specific FHA continuous 0.00-0.160.06 p=0.721 ns
Antigen Specific PRN continuous 0.00-0.110.12 p=0.921 ns
Antigen Specific PT continuous 0.00-0.140.07 p=0.729 ns
Antigen Specific TT continuous 0.00-0.140.18 p=0.919 ns
Unsupervised RClust1 continuous 0.00-0.050.30 p=0.638 ns
Unsupervised RClust2 continuous 0.00-0.080.03 p=0.721 ns
Unsupervised RClust3 continuous 0.00-0.200.08 p=0.721 ns
Unsupervised RClust4 continuous 0.00-0.200.02 p=0.614 ns
Unsupervised RClust5 continuous 0.00-0.110.09 p=0.919 ns
Unsupervised RClust6 continuous 0.00-0.150.06 p=0.721 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.130.15 p=0.899 ns
Antigen Specific FHA continuous 0.00-0.180.15 p=0.899 ns
Antigen Specific PRN continuous 0.00-0.180.08 p=0.817 ns
Antigen Specific PT continuous 0.00-0.070.27 p=0.817 ns
Antigen Specific TT continuous 0.00-0.120.19 p=0.899 ns
Unsupervised RClust1 continuous 0.00-0.370.17 p=0.817 ns
Unsupervised RClust3 continuous 0.00-0.140.12 p=0.899 ns
Unsupervised RClust4 continuous 0.00-0.290.07 p=0.817 ns
Unsupervised RClust5 continuous 0.00-0.080.22 p=0.817 ns
Unsupervised RClust7 continuous 0.00-0.070.18 p=0.817 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.180.07 p=0.907 ns
Antigen Specific FHA continuous 0.00-0.160.08 p=0.907 ns
Antigen Specific PRN continuous 0.00-0.280.04 p=0.491 ns
Antigen Specific PT continuous 0.00-0.090.16 p=0.907 ns
Antigen Specific TT continuous 0.00-0.140.19 p=0.907 ns
Unsupervised RClust1 continuous 0.00-0.130.17 p=0.907 ns
Unsupervised RClust3 continuous 0.00-0.090.11 p=0.907 ns
Unsupervised RClust4 continuous 0.00-0.150.15 p=0.988 ns
Unsupervised RClust5 continuous 0.00-0.210.00 p=0.349 ns
Unsupervised RClust7 continuous 0.00-0.190.00 p=0.349 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.130.15 p=0.899 ns
Antigen Specific FHA continuous 0.00-0.180.15 p=0.899 ns
Antigen Specific PRN continuous 0.00-0.180.08 p=0.817 ns
Antigen Specific PT continuous 0.00-0.070.27 p=0.817 ns
Antigen Specific TT continuous 0.00-0.120.19 p=0.899 ns
Unsupervised RClust1 continuous 0.00-0.370.17 p=0.817 ns
Unsupervised RClust2 continuous 0.00-0.290.02 p=0.817 ns
Unsupervised RClust3 continuous 0.00-0.140.12 p=0.899 ns
Unsupervised RClust4 continuous 0.00-0.290.07 p=0.817 ns
Unsupervised RClust6 continuous 0.00-0.070.18 p=0.817 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.180.07 p=0.907 ns
Antigen Specific FHA continuous 0.00-0.160.08 p=0.907 ns
Antigen Specific PRN continuous 0.00-0.280.04 p=0.491 ns
Antigen Specific PT continuous 0.00-0.090.16 p=0.907 ns
Antigen Specific TT continuous 0.00-0.140.19 p=0.907 ns
Unsupervised RClust1 continuous 0.00-0.130.17 p=0.907 ns
Unsupervised RClust2 continuous 0.000.020.29 p=0.263 *
Unsupervised RClust3 continuous 0.00-0.090.11 p=0.907 ns
Unsupervised RClust4 continuous 0.00-0.150.15 p=0.988 ns
Unsupervised RClust6 continuous 0.00-0.190.00 p=0.349 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.130.15 p=0.901 ns
Antigen Specific FHA continuous 0.00-0.150.18 p=0.901 ns
Antigen Specific PRN continuous 0.00-0.080.18 p=0.899 ns
Antigen Specific PT continuous 0.00-0.270.07 p=0.726 ns
Antigen Specific TT continuous 0.00-0.190.13 p=0.901 ns
Unsupervised RClust1 continuous 0.00-0.370.17 p=0.899 ns
Unsupervised RClust2 continuous 0.00-0.290.02 p=0.488 ns
Unsupervised RClust3 continuous 0.00-0.120.14 p=0.901 ns
Unsupervised RClust4 continuous 0.00-0.140.21 p=0.901 ns
Unsupervised RClust5 continuous 0.00-0.070.29 p=0.726 ns
Unsupervised RClust6 continuous 0.00-0.26-0.04 p=0.129 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.18 p=0.903 ns
Antigen Specific FHA continuous 0.00-0.080.16 p=0.903 ns
Antigen Specific PRN continuous 0.00-0.290.04 p=0.785 ns
Antigen Specific PT continuous 0.00-0.090.17 p=0.903 ns
Antigen Specific TT continuous 0.00-0.190.15 p=0.903 ns
Unsupervised RClust1 continuous 0.00-0.170.13 p=0.903 ns
Unsupervised RClust2 continuous 0.00-0.29-0.02 p=0.289 *
Unsupervised RClust3 continuous 0.00-0.090.11 p=0.903 ns
Unsupervised RClust4 continuous 0.00-0.080.12 p=0.903 ns
Unsupervised RClust5 continuous 0.00-0.150.15 p=0.988 ns
Unsupervised RClust6 continuous 0.00-0.070.17 p=0.903 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.130.15 p=0.901 ns
Antigen Specific FHA continuous 0.00-0.150.18 p=0.901 ns
Antigen Specific PRN continuous 0.00-0.080.18 p=0.899 ns
Antigen Specific PT continuous 0.00-0.270.07 p=0.726 ns
Antigen Specific TT continuous 0.00-0.190.13 p=0.901 ns
Unsupervised RClust1 continuous 0.00-0.370.17 p=0.899 ns
Unsupervised RClust2 continuous 0.00-0.290.02 p=0.488 ns
Unsupervised RClust3 continuous 0.00-0.120.14 p=0.901 ns
Unsupervised RClust4 continuous 0.00-0.140.21 p=0.901 ns
Unsupervised RClust5 continuous 0.00-0.070.29 p=0.726 ns
Unsupervised RClust7 continuous 0.00-0.24-0.02 p=0.301 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.18 p=0.903 ns
Antigen Specific FHA continuous 0.00-0.080.16 p=0.903 ns
Antigen Specific PRN continuous 0.00-0.290.04 p=0.785 ns
Antigen Specific PT continuous 0.00-0.090.17 p=0.903 ns
Antigen Specific TT continuous 0.00-0.190.15 p=0.903 ns
Unsupervised RClust1 continuous 0.00-0.170.13 p=0.903 ns
Unsupervised RClust2 continuous 0.00-0.29-0.02 p=0.289 *
Unsupervised RClust3 continuous 0.00-0.090.11 p=0.903 ns
Unsupervised RClust4 continuous 0.00-0.080.12 p=0.903 ns
Unsupervised RClust5 continuous 0.00-0.150.15 p=0.988 ns
Unsupervised RClust7 continuous 0.00-0.090.12 p=0.903 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.230.20 p=0.993 ns
Antigen Specific FHA continuous 0.00-0.450.11 p=0.726 ns
Antigen Specific PRN continuous 0.00-0.450.10 p=0.726 ns
Antigen Specific PT continuous 0.00-0.200.20 p=0.993 ns
Antigen Specific TT continuous 0.00-0.060.34 p=0.726 ns
Unsupervised RClust1 continuous 0.00-0.150.38 p=0.783 ns
Unsupervised RClust2 continuous 0.00-0.210.20 p=0.993 ns
Unsupervised RClust3 continuous 0.00-0.420.08 p=0.726 ns
Unsupervised RClust4 continuous 0.00-0.120.32 p=0.783 ns
Unsupervised RClust5 continuous 0.00-0.150.22 p=0.976 ns
Unsupervised RClust6 continuous 0.00-0.270.19 p=0.976 ns
Unsupervised RClust7 continuous 0.00-0.170.31 p=0.976 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.060.17 p=0.827 ns
Antigen Specific FHA continuous 0.00-0.120.13 p=0.934 ns
Antigen Specific PRN continuous 0.00-0.080.19 p=0.827 ns
Antigen Specific PT continuous 0.00-0.230.10 p=0.827 ns
Antigen Specific TT continuous 0.00-0.080.25 p=0.827 ns
Unsupervised RClust1 continuous 0.00-0.160.11 p=0.841 ns
Unsupervised RClust2 continuous 0.00-0.140.19 p=0.841 ns
Unsupervised RClust3 continuous 0.00-0.010.11 p=0.827 ns
Unsupervised RClust4 continuous 0.00-0.030.11 p=0.827 ns
Unsupervised RClust5 continuous 0.00-0.090.17 p=0.827 ns
Unsupervised RClust6 continuous 0.00-0.180.10 p=0.827 ns
Unsupervised RClust7 continuous 0.00-0.150.10 p=0.841 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.230.20 p=0.993 ns
Antigen Specific FHA continuous 0.00-0.450.11 p=0.861 ns
Antigen Specific PRN continuous 0.00-0.450.10 p=0.861 ns
Antigen Specific PT continuous 0.00-0.200.20 p=0.993 ns
Antigen Specific TT continuous 0.00-0.060.34 p=0.861 ns
Unsupervised RClust1 continuous 0.00-0.150.38 p=0.861 ns
Unsupervised RClust2 continuous 0.00-0.210.20 p=0.993 ns
Unsupervised RClust3 continuous 0.00-0.400.22 p=0.993 ns
Unsupervised RClust4 continuous 0.00-0.120.32 p=0.861 ns
Unsupervised RClust5 continuous 0.00-0.150.22 p=0.993 ns
Unsupervised RClust6 continuous 0.00-0.270.19 p=0.993 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.060.17 p=0.758 ns
Antigen Specific FHA continuous 0.00-0.120.13 p=0.934 ns
Antigen Specific PRN continuous 0.00-0.080.19 p=0.758 ns
Antigen Specific PT continuous 0.00-0.230.10 p=0.758 ns
Antigen Specific TT continuous 0.00-0.080.25 p=0.758 ns
Unsupervised RClust1 continuous 0.00-0.160.11 p=0.848 ns
Unsupervised RClust2 continuous 0.00-0.140.19 p=0.848 ns
Unsupervised RClust3 continuous 0.00-0.020.36 p=0.758 ns
Unsupervised RClust4 continuous 0.00-0.030.11 p=0.758 ns
Unsupervised RClust5 continuous 0.00-0.090.17 p=0.758 ns
Unsupervised RClust6 continuous 0.00-0.180.10 p=0.758 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.120.15 p=0.991 ns
Antigen Specific FHA continuous 0.00-0.420.06 p=0.991 ns
Antigen Specific PRN continuous 0.00-0.210.22 p=0.991 ns
Antigen Specific PT continuous 0.00-0.130.21 p=0.991 ns
Antigen Specific TT continuous 0.00-0.230.11 p=0.991 ns
Unsupervised RClust1 continuous 0.00-0.290.24 p=0.991 ns
Unsupervised RClust2 continuous 0.00-0.170.26 p=0.991 ns
Unsupervised RClust3 continuous 0.00-0.110.44 p=0.991 ns
Unsupervised RClust4 continuous 0.00-0.180.20 p=0.991 ns
Unsupervised RClust5 continuous 0.00-0.170.11 p=0.991 ns
Unsupervised RClust6 continuous 0.00-0.170.18 p=0.991 ns
Unsupervised RClust7 continuous 0.00-0.230.24 p=0.991 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.210.11 p=0.788 ns
Antigen Specific FHA continuous 0.00-0.110.14 p=0.942 ns
Antigen Specific PRN continuous 0.00-0.080.24 p=0.752 ns
Antigen Specific PT continuous 0.00-0.120.22 p=0.788 ns
Antigen Specific TT continuous 0.00-0.120.11 p=0.942 ns
Unsupervised RClust1 continuous 0.00-0.140.08 p=0.788 ns
Unsupervised RClust2 continuous 0.00-0.020.25 p=0.699 ns
Unsupervised RClust3 continuous 0.00-0.060.21 p=0.752 ns
Unsupervised RClust4 continuous 0.00-0.070.16 p=0.788 ns
Unsupervised RClust5 continuous 0.00-0.100.09 p=0.942 ns
Unsupervised RClust6 continuous 0.00-0.040.15 p=0.752 ns
Unsupervised RClust7 continuous 0.00-0.230.00 p=0.675 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.120.15 p=0.979 ns
Antigen Specific FHA continuous 0.00-0.420.06 p=0.979 ns
Antigen Specific PRN continuous 0.00-0.210.22 p=0.979 ns
Antigen Specific PT continuous 0.00-0.130.21 p=0.979 ns
Antigen Specific TT continuous 0.00-0.230.11 p=0.979 ns
Unsupervised RClust1 continuous 0.00-0.290.24 p=0.979 ns
Unsupervised RClust2 continuous 0.00-0.170.26 p=0.979 ns
Unsupervised RClust3 continuous 0.00-0.110.44 p=0.979 ns
Unsupervised RClust4 continuous 0.00-0.180.20 p=0.979 ns
Unsupervised RClust5 continuous 0.00-0.250.22 p=0.979 ns
Unsupervised RClust6 continuous 0.00-0.170.18 p=0.979 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.210.11 p=0.722 ns
Antigen Specific FHA continuous 0.00-0.110.14 p=0.916 ns
Antigen Specific PRN continuous 0.00-0.080.24 p=0.722 ns
Antigen Specific PT continuous 0.00-0.120.22 p=0.722 ns
Antigen Specific TT continuous 0.00-0.120.11 p=0.942 ns
Unsupervised RClust1 continuous 0.00-0.140.08 p=0.722 ns
Unsupervised RClust2 continuous 0.00-0.020.25 p=0.722 ns
Unsupervised RClust3 continuous 0.00-0.060.21 p=0.722 ns
Unsupervised RClust4 continuous 0.00-0.070.16 p=0.722 ns
Unsupervised RClust5 continuous 0.00-0.080.22 p=0.722 ns
Unsupervised RClust6 continuous 0.00-0.040.15 p=0.722 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.190.13 p=0.995 ns
Antigen Specific FHA continuous 0.00-0.420.06 p=0.995 ns
Antigen Specific PRN continuous 0.00-0.220.22 p=0.995 ns
Antigen Specific PT continuous 0.00-0.210.13 p=0.995 ns
Antigen Specific TT continuous 0.00-0.190.16 p=0.995 ns
Unsupervised RClust1 continuous 0.00-0.260.28 p=0.995 ns
Unsupervised RClust2 continuous 0.00-0.260.17 p=0.995 ns
Unsupervised RClust3 continuous 0.00-0.110.44 p=0.995 ns
Unsupervised RClust4 continuous 0.00-0.160.37 p=0.995 ns
Unsupervised RClust5 continuous 0.00-0.250.22 p=0.995 ns
Unsupervised RClust6 continuous 0.00-0.180.17 p=0.995 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.190.13 p=0.840 ns
Antigen Specific FHA continuous 0.00-0.140.14 p=0.998 ns
Antigen Specific PRN continuous 0.00-0.080.24 p=0.630 ns
Antigen Specific PT continuous 0.00-0.130.23 p=0.791 ns
Antigen Specific TT continuous 0.00-0.190.05 p=0.630 ns
Unsupervised RClust1 continuous 0.00-0.220.16 p=0.840 ns
Unsupervised RClust2 continuous 0.00-0.250.02 p=0.630 ns
Unsupervised RClust3 continuous 0.00-0.210.06 p=0.630 ns
Unsupervised RClust4 continuous 0.00-0.120.05 p=0.658 ns
Unsupervised RClust5 continuous 0.00-0.220.08 p=0.630 ns
Unsupervised RClust6 continuous 0.00-0.040.15 p=0.630 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.190.13 p=0.995 ns
Antigen Specific FHA continuous 0.00-0.420.06 p=0.995 ns
Antigen Specific PRN continuous 0.00-0.220.22 p=0.995 ns
Antigen Specific PT continuous 0.00-0.210.13 p=0.995 ns
Antigen Specific TT continuous 0.00-0.190.16 p=0.995 ns
Unsupervised RClust1 continuous 0.00-0.240.29 p=0.995 ns
Unsupervised RClust2 continuous 0.00-0.260.17 p=0.995 ns
Unsupervised RClust3 continuous 0.00-0.110.44 p=0.995 ns
Unsupervised RClust4 continuous 0.00-0.160.37 p=0.995 ns
Unsupervised RClust5 continuous 0.00-0.200.18 p=0.995 ns
Unsupervised RClust6 continuous 0.00-0.250.22 p=0.995 ns
Unsupervised RClust7 continuous 0.00-0.180.17 p=0.995 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.190.13 p=0.752 ns
Antigen Specific FHA continuous 0.00-0.140.14 p=0.998 ns
Antigen Specific PRN continuous 0.00-0.080.24 p=0.667 ns
Antigen Specific PT continuous 0.00-0.130.23 p=0.709 ns
Antigen Specific TT continuous 0.00-0.190.05 p=0.667 ns
Unsupervised RClust1 continuous 0.00-0.140.08 p=0.709 ns
Unsupervised RClust2 continuous 0.00-0.250.02 p=0.667 ns
Unsupervised RClust3 continuous 0.00-0.210.06 p=0.667 ns
Unsupervised RClust4 continuous 0.00-0.120.05 p=0.667 ns
Unsupervised RClust5 continuous 0.00-0.070.16 p=0.667 ns
Unsupervised RClust6 continuous 0.00-0.220.08 p=0.667 ns
Unsupervised RClust7 continuous 0.00-0.040.15 p=0.667 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

infant_interval_between_vaccination_and_delivery_days

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.04 p=0.669 ns
Antigen Specific FHA continuous 0.000.000.07 p=0.258 ns
Antigen Specific PRN continuous 0.00-0.08-0.01 p=0.146 *
Antigen Specific PT continuous 0.00-0.060.01 p=0.310 ns
Antigen Specific TT continuous 0.000.000.05 p=0.258 ns
Unsupervised RClust1 continuous 0.00-0.010.05 p=0.276 ns
Unsupervised RClust2 continuous 0.00-0.050.01 p=0.337 ns
Unsupervised RClust3 continuous 0.00-0.010.04 p=0.301 ns
Unsupervised RClust4 continuous 0.00-0.07-0.01 p=0.146 *
Unsupervised RClust5 continuous 0.00-0.060.01 p=0.276 ns
Unsupervised RClust6 continuous 0.00-0.020.02 p=0.800 ns
Unsupervised RClust7 continuous 0.00-0.020.03 p=0.800 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.02 p=0.984 ns
Antigen Specific FHA continuous 0.00-0.020.01 p=0.779 ns
Antigen Specific PRN continuous 0.00-0.010.03 p=0.779 ns
Antigen Specific PT continuous 0.00-0.020.02 p=0.984 ns
Antigen Specific TT continuous 0.00-0.020.03 p=0.984 ns
Unsupervised RClust1 continuous 0.00-0.010.03 p=0.779 ns
Unsupervised RClust2 continuous 0.000.000.01 p=0.779 ns
Unsupervised RClust3 continuous 0.00-0.030.02 p=0.984 ns
Unsupervised RClust4 continuous 0.000.000.03 p=0.613 ns
Unsupervised RClust5 continuous 0.00-0.010.03 p=0.779 ns
Unsupervised RClust6 continuous 0.00-0.020.02 p=0.984 ns
Unsupervised RClust7 continuous 0.00-0.020.02 p=0.984 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.04 p=0.682 ns
Antigen Specific FHA continuous 0.000.000.07 p=0.189 ns
Antigen Specific PRN continuous 0.00-0.08-0.01 p=0.133 *
Antigen Specific PT continuous 0.00-0.060.01 p=0.324 ns
Antigen Specific TT continuous 0.000.000.05 p=0.189 ns
Unsupervised RClust1 continuous 0.000.000.07 p=0.189 ns
Unsupervised RClust2 continuous 0.00-0.050.01 p=0.348 ns
Unsupervised RClust3 continuous 0.00-0.010.04 p=0.322 ns
Unsupervised RClust4 continuous 0.00-0.07-0.01 p=0.133 *
Unsupervised RClust5 continuous 0.00-0.020.02 p=0.800 ns
Unsupervised RClust6 continuous 0.00-0.020.03 p=0.800 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.02 p=0.984 ns
Antigen Specific FHA continuous 0.00-0.020.01 p=0.960 ns
Antigen Specific PRN continuous 0.00-0.010.03 p=0.960 ns
Antigen Specific PT continuous 0.00-0.020.02 p=0.984 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.984 ns
Unsupervised RClust1 continuous 0.00-0.030.03 p=0.984 ns
Unsupervised RClust2 continuous 0.000.000.01 p=0.960 ns
Unsupervised RClust3 continuous 0.00-0.030.02 p=0.984 ns
Unsupervised RClust4 continuous 0.000.000.03 p=0.562 ns
Unsupervised RClust5 continuous 0.00-0.020.02 p=0.984 ns
Unsupervised RClust6 continuous 0.00-0.020.02 p=0.984 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.932 ns
Antigen Specific FHA continuous 0.00-0.040.01 p=0.932 ns
Antigen Specific PRN continuous 0.00-0.020.02 p=0.932 ns
Antigen Specific PT continuous 0.00-0.040.01 p=0.932 ns
Antigen Specific TT continuous 0.00-0.020.03 p=0.932 ns
Unsupervised RClust1 continuous 0.00-0.040.04 p=0.949 ns
Unsupervised RClust3 continuous 0.00-0.020.02 p=0.932 ns
Unsupervised RClust4 continuous 0.00-0.030.02 p=0.932 ns
Unsupervised RClust5 continuous 0.00-0.020.03 p=0.932 ns
Unsupervised RClust7 continuous 0.00-0.030.01 p=0.932 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.851 ns
Antigen Specific FHA continuous 0.00-0.030.01 p=0.851 ns
Antigen Specific PRN continuous 0.00-0.010.04 p=0.851 ns
Antigen Specific PT continuous 0.00-0.030.01 p=0.851 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.984 ns
Unsupervised RClust1 continuous 0.00-0.020.02 p=0.984 ns
Unsupervised RClust3 continuous 0.00-0.020.02 p=0.984 ns
Unsupervised RClust4 continuous 0.00-0.020.03 p=0.984 ns
Unsupervised RClust5 continuous 0.00-0.010.02 p=0.851 ns
Unsupervised RClust7 continuous 0.000.000.03 p=0.130 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.920 ns
Antigen Specific FHA continuous 0.00-0.040.01 p=0.920 ns
Antigen Specific PRN continuous 0.00-0.020.02 p=0.932 ns
Antigen Specific PT continuous 0.00-0.040.01 p=0.920 ns
Antigen Specific TT continuous 0.00-0.020.03 p=0.932 ns
Unsupervised RClust1 continuous 0.00-0.040.04 p=0.949 ns
Unsupervised RClust2 continuous 0.00-0.010.03 p=0.920 ns
Unsupervised RClust3 continuous 0.00-0.020.02 p=0.932 ns
Unsupervised RClust4 continuous 0.00-0.030.02 p=0.932 ns
Unsupervised RClust6 continuous 0.00-0.030.01 p=0.920 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.851 ns
Antigen Specific FHA continuous 0.00-0.030.01 p=0.851 ns
Antigen Specific PRN continuous 0.00-0.010.04 p=0.851 ns
Antigen Specific PT continuous 0.00-0.030.01 p=0.851 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.984 ns
Unsupervised RClust1 continuous 0.00-0.020.02 p=0.984 ns
Unsupervised RClust2 continuous 0.00-0.05-0.01 p=0.040 **
Unsupervised RClust3 continuous 0.00-0.020.02 p=0.984 ns
Unsupervised RClust4 continuous 0.00-0.020.03 p=0.984 ns
Unsupervised RClust6 continuous 0.000.000.03 p=0.065 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.775 ns
Antigen Specific FHA continuous 0.00-0.010.04 p=0.809 ns
Antigen Specific PRN continuous 0.00-0.020.02 p=0.949 ns
Antigen Specific PT continuous 0.00-0.010.04 p=0.693 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.949 ns
Unsupervised RClust1 continuous 0.00-0.040.04 p=0.949 ns
Unsupervised RClust2 continuous 0.00-0.010.03 p=0.809 ns
Unsupervised RClust3 continuous 0.00-0.020.02 p=0.949 ns
Unsupervised RClust4 continuous 0.000.000.05 p=0.459 ns
Unsupervised RClust5 continuous 0.00-0.020.03 p=0.949 ns
Unsupervised RClust6 continuous 0.000.000.03 p=0.459 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.03 p=0.924 ns
Antigen Specific FHA continuous 0.00-0.010.03 p=0.924 ns
Antigen Specific PRN continuous 0.00-0.010.04 p=0.924 ns
Antigen Specific PT continuous 0.00-0.030.01 p=0.924 ns
Antigen Specific TT continuous 0.00-0.020.03 p=0.984 ns
Unsupervised RClust1 continuous 0.00-0.020.02 p=0.984 ns
Unsupervised RClust2 continuous 0.000.010.05 p=0.044 **
Unsupervised RClust3 continuous 0.00-0.020.02 p=0.984 ns
Unsupervised RClust4 continuous 0.00-0.020.01 p=0.924 ns
Unsupervised RClust5 continuous 0.00-0.020.03 p=0.984 ns
Unsupervised RClust6 continuous 0.00-0.010.02 p=0.984 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.01 p=0.775 ns
Antigen Specific FHA continuous 0.00-0.010.04 p=0.809 ns
Antigen Specific PRN continuous 0.00-0.020.02 p=0.949 ns
Antigen Specific PT continuous 0.00-0.010.04 p=0.693 ns
Antigen Specific TT continuous 0.00-0.030.02 p=0.949 ns
Unsupervised RClust1 continuous 0.00-0.040.04 p=0.949 ns
Unsupervised RClust2 continuous 0.00-0.010.03 p=0.809 ns
Unsupervised RClust3 continuous 0.00-0.020.02 p=0.949 ns
Unsupervised RClust4 continuous 0.000.000.05 p=0.459 ns
Unsupervised RClust5 continuous 0.00-0.020.03 p=0.949 ns
Unsupervised RClust7 continuous 0.000.000.03 p=0.459 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.03 p=0.792 ns
Antigen Specific FHA continuous 0.00-0.010.03 p=0.792 ns
Antigen Specific PRN continuous 0.00-0.010.04 p=0.792 ns
Antigen Specific PT continuous 0.00-0.030.01 p=0.792 ns
Antigen Specific TT continuous 0.00-0.020.03 p=0.984 ns
Unsupervised RClust1 continuous 0.00-0.020.02 p=0.984 ns
Unsupervised RClust2 continuous 0.000.010.05 p=0.044 **
Unsupervised RClust3 continuous 0.00-0.020.02 p=0.984 ns
Unsupervised RClust4 continuous 0.00-0.020.01 p=0.792 ns
Unsupervised RClust5 continuous 0.00-0.020.03 p=0.984 ns
Unsupervised RClust7 continuous 0.00-0.020.01 p=0.792 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.02 p=0.924 ns
Antigen Specific FHA continuous 0.00-0.040.05 p=0.924 ns
Antigen Specific PRN continuous 0.00-0.010.07 p=0.562 ns
Antigen Specific PT continuous 0.00-0.060.01 p=0.562 ns
Antigen Specific TT continuous 0.00-0.040.03 p=0.924 ns
Unsupervised RClust1 continuous 0.00-0.030.06 p=0.924 ns
Unsupervised RClust2 continuous 0.00-0.040.03 p=0.924 ns
Unsupervised RClust3 continuous 0.00-0.040.04 p=0.924 ns
Unsupervised RClust4 continuous 0.00-0.060.01 p=0.562 ns
Unsupervised RClust5 continuous 0.00-0.050.01 p=0.562 ns
Unsupervised RClust6 continuous 0.00-0.010.06 p=0.562 ns
Unsupervised RClust7 continuous 0.00-0.040.04 p=0.924 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.03 p=0.951 ns
Antigen Specific FHA continuous 0.00-0.020.02 p=0.951 ns
Antigen Specific PRN continuous 0.00-0.030.01 p=0.951 ns
Antigen Specific PT continuous 0.00-0.020.03 p=0.951 ns
Antigen Specific TT continuous 0.00-0.020.03 p=0.951 ns
Unsupervised RClust1 continuous 0.00-0.030.02 p=0.951 ns
Unsupervised RClust2 continuous 0.00-0.030.03 p=0.951 ns
Unsupervised RClust3 continuous 0.00-0.010.01 p=0.951 ns
Unsupervised RClust4 continuous 0.00-0.010.01 p=0.951 ns
Unsupervised RClust5 continuous 0.00-0.020.02 p=0.951 ns
Unsupervised RClust6 continuous 0.00-0.010.04 p=0.951 ns
Unsupervised RClust7 continuous 0.00-0.020.02 p=0.951 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.02 p=0.926 ns
Antigen Specific FHA continuous 0.00-0.040.05 p=0.939 ns
Antigen Specific PRN continuous 0.00-0.010.07 p=0.515 ns
Antigen Specific PT continuous 0.00-0.060.01 p=0.515 ns
Antigen Specific TT continuous 0.00-0.040.03 p=0.939 ns
Unsupervised RClust1 continuous 0.00-0.030.06 p=0.926 ns
Unsupervised RClust2 continuous 0.00-0.040.03 p=0.939 ns
Unsupervised RClust3 continuous 0.00-0.050.05 p=0.939 ns
Unsupervised RClust4 continuous 0.00-0.060.01 p=0.515 ns
Unsupervised RClust5 continuous 0.00-0.050.01 p=0.515 ns
Unsupervised RClust6 continuous 0.00-0.010.06 p=0.515 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.03 p=0.951 ns
Antigen Specific FHA continuous 0.00-0.020.02 p=0.951 ns
Antigen Specific PRN continuous 0.00-0.030.01 p=0.951 ns
Antigen Specific PT continuous 0.00-0.020.03 p=0.951 ns
Antigen Specific TT continuous 0.00-0.020.03 p=0.951 ns
Unsupervised RClust1 continuous 0.00-0.030.02 p=0.951 ns
Unsupervised RClust2 continuous 0.00-0.030.03 p=0.951 ns
Unsupervised RClust3 continuous 0.00-0.040.03 p=0.951 ns
Unsupervised RClust4 continuous 0.00-0.010.01 p=0.951 ns
Unsupervised RClust5 continuous 0.00-0.020.02 p=0.951 ns
Unsupervised RClust6 continuous 0.00-0.010.04 p=0.951 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.01 p=0.755 ns
Antigen Specific FHA continuous 0.00-0.040.03 p=0.886 ns
Antigen Specific PRN continuous 0.00-0.050.02 p=0.755 ns
Antigen Specific PT continuous 0.00-0.040.02 p=0.755 ns
Antigen Specific TT continuous 0.00-0.040.02 p=0.755 ns
Unsupervised RClust1 continuous 0.00-0.060.02 p=0.755 ns
Unsupervised RClust2 continuous 0.00-0.030.04 p=0.907 ns
Unsupervised RClust3 continuous 0.00-0.030.06 p=0.755 ns
Unsupervised RClust4 continuous 0.000.000.05 p=0.698 ns
Unsupervised RClust5 continuous 0.00-0.040.00 p=0.698 ns
Unsupervised RClust6 continuous 0.00-0.020.03 p=0.836 ns
Unsupervised RClust7 continuous 0.00-0.050.03 p=0.755 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.01 p=0.504 ns
Antigen Specific FHA continuous 0.00-0.020.02 p=0.964 ns
Antigen Specific PRN continuous 0.00-0.050.00 p=0.492 ns
Antigen Specific PT continuous 0.00-0.030.03 p=0.964 ns
Antigen Specific TT continuous 0.00-0.020.02 p=0.964 ns
Unsupervised RClust1 continuous 0.00-0.020.02 p=0.964 ns
Unsupervised RClust2 continuous 0.00-0.020.02 p=0.964 ns
Unsupervised RClust3 continuous 0.00-0.030.02 p=0.964 ns
Unsupervised RClust4 continuous 0.00-0.020.01 p=0.964 ns
Unsupervised RClust5 continuous 0.00-0.020.01 p=0.964 ns
Unsupervised RClust6 continuous 0.00-0.010.02 p=0.964 ns
Unsupervised RClust7 continuous 0.000.000.04 p=0.492 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.01 p=0.740 ns
Antigen Specific FHA continuous 0.00-0.040.03 p=0.893 ns
Antigen Specific PRN continuous 0.00-0.050.02 p=0.740 ns
Antigen Specific PT continuous 0.00-0.040.02 p=0.740 ns
Antigen Specific TT continuous 0.00-0.040.02 p=0.740 ns
Unsupervised RClust1 continuous 0.00-0.060.02 p=0.740 ns
Unsupervised RClust2 continuous 0.00-0.030.04 p=0.907 ns
Unsupervised RClust3 continuous 0.00-0.030.06 p=0.779 ns
Unsupervised RClust4 continuous 0.000.000.05 p=0.740 ns
Unsupervised RClust5 continuous 0.00-0.060.02 p=0.740 ns
Unsupervised RClust6 continuous 0.00-0.020.03 p=0.851 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.01 p=0.693 ns
Antigen Specific FHA continuous 0.00-0.020.02 p=0.964 ns
Antigen Specific PRN continuous 0.00-0.050.00 p=0.693 ns
Antigen Specific PT continuous 0.00-0.030.03 p=0.964 ns
Antigen Specific TT continuous 0.00-0.020.02 p=0.964 ns
Unsupervised RClust1 continuous 0.00-0.020.02 p=0.964 ns
Unsupervised RClust2 continuous 0.00-0.020.02 p=0.964 ns
Unsupervised RClust3 continuous 0.00-0.030.02 p=0.964 ns
Unsupervised RClust4 continuous 0.00-0.020.01 p=0.964 ns
Unsupervised RClust5 continuous 0.00-0.020.03 p=0.964 ns
Unsupervised RClust6 continuous 0.00-0.010.02 p=0.964 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.03 p=0.907 ns
Antigen Specific FHA continuous 0.00-0.040.03 p=0.907 ns
Antigen Specific PRN continuous 0.00-0.050.02 p=0.907 ns
Antigen Specific PT continuous 0.00-0.020.04 p=0.907 ns
Antigen Specific TT continuous 0.00-0.040.02 p=0.907 ns
Unsupervised RClust1 continuous 0.00-0.030.06 p=0.907 ns
Unsupervised RClust2 continuous 0.00-0.040.03 p=0.907 ns
Unsupervised RClust3 continuous 0.00-0.030.06 p=0.907 ns
Unsupervised RClust4 continuous 0.00-0.040.05 p=0.907 ns
Unsupervised RClust5 continuous 0.00-0.060.02 p=0.907 ns
Unsupervised RClust6 continuous 0.00-0.030.02 p=0.907 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.050.00 p=0.326 ns
Antigen Specific FHA continuous 0.00-0.020.02 p=0.957 ns
Antigen Specific PRN continuous 0.00-0.050.00 p=0.326 ns
Antigen Specific PT continuous 0.00-0.030.03 p=0.957 ns
Antigen Specific TT continuous 0.00-0.020.02 p=0.957 ns
Unsupervised RClust1 continuous 0.00-0.060.00 p=0.326 ns
Unsupervised RClust2 continuous 0.00-0.020.02 p=0.957 ns
Unsupervised RClust3 continuous 0.00-0.020.03 p=0.957 ns
Unsupervised RClust4 continuous 0.000.000.02 p=0.461 ns
Unsupervised RClust5 continuous 0.00-0.030.02 p=0.957 ns
Unsupervised RClust6 continuous 0.00-0.010.02 p=0.957 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.020.03 p=0.850 ns
Antigen Specific FHA continuous 0.00-0.040.03 p=0.907 ns
Antigen Specific PRN continuous 0.00-0.050.02 p=0.850 ns
Antigen Specific PT continuous 0.00-0.020.04 p=0.850 ns
Antigen Specific TT continuous 0.00-0.040.02 p=0.850 ns
Unsupervised RClust1 continuous 0.00-0.020.06 p=0.850 ns
Unsupervised RClust2 continuous 0.00-0.040.03 p=0.907 ns
Unsupervised RClust3 continuous 0.00-0.030.06 p=0.850 ns
Unsupervised RClust4 continuous 0.00-0.040.05 p=0.907 ns
Unsupervised RClust5 continuous 0.00-0.050.00 p=0.850 ns
Unsupervised RClust6 continuous 0.00-0.060.02 p=0.850 ns
Unsupervised RClust7 continuous 0.00-0.030.02 p=0.907 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.050.00 p=0.534 ns
Antigen Specific FHA continuous 0.00-0.020.02 p=0.957 ns
Antigen Specific PRN continuous 0.00-0.050.00 p=0.534 ns
Antigen Specific PT continuous 0.00-0.030.03 p=0.957 ns
Antigen Specific TT continuous 0.00-0.020.02 p=0.957 ns
Unsupervised RClust1 continuous 0.00-0.020.02 p=0.957 ns
Unsupervised RClust2 continuous 0.00-0.020.02 p=0.957 ns
Unsupervised RClust3 continuous 0.00-0.020.03 p=0.957 ns
Unsupervised RClust4 continuous 0.000.000.02 p=0.671 ns
Unsupervised RClust5 continuous 0.00-0.020.01 p=0.957 ns
Unsupervised RClust6 continuous 0.00-0.030.02 p=0.957 ns
Unsupervised RClust7 continuous 0.00-0.010.02 p=0.957 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

gestational_age_at_delivery

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.63 p=0.714 ns
Antigen Specific FHA continuous 0.00-0.600.25 p=0.732 ns
Antigen Specific PRN continuous 0.00-0.640.23 p=0.714 ns
Antigen Specific PT continuous 0.00-0.350.56 p=0.799 ns
Antigen Specific TT continuous 0.00-0.110.78 p=0.714 ns
Unsupervised RClust1 continuous 0.00-0.450.40 p=0.909 ns
Unsupervised RClust2 continuous 0.00-0.290.54 p=0.760 ns
Unsupervised RClust3 continuous 0.00-0.240.30 p=0.891 ns
Unsupervised RClust4 continuous 0.00-0.640.14 p=0.714 ns
Unsupervised RClust5 continuous 0.00-0.830.25 p=0.714 ns
Unsupervised RClust6 continuous 0.00-0.310.10 p=0.714 ns
Unsupervised RClust7 continuous 0.00-0.220.40 p=0.760 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.40 p=0.537 ns
Antigen Specific FHA continuous 0.00-0.290.17 p=0.729 ns
Antigen Specific PRN continuous 0.00-0.130.26 p=0.729 ns
Antigen Specific PT continuous 0.00-0.200.22 p=0.973 ns
Antigen Specific TT continuous 0.00-0.320.12 p=0.724 ns
Unsupervised RClust1 continuous 0.00-0.430.09 p=0.537 ns
Unsupervised RClust2 continuous 0.00-0.090.18 p=0.729 ns
Unsupervised RClust3 continuous 0.00-0.56-0.12 p=0.043 **
Unsupervised RClust4 continuous 0.00-0.060.26 p=0.537 ns
Unsupervised RClust5 continuous 0.00-0.020.43 p=0.428 ns
Unsupervised RClust6 continuous 0.00-0.120.22 p=0.729 ns
Unsupervised RClust7 continuous 0.00-0.190.18 p=0.973 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.63 p=0.696 ns
Antigen Specific FHA continuous 0.00-0.600.25 p=0.696 ns
Antigen Specific PRN continuous 0.00-0.640.23 p=0.696 ns
Antigen Specific PT continuous 0.00-0.350.56 p=0.733 ns
Antigen Specific TT continuous 0.00-0.110.78 p=0.696 ns
Unsupervised RClust1 continuous 0.00-0.410.88 p=0.696 ns
Unsupervised RClust2 continuous 0.00-0.290.54 p=0.696 ns
Unsupervised RClust3 continuous 0.00-0.240.30 p=0.817 ns
Unsupervised RClust4 continuous 0.00-0.640.14 p=0.696 ns
Unsupervised RClust5 continuous 0.00-0.310.10 p=0.696 ns
Unsupervised RClust6 continuous 0.00-0.220.40 p=0.696 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.400.07 p=0.606 ns
Antigen Specific FHA continuous 0.00-0.290.17 p=0.742 ns
Antigen Specific PRN continuous 0.00-0.130.26 p=0.742 ns
Antigen Specific PT continuous 0.00-0.220.20 p=0.973 ns
Antigen Specific TT continuous 0.00-0.120.32 p=0.742 ns
Unsupervised RClust1 continuous 0.00-0.62-0.04 p=0.148 *
Unsupervised RClust2 continuous 0.00-0.090.18 p=0.742 ns
Unsupervised RClust3 continuous 0.00-0.56-0.12 p=0.039 **
Unsupervised RClust4 continuous 0.00-0.060.26 p=0.615 ns
Unsupervised RClust5 continuous 0.00-0.120.22 p=0.742 ns
Unsupervised RClust6 continuous 0.00-0.190.18 p=0.973 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.470.15 p=0.977 ns
Antigen Specific FHA continuous 0.00-0.280.45 p=0.977 ns
Antigen Specific PRN continuous 0.00-0.380.27 p=0.977 ns
Antigen Specific PT continuous 0.00-0.430.38 p=0.977 ns
Antigen Specific TT continuous 0.00-0.270.48 p=0.977 ns
Unsupervised RClust1 continuous 0.00-0.810.64 p=0.977 ns
Unsupervised RClust3 continuous 0.00-0.100.31 p=0.977 ns
Unsupervised RClust4 continuous 0.00-0.430.22 p=0.977 ns
Unsupervised RClust5 continuous 0.00-0.240.22 p=0.977 ns
Unsupervised RClust7 continuous 0.00-0.200.21 p=0.977 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.460.00 p=0.267 ns
Antigen Specific FHA continuous 0.00-0.310.15 p=0.723 ns
Antigen Specific PRN continuous 0.00-0.200.25 p=0.820 ns
Antigen Specific PT continuous 0.00-0.270.15 p=0.723 ns
Antigen Specific TT continuous 0.00-0.110.35 p=0.723 ns
Unsupervised RClust1 continuous 0.00-0.370.20 p=0.723 ns
Unsupervised RClust3 continuous 0.00-0.220.12 p=0.723 ns
Unsupervised RClust4 continuous 0.00-0.310.09 p=0.723 ns
Unsupervised RClust5 continuous 0.00-0.110.18 p=0.730 ns
Unsupervised RClust7 continuous 0.000.040.37 p=0.148 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.470.15 p=0.977 ns
Antigen Specific FHA continuous 0.00-0.280.45 p=0.977 ns
Antigen Specific PRN continuous 0.00-0.380.27 p=0.977 ns
Antigen Specific PT continuous 0.00-0.430.38 p=0.977 ns
Antigen Specific TT continuous 0.00-0.270.48 p=0.977 ns
Unsupervised RClust1 continuous 0.00-0.810.64 p=0.977 ns
Unsupervised RClust2 continuous 0.00-0.180.29 p=0.977 ns
Unsupervised RClust3 continuous 0.00-0.100.31 p=0.977 ns
Unsupervised RClust4 continuous 0.00-0.430.22 p=0.977 ns
Unsupervised RClust6 continuous 0.00-0.200.21 p=0.977 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.460.00 p=0.267 ns
Antigen Specific FHA continuous 0.00-0.310.15 p=0.643 ns
Antigen Specific PRN continuous 0.00-0.200.25 p=0.820 ns
Antigen Specific PT continuous 0.00-0.270.15 p=0.643 ns
Antigen Specific TT continuous 0.00-0.110.35 p=0.598 ns
Unsupervised RClust1 continuous 0.00-0.370.20 p=0.643 ns
Unsupervised RClust2 continuous 0.00-0.300.08 p=0.598 ns
Unsupervised RClust3 continuous 0.00-0.220.12 p=0.643 ns
Unsupervised RClust4 continuous 0.00-0.310.09 p=0.598 ns
Unsupervised RClust6 continuous 0.000.040.37 p=0.148 *

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.480.15 p=0.895 ns
Antigen Specific FHA continuous 0.00-0.450.28 p=0.895 ns
Antigen Specific PRN continuous 0.00-0.270.38 p=0.895 ns
Antigen Specific PT continuous 0.00-0.380.43 p=0.895 ns
Antigen Specific TT continuous 0.00-0.480.26 p=0.895 ns
Unsupervised RClust1 continuous 0.00-0.810.64 p=0.895 ns
Unsupervised RClust2 continuous 0.00-0.180.29 p=0.895 ns
Unsupervised RClust3 continuous 0.00-0.310.10 p=0.895 ns
Unsupervised RClust4 continuous 0.00-0.160.44 p=0.895 ns
Unsupervised RClust5 continuous 0.00-0.220.43 p=0.895 ns
Unsupervised RClust6 continuous 0.00-0.190.23 p=0.895 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.46 p=0.520 ns
Antigen Specific FHA continuous 0.00-0.150.31 p=0.645 ns
Antigen Specific PRN continuous 0.00-0.190.26 p=0.766 ns
Antigen Specific PT continuous 0.00-0.270.15 p=0.645 ns
Antigen Specific TT continuous 0.00-0.360.10 p=0.520 ns
Unsupervised RClust1 continuous 0.00-0.200.37 p=0.645 ns
Unsupervised RClust2 continuous 0.00-0.080.30 p=0.520 ns
Unsupervised RClust3 continuous 0.00-0.220.12 p=0.645 ns
Unsupervised RClust4 continuous 0.00-0.290.08 p=0.520 ns
Unsupervised RClust5 continuous 0.00-0.310.09 p=0.520 ns
Unsupervised RClust6 continuous 0.00-0.050.32 p=0.520 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.480.15 p=0.887 ns
Antigen Specific FHA continuous 0.00-0.450.28 p=0.887 ns
Antigen Specific PRN continuous 0.00-0.270.38 p=0.895 ns
Antigen Specific PT continuous 0.00-0.380.43 p=0.895 ns
Antigen Specific TT continuous 0.00-0.480.26 p=0.887 ns
Unsupervised RClust1 continuous 0.00-0.810.64 p=0.895 ns
Unsupervised RClust2 continuous 0.00-0.180.29 p=0.887 ns
Unsupervised RClust3 continuous 0.00-0.310.10 p=0.887 ns
Unsupervised RClust4 continuous 0.00-0.160.44 p=0.887 ns
Unsupervised RClust5 continuous 0.00-0.220.43 p=0.887 ns
Unsupervised RClust7 continuous 0.00-0.160.26 p=0.887 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.000.000.46 p=0.404 ns
Antigen Specific FHA continuous 0.00-0.150.31 p=0.645 ns
Antigen Specific PRN continuous 0.00-0.190.26 p=0.766 ns
Antigen Specific PT continuous 0.00-0.270.15 p=0.645 ns
Antigen Specific TT continuous 0.00-0.360.10 p=0.520 ns
Unsupervised RClust1 continuous 0.00-0.200.37 p=0.645 ns
Unsupervised RClust2 continuous 0.00-0.080.30 p=0.520 ns
Unsupervised RClust3 continuous 0.00-0.220.12 p=0.645 ns
Unsupervised RClust4 continuous 0.00-0.290.08 p=0.520 ns
Unsupervised RClust5 continuous 0.00-0.310.09 p=0.520 ns
Unsupervised RClust7 continuous 0.00-0.310.01 p=0.404 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.530.14 p=0.583 ns
Antigen Specific FHA continuous 0.00-0.280.58 p=0.583 ns
Antigen Specific PRN continuous 0.00-0.190.65 p=0.583 ns
Antigen Specific PT continuous 0.00-0.010.76 p=0.528 ns
Antigen Specific TT continuous 0.00-0.530.09 p=0.528 ns
Unsupervised RClust1 continuous 0.00-0.490.28 p=0.664 ns
Unsupervised RClust2 continuous 0.00-0.290.28 p=0.990 ns
Unsupervised RClust3 continuous 0.00-0.240.54 p=0.583 ns
Unsupervised RClust4 continuous 0.00-0.570.21 p=0.583 ns
Unsupervised RClust5 continuous 0.00-0.060.67 p=0.528 ns
Unsupervised RClust6 continuous 0.00-0.080.57 p=0.528 ns
Unsupervised RClust7 continuous 0.00-0.500.19 p=0.583 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.190.29 p=0.820 ns
Antigen Specific FHA continuous 0.00-0.060.35 p=0.455 ns
Antigen Specific PRN continuous 0.00-0.43-0.01 p=0.273 *
Antigen Specific PT continuous 0.00-0.080.38 p=0.455 ns
Antigen Specific TT continuous 0.00-0.240.23 p=0.970 ns
Unsupervised RClust1 continuous 0.00-0.220.20 p=0.970 ns
Unsupervised RClust2 continuous 0.00-0.400.04 p=0.443 ns
Unsupervised RClust3 continuous 0.00-0.47-0.11 p=0.030 **
Unsupervised RClust4 continuous 0.00-0.270.14 p=0.720 ns
Unsupervised RClust5 continuous 0.00-0.280.08 p=0.455 ns
Unsupervised RClust6 continuous 0.00-0.150.30 p=0.720 ns
Unsupervised RClust7 continuous 0.00-0.090.35 p=0.455 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.530.14 p=0.535 ns
Antigen Specific FHA continuous 0.00-0.280.58 p=0.668 ns
Antigen Specific PRN continuous 0.00-0.190.65 p=0.535 ns
Antigen Specific PT continuous 0.00-0.010.76 p=0.484 ns
Antigen Specific TT continuous 0.00-0.530.09 p=0.484 ns
Unsupervised RClust1 continuous 0.00-0.490.28 p=0.744 ns
Unsupervised RClust2 continuous 0.00-0.290.28 p=0.990 ns
Unsupervised RClust3 continuous 0.00-0.430.49 p=0.990 ns
Unsupervised RClust4 continuous 0.00-0.570.21 p=0.593 ns
Unsupervised RClust5 continuous 0.00-0.060.67 p=0.484 ns
Unsupervised RClust6 continuous 0.00-0.080.57 p=0.484 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.190.29 p=0.835 ns
Antigen Specific FHA continuous 0.00-0.060.35 p=0.553 ns
Antigen Specific PRN continuous 0.00-0.43-0.01 p=0.501 *
Antigen Specific PT continuous 0.00-0.080.38 p=0.553 ns
Antigen Specific TT continuous 0.00-0.240.23 p=0.970 ns
Unsupervised RClust1 continuous 0.00-0.220.20 p=0.970 ns
Unsupervised RClust2 continuous 0.00-0.400.04 p=0.553 ns
Unsupervised RClust3 continuous 0.00-0.420.15 p=0.650 ns
Unsupervised RClust4 continuous 0.00-0.270.14 p=0.742 ns
Unsupervised RClust5 continuous 0.00-0.280.08 p=0.584 ns
Unsupervised RClust6 continuous 0.00-0.150.30 p=0.742 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.280.22 p=0.880 ns
Antigen Specific FHA continuous 0.00-0.290.38 p=0.880 ns
Antigen Specific PRN continuous 0.00-0.210.38 p=0.880 ns
Antigen Specific PT continuous 0.00-0.040.55 p=0.720 ns
Antigen Specific TT continuous 0.00-0.300.22 p=0.880 ns
Unsupervised RClust1 continuous 0.00-0.450.39 p=0.880 ns
Unsupervised RClust2 continuous 0.00-0.440.14 p=0.880 ns
Unsupervised RClust3 continuous 0.00-0.450.35 p=0.880 ns
Unsupervised RClust4 continuous 0.00-0.110.57 p=0.720 ns
Unsupervised RClust5 continuous 0.00-0.310.15 p=0.880 ns
Unsupervised RClust6 continuous 0.00-0.320.27 p=0.880 ns
Unsupervised RClust7 continuous 0.00-0.570.07 p=0.720 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.380.11 p=0.532 ns
Antigen Specific FHA continuous 0.00-0.350.12 p=0.532 ns
Antigen Specific PRN continuous 0.00-0.53-0.07 p=0.082 *
Antigen Specific PT continuous 0.00-0.360.10 p=0.532 ns
Antigen Specific TT continuous 0.000.020.49 p=0.143 *
Unsupervised RClust1 continuous 0.00-0.50-0.09 p=0.069 **
Unsupervised RClust2 continuous 0.00-0.230.17 p=0.788 ns
Unsupervised RClust3 continuous 0.00-0.160.35 p=0.588 ns
Unsupervised RClust4 continuous 0.00-0.200.14 p=0.788 ns
Unsupervised RClust5 continuous 0.00-0.210.07 p=0.532 ns
Unsupervised RClust6 continuous 0.00-0.250.10 p=0.532 ns
Unsupervised RClust7 continuous 0.00-0.080.33 p=0.532 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.280.22 p=0.880 ns
Antigen Specific FHA continuous 0.00-0.290.38 p=0.880 ns
Antigen Specific PRN continuous 0.00-0.210.38 p=0.880 ns
Antigen Specific PT continuous 0.00-0.040.55 p=0.660 ns
Antigen Specific TT continuous 0.00-0.300.22 p=0.880 ns
Unsupervised RClust1 continuous 0.00-0.450.39 p=0.880 ns
Unsupervised RClust2 continuous 0.00-0.440.14 p=0.858 ns
Unsupervised RClust3 continuous 0.00-0.450.35 p=0.880 ns
Unsupervised RClust4 continuous 0.00-0.110.57 p=0.660 ns
Unsupervised RClust5 continuous 0.00-0.600.08 p=0.660 ns
Unsupervised RClust6 continuous 0.00-0.320.27 p=0.880 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.380.11 p=0.596 ns
Antigen Specific FHA continuous 0.00-0.350.12 p=0.596 ns
Antigen Specific PRN continuous 0.00-0.53-0.07 p=0.075 *
Antigen Specific PT continuous 0.00-0.360.10 p=0.596 ns
Antigen Specific TT continuous 0.000.020.49 p=0.131 *
Unsupervised RClust1 continuous 0.00-0.50-0.09 p=0.064 **
Unsupervised RClust2 continuous 0.00-0.230.17 p=0.788 ns
Unsupervised RClust3 continuous 0.00-0.160.35 p=0.662 ns
Unsupervised RClust4 continuous 0.00-0.200.14 p=0.788 ns
Unsupervised RClust5 continuous 0.00-0.290.15 p=0.662 ns
Unsupervised RClust6 continuous 0.00-0.250.10 p=0.627 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.320.19 p=0.868 ns
Antigen Specific FHA continuous 0.00-0.290.38 p=0.868 ns
Antigen Specific PRN continuous 0.00-0.200.39 p=0.868 ns
Antigen Specific PT continuous 0.00-0.540.04 p=0.791 ns
Antigen Specific TT continuous 0.00-0.400.12 p=0.858 ns
Unsupervised RClust1 continuous 0.00-0.480.38 p=0.868 ns
Unsupervised RClust2 continuous 0.00-0.140.44 p=0.858 ns
Unsupervised RClust3 continuous 0.00-0.450.35 p=0.868 ns
Unsupervised RClust4 continuous 0.00-0.480.22 p=0.868 ns
Unsupervised RClust5 continuous 0.00-0.600.08 p=0.791 ns
Unsupervised RClust6 continuous 0.00-0.270.32 p=0.868 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.390.11 p=0.588 ns
Antigen Specific FHA continuous 0.00-0.130.35 p=0.627 ns
Antigen Specific PRN continuous 0.00-0.53-0.06 p=0.163 *
Antigen Specific PT continuous 0.00-0.390.08 p=0.584 ns
Antigen Specific TT continuous 0.00-0.020.47 p=0.291 ns
Unsupervised RClust1 continuous 0.00-0.640.03 p=0.291 ns
Unsupervised RClust2 continuous 0.00-0.170.23 p=0.853 ns
Unsupervised RClust3 continuous 0.00-0.350.16 p=0.662 ns
Unsupervised RClust4 continuous 0.00-0.170.14 p=0.853 ns
Unsupervised RClust5 continuous 0.00-0.150.29 p=0.662 ns
Unsupervised RClust6 continuous 0.00-0.250.10 p=0.627 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.320.19 p=0.880 ns
Antigen Specific FHA continuous 0.00-0.290.38 p=0.880 ns
Antigen Specific PRN continuous 0.00-0.200.39 p=0.880 ns
Antigen Specific PT continuous 0.00-0.540.04 p=0.720 ns
Antigen Specific TT continuous 0.00-0.400.12 p=0.749 ns
Unsupervised RClust1 continuous 0.00-0.390.45 p=0.880 ns
Unsupervised RClust2 continuous 0.00-0.140.44 p=0.749 ns
Unsupervised RClust3 continuous 0.00-0.450.35 p=0.880 ns
Unsupervised RClust4 continuous 0.00-0.480.22 p=0.880 ns
Unsupervised RClust5 continuous 0.00-0.570.11 p=0.720 ns
Unsupervised RClust6 continuous 0.00-0.600.08 p=0.720 ns
Unsupervised RClust7 continuous 0.00-0.270.32 p=0.880 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.390.11 p=0.641 ns
Antigen Specific FHA continuous 0.00-0.350.13 p=0.684 ns
Antigen Specific PRN continuous 0.00-0.53-0.06 p=0.089 *
Antigen Specific PT continuous 0.00-0.390.08 p=0.637 ns
Antigen Specific TT continuous 0.00-0.020.47 p=0.293 ns
Unsupervised RClust1 continuous 0.00-0.50-0.09 p=0.069 **
Unsupervised RClust2 continuous 0.00-0.170.23 p=0.853 ns
Unsupervised RClust3 continuous 0.00-0.350.16 p=0.722 ns
Unsupervised RClust4 continuous 0.00-0.170.14 p=0.853 ns
Unsupervised RClust5 continuous 0.00-0.200.14 p=0.853 ns
Unsupervised RClust6 continuous 0.00-0.150.29 p=0.722 ns
Unsupervised RClust7 continuous 0.00-0.250.10 p=0.684 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

maternal_age_at_delivery

Visit: vaccinated

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.06 p=0.735 ns
Antigen Specific FHA continuous 0.00-0.160.01 p=0.635 ns
Antigen Specific PRN continuous 0.00-0.050.13 p=0.686 ns
Antigen Specific PT continuous 0.00-0.140.05 p=0.686 ns
Antigen Specific TT continuous 0.00-0.090.10 p=0.928 ns
Unsupervised RClust1 continuous 0.00-0.130.04 p=0.686 ns
Unsupervised RClust2 continuous 0.00-0.120.05 p=0.686 ns
Unsupervised RClust3 continuous 0.00-0.100.01 p=0.635 ns
Unsupervised RClust4 continuous 0.00-0.050.11 p=0.686 ns
Unsupervised RClust5 continuous 0.00-0.100.13 p=0.861 ns
Unsupervised RClust6 continuous 0.00-0.030.06 p=0.706 ns
Unsupervised RClust7 continuous 0.00-0.020.10 p=0.686 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, FHA_ADNP, PRN_ADNP, FHA_FcgR2a, FHA_FcgR3b, DT_IgG, DT_IgG1, FHA_IgG1
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 TT_ADCP, PT_ADNP, TT_ADNP, DT_FcgR2a, TT_FcgR2a, DT_FcgR3b, TT_FcgR3b, TT_IgG, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_6 DT_ADNP, PT_IgG2
Cluster_7 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.03 p=0.748 ns
Antigen Specific FHA continuous 0.00-0.010.08 p=0.656 ns
Antigen Specific PRN continuous 0.00-0.050.03 p=0.925 ns
Antigen Specific PT continuous 0.00-0.070.02 p=0.656 ns
Antigen Specific TT continuous 0.00-0.050.04 p=0.925 ns
Unsupervised RClust1 continuous 0.00-0.080.02 p=0.656 ns
Unsupervised RClust2 continuous 0.00-0.040.01 p=0.656 ns
Unsupervised RClust3 continuous 0.00-0.040.06 p=0.925 ns
Unsupervised RClust4 continuous 0.00-0.030.04 p=0.925 ns
Unsupervised RClust5 continuous 0.00-0.010.09 p=0.656 ns
Unsupervised RClust6 continuous 0.00-0.030.04 p=0.925 ns
Unsupervised RClust7 continuous 0.00-0.020.06 p=0.656 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.06 p=0.674 ns
Antigen Specific FHA continuous 0.00-0.160.01 p=0.582 ns
Antigen Specific PRN continuous 0.00-0.050.13 p=0.674 ns
Antigen Specific PT continuous 0.00-0.140.05 p=0.674 ns
Antigen Specific TT continuous 0.00-0.090.10 p=0.928 ns
Unsupervised RClust1 continuous 0.00-0.170.09 p=0.674 ns
Unsupervised RClust2 continuous 0.00-0.120.05 p=0.674 ns
Unsupervised RClust3 continuous 0.00-0.100.01 p=0.582 ns
Unsupervised RClust4 continuous 0.00-0.050.11 p=0.674 ns
Unsupervised RClust5 continuous 0.00-0.030.06 p=0.674 ns
Unsupervised RClust6 continuous 0.00-0.020.10 p=0.674 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, TT_ADCD, TT_ADCP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP, DT_FcgR2a, FHA_FcgR2a, TT_FcgR2a, DT_FcgR3b, FHA_FcgR3b, TT_FcgR3b, DT_IgG, TT_IgG, DT_IgG1, FHA_IgG1, TT_IgG1, DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_2 PT_ADCD, PT_ADCP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_3 DT_ADCP, FHA_ADCP, FHA_IgG, DT_IgG2, FHA_IgG2, TT_IgG2
Cluster_4 PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG, PRN_IgG1, PRN_IgG2
Cluster_5 DT_ADNP, PT_IgG2
Cluster_6 DT_IgG4, FHA_IgG4, PRN_IgG4, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.07 p=0.799 ns
Antigen Specific FHA continuous 0.00-0.010.08 p=0.780 ns
Antigen Specific PRN continuous 0.00-0.050.03 p=0.925 ns
Antigen Specific PT continuous 0.00-0.020.07 p=0.780 ns
Antigen Specific TT continuous 0.00-0.040.05 p=0.925 ns
Unsupervised RClust1 continuous 0.00-0.090.03 p=0.780 ns
Unsupervised RClust2 continuous 0.00-0.040.01 p=0.780 ns
Unsupervised RClust3 continuous 0.00-0.040.06 p=0.925 ns
Unsupervised RClust4 continuous 0.00-0.030.04 p=0.925 ns
Unsupervised RClust5 continuous 0.00-0.030.04 p=0.925 ns
Unsupervised RClust6 continuous 0.00-0.020.06 p=0.780 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.080.05 p=0.982 ns
Antigen Specific FHA continuous 0.00-0.030.12 p=0.982 ns
Antigen Specific PRN continuous 0.00-0.070.07 p=0.982 ns
Antigen Specific PT continuous 0.00-0.090.08 p=0.982 ns
Antigen Specific TT continuous 0.00-0.060.10 p=0.982 ns
Unsupervised RClust1 continuous 0.00-0.150.15 p=0.982 ns
Unsupervised RClust3 continuous 0.00-0.060.03 p=0.982 ns
Unsupervised RClust4 continuous 0.00-0.030.11 p=0.982 ns
Unsupervised RClust5 continuous 0.00-0.050.05 p=0.982 ns
Unsupervised RClust7 continuous 0.00-0.040.05 p=0.982 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 FHA_ADCP, PRN_ADCP
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.06 p=0.950 ns
Antigen Specific FHA continuous 0.000.000.10 p=0.414 *
Antigen Specific PRN continuous 0.00-0.050.05 p=0.986 ns
Antigen Specific PT continuous 0.00-0.070.02 p=0.781 ns
Antigen Specific TT continuous 0.00-0.040.05 p=0.950 ns
Unsupervised RClust1 continuous 0.00-0.090.03 p=0.781 ns
Unsupervised RClust3 continuous 0.00-0.040.03 p=0.950 ns
Unsupervised RClust4 continuous 0.00-0.070.02 p=0.781 ns
Unsupervised RClust5 continuous 0.00-0.030.03 p=0.950 ns
Unsupervised RClust7 continuous 0.00-0.020.05 p=0.781 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.080.05 p=0.982 ns
Antigen Specific FHA continuous 0.00-0.030.12 p=0.982 ns
Antigen Specific PRN continuous 0.00-0.070.07 p=0.982 ns
Antigen Specific PT continuous 0.00-0.090.08 p=0.982 ns
Antigen Specific TT continuous 0.00-0.060.10 p=0.982 ns
Unsupervised RClust1 continuous 0.00-0.150.15 p=0.982 ns
Unsupervised RClust2 continuous 0.00-0.040.06 p=0.982 ns
Unsupervised RClust3 continuous 0.00-0.060.03 p=0.982 ns
Unsupervised RClust4 continuous 0.00-0.030.11 p=0.982 ns
Unsupervised RClust6 continuous 0.00-0.040.05 p=0.982 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_5 PRN_ADNP
Cluster_6 PRN_IgG2, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.040.06 p=0.950 ns
Antigen Specific FHA continuous 0.000.000.10 p=0.414 *
Antigen Specific PRN continuous 0.00-0.050.05 p=0.986 ns
Antigen Specific PT continuous 0.00-0.070.02 p=0.618 ns
Antigen Specific TT continuous 0.00-0.040.05 p=0.950 ns
Unsupervised RClust1 continuous 0.00-0.090.03 p=0.651 ns
Unsupervised RClust2 continuous 0.00-0.060.01 p=0.618 ns
Unsupervised RClust3 continuous 0.00-0.040.03 p=0.950 ns
Unsupervised RClust4 continuous 0.00-0.070.02 p=0.618 ns
Unsupervised RClust6 continuous 0.00-0.020.05 p=0.651 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.080.05 p=0.873 ns
Antigen Specific FHA continuous 0.00-0.120.03 p=0.873 ns
Antigen Specific PRN continuous 0.00-0.070.07 p=0.983 ns
Antigen Specific PT continuous 0.00-0.080.09 p=0.983 ns
Antigen Specific TT continuous 0.00-0.100.06 p=0.873 ns
Unsupervised RClust1 continuous 0.00-0.150.15 p=0.983 ns
Unsupervised RClust2 continuous 0.00-0.040.06 p=0.873 ns
Unsupervised RClust3 continuous 0.00-0.030.06 p=0.873 ns
Unsupervised RClust4 continuous 0.00-0.090.03 p=0.873 ns
Unsupervised RClust5 continuous 0.00-0.110.03 p=0.873 ns
Unsupervised RClust6 continuous 0.00-0.020.06 p=0.873 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP, PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.060.04 p=0.941 ns
Antigen Specific FHA continuous 0.00-0.100.00 p=0.461 *
Antigen Specific PRN continuous 0.00-0.050.05 p=0.948 ns
Antigen Specific PT continuous 0.00-0.070.02 p=0.661 ns
Antigen Specific TT continuous 0.00-0.050.04 p=0.941 ns
Unsupervised RClust1 continuous 0.00-0.030.09 p=0.753 ns
Unsupervised RClust2 continuous 0.00-0.010.06 p=0.661 ns
Unsupervised RClust3 continuous 0.00-0.040.03 p=0.941 ns
Unsupervised RClust4 continuous 0.00-0.060.02 p=0.753 ns
Unsupervised RClust5 continuous 0.00-0.070.02 p=0.661 ns
Unsupervised RClust6 continuous 0.00-0.030.04 p=0.941 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.080.05 p=0.873 ns
Antigen Specific FHA continuous 0.00-0.120.03 p=0.873 ns
Antigen Specific PRN continuous 0.00-0.070.07 p=0.983 ns
Antigen Specific PT continuous 0.00-0.080.09 p=0.983 ns
Antigen Specific TT continuous 0.00-0.100.06 p=0.873 ns
Unsupervised RClust1 continuous 0.00-0.150.15 p=0.983 ns
Unsupervised RClust2 continuous 0.00-0.040.06 p=0.873 ns
Unsupervised RClust3 continuous 0.00-0.030.06 p=0.873 ns
Unsupervised RClust4 continuous 0.00-0.090.03 p=0.873 ns
Unsupervised RClust5 continuous 0.00-0.110.03 p=0.873 ns
Unsupervised RClust7 continuous 0.00-0.020.07 p=0.873 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_FcgR3b, DT_IgG1, DT_IgG3, FHA_ADCD, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG1, FHA_IgG3, PRN_ADCD, PRN_FcgR2a, PRN_FcgR3b, PRN_IgG1, PRN_IgG3, PT_ADCD, PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG1, PT_IgG3, TT_ADCD, TT_ADCP, TT_ADNP, TT_FcgR2a, TT_FcgR3b, TT_IgG1, TT_IgG3
Cluster_2 DT_ADCP, FHA_ADCP, PRN_ADCP
Cluster_3 DT_ADNP, PT_IgG2
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PRN_IgG4, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PT_IgG4, TT_IgG2, TT_IgG4
Cluster_6 PRN_ADNP
Cluster_7 PRN_IgG2, PT_IgG
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.060.04 p=0.941 ns
Antigen Specific FHA continuous 0.00-0.100.00 p=0.461 *
Antigen Specific PRN continuous 0.00-0.050.05 p=0.948 ns
Antigen Specific PT continuous 0.00-0.070.02 p=0.661 ns
Antigen Specific TT continuous 0.00-0.050.04 p=0.941 ns
Unsupervised RClust1 continuous 0.00-0.030.09 p=0.753 ns
Unsupervised RClust2 continuous 0.00-0.010.06 p=0.661 ns
Unsupervised RClust3 continuous 0.00-0.040.03 p=0.941 ns
Unsupervised RClust4 continuous 0.00-0.060.02 p=0.753 ns
Unsupervised RClust5 continuous 0.00-0.070.02 p=0.661 ns
Unsupervised RClust7 continuous 0.00-0.030.04 p=0.941 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Visit: boosted

Not Standardized - IgG included

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.060.07 p=0.910 ns
Antigen Specific FHA continuous 0.000.000.17 p=0.432 ns
Antigen Specific PRN continuous 0.00-0.110.06 p=0.910 ns
Antigen Specific PT continuous 0.00-0.080.08 p=0.910 ns
Antigen Specific TT continuous 0.00-0.090.04 p=0.910 ns
Unsupervised RClust1 continuous 0.00-0.120.04 p=0.910 ns
Unsupervised RClust2 continuous 0.00-0.050.06 p=0.910 ns
Unsupervised RClust3 continuous 0.00-0.010.15 p=0.432 ns
Unsupervised RClust4 continuous 0.00-0.060.10 p=0.910 ns
Unsupervised RClust5 continuous 0.00-0.090.07 p=0.910 ns
Unsupervised RClust6 continuous 0.00-0.080.06 p=0.910 ns
Unsupervised RClust7 continuous 0.00-0.040.10 p=0.910 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, FHA_IgG1
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_7 TT_IgG, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.07 p=0.745 ns
Antigen Specific FHA continuous 0.00-0.040.04 p=0.971 ns
Antigen Specific PRN continuous 0.00-0.060.03 p=0.745 ns
Antigen Specific PT continuous 0.00-0.070.02 p=0.745 ns
Antigen Specific TT continuous 0.00-0.060.04 p=0.745 ns
Unsupervised RClust1 continuous 0.00-0.060.02 p=0.745 ns
Unsupervised RClust2 continuous 0.00-0.030.06 p=0.745 ns
Unsupervised RClust3 continuous 0.00-0.050.02 p=0.745 ns
Unsupervised RClust4 continuous 0.00-0.030.05 p=0.776 ns
Unsupervised RClust5 continuous 0.00-0.060.01 p=0.745 ns
Unsupervised RClust6 continuous 0.00-0.020.07 p=0.745 ns
Unsupervised RClust7 continuous 0.000.000.09 p=0.745 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.060.07 p=0.910 ns
Antigen Specific FHA continuous 0.000.000.17 p=0.511 ns
Antigen Specific PRN continuous 0.00-0.110.06 p=0.910 ns
Antigen Specific PT continuous 0.00-0.080.08 p=0.910 ns
Antigen Specific TT continuous 0.00-0.090.04 p=0.910 ns
Unsupervised RClust1 continuous 0.00-0.120.04 p=0.910 ns
Unsupervised RClust2 continuous 0.00-0.050.06 p=0.910 ns
Unsupervised RClust3 continuous 0.00-0.010.17 p=0.511 ns
Unsupervised RClust4 continuous 0.00-0.060.10 p=0.910 ns
Unsupervised RClust5 continuous 0.00-0.090.07 p=0.910 ns
Unsupervised RClust6 continuous 0.00-0.080.06 p=0.910 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, FHA_ADCD, PRN_ADCD, PT_ADCD, TT_ADCD, DT_FcgR2a, TT_FcgR2a
Cluster_2 DT_ADCP, DT_ADNP, PRN_ADNP, TT_ADNP, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_3 FHA_ADCP, TT_ADCP, FHA_ADNP, FHA_FcgR2a, FHA_FcgR3b, FHA_IgG, TT_IgG, FHA_IgG1, TT_IgG1, FHA_IgG2, TT_IgG2, DT_IgG3, FHA_IgG3, PT_IgG3, TT_IgG3, FHA_IgG4
Cluster_4 PRN_ADCP, PRN_FcgR2a, DT_FcgR3b, PRN_FcgR3b, TT_FcgR3b, PRN_IgG, PRN_IgG1
Cluster_5 PT_ADCP, PT_ADNP, PT_FcgR2a, PT_FcgR3b, PT_IgG, PT_IgG1
Cluster_6 DT_IgG, DT_IgG1, DT_IgG2, PRN_IgG2, PRN_IgG3, DT_IgG4, PRN_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.030.07 p=0.758 ns
Antigen Specific FHA continuous 0.00-0.040.04 p=0.971 ns
Antigen Specific PRN continuous 0.00-0.060.03 p=0.758 ns
Antigen Specific PT continuous 0.00-0.070.02 p=0.758 ns
Antigen Specific TT continuous 0.00-0.060.04 p=0.758 ns
Unsupervised RClust1 continuous 0.00-0.060.02 p=0.758 ns
Unsupervised RClust2 continuous 0.00-0.030.06 p=0.758 ns
Unsupervised RClust3 continuous 0.00-0.080.04 p=0.758 ns
Unsupervised RClust4 continuous 0.00-0.030.05 p=0.783 ns
Unsupervised RClust5 continuous 0.00-0.060.01 p=0.758 ns
Unsupervised RClust6 continuous 0.00-0.020.07 p=0.758 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG excluded

7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.09 p=0.661 ns
Antigen Specific FHA continuous 0.00-0.030.10 p=0.661 ns
Antigen Specific PRN continuous 0.00-0.050.07 p=0.844 ns
Antigen Specific PT continuous 0.00-0.050.07 p=0.838 ns
Antigen Specific TT continuous 0.00-0.030.08 p=0.661 ns
Unsupervised RClust1 continuous 0.00-0.040.13 p=0.661 ns
Unsupervised RClust2 continuous 0.00-0.070.05 p=0.838 ns
Unsupervised RClust3 continuous 0.00-0.100.06 p=0.838 ns
Unsupervised RClust4 continuous 0.00-0.110.03 p=0.661 ns
Unsupervised RClust5 continuous 0.00-0.070.03 p=0.661 ns
Unsupervised RClust6 continuous 0.00-0.110.01 p=0.661 ns
Unsupervised RClust7 continuous 0.00-0.060.08 p=0.838 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_7 FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.03 p=0.798 ns
Antigen Specific FHA continuous 0.00-0.030.07 p=0.723 ns
Antigen Specific PRN continuous 0.00-0.060.04 p=0.851 ns
Antigen Specific PT continuous 0.00-0.020.08 p=0.680 ns
Antigen Specific TT continuous 0.00-0.040.06 p=0.851 ns
Unsupervised RClust1 continuous 0.00-0.060.03 p=0.798 ns
Unsupervised RClust2 continuous 0.00-0.060.02 p=0.680 ns
Unsupervised RClust3 continuous 0.00-0.040.06 p=0.845 ns
Unsupervised RClust4 continuous 0.00-0.010.06 p=0.680 ns
Unsupervised RClust5 continuous 0.000.000.06 p=0.680 ns
Unsupervised RClust6 continuous 0.00-0.060.01 p=0.680 ns
Unsupervised RClust7 continuous 0.00-0.040.04 p=0.935 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.010.09 p=0.707 ns
Antigen Specific FHA continuous 0.00-0.030.10 p=0.707 ns
Antigen Specific PRN continuous 0.00-0.050.07 p=0.928 ns
Antigen Specific PT continuous 0.00-0.050.07 p=0.912 ns
Antigen Specific TT continuous 0.00-0.030.08 p=0.707 ns
Unsupervised RClust1 continuous 0.00-0.040.13 p=0.707 ns
Unsupervised RClust2 continuous 0.00-0.070.05 p=0.912 ns
Unsupervised RClust3 continuous 0.00-0.100.06 p=0.912 ns
Unsupervised RClust4 continuous 0.00-0.110.03 p=0.707 ns
Unsupervised RClust5 continuous 0.00-0.070.07 p=0.949 ns
Unsupervised RClust6 continuous 0.00-0.110.01 p=0.707 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.070.03 p=0.731 ns
Antigen Specific FHA continuous 0.00-0.030.07 p=0.678 ns
Antigen Specific PRN continuous 0.00-0.060.04 p=0.780 ns
Antigen Specific PT continuous 0.00-0.020.08 p=0.678 ns
Antigen Specific TT continuous 0.00-0.040.06 p=0.780 ns
Unsupervised RClust1 continuous 0.00-0.060.03 p=0.731 ns
Unsupervised RClust2 continuous 0.00-0.060.02 p=0.678 ns
Unsupervised RClust3 continuous 0.00-0.040.06 p=0.775 ns
Unsupervised RClust4 continuous 0.00-0.010.06 p=0.678 ns
Unsupervised RClust5 continuous 0.00-0.020.06 p=0.678 ns
Unsupervised RClust6 continuous 0.00-0.060.01 p=0.678 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns

Standardized by Total IgG - IgG included

6 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.01 p=0.725 ns
Antigen Specific FHA continuous 0.00-0.030.10 p=0.919 ns
Antigen Specific PRN continuous 0.00-0.050.07 p=0.936 ns
Antigen Specific PT continuous 0.00-0.070.05 p=0.919 ns
Antigen Specific TT continuous 0.00-0.040.07 p=0.919 ns
Unsupervised RClust1 continuous 0.00-0.120.05 p=0.919 ns
Unsupervised RClust2 continuous 0.00-0.050.07 p=0.919 ns
Unsupervised RClust3 continuous 0.00-0.100.06 p=0.919 ns
Unsupervised RClust4 continuous 0.00-0.060.08 p=0.919 ns
Unsupervised RClust5 continuous 0.00-0.070.07 p=0.949 ns
Unsupervised RClust6 continuous 0.00-0.010.11 p=0.725 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
6 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, DT_IgG1, FHA_ADCD, FHA_IgG1, PRN_ADCD, PRN_IgG1, PT_ADCD, PT_FcgR2a, PT_IgG1, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG1, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_6 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.050.05 p=0.893 ns
Antigen Specific FHA continuous 0.00-0.070.02 p=0.581 ns
Antigen Specific PRN continuous 0.00-0.060.04 p=0.844 ns
Antigen Specific PT continuous 0.00-0.020.08 p=0.581 ns
Antigen Specific TT continuous 0.00-0.030.07 p=0.581 ns
Unsupervised RClust1 continuous 0.00-0.020.12 p=0.581 ns
Unsupervised RClust2 continuous 0.00-0.020.06 p=0.581 ns
Unsupervised RClust3 continuous 0.00-0.060.04 p=0.844 ns
Unsupervised RClust4 continuous 0.00-0.030.04 p=0.844 ns
Unsupervised RClust5 continuous 0.00-0.060.02 p=0.581 ns
Unsupervised RClust6 continuous 0.00-0.060.01 p=0.581 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC1

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.090.01 p=0.791 ns
Antigen Specific FHA continuous 0.00-0.030.10 p=0.819 ns
Antigen Specific PRN continuous 0.00-0.050.07 p=0.929 ns
Antigen Specific PT continuous 0.00-0.070.05 p=0.902 ns
Antigen Specific TT continuous 0.00-0.040.07 p=0.902 ns
Unsupervised RClust1 continuous 0.00-0.130.04 p=0.819 ns
Unsupervised RClust2 continuous 0.00-0.050.07 p=0.902 ns
Unsupervised RClust3 continuous 0.00-0.100.06 p=0.902 ns
Unsupervised RClust4 continuous 0.00-0.060.08 p=0.902 ns
Unsupervised RClust5 continuous 0.00-0.030.11 p=0.819 ns
Unsupervised RClust6 continuous 0.00-0.070.07 p=0.949 ns
Unsupervised RClust7 continuous 0.00-0.010.11 p=0.791 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
7 clusters - PC2

Unsupervised Cluster Contents
name contents
Cluster_1 DT_ADCD, DT_FcgR2a, FHA_ADCD, PRN_ADCD, PT_ADCD, PT_FcgR2a, TT_ADCD, TT_ADCP, TT_FcgR2a, TT_IgG2
Cluster_2 DT_ADCP, DT_ADNP, FHA_ADNP, PRN_ADNP, PT_ADNP, TT_ADNP
Cluster_3 DT_FcgR3b, FHA_ADCP, FHA_FcgR2a, FHA_FcgR3b, PRN_ADCP, PRN_FcgR2a, PRN_FcgR3b, PT_ADCP, PT_FcgR3b, TT_FcgR3b
Cluster_4 DT_IgG, FHA_IgG, PRN_IgG, PT_IgG, TT_IgG
Cluster_5 DT_IgG1, FHA_IgG1, PRN_IgG1, PT_IgG1, TT_IgG1
Cluster_6 DT_IgG2, DT_IgG4, FHA_IgG2, FHA_IgG4, PRN_IgG2, PRN_IgG4, PT_IgG2, PT_IgG4, TT_IgG4
Cluster_7 DT_IgG3, FHA_IgG3, PRN_IgG3, PT_IgG3, TT_IgG3
Cluster_Type Feature Referent estimate P-Value
Antigen Specific DT continuous 0.00-0.050.05 p=0.893 ns
Antigen Specific FHA continuous 0.00-0.020.07 p=0.634 ns
Antigen Specific PRN continuous 0.00-0.060.04 p=0.837 ns
Antigen Specific PT continuous 0.00-0.020.08 p=0.634 ns
Antigen Specific TT continuous 0.00-0.030.07 p=0.634 ns
Unsupervised RClust1 continuous 0.00-0.060.03 p=0.798 ns
Unsupervised RClust2 continuous 0.00-0.020.06 p=0.634 ns
Unsupervised RClust3 continuous 0.00-0.060.04 p=0.837 ns
Unsupervised RClust4 continuous 0.00-0.030.04 p=0.837 ns
Unsupervised RClust5 continuous 0.00-0.010.06 p=0.634 ns
Unsupervised RClust6 continuous 0.00-0.060.02 p=0.634 ns
Unsupervised RClust7 continuous 0.00-0.060.01 p=0.634 ns

Cluster_Type Feature Referent Contrast estimate P-Value
Unsupervised RClust1 1 2+ 0.00-0.270.70 p=0.904 ns
Unsupervised RClust2 1 2+ 0.00-0.290.62 p=0.904 ns
Unsupervised RClust3 1 2+ 0.00-0.770.39 p=0.904 ns
Unsupervised RClust4 1 2+ 0.00-0.280.41 p=0.995 ns
Unsupervised RClust5 1 2+ 0.00-0.410.37 p=0.995 ns
Unsupervised RClust6 1 2+ 0.00-0.690.30 p=0.904 ns
Unsupervised RClust7 1 2+ 0.00-0.400.40 p=0.995 ns
 

sessionInfo()
R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/New_York
tzcode source: internal

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] RColorBrewer_1.1-3 rstatix_0.7.2      lubridate_1.9.2    forcats_1.0.0     
 [5] purrr_1.0.1        readr_2.1.4        tidyverse_2.0.0    stringr_1.5.0     
 [9] tibble_3.2.1       tidyr_1.3.0        data.table_1.14.8  pBrackets_1.0.1   
[13] htmltools_0.5.8    plotly_4.10.4      cowplot_1.1.1      ggtext_0.1.2      
[17] ggridges_0.5.6     ggfortify_0.4.16   ggpubr_0.6.0       gtExtras_0.5.0    
[21] ggExtra_0.10.1     ggrepel_0.9.3      ggplot2_3.4.4      gt_0.10.1         
[25] gdata_2.19.0       tidyquery_0.2.4    DT_0.28            DBI_1.1.3         
[29] RPostgres_1.4.5    scales_1.3.0       dplyr_1.1.2        here_1.0.1        
[33] workflowr_1.7.1   

loaded via a namespace (and not attached):
 [1] gridExtra_2.3     rematch2_2.1.2    rlang_1.1.1       magrittr_2.0.3   
 [5] git2r_0.32.0      compiler_4.3.1    getPass_0.2-2     systemfonts_1.0.5
 [9] callr_3.7.5       vctrs_0.6.3       pkgconfig_2.0.3   fastmap_1.1.1    
[13] backports_1.4.1   ellipsis_0.3.2    labeling_0.4.3    fontawesome_0.5.2
[17] utf8_1.2.3        promises_1.2.0.1  rmarkdown_2.25    markdown_1.11    
[21] tzdb_0.4.0        ps_1.7.5          ragg_1.2.6        bit_4.0.5        
[25] xfun_0.45         cachem_1.0.8      jsonlite_1.8.7    blob_1.2.4       
[29] highr_0.11        later_1.3.1       broom_1.0.5       R6_2.5.1         
[33] bslib_0.7.0       stringi_1.7.12    car_3.1-2         jquerylib_0.1.4  
[37] Rcpp_1.0.11       knitr_1.47        httpuv_1.6.11     timechange_0.2.0 
[41] tidyselect_1.2.0  rstudioapi_0.15.0 abind_1.4-5       yaml_2.3.7       
[45] miniUI_0.1.1.1    processx_3.8.2    shiny_1.7.4.1     withr_3.0.0      
[49] evaluate_0.23     xml2_1.3.5        pillar_1.9.0      carData_3.0-5    
[53] whisker_0.4.1     generics_0.1.3    rprojroot_2.0.4   paletteer_1.6.0  
[57] hms_1.1.3         commonmark_1.9.0  munsell_0.5.0     gtools_3.9.4     
[61] xtable_1.8-4      glue_1.6.2        lazyeval_0.2.2    tools_4.3.1      
[65] ggsignif_0.6.4    fs_1.6.3          grid_4.3.1        colorspace_2.1-0 
[69] cli_3.6.1         queryparser_0.3.2 textshaping_0.3.7 fansi_1.0.4      
[73] viridisLite_0.4.2 svglite_2.1.2     gtable_0.3.4      sass_0.4.9       
[77] digest_0.6.33     farver_2.1.1      htmlwidgets_1.6.2 lifecycle_1.0.4  
[81] httr_1.4.7        mime_0.12         gridtext_0.1.5    bit64_4.0.5