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--- guides:ppintro [2013/06/01 22:21]
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-The basic phase precession phenomenon is apparent when you look at the timing of place cell spikes relative to the hippocampal theta rhythm:
-{{ :guides:sm_rwc_mvdm_fig1.png?600 |}}
-(Figure from Malhotra et al. 2012) Each spike is assigned a color based on the /phase/ of the theta rhythm (a component of the LFP or "local field potential") at which it occurs. Note the smooth color change as the animal runs through the place field.
-Thus, when looking at a typical place cell like the above, phase precession manifests as (1) a relationship between *location* on the maze and the theta phase of a place cell's spikes, as shown when plotting spikes "in space" and (2) a relationship between *time* and the theta phase of a place cell's spikes, as shown when plotting spikes "in time" aligned to the LFP.
-When a rat runs through a place field, space and time will be correlated, so it is not a priori clear if either one is somehow "primary". There are numerous papers that explore this issue.
-An important conceptual step is to extend this idea to what happens in a population of place cells which are all phase precessing:
-{{ :guides:skaggs_mcnaughton_pp.png?600 |}}
-(Figure from Skaggs & McNaughton 1996, which is well worth reading)
-Note how in each theta cycle, there is now a *sequence* of place cells occurring!